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Risk stratification for malignant progression in Barrett's esophagus: Gender, age, duration and year of surveillance

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World Journal of Gastroenterology 2016年第48期22卷 10592-10600页

作者： Piers Gatenby Santanu Bhattacharjee Christine Wall Christine Caygill anthony watson United Kingdom Barrett’s Oesophagus Registry UCL Regional Oesophagogastric Unit Royal Surrey County Hospital Department of Clinical and Experimental Medicine University of Surrey Division of Surgery and Interventional Science UCL Royal Free Campus

AIM To clarify risk based upon segment length, diagnostic histological findings, patient age and year of surveillance, duration of surveillance and *** Patients registered with the United Kingdom Barrett's Oesophagus Registry from 9 United Kingdom centers were included. The outcome measures were(1) development of all grades of dysplasia;(2) development of high-grade of dysplasia or adenocarcinoma; and(3) development of adenocarcinoma. Prevalent cases and subjects with < 1 year of follow-up were excluded. The covariates examined were segment length, previous biopsy findings, age at surveillance, duration of surveillance, year of surveillance and *** One thousand and one hundred thirty six patients were included(total 6474 patient-years). Fifty-four patients developed adenocarcinoma(0.83% per annum), 70 developed high-grade dysplasia/adenocarcinoma(1.1% per annum) and 190 developed any grade of dysplasia(3.5% per annum). High grade dysplasia and adenocarcinoma increased with age and duration of surveillance. The risk of low-grade dysplasia development was not dependent on age at surveillance. Segment length and previous biopsy findings were also significant factors for development of dysplasia and *** The risk of development of low-grade dysplasia is independent of age at surveillance, but high-grade dysplasia and adenocarcinoma were more commonly found at older age. Segment length and previous biopsy findings are also markers of risk. This study did not demonstrate stabilisation of the metaplastic segment with prolonged surveillance.

关键词： Dysplasia Barrett’s esophagus Esophageal neoplasms Public health Epidemiology Surveillance

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Lifetime risk of esophageal adenocarcinoma in patients with Barrett's esophagus

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World Journal of Gastroenterology 2014年第28期20卷 9611-9617页

作者： Piers Gatenby Christine Caygill Christine Wall Santanu Bhatacharjee James Ramus anthony watson Marc Winslet Division of Surgery and Interventional Science UCLLondonNW32QGUnited Kingdom

AIM:To investigate the lifetime risk of development of esophageal adenocarcinoma and/or high-grade dysplasia in patients diagnosed with Barrett’s ***:Data were extracted from the United Kingdom National Barrett’s Oesophagus Registry on date of diagnosis,patient age and gender of 7877 patients from who had been registered from 35 United Kingdom *** expectancy was evaluated from United Kingdom National Statistics data based upon gender and age at year at *** data were then used with published estimates of annual adenocarcinoma and high-grade dysplasia incidences from metaanalyses and large population-based studies to estimate overall lifetime risk of development of these study ***:The mean age at diagnosis of Barrett’s esophagus was 61.6 years in males and 67.3 years in *** mean life expectancy at diagnosis was23.1 years in males,20.7 years in females and 22.2years *** data from published meta-analyses,the lifetime risk of development of adenocarcinoma was between 1 in 8 and 1 in 14 and the lifetime risk of high-grade dysplasia or adenocarcinoma was 1 in 5 to1 in *** data from 3 large recent population-based cohort studies the lifetime risk of adenocarcinoma was between 1 in 10 and 1 in 37 and of the combined endpoint of high-grade dysplasia and adenocarcinoma was between 1 in 8 and 1 in *** at Barrett’s esophagus diagnosis is reducing and life expectancy is increasing,which will partially counter-balance lower annual cancer ***:There is a significant lifetime risk of development of high-grade dysplasia and adenocarcinoma in Barrett’s esophagus.

关键词： Barrett esophagus Esophageal neoplasms Forecasting Meta-analysis Cohort studies

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Towards 10 Gb/s orthogonal frequency division multiplexing-based visible light communication using a GaN violet micro-LED

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Photonics Research 2017年第2期5卷 35-43页

作者： MOHAMED SUFYAN ISLIM RICARDO X.FERREIRA XIANGYU HE ENYUAN XIE STEFAN VIDEV SHAUN VIOLA SCOTT watson NIKOLAOS BAMIEDAKIS RICHARD V.PENTY IAN H.WHITE anthony E.KELLY ERDAN GU HARALD HAAS MARTIN D.DAWSON Li–Fi R&D Centre the University of Edinburgh Institute for Digital Communications Institute of Photonics Department of Physics University of Strathclyde Institute for Digital Communications Li–Fi R&D Centre the University of Edinburgh School of Engineering University of Glasgow Centre for Advanced Photonics and Electronics Electrical Engineering Division Department of Engineering University of Cambridge

Visible light communication(VLC)is a promising solution to the increasing demands for wireless *** nitride micro-sized light emitting diodes(micro-LEDs)are strong candidates for VLC due to their high *** violet micro-LEDs are reported in this work with electrical-to-optical bandwidths up to 655 *** orthogonal frequency division multiplexing-based VLC system with adaptive bit and energy loading is demonstrated,and a data transmission rate of 11.95 Gb/s is achieved with a violet micro-LED,when the nonlinear distortion of the micro-LED is the dominant noise source of the VLC system.A record 7.91 Gb/s data transmission rate is reported below the forward error correction threshold using a single pixel of the segmented array when all the noise sources of the VLC system are present.

关键词： Towards 10 Gb/s orthogonal frequency division multiplexing-based visible light communication using a GaN violet micro-LED VLC OFDM LEDs

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Physical and toxicological profiles of human IAPP amyloids and plaques

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Science Bulletin 2019年第1期64卷 26-35页

作者： Aleksandr Kakinen Yunxiang Sun Ibrahim Javed Ava Faridi Emily H.Pilkington Pouya Faridi anthony W.Purcell Ruhong Zhou Feng Ding Sijie Lin Pu Chun Ke Thomas P.Davis ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical Sciences Monash University Department of Physics and Astronomy Clemson University College of Environmental Science and Engineering Shanghai Institute of Pollution Control and Ecological Security Biomedical Multidisciplinary Innovation Research Institute Shanghai East Hospital Tongji University Infection and Immunity Program & Department of Biochemistry and Molecular Biology Biomedicine Discovery Institute Monash University IBM Thomas J.watson Research Center Department of Chemistry Columbia University

Although much has been learned about the fibrillization kinetics, structure and toxicity of amyloid proteins, the properties of amyloid fibrils beyond the saturation phase are often perceived as chemically and biologically inert, despite evidence suggesting otherwise. To fill this knowledge gap, we examined the physical and biological characteristics of human islet amyloid polypeptide(IAPP) fibrils that were aged up to two months. Not only did aging decrease the toxicity of IAPP fibrils, but the fibrils also sequestered fresh IAPP and suppressed their toxicity in an embryonic zebrafish model. The mechanical properties of IAPP fibrils in different aging stages were probed by atomic force microscopy and sonication, which displayed comparable stiffness but age-dependent fragmentation, followed by self-assembly of such fragments into the largest lamellar amyloid structures reported to date. The dynamic structural and toxicity profiles of amyloid fibrils and plaques suggest that they play active, long-term roles in cell degeneration and may be a therapeutic target for amyloid diseases.

关键词： IAPP Amyloid Plaque Self assembly Toxicity

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A single-cell anatomical blueprint for intracortical information transfer from primary visual cortex

A single-cell anatomical blueprint for intracortical informa...

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中国神经科学学会第十二届全国学术会议

作者： Yunyun Han Justus M Kebschull Robert AA Campbell Devon Cowan Fabia Imhof anthony M Zador Thomas D Mrsic-Flogel Department of Neurobiology School of Basic Medicine and Tongji Medical College Huazhong University of Science and Technology The Institute for Brain Research Collaborative Innovation Center for Brain Science Huazhong University of Science and Technology Biozentrum University of Basel watson School of Biological Sciences Cold Spring Harbor Laboratory Sainsbury Wellcome Centre University College London

The function of any neuron in the brain is defined not only by what information it represents, but also by the projection pattern of its axonal arbor, which determines its impact on other neurons. Moreover, single-neuron projection pattern dictates how information flows from a source area to downstream targets and thus are of critical importance for understanding the computations performed between areas. To date, however, the organization of cortical information flow is unknown, because the projections of no cortical area have been mapped with the requisite single-neuron resolution. Here we map the long-range projection patterns of individual neurons in the mouse primary visual cortex（V1） by capitalizing on two high-throughput methods for single neuron tracing: serial two-photon tomography and DNA sequencing of genetically barcoded neurons（MAPseq）. By comparing single neuron projection patterns from V1, we can explore the single-cell projectional logic of long-range communication between a sensory cortical area and its targets, which will inform future research on cell-type classification and information processing in hierarchical networks.

关键词： single-cell tracing whole-brain imaging MAPseq long-range projection circuit structure visual cortex

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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