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Cinobufotalin as a Novel Agent to Inhibit in Vitro Epithelial Ovarian Cancer Cell Proliferation, Migration and Invasion

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Open Journal of Obstetrics and Gynecology 2016年第6期6卷 343-351页

作者： anthony mcdowell Syeda H. Afroze Richard Tobin Timothy C. McCormick Martha Karen Newell-Rogers David C. Zawieja Thomas J. Kuehl Mohammad Nasir Uddin Departments of Obstetrics & Gynecology Baylor Scott & White Health and Texas A&M Health Science Center College of Medicine Temple TX USA Departments of Medical Physiology Baylor Scott & White Health and Texas A&M Health Science Center College of Medicine Temple TX USA Departments of Surgery Baylor Scott & White Health and Texas A&M Health Science Center College of Medicine Temple TX USA Departments of Pediatrics Baylor Scott & White Health and Texas A&M Health Science Center College of Medicine Temple TX USA Departments of Internal Medicine Baylor Scott & White Health and Texas A&M Health Science Center College of Medicine Temple TX USA

Objective: Cinobufotalin (CINO), a cardiotonic steroid (CTS) or bufadienolide, is extracted from the skin secretions of giant toads and is utilized in traditional Chinese medicine (Chan Su). CINO has been used as a cardiotonic, diuretic and a hemostatic agent. Recently, CINO has been shown to inhibit lung cancer cell function and has been implicated in several other disease processes. In this study, we pursued the potential anticancer application of CINO using the ovarian tumor cell line SK-OV-3. Study Design: We evaluated the effect of CINO on cultures of SK-OV-3. Cells were treated with 0.1, 0.5, 1, 5, and 10 μM CINO. Cell proliferation, migration, invasion, and viability were measured using commercially available kits. Cell cycle progression was evaluated by a Cell Cycle Phase Determination Kit. Apoptosis was evaluated by an Apoptotic Blebs Assay Kit;cell cycle arrest and apoptotic signaling were determined by fluorescence-activated cell sorting (FACS) analysis. Results: CINO at ≥ 0.5 μM inhibited SKOV-3 cell proliferation, migration, and invasion (p < 0.05). There was a higher (p < 0.05) percentage of S phase cells in groups treated with CINO at 0.5 μM. CINO at ≥ 0.5 μM down regulated expression of Proliferating Cell Nuclear Antigen (PCNA) and caused cell death. Conclusion: This data demonstrates that CINO impairs SK-OV-3 cell function via cell cycle arrest and apoptotic signaling, suggesting CINO be further investigated as a novel anti-ovarian cancer agent.

关键词： Cinobufotalin Ovarian Cancer SK-OV-3 Apoptosis Cell Cycle Arrest

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： anthony Procès Sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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Host-guest complexes of cucubit[8]uril with phenanthrolines and some methyl derivatives

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Science China Chemistry 2005年第4期48卷 305-314页

作者： DAY anthony I Chemistry Discipline School of Physical Environmental and Mathematical SciencesUniversity College UNSWAustralian Defence Force AcademyCanberraACT2600 Australia

The host-guest relationship between cucurbit[8]uril,phenanthrolines and some methyl substituted 1,10-phenanthrolines has been investigated by using 1H NMR spectroscopy and fluorescence *** results showed that phenanthrolines as molecular guests bind in the cavity and portal of cucurbit[8]uril in a ratio of 2:1 (guest to host).The phenanthroline isomers 1,10-,1,7-and 4,7-showed red shifts between 47 and 108 nm and pronounced in-creases in fluorescent *** same isomers produced inclusion complexes with cucur-bit[8]uril which had moderate to fast exchange rates on the 1H NMR time *** methyl substituted 1,10-phenanthrolines studied gave stable inclusion complexes in a ratio of 2:1 which showed slow exchange *** guests formed p-p stacked pairs which were cavity bound but also partly protruded from only one portal forming unsymmetrical host-guest *** addition,these p-p stacked pairs formed orientation isomers within the confines of the cucur-bit[8]uril cavity.

关键词： 1H NMR technique, fluorescence, cucurbituril, phenanthroline, host-guest, orientation isomers.

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Multi-agent systems for simulating spatial decision behaviors and land-use dynamics

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Science China Earth Sciences 2006年第11期49卷 1184-1194页

作者： anthony Gar-On Yeh Center of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

A new method to simulate urban land-use dynamics is proposed based on multi-agent systems (MAS). The model consists of a series of environmental layers and multi-agent layers, which can interact with each other. It attempts to explore the interactions between different players or agents, such as residents, property developers, and governments, and between these players and the envi- ronment. These interactions can give rise to urban macro-spatial patterns. This model is used to simulate the land-use dynamics of the Haizhu district of Guangzhou City in 1995―2004. Cellular automata (CA) were also used for the simulation of land use changes as a comparison. The study indicates that MAS has better performance for simulating complex cities than CA.

关键词： multi-agent systems, cellular automata, complex systems, cities, land use.

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Discovery of transition rules for geographical cellular automata by using ant colony optimization

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Science China Earth Sciences 2007年第10期50卷 1578-1588页

作者： anthony Gar-On YEH Center of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

A new intelligent algorithm of geographical cellular automata (CA) based on ant colony optimization (ACO) is proposed in this paper. CA is capable of simulating the evolution of complex geographical phenomena, and the core of CA models is how to define transition rules. However, most of the transition rules are defined by mathematical equations, and are hence not explicit. When the study area is complicated, it is much more difficult to extract parameters for geographical CA. As a result, ACO is applied to geographical CA to automatically and intelligently obtain transition rules in this paper. The transition rules extracted by ACO are defined as logical expressions rather than implicit mathematical equations to describe the complex relationships of the nature, and easy for people to understand. The ACO-CA model was applied to simulating rural-urban land conversions in Guangzhou City, China, and appropriate simulation results were generated. Compared with See5.0 decision tree model, ACO-CA is more suitable to discovering transition rules for geographical CA.

关键词： ant colony optimization, CA, geographical simulation, artificial intelligence

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Knowledge discovery for geographical cellular automata

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Science China Earth Sciences 2005年第10期48卷 1758-1767页

作者： anthony Gar-On Yeh Centre of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

This paper proposes a new method for geographical simulation by applying data mining techniques to cellular automata. CA has strong capabilities in simulating complex systems. The core of CA is how to define transition rules. There are no good methods for defining these transition rules. They are usually defined by using heuristic methods and thus subject to uncer-tainties. Mathematical equations are used to represent transition rules implicitly and have limita-tions in capturing complex relationships. This paper demonstrates that the explicit transition rules of CA can be automatically reconstructed through the rule induction procedure of data mining. The proposed method can reduce the influences of individual knowledge and preferences in de-fining transition rules and generate more reliable simulation results. It can efficiently discover knowledge from a vast volume of spatial data.

关键词： knowledge discovery, cellular automata, geographical simulation, geographical information systems.

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Coronatine Alleviates Water Deficiency Stress on Winter Wheat Seedlings

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Journal of Integrative Plant Biology 2010年第7期52卷 616-625页

作者： anthony Egrinya Eneji State Key Laboratory of Plant Physiology and Biochemistry College of Agronomy and BiotechnologyChina Agricultural University

With the aim to determine whether coronatine （COR） alleviates drought stress on wheat, two winter wheat （Triticum aestivum L.） cultivars, ChangWu134 （drought-tolerant） and Shan253 （drought-sensitive） were studied under hydroponic conditions. Seedlings at the three-leaf stage were eultured in a Hoagland solution containing COR at 0.1 ~M for 24 h, and then exposed to 20% polyethylene glycol 6000 （PEG- 6000）. Under simulated drought （SD）, COR increased the dry weight of shoots and roots of the two cultivars significantly; the root/shoot ratio also increased by 30% for Shan253 and 40% for ChangWu134. Both cultivars treated with COR under SD （0.1COR-I-PEG） maintained significantly higher relative water content, photosynthesis, transpiration, intercellular concentration of CO2 and stomatal conductance in leaves than those not treated with PEG. Under drought, COR significantly decreased the relative conductivity and malondialdehyde production, and the loss of 1,1-diphenyl-2-picrylhydrazyl scavenging activity in leaves was significantly alleviated in COR-treated plants. The activity of peroxidase, catalase, glutathione reductase and ascorbate peroxidase were adversely affected by drought. Leaves of plants treated with COR under drought produced less abscisic acid （ABA） than those not treated. Thus, COR might alleviate drought effects on wheat by reducing active oxygen species production, activating antioxidant enzymes and changing the ABA level.

关键词： RWC Coronatine Alleviates Water Deficiency Stress on Winter Wheat Seedlings PEG Figure

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Profile of anthony Trewavas

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Molecular Plant 2015年第3期8卷 345-351页

作者： anthony Trewavas Institute of Molecular Plant Science University of Edinburgh Mayfield Road Edinburgh EH9 3 JH UK

When asked to write on my experience in science and give some background, it sounded remarkably easy at first. In fact, it has proved very difficult. Apart from the short introduction below, I decided to write on four topics to which I have made a minor contribution. These are used to illustrate how I often fumbled my way through research and the ideas that I found fascinating. Investigation is never a direct path but a road full of obstacles.

关键词：胰岛素

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Investigations on longwall mining subsidence impacts on Pennsylvania highway alignments

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International Journal of Mining Science and Technology 2020年第1期30卷 85-92页

作者： Emily Adelsohn anthony Iannacchione Robert Winn Civil and Environmental Engineering University of PittsburghPittsburghPA 15213USA

Over 600 longwall panels have been mined in Pennsylvania in the last 50 years. Of those 600 panels, 25 panels undermined interstates highways. Despite this quantity of panels, much is still unknown regarded the detailed effects of undermining highways. The Gateway Mine, the Emerald Mine, and the Cumberland Mine undermined I-79 with 17 panels in 1982–1989 and in 2003–2008, respectively;Mine 84 undermined I-70 with 4 panels in 1987–2000. Through the examination of the panels that undermined I-70 and I-79, it is possible to determine which factors have most impacted the highway alignments. In some locations, the highway intersects with panels at angles ranging from 45° to 80°;and at the others, it runs between two panels, which simulates the effect of gateroads on the subsidence. The panel width to overburden ratio varies between 0.64 and 1.7, meaning that the interstates were influenced by both subcritical and supercritical subsidence basins. The face advance rates and overburden depths also vary between the panels. Unfortunately, specific information detailing highway impacts associated with unique characteristics of the subsidence basins are limited. In this paper, using the profile function model and influence function model within the surface deformation prediction system(SDPS), the effects of overburden,panel size, and orientation of the road on the highway can be indirectly assessed.

关键词： Longwall mining Subsidence Coal Interstate damage

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Situating and teaching 21st century zoology: revealing pattern in the form and function of animals

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Integrative Zoology 2009年第3期4卷 309-315页

作者： anthony P.RUSSELL Biological Sciences University Department of of CalgaryCalgaryCanada

The current challenges(increasing levels of integration in the biological sciences)facing the teaching of zoology and the structure of the zoology curriculum are explored *** context is provided and a more focused scrutiny of the situation in North America is *** changing emphases in more broadly-based biological sciences programs in North America are outlined,and their influence on the role of zoology as part of fundamental biological training is *** longer term impact of such changes in emphasis on the teaching of zoology is discussed,and the central role that zoology can play in dealing with both science content and science education is *** upon a focal workshop on the future of the zoology curriculum in Canada,a perspective on the challenges facing curriculum evolution is *** curriculum redesign is called for to ensure that zoology provides a broad-scale integrative approach to the understanding of biodiversity in evolutionary,ecologi-cal and functional *** to,and drivers of change are identified and the need for collaborative ap-proaches to curricular evolution is emphasized.

关键词： curriculum education program undergraduate zoology.

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