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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： anthony Procès Sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Hepatitis C virus cures after direct acting antiviral-related drug-induced liver injury: Case report

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World Journal of Hepatology 2016年第20期8卷 858-862页

作者： Yaakov Hasin Shimon Shteingart Harel Dahari Inna Gafanovich Sharon Floru Marius Braun Amir Shlomai anthony Verstandig Ilana dery Susan L Uprichard Scott J Cotler Yoav Lurie Liver Unit Digestive Disease Institute Shaare Zedek Medical Center the Program for Experimental and Theoretical Modeling Division of Hepa-tology Department of Medicine Loyola University Medical Center "Bat Yamon" Internal Medicine Day Care Clalit Health Care Organization Liver Institute Rabin Medical Center Beilinson Hospital Petah-Tiqwa Affiliated with the Sackler Faculty of Medicine Invasive Radiology Unit Shaare Zedek Medical Center

The United States Food and Drug Administration recently warned that the direct acting antiviral(DAA) combination hepatitis C virus(HCV) treatment of Paritaprevir, Ombitasvir, Dasabuvir, Ritonavir, and Ribavirin(PODr + R) can cause severe liver injury in patients with advanced liver disease. Drug induced liver injury was observed in a small number of patients with decompensated cirrhosis treated with other DAAs, but has not been reported in patients with compensated cirrhosis. We report a case of a 74-year-old woman with chronic HCV and Child-Pugh class A cirrhosis(compensated cirrhosis) treated with PODr + R. The patient presented on day 14 of PODr + R therapy with jaundice and new-onset ascites. Her total bilirubin level increased to 23 mg/dL and international normalized ratio rose to 1.65, while aminotransferase levels remained relatively stable. Hepatitis C treatment was discontinued on day 24 and she gradually recovered. Follow-up testing showed that she achieved a sustained virologic response. In conclusion, hepatic decompensation developed within two weeks of starting treatment withPODr + R in a patient with Child-Pugh class A cirrhosis and was characterized by jaundice and ascites with stable aminotransferase levels. Careful monitoring is warranted in patients with HCV-related cirrhosis treated with PODr + R.

关键词： Direct antiviral agent Drug-induced liver injury Hepatitis C Mathematical modeling Sustained virological response Viral kinetics

Host-guest complexes of cucubit[8]uril with phenanthrolines and some methyl derivatives

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Science China Chemistry 2005年第4期48卷 305-314页

作者： DAY anthony I Chemistry Discipline School of Physical Environmental and Mathematical SciencesUniversity College UNSWAustralian Defence Force AcademyCanberraACT2600 Australia

The host-guest relationship between cucurbit[8]uril,phenanthrolines and some methyl substituted 1,10-phenanthrolines has been investigated by using 1H NMR spectroscopy and fluorescence *** results showed that phenanthrolines as molecular guests bind in the cavity and portal of cucurbit[8]uril in a ratio of 2:1 (guest to host).The phenanthroline isomers 1,10-,1,7-and 4,7-showed red shifts between 47 and 108 nm and pronounced in-creases in fluorescent *** same isomers produced inclusion complexes with cucur-bit[8]uril which had moderate to fast exchange rates on the 1H NMR time *** methyl substituted 1,10-phenanthrolines studied gave stable inclusion complexes in a ratio of 2:1 which showed slow exchange *** guests formed p-p stacked pairs which were cavity bound but also partly protruded from only one portal forming unsymmetrical host-guest *** addition,these p-p stacked pairs formed orientation isomers within the confines of the cucur-bit[8]uril cavity.

关键词： 1H NMR technique, fluorescence, cucurbituril, phenanthroline, host-guest, orientation isomers.

Multi-agent systems for simulating spatial decision behaviors and land-use dynamics

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Science China Earth Sciences 2006年第11期49卷 1184-1194页

作者： anthony Gar-On Yeh Center of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

A new method to simulate urban land-use dynamics is proposed based on multi-agent systems (MAS). The model consists of a series of environmental layers and multi-agent layers, which can interact with each other. It attempts to explore the interactions between different players or agents, such as residents, property developers, and governments, and between these players and the envi- ronment. These interactions can give rise to urban macro-spatial patterns. This model is used to simulate the land-use dynamics of the Haizhu district of Guangzhou City in 1995―2004. Cellular automata (CA) were also used for the simulation of land use changes as a comparison. The study indicates that MAS has better performