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Exercise and cardiovascular protection:Update and future

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Journal of Sport and Health Science 2021年第6期10卷 607-608,I0001页

作者： Junjie Xiao anthony rosenzweig Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Research Center Division of CardiologyCorrigan Minehan Heart CenterDepartment of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA

Cardiovascular disease(CVD)is a major cause of mortality and morbidity worldwide.In China,it is estimated that 330 million people are CVD patients.With the rapid aging of populations around the world,the number of CVD patients and death due to CVD are continuously rising.1 Exercise and physical activity have been recognized as economical and effective ways to enhance cardiovascular health and reduce CVD.Pathways mediating the cardiovascular benefits of exercise are promising therapeutic targets for CVD.

关键词： cardiovascular mortality patients

An assessment of racial differences in epidemiological, clinical and psychosocial factors among head and neck cancer patients at the time of surgery

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第1期6卷 41-48页

作者： Anvesh Kompelli Kathleen B.Cartmell Katherine R.Sterba anthony J.Alberg Christopher C.Xiao Amit J.Sood Elizabeth Garrett-Mayer Shai J.White-Gilbertson Steven A.rosenzweig Terry A.Day Department of Otoloryngology-Head and Neck Surgery Medical University of South Carolina(MUSC)CharlestonSC29425USA College of Nursing MUSCCharlestonSC29425USA Hollings Cancer Center MUSCCharlestonSC29425USA Department of Public Health Sciences MUSCCharlestonSC29425USA Cancer Resistry Hollings Cancer CenterMUSCCharlestonSC29425USA Department of Pharmacology MUSCCharlestonSC29425USA

Objective:Racial disparities have been well characterized and African American(AA)patients have 30%lower 5-year survival rates than European Americans(EAs)for head and neck squamous carcinoma(HNSCC).This poorer survival can be attributed to a myriad of different factors.The purpose of this study was to characterize AA-EA similarities and differences in sociodemographic,lifestyle,clinical,and psychosocial characteristics in HNSCC patients near the time of surgery.Methods:Setting:Single tertiary care center.Participants:Thirty-nine newly diagnosed,untreated HNSCC patients(n=24 EAs,n=15 AAs)who were to undergo surgery were recruited.Study Design:Cross-sectional study Sociodemographic,lifestyle factors,and disease factors(cancer site,AJCC clinical and pathologic stage,and HPV status)were assessed.Risk factors,leisure time,quality of life and social support were also assessed using validated questionnaires.Exposures:EA and AA patients were similar in the majority of sociodemographic factors assessed.AAs had a higher trend toward pathologically later stage disease compared to EAs and significantly increased time to treatment.Results:EA and AA patients were similar in the majority of sociodemographic factors assessed.AAs had a higher trend toward pathologically later stage disease compared to EAs.AAs also had significantly increased time to treatment(P=0.05).The majority of AA patients(62%)had later stage pathologic disease.AA were less likely to complete high school or college(P=0.01)than their EA counterparts.Additionally,AAs were more likely to report having a gap in health insurance during the past decade(37%vs.15%).Conclusions:This preliminary study demonstrates a similar profile of demographics,clinical and psychosocial characteristics preoperatively for AAs and EAs.Key differences were AAs tending to have later pathologic stage disease,educational status,delays in treatment initiation,and gaps in health insurance.

关键词： Head and neck cancer Healthcare disparities Treatment delay Health services Quality care HPV

C/EBPβ控制耐力运动诱发的心脏生理性生长和抗病理性重构

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中南医学科学杂志 2013年第5期41卷 519-519页

作者： Pontus Bostrm Nina Mann Jun Wu Pablo A Quintero Eva R Plovie Daniela Panáková Rana K Gupta Chun-yang Xiao Calum A MacRae anthony rosenzweig Bruce M Spiegelman

心肌能通过使其细胞增大来适应外界压力的增加，这一应激反应适应于生理性刺激或病理性刺激对心脏造成的高负荷压力。例如，在负荷运动，高血压等刺激下，心肌都会出现明显的肥大和增殖现象。病理性心肌肥大可导致心力衰竭或心律失常，... 详细信息

心肌能通过使其细胞增大来适应外界压力的增加，这一应激反应适应于生理性刺激或病理性刺激对心脏造成的高负荷压力。例如，在负荷运动，高血压等刺激下，心肌都会出现明显的肥大和增殖现象。病理性心肌肥大可导致心力衰竭或心律失常，但生理性肥厚却不能引起这些疾病，所以弄清楚这两种类型的心肌肥大分子机制具有重要的临床意义。

关键词：病理性重构生理性 C EBPβ 运动诱发心脏心肌肥大生长耐力