检索结果-南通市图书馆

Low-intensity extracorporeal shock wave therapy for Peyronie’s disease:a single-center experience

Asian j.urnal of Andrology 2022年第1期24卷 45-49页

作者： Maher Abdessater William Akakpo anthony Kanbar j.rome Parra Thomas Seisen Emmanuel Chartier-Kastler Sarah j.Drouin Morgan Roupret APHP-Sorbonne University PitiéSalpêtrièreAcademic Urology Unit83 bvd HopitalParis 75013France

The aim of this article is to assess the outcomes of a low-intensity extracorporeal shock wave therapy(LiESWT)protocol for the treatment of Peyronie’s disease(PD).Patients treated for PD were prospectively recorded,and data were retrospectively ***,characteristics of fibrous plaques,concomitant treatments,International Index of Erectile Function(IIEF-5),Lue score,and pain score on Likert scale were *** in acute phase of PD and an angulation of<40°were *** protocol consisted of 6 weekly sessions of 4000 pulses each,applied from different directions,with a maximal power of 20 W and 8 Hz *** included 39 patients(median age:56.8 years,interquartile range[IQR]:35.8–62.2 years).The median number of sessions received per patient was *** treatment,the median Lue score decreased from 6.8 initially to 3.3(P=0.003),the median Likert pain score dropped from 1.8 to 0.7(P=0.004),the median plaque size was reduced from 2 cm to 1.2 cm(P=0.08),and the median penile curvature diminished from 31°to 17°(P=0.07).On univariate and multivariate analysis,the only predictors of success were younger age(odds ratio[OR]=0.95,P=0.03 and OR=0.91,P=0.04,respectively)and concomitant use of phosphodiesterase-5 inhibitors(PDE5i;OR=0.92,P=0.02 and OR=0.93,P=0.01,respectively).LiESWT had a favorable impact on Lue score and notably penile pain,curvature,plaque size,and erectile function in patients treated for PD during the early inflammatory phase,with no side *** age and concomitant use of PDE5i were the only success predictors.

关键词： erectile dysfunction extracorporeal shock wave therapy Peyronie’s disease piezoelectric waves

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cleft foot: A case report and review of literature

引用

World j.urnal of Orthopedics 2020年第2期11卷 129-136页

作者： Sergey S Leonchuk Andrey S Neretin anthony j.Blanchard 6^th and 5^th Orthopedic Departments Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopedics 6Kurgan 640014Russia Department of Surgery University of CincinnatiCollege of MedicineCincinnatiOH 45219United States

BACKGROUND Cleft foot is a very rare congenital anomaly,which is characterized by central rays deficiency of the *** is also known as split foot or ectrodactyly of the foot,and it is very often combined with splitting of the *** defect develops due to insufficient activity of the median apical ectodermal ridge,which leads to an increase in cell death or a decrease in cell *** to the rarity of the pathology,there are few papers on the surgical treatment of this congenital foot disease,and publications to date concern the treatment of *** SUMMARY We present a clinical case of congenital splitting of the feet and hands in a 31-year-old woman and a long-term result of foot treatment using the minimal arrangement of the Ilizarov *** patient had paternal inheritance of the *** the surgical treatment,cosmetic view and functional condition of the foot were improved and persisted two years after *** were no complications in the treatment *** The possibility of dosed control and stable fixation of the foot rays made it possible to create favorable conditions for the healing of the central wound and the closure of the segment splitting without *** long-term outcome of the treatment of foot congenital splitting using the proposed Ilizarov apparatus arrangement has shown its *** approach should be considered as an option of treatment in similar cases.

关键词： Cleft foot Split foot Ectrodactyly Congenital malformation Ilizarov Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vapors in the ambient-A complication in tribological studies or an engineering solution of tribological problems?

