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成人慢性心力衰竭:NICE指南更新概要

英国医学杂志中文版 2019年第4期22卷 232-238页

作者： Jacqui Real Emma Cowles anthony s Vi ierzbicki 王乙茹(译) 周国鹏(校) National Guideline Centre Royal College of Physicians London UK Department of Metabolic Medicine/Chemical Pathology Guy′s & St Thomas′ Hospitals London UK 北京大学第一医院全科

由于人口老龄化和与心力衰竭相关的慢性病生存率的提高,心力衰竭的患病率正在上升。其中包括射血分数降低的(50%)心力衰竭。英国国家健康与临床优选研究所(NICE)关于慢性心力衰竭的指南上次更新是在2010年。从那时起,新兴的和现存的治... 详细信息

由于人口老龄化和与心力衰竭相关的慢性病生存率的提高,心力衰竭的患病率正在上升。其中包括射血分数降低的(50%)心力衰竭。英国国家健康与临床优选研究所(NICE)关于慢性心力衰竭的指南上次更新是在2010年。从那时起,新兴的和现存的治疗方法都出现了更多证据,例如盐皮质激素受体拮抗剂(MRA)的作用已经得到了证实。关于心力衰竭的诊断和心力衰竭的治疗研究进展也已发表,包括监测、康复和多学科合作小组(MDT)的组成。

关键词：慢性心力衰竭 NICE 指南成人治疗方法人口老龄化受体拮抗剂盐皮质激素

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成人高血压:NICE指南更新概要

英国医学杂志中文版 2020年第4期23卷 225-231页

作者： Rebecca J Boffa Margaret Constanti Christopher N Floyd anthony s wierzbicki 杨靓(译) 刘靖(校) National Guideline Centre LondonUK Department of Clinical Pharmacology King's College London British Heart Foundation CentreLondonUK Biomedical Research Centre Clinical Research FacilityGuy's and St Thomas'NHS Foundation TrustLondonUK Guy’s&st Thomas'NHs Foundation Trust LondonUK 北京大学人民医院急诊科

高血压是全球发病率和死亡率的首位原因。超过25%的英国成年人患有高血压,其中有近30%患者的血压未得到控制。8月,英国国家健康与临床优选研究所(NICE)发表了更新的高血压诊疗指南。指南回顾了自2011年更新指南以来有关启动、监测及降... 详细信息

高血压是全球发病率和死亡率的首位原因。超过25%的英国成年人患有高血压,其中有近30%患者的血压未得到控制。8月,英国国家健康与临床优选研究所(NICE)发表了更新的高血压诊疗指南。指南回顾了自2011年更新指南以来有关启动、监测及降压治疗内容,选择新的随机临床试验证据。更新指南的内容有所增加,纳人了合并2型糖尿病的患者,但对合并慢性肾脏疾病、心血管疾病或妊娠期高血压未给予推荐(译者注:这些部分有专业指南)。

关键词：慢性肾脏疾病随机临床试验妊娠期高血压降压治疗心血管疾病诊疗指南成年人

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Evaluation of a software positioning tool to support sMEs in adoption of big data analytics

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Journal of Electronic science and Technology 2024年第1期22卷 13-24页

作者： Matthew Willetts anthony s.Atkins Faculty of Digital TechnologyInnovationand BusinessStaffordshire UniversityStoke-on-TrentST42DEUnited Kingdom

Big data analytics has been widely adopted by large companies to achieve measurable benefits including increased profitability,customer demand forecasting,cheaper development of products,and improved stock *** and medium sized enterprises(sMEs)are the backbone of the global economy,comprising of 90%of businesses ***,only 10%sMEs have adopted big data analytics despite the competitive advantage they could *** research has analysed the barriers to adoption and a strategic framework has been developed to help sMEs adopt big data *** framework was converted into a scoring tool which has been applied to multiple case studies of sMEs in the *** paper documents the process of evaluating the framework based on the structured feedback from a focus group composed of experienced *** results of the evaluation are presented with a discussion on the results,and the paper concludes with recommendations to improve the scoring tool based on the proposed *** research demonstrates that this positioning tool is beneficial for sMEs to achieve competitive advantages by increasing the application of business intelligence and big data analytics.

关键词： Big data analytics Evaluation small and medium sized enterprises (sMEs) strategic framework

Big data challenge for monitoring quality in higher education institutions using business intelligence dashboards

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Journal of Electronic science and Technology 2024年第1期22卷 25-41页

作者： Ali sorour anthony s.Atkins Faculty of Digital TechnologyInnovationand BusinessStaffordshire UniversityStoke-on-TrentST42DEUnited Kingdom

As big data becomes an apparent challenge to handle when building a business intelligence(BI)system,there is a motivation to handle this challenging issue in higher education institutions(HEIs).Monitoring quality in HEIs encompasses handling huge amounts of data coming from different *** paper reviews big data and analyses the cases from the literature regarding quality assurance(QA)in *** also outlines a framework that can address the big data challenge in HEIs to handle QA monitoring using BI dashboards and a prototype dashboard is presented in this *** dashboard was developed using a utilisation tool to monitor QA in HEIs to provide visual representations of big *** prototype dashboard enables stakeholders to monitor compliance with QA standards while addressing the big data challenge associated with the substantial volume of data managed by HEIs’QA *** paper also outlines how the developed system integrates big data from social media into the monitoring dashboard.

