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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： anthony Procès Sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Burrowing Richardson's ground squirrels affect plant seedling assemblages via environmental but not seed bank changes

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Current Zoology 2020年第3期66卷 219-226页

作者： levi j.Newediuk james f.Hare Department of Biological Sciences University of ManitobaWinnipegManitobaCanada R3T 2N2

In grassland ecosystems,burrowing mammals create disturbances,providing habitat for animal species and increasing plant community *** investigated whether seedling assemblages on Richardson's ground squirrel Urocitellus richardsonii mounds result from seed rearrangement or environmental changes that favor germination of certain species over *** test whether ground squirrels rearrange the seed bank by burrowing,we compared seed compositions among mounds,burrows,and undisturbed *** test whether ground squirrels change environmental conditions,we compared soil nitrate and bare ground cover on and off *** also compared seedlings that germinated on mounds with seedlings that germinated on artificial disturbances from which we removed aboveground *** nitrate and bare ground cover were significantly higher on mounds than artificial *** seed richness and abundance did not differ among mounds,burrows,and undisturbed soil,seedling richness was reduced on mounds relative to artificial *** disturbance favors seedlings that can capitalize on bare ground availability but are less able to immobilize nitrate,as opposed to perennial species that immobilize more nitrate but take longer to *** results suggest that Richardson's ground squirrels act as ecosystem engineers,although future research following succession on ground squirrel mounds is necessary to understand how they influence plant communities past the seedling stage.

关键词： burrowing disturbance ecosystem engineering Richardsons ground squirrel seed bank seedling species composition

Molecular nature of sulfhydryl modification by hydrogen peroxide on type 1 ryanodine receptor

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Acta Pharmacologica Sinica 2006年第7期27卷 888-894页

作者： anthony f LAI Cardiff Cf14 4XN Cardiff University UK Wales Heart Research Institute Wales College of Medicine

Aim:To elucidate the molecular nature of sulfhydryl modification by hydrogenperoxide on type 1 ryanodine receptor(RyR1).Methods:Rabbit skeletal musclesarcoplasmic reticulum was treated with hydrogen peroxide,then RyR1 complexwas *** proteins in the complex were analysed by electrophoresis,Western blot and electron ***:(1)Hydrogen peroxide inducesinter-subunit cross-linking within the tetrameric RyR1 molecule;(2)in parallel tointer-subunit cross-linking,the RyR1 molecule changes morphology;(3)the chemi-cal and morphological changes are reversible:upon reduction by reducing agents,the RyR1 molecule regains its original ***:These findings suggestthat the molecular mechanism of RyR1 channel activity in sarcoplasmic reticulumregulated by hydrogen peroxide is through inter-subunit cross-linking within thetetrameric RyR1 molecule,which in turn induces structural changes of RyR1.

关键词： Ca2+ release channel/ryanodine receptor hydrogen peroxide reactive oxygen redoxsensitive ion channel

Patent Citations Analysis and Its Value in Research Evaluation： A Review and a New Approach to Map Technology-relevant Research

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journal of Data and Information Science 2017年第1期2卷 13-50页

作者： anthony f.j. van Raan Centre for Science and Technology Studies (CWTS) Leiden University Leiden the Netherlands

Purpose： first, to review the state-of-the-art in patent citation analysis, particularly characteristics of patent citations to scientific literature （scientific non-patent references, SNPRs）. Second, to present a novel mapping approach to identify technology-relevant research based on the papers cited by and referring to the SNPRs. Design/methodology/approach： In the review part we discuss the context of SNPRs such as the time lags between scientific achievements and inventions. Also patent-to-patent citation is addressed particularly because this type of patent citation analysis is a major element in the assessment of the economic value of patents. We also review the research on the role of universities and researchers in technological development, with important issues such as universities as sources of technological knowledge and inventor-author relations. We conclude the review part of this paper with an overview of recent research on mapping and network analysis of the science and technology interface and of technological progress in interaction with science. In the second part we apply new techniques for the direct visualization of the cited and citing relations of SNPRs, the mapping of the landscape around SNPRs by bibliographic coupling and co-citation analysis, and the mapping of the conceptual environment of SNPRs by keyword co-occurrence analysis. findings： We discuss several properties of SNPRs. Only a small minority of publications covered by the Web of Science or Scopus are cited by patents, about 3%-4%. However, for publications based on university-industry collaboration the number of SNPRs is considerably higher, around 15%. The proposed mapping methodology based on a ＂second order SNPR approach＂ enables a better assessment of the technological relevance of research. Research limitations： The main limitation is that a more advanced merging of patent and publication data, in particular unification of author and inventor names, in still a necessity. P