引用

Friction 2015年第2期3卷 85-114页

作者： Ala ALAZIZI anthony j.BARTHEL Nicholas D.SURDYKA j.awei LUO Seong H.KIM Department of Chemical Engineering and Materials Research Institute Pennsylvania State UniversityUniversity ParkPA 16802USA

Tribology involves not only two-body contacts of two solid materials-a substrate and a counter-surface;it often involves three-body contacts whether the third body is intentionally introduced or inevitably added during the sliding or *** intentionally added third body could be lubricant oil or engineered nano-material used to mitigate the friction and wear of the sliding *** inevitably added third body could be wear debris created from the substrate or the counter surface during *** in the absence of any solid third-body between the sliding surfaces,molecular adsorption of water or organic vapors from the surrounding environment can dramatically alter the friction and wear behavior of solid surfaces tested in the absence of lubricant *** review article covers the last case:the effects of molecular adsorption on sliding solid surfaces both inevitably occurring due to the ambient test and intentionally introduced as a solution for engineering *** will review how adsorbed molecules can change the course of wear and friction,as well as the mechanical and chemical behavior,of a wide range of materials under sliding conditions.

关键词： vapor phase lubrication environmental effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Embedded software development with e-Cos

引用

1000年

作者： Massa anthony j.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Chain length-dependent cooperativity in fatty acid binding and oxidation by cytochrome P450_(BM3)(CYP102A1)

引用

Protein & Cell 2011年第8期2卷 656-671页

作者： Benj.min Rowlatt j.ke A.Yorke anthony j.Strong Christopher j.C.Whitehouse Stephen G.Bell Luet-Lok Wong Department of Chemistry University of OxfordInorganic Chemistry LaboratorySouth Parks RoadOxford OX13QRUK

Fatty acid binding and oxidation kinetics for wild type P450_(BM3)(CYP102A1)from Bacillus megaterium have been found to display chain length-dependent homotropic *** and 13-methyl-myristate display Michaelis-Menten behavior while there are slight deviations with myristate at low ionic *** shows Michaelis-Menten kinetics and hyperbolic binding behavior in 100 mmol/L phosphate,pH 7.4,but sigmoidal kinetics(with an apparent intercept)in low ionic strength buffers and at physiological phosphate *** low ionic strength buffers both the heme domain and the full-length enzyme show complex palmitate binding behavior that indicates a minimum of four fatty acid binding sites,with high cooperativity for the binding of the fourth palmitate molecule,and the full-length enzyme showing tighter palmitate binding than the heme *** first flavin-to-heme electron transfer is faster for laurate,myristate and palmitate in 100 mmol/L phosphate than in 50mmol/L Tris(pH 7.4),yet each substrate induces similar high-spin heme *** palmitate in low phosphate buffer concentrations,the rate constant of the first electron transfer is much larger than *** results suggest that phosphate has a specific effect in promoting the first electron transfer step,and that P450_(BM3) could modulate Bacillus membrane morphology and fluidity via palmitate oxidation in response to the external phosphate concentration.

关键词： P450_(BM3) monooxygenase fatty acid cooperativity allosteric effect CYP102A1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel triple immunoenzyme staining enables simultaneous identification of all muscle fiber types on a single skeletal muscle cryosection from normal, denervated or reinnervated rats

引用

Neural Regeneration Research 2017年第8期12卷 1357-1364页

作者： Peng Wu Shuya Zhang Robert j.Spinner Michael Torres Lizardi Yudong Gu Cong Yu Michael j.Yaszemski anthony j.Windebank Huan Wang Department of Neurological Surgery Mayo Clinic Rochester MN USA Department of Hand Surgery Huashan Hospital Fudan University Shanghai China Shanghai Tenth People's Hospital Tongji University Shanghai China Department of Neurology Mayo Clinic Rochesterl MN USA Department of Medicine New York Presbyterian Weill Cornell Medical Center New York NY USA Shanghai Key Laboratory of Peripheral Nerve and Microsurgery Shanghai China Departments of Orthopedic Surgery and Biomedical Engineering Mayo Clinic Rochester MN USA