关键词： Big data Business intelligence(BI) Dashboards Higher education(HE) Quality assurance(QA) social media

scenario-based verification in presence of variability using a synchronous approach

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Frontiers of Computer science 2013年第5期7卷 650-672页

作者： Jean-Vivien MILLO Frederic MALLET anthony COADOU s RAMEsH INRIA sophia-Antipolis Aoste team (INRIA/I3S/CNRS/UNS) Sophia-Antipolis 06560 France University of Nice sophia Antipolis Sophia-Antipolis 06900 France Global General Motors R&D India Science Lab GM Technical Center India Bangalore 560066 India

This paper presents a new model of scenarios, dedicated to the specification and verification of system be- haviours in the context of software product lines （sPL）. We draw our inspiration from some techniques that are mostly used in the hardware community, and we show how they could be applied to the verification of software components. We point out the benefits of synchronous languages and mod- els to bridge the gap between both worlds.

关键词： Esterel UML MARTE scenario verification,feature interaction variability

seismic Performance Assessment of a Conventional Multi-storey Building

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International Journal of Disaster Risk science 2017年第3期8卷 237-245页

作者： Giuseppe Marcantonio Del Gobbo Martin s.Williams anthony Blakeborough Department of Engineering science University of OxfordOxford OX1 3PJUK

Recent earthquakes have revealed that conventional seismic design philosophy allows for large levels of nonstructural damage. Nonstructural earthquake damage results in extensive repair costs and lengthy functional disruptions, as nonstructural systems comprise the majority of building investment and are essential to building operations. A better understanding of the expected overall seismic performance of code-compliant buildings is needed. This study investigates the seismic performance of a conventional building. A 16-storey steel office building was designed using a modern seismic structural code(Eurocode 8). This study is the first to assess in detail the substantial earthquake repair costs expected in a modern Eurocode concentric braced frame structure, considering nonstructural systems with the FEMA P-58 procedure. The breakdown of total repair costs by engineering demand parameter and by fragility group is novel. The seismic performance assessment indicated that substantial earthquake repair costs are expected. Limitations of the Eurocode nonstructural damage methodology were revealed in a novel manner using FEMA P-58, as the prescribed drift limits did not minimize nonstructural repair costs. These findings demonstrate the need for design procedures that improve nonstructural seismic performance. The study results provide a benchmark on which to evaluate retrofit alternatives for existing buildings and design options for new structures.

关键词： Eurocode 8 FEMA P-58 Nonstructural systems seismic performance assessment

single-atom Pt on carbon nanotubes for selective electrocatalysis

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Carbon Energy 2024年第1期6卷 63-71页

作者： samuel s.Hardisty Xiaoqian Lin anthony R.J.Kucernak David Zitoun Department of Chemistry Bar Ilan Institute of Nanotechnology and Advanced Materials(BINA)Bar Ilan UniversityRamat GanIsrael Department of Chemistry Molecular Science Research HubImperial College LondonLondonUK

Utilizing supported single atoms as catalysts presents an opportunity to reduce the usage of critical raw materials such as platinum,which are essential for electrochemical reactions such as hydrogen oxidation reaction(HOR).Herein,we describe the synthesis of a Pt single electrocatalyst inside single-walled carbon nanotubes(sWCNTs)via a redox *** via electron microscopy,X-ray photoelectron microscopy,and X-ray absorption spectroscopy show the single-atom nature of the *** electrochemical behavior of the sample to hydrogen and oxygen was investigated using the advanced floating electrode technique,which minimizes mass transport limitations and gives a thorough insight into the activity of the *** single-atom samples showed higher HOR activity than state-of-the-art 30%Pt/C while almost no oxygen reduction reaction activity in the proton exchange membrane fuel cell operating *** selective activity toward HOR arose as the main fingerprint of the catalyst confinement in the sWCNTs.

关键词： confinement electrocatalysis hydrogen platinum single atom catalysts

THE LIMITATIONs OF LEED: A CAsE sTUDY

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Journal of Green Building 2011年第1期6卷 25-33页

作者： anthony s.Denzer Keith E.Hedges University of Wyoming Dept.32951000 E.University AvenueLaramieWY 82071 Hammons school of Architecture Drury University.

The Xanterra houses are situated against the backdrop of one of America’s most spectacular natural landscapes,just a few hundred yards from the north entrance to Yellowstone National *** project consists of two single-family homes for seasonal workers,approximately 2000 square feet *** are mirrored east-to-west but otherwise identical(see Figure 1).The project was completed in 2003,and certified under LEED-NC v2.0,project#1353 on December 10,2004-the first building project in the National Park system to receive LEED(Leadership in Energy and Environmental Design)certification from the UsGBC(United states Green Building Council).1 The houses were built with the explicit intent that they would become a model for future green building projects at Yellowstone and other national parks,2 and the project team felt it was fitting that these houses be situated in the nation’s first national ***,they were fundamentally well-designed and constructed,and they incorporated some of the latest technologies for saving energy and water,authentically earning the label“high-performance.”Yet the project only earned the lowest possible rating(“certified”)from LEED,meaning it is barely considered *** paper documents the green design strategies through the design and construction process,with special attention paid to the influence of the LEED scorecard on collaborative decision-making and to the difficulties this project encountered during the LEED assessment *** academic studies have examined the process of LEED self-reporting and scoring within a professional setting,3 even though contingencies such as common business practices and human limitations clearly affect a project’s LEED *** paper will show that the LEED scorecard turned out to be a poor assessment tool in this case study,because the reporting procedure inaccurately reflected the architectural design and ***,there have been a few important papers that conclude that

关键词： LEED energy modeling insulated concrete passive solar heating construction waste management