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World Journal of Cardiology 2021年第9期13卷 446-455页

作者： anthony georges matta Nabil Yaacoub Vanessa Nader Nicolas Moussallem Didier Carrie Jerome Roncalli Department of Cardiology Toulouse University HospitalRangueilToulouse 31400France Faculty of Medicine Holy Spirit University of KaslikJounieh 961Lebanon Faculty of Pharmacy Lebanese UniversityHadath 961Lebanon Division of Cardiology Faculty of MedicineHoly Spirit University of KaslikJounieh 961Lebanon Department of Cardiology University Hospital RangueilToulouse 31059France Department of Cardiology University Hospital of Toulouse/Institute CardiometToulouse 31400France

Coronary artery aneurysm(CAA)is a clinical entity defined by a focal enlargement of the coronary artery exceeding the 1.5-fold diameter of the adjacent normal *** is the main cause in adults and Kawasaki disease in *** is a silent progressive disorder incidentally detected by coronary angiography,but it may end with fatal complications such as rupture,compression of adjacent cardiopulmonary structures,thrombus formation and distal *** pathophysiological mechanisms are not well ***,proteolytic imbalance and inflammatory reaction are involved in aneurysmal *** from previously published studies are scarce and controversial,thereby the management of CAA is individualized depending on clinical presentation,CAA characteristics,patient profile and physician *** therapeutic approaches including medical treatment,covered stent angioplasty,coil insertion and surgery were ***,we provide an up-to-date systematic review on the pathophysiology,complications and management of CAA.

关键词： Coronary artery aneurysm Complications Atherosclerosis Coronary artery ectasia

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Correlation of Urinary Engrailed-2 Levels to Tumour Volume and Pathological Stage in Men Undergoing Radical Prostatectomy

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Journal of Cancer Therapy 2013年第3期4卷 726-733页

作者： Hardev Pandha Saqib Javed Prasanna Sooriakumaran Simon Bott Bruce Montgomery anthony Hutton Christopher Eden Christopher Eden Stephen E. Langley Richard Morgan Frimley Park Hospital NHS Foundation Trust Portsmouth Road Frimley UK Oncology Faculty of Health and Medical Sciences University of Surrey Guildford UK Royal Surrey County Hospital Guildford UK St. georges Hospital London UK

The aim of this study was to assess the relationship between pre-prostatectomy urinary Engrailed-2 (EN2), a transcription factor secreted by prostate cancer cells, with tumour volume and pathological characteristics in resected prostate specimens. First pass urine samples (10 ml) without prior prostatic massage were collected and stored at –80°C. EN2 levels were measured using an enzyme-linked immunoabsorbent assay. Tumour volume in the prostatectomy specimens was determined histologically. 57 men undergoing RP in one urological cancer network were evaluated. EN2 was detected in 85% of RP patients. EN2 correlated with tumour volume (but not total prostatic volume) in a linear regression analysis, with increasing pathological T stage and margin positivity. Using three “cutoff levels” of tumour volume (0.5 ml, 1.3 ml and 2.5 ml) to define “significant disease”, men with “significant disease” had markedly higher levels of urinary EN2 (p Levels of urinary EN2 may be useful in predicting tumour volume in men with prostate cancer by potentially identifying men with small volume “insignificant” disease. This study justifies a larger multicentre evaluation of urinary EN2 levels as a biomarker of PC significance using cancer volume, pathological and PSA criteria.

关键词： Biomarker Prostate Cancer Urine

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