Triple immunofluorescence staining has recently been developed to simultaneously identify all muscle fibers on a single cryosection which is helpful for clinical and basic research, but it has disadvantages such as fast photobleaching and unclear outlines of muscle fibers. Triple immunoenzyme staining（TIE） is likely to avoid these disadvantages. In this study, we aimed to establish a sensitive and specific TIE technique to identify fiber types in normal, denervated, and reinnervated rat muscles, and to develop a systematic sampling method for muscle fiber quantification. Tibialis anterior and soleus from normal, denervated, and reinnervated Lewis rat hind limbs were used. Five consecutive cryosections were cut from each muscle, including one for TIE and four for single immunoenzyme staining（SIE）. The TIE was performed using the polymerized reporter enzyme staining system for the first two antigens（A4.74 for My HC-IIA, BA-F8 for My HC-I） and alkaline phosphatase staining system for the third antigen（BF-F3 for My HC-IIB）, followed by corresponding detective systems and respective chromogens. The type of muscle fibers was quantified by systematic sampling at 12.5%, 25%, 33% and 50% of all muscle fibers, and was compared with that acquired from counting all the fibers（100%）. All muscle fiber phenotypes, including pure and hybrid, could be simultaneously identified on a single TIE cryosection with clear outlines. The fiber types on TIE slides matched well with their respective counterpart on the consecutive SIE slides with a 95% match rate. Systematic sampling of 12.5% fibers could represent the true fiber type distribution of the entire muscle section. Our results suggest that novel TIE can effectively visualize fiber types in normal, denervated or reinnervated rat muscles.

关键词： nerve regeneration muscle fiber phenotyping immunohistochemistry triple immunoenzymestaining myosin heavy chain rats neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ULTRASHORT PULSE MULTISPECTRAL NON-LINEAR OPTICAL MICROSCOPY

引用

j.urnal of Innovative Optical Health Sciences 2009年第1期2卷 27-35页

作者： ADAM M.LARSON anthony LEE PO-FENG LEE KAYLA j.BAYLESS ALVIN T.YEH Department of Biomedical Engineering Texas A&M University College Station TexasUSA Department of Molecular and Cellular Medicine Texas A&M Health Science Center College Station TexasUSA

Ultrashort pulse,multispectral non-linear optical microscopy(NLOM)is developed and used to image,simultaneously,a mixed population of cells expressing different fluorescent protein mutants in a 3D tissue model of ***,sub-10-fs pulses are used to excite multiple fluorescent proteins and generate second harmonic in collagen.A 16-channel multispectral detector is used to delineate the multiple non-linear optical signals,pixel by pixel,in *** ability to image multiple fluorescent protein mutants and collagen,enables serial measurements of cell-cell and cell-matrix interactions in our 3D tissue model and characterization of fundamental processes in angiogenic morphogenesis.

关键词： Two-photon excited fluorescence second harmonic generation multiple molecular imaging angiogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Indications for and techniques of keratoplasty at Vietnam National Institute of Ophthalmology

引用

International j.urnal of Ophthalmology(English edition) 2016年第3期9卷 379-383页

作者： Pham Ngoc Dong Truong Nhu Han anthony j.Aldave Hoang Thi Minh Chau Vietnam National Institute of Ophthalmology HanoiVietnam Stein Eye Institute the University of California Los Angeles CA 90095-7003 USA

AIM： To report the indications for and techniques of corneal transplantation at Vietnam National Institute of Ophthalmology （VNIO） over a period of 12y （2002-2013）, METHODS： Records of patients who had undergone corneal transplantation at VNIO from j.nuary 1, 2002 to j.nuary 1, 2014 were reviewed to determine the indication for and type of corneal transplant performed. Patient age, gender, indication for corneal transplantation and surgical technique were recorded and analyzed. RESULTS： Corneal transplantation were underwent in 1390 eyes of 1278 patients with a mean age of 44.9±18.1y during the period under review. The most common indication was infectious corneal ulcer （n=670; 48.2%）, followed by corneal scar （n=333, 24.0% ）, corneal dystrophy （n=138, 9.9%） and failed graft （n=112, 8.1%）. Nearly all procedures performed were penetrating keratoplasty （n=1300, 93.5% ）, with a few lamellar keratoplasty procedures performed： lamellar keratoplasty （n=52, 3.7%）, Descemet＇s stripping automated endothelial keratoplasty （n =27, 1.9% ） and deep anterior lamellar keratoplasty （n =11, 0.8%）.CONCLUSION： While the most common indication for keratoplasty was infectious keratitis, nearly all indications for corneal transplantation were managed with penetrating keratoplasty, However, lamellar keratoplasty techniques, including deep anterior lamellar keratoplasty and Descemet＇s stripping automated endothelial keratoplasty, are being performed with increasing frequency for isolated stromal and endothelial disorders, respectively,