关键词： Patent citations Scientific non-patent references Inventor-author relations Bibliometric mapping Science and technology interface Research evaluation Technologyrelevant publications

Emerging neuromodulatory molecules for the treatment of neurogenic erectile dysfunction caused by cavernous nerve injury

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Asian journal of Andrology 2008年第1期10卷 54-59页

作者： anthony j. Bella Guiting Lin Ilias Cagiannos Tom f. Lue Department of Surgery Division of UrologyUniversity of Ottawa Ottawa KIY4E9 Canada Department of Neuroscience Ottawa Health Research Institute University of Ottawa Ottawa KIY4E9 Canada Knuppe Molecular Urology Laboratory San francisco CA 94143 USA Department of Urology University of California San Francisco CA 94143 USA

Advances in the neurobiology of growth factors, neural development, and prevention of cell death have resulted in a heightened clinical interest for the development of protective and regenerative neuromodulatory strategies for the cavernous nerves （CNs）, as therapies for prostate cancer and other pelvic malignancies often result in neuronal damage and debilitating loss of sexual function. Nitric oxide released from the axonal end plates of these nerves within the corpora cavernosa causes relaxation of smooth muscle, initiating the haemodynamic changes of penile erection as well as contributing to maintained tumescence; the loss of CN function is primarily responsible for the development of erectile dysfunction （ED） after pelvic surgery and serves as the primary target for potential neuroprotective or regenerative strategies. Evidence from pre-clinical studies for select neuromodulatory approaches is reviewed, including neurotrophins, glial cell line-derived neurotrophic factors （GDNf）, bone morphogenic proteins, immunophilin ligands, erythropoetin （EPO）, and stem cells.

关键词： erectile dysfunction prostate cancer radical prostatectomy postoperative complications neuroprotection nerve regeneration neurotrophins brain-derived nerve growth factor immunophilin ligands stem cells

SIMULTANEOUS SAXS/WAXS/DSC STUDIES ON MICROSTRUCTURE Of CONVENTIONAL AND METALLOCENE-BASED ETHYLENE-BUTENE COPOLYMERS

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Chinese journal of Polymer Science 2004年第3期22卷 279-287页

作者：徐君庭 anthony j. Ryan Department of Polymer Science & Engineering Zhejiang University Hangzhou 310027 China Chemistry Department The University of Sheffield Sheffield S3 7HF UK

The fractions of one metallocene-based (mPE) and one conventional (znPE) ethylene-butene copolymer eluted at from temperature rising elution fractionation were selected for DSC and time-resolved small angle X-ray scattering (SAXS) and wide angle X-ray scattering (WAXS) characterization. The DSC and WAXS results show that two crystal structures exist in both mPE and znPE: structure A with higher melting temperature and structure B with lower melting temperature. It was found that original znPE (s-znPE) contains more highly ordered structure A than original mPE (s-mPE) in spite of the higher comonomer content of znPE. Another structure C is also identified because of higher crystallinity measured by WAXS than by DSC and is attributed to the interfacial region. The SAXS data were analyzed with correlation function and two maxima were observed in s-mPE and s-znPE, in agreement with the conclusion of two crystal populations drawn from DSC and WAXS results. These two crystal populations have close long periods in s-mPE, but very different long periods in s-znPE. In contrast, freshly crystallized mPE and znPE (f-mPE and f-znPE) contain only a single crystal population with a broader distribution of long period

关键词： SAXS WAXS Microstructure Metallocene Ethylene-butene copolymer

A nano-engineered graphene/carbon nitride hybrid for photocatalytic hydrogen evolution

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journal of Energy Chemistry 2016年第2期25卷 223-225页

作者： Xiaobo Li Yao Zheng anthony f.Masters Thomas Maschmeyer Laboratory of Advanced Catalysis for Sustainability School of ChemistryThe University of Sydney School of Chemical Engineering University of AdelaideAdelaide Australian Institute of Nanoscale Science and Technology The University of Sydney

A metal-free photocatalytic hydrogen evolution system was successfully fabricated using heteroatom doped graphene materials as electron-transfer co-catalysts and carbon nitride as a semiconductor. The catalytic role of graphene is significantly dependent on the heteroatom dopant of the graphene, such as O, S, B, N doped/undoped graphene co-catalysts, and N-graphene shows the best catalytic hydrogen evolution rate.

关键词： Carbon nitride Co-catalyst Graphene Hydrogen evolution Photocatalysis

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硅光子学的“最后一米”难题

科技纵览 2018年第9期 38-43页

作者： anthony f.j. levi

“光纤接入处理器”技术仍面临经济及物理挑战。如果你认为当今时代正处于技术革命的风口浪尖，那么请回想一下20世纪80年代中期，那时硅片使用的是微米级晶体管，光纤系统在世界各地以每秒钟数万亿比特的速度传送数据。综合硅数字逻辑... 详细信息

“光纤接入处理器”技术仍面临经济及物理挑战。如果你认为当今时代正处于技术革命的风口浪尖，那么请回想一下20世纪80年代中期，那时硅片使用的是微米级晶体管，光纤系统在世界各地以每秒钟数万亿比特的速度传送数据。综合硅数字逻辑、光电子学以及光纤通信技术的潜力，一切似乎皆有可能。

关键词：硅片光子学光纤通信技术技术革命光纤接入传送数据光纤系统数字逻辑

The integrated use of chemical insecticides and the entomopathogenic nematode, Steinemema carpocapsae （Nematoda： Steinernematidae）, for the control of sweetpotato whitefly, Bemisia tabaci （Hemiptera： Aleyrodidae）

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Insect Science 2008年第5期15卷 447-453页

作者： Andrew G. S. Cuthbertson james j. Mathers Phil Northing anthony j. Prickett Keith f. A. Waiters Central Science Laboratory Sand Hutton York YO41 1LZ UK

The integration of chemical insecticides and infective juveniles of the entomopathogenic nematode Steinernema carpocapsae （Wesier）（Nematoda： Steinernematidae）, to control second instars of the sweetpotato whitefly, Bemisia tabaci Gennadius （Hemiptera： Aleyrodidae） was investigated. Using a sand bioassay, the effects of direct exposure of S. carpocapsae for 24 h to field rate dilutions of four insecticides （spiromesifen, thiacloprid, imidacloprid and pymetrozine） on infectivity to Galleria mellonella larvae were tested. Although all chemicals tested, except spiromesifen, produced acceptable nematode infectivity rates, they were all significantly less than the water control. The effect of insecticide treatment （dry residues of spiromesifen, thiacloprid and pymetrozine and soil drench of imidacloprid） on the efficacy of the nematode against B. tabaci was also investigated. Nematodes in combination with thiacloprid and spiromesifen gave higher B. tabaci mortality （86.5% and 94.3% respectively） compared to using nematodes alone （75.2%） on tomato plants. There was no significant difference in B. tabaci mortality when using the chemicals imidacloprid, pymetrozine and spiromesifen in conjunction with nematodes compared to using the chemicals alone. However, using thiacloprid in combination with the nematodes produced significantly higher B. tabaci mortality than using the chemical alone. The integration of S. carpocapsae and these chemical agents into current integrated pest management programmes for the control of B. tabaci is discussed.

关键词： entomopathogenic nematode infectivity insecticide residue pest management