关键词： penetratingkeratoplasty, lamellarkeratoplasty endothelial keratoplasty indication for keratoplasty technique of keratoplasty

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tracking the Cretaceous transcontinental Ceduna River through Australia:The hafnium isotope record of detrital zircons from offshore southern Australia

引用

Geoscience Frontiers 2016年第2期7卷 237-244页

作者： j.rred Lloyd Alan S.Collins j.stin L.Payne Stij. Glorie Simon Holford anthony j.Reid Centre for Tectonics Resources and Exploration(TRaX)Department of Earth SciencesThe University of Adelaide Centre for Tectonics Resources and Exploration(TRaX)School of Built and Natural EnvironmentsThe University of South Australia Centre for Tectonics Resources and Exploration(TRaX)Australian School of PetroleumThe University of Adelaide Geological Survey of South Australia Department of State DevelopmentGovernment of South Australia

The middle-upper Cretaceous Ceduna River system traversed continental Australia from the NE coast to the centre of the southern coast. At its mouth, it formed a vast delta system that is similar in scale to the Niger delta of West Africa. The delta system is composed of two main lobes that represent different phases of delta construction. A recent hypothesis has challenged the traditional idea that both lobes of the delta were derived from a transcontinental river system by suggesting that the upper lobe （Santonian -Maastrichtian） is instead derived from a restricted catchment within southern Australia. Hf isotopic data presented here fingerprint the original source of the upper delta lobe zircons to NE Australia, with data comparing well with similar U-Pb and Lu-Hf isotopic data from the Lachlan Orogen, the New England Orogen, the eastern Musgraves Province and the northern Flinders Ranges. These data do not preclude a model where the lobe is derived from recycled Eromanga Basin sediments during a phase of late Cretaceous inland Australian uplift, but when coupled with reconnaissance low-temperature thermochronometry from the region of the Ceduna River course indicating widespread Triassic-j.rassic exhumation, and comparisons with detrital zircon data from the Winton Formation upstream of any proposed uplift, we suggest that both lobes of the Ceduna Delta are likely to be derived from a transcontinental Ceduna River.

关键词： Detrital zircon Hf U-Pb Ceduna sub-basin Bight basin Australia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimising validity and translational potential in rodent models of brain disorders

引用

j.urnal of Translational Neuroscience 2016年第2期1卷 56-62页

作者： anthony j.Hannan Florey Institute of Neuroscience and Mental Health Melbourne Brain CentreUniversity of MelbourneParkvilleVIC3010Australia Department of Anatomy and Neuroscience University of MelbourneParkvilleVIC3010Australia

Neurological and psychiatric disorders collectively constitute the greatest burden of disease. However, the human brain is the most complex of biological systems and therefore accurately modeling brain disorders presents enormous challenges. A large range of therapeutic approaches across a diverse collection of brain disorders have been found to show great promise in preclinical testing and then failed during clinical trials. There are a variety of potential reasons for such failures, on both the preclinical and clinical sides of the equation. In this article, I wi l l focus on the key issues of validity in animal models. I wi l l discuss two forms of construct validity,‘genetic construct validity’ and ‘environmental construct val idity’,which model specific aspects of the genome and ‘envirome’ relevant to the disorder in question. The generation of new gene-edited animal models has been facilitated by new technologies, the most notable of which are CRISPR-Cas systems. These and other technologies can be used to enhance contruct validity. Finally, I wi l l discuss how face validity can be optimized, via more sophisticated cognitive, affective and motor behavioural tests, translational tools and the integration of molecular, cellular and systems data. Predictive validity cannot yet be assessed for the many preclinical models where we currently lack effective clinical interventions, however this wi l l change as the translational pipeline is honed to deliver therapies for a range of devastating disorders.

关键词： neurological diseases psychiatric disorders schizophrenia Huntington's disease genomics enviromics gene-environment interactions enviromimetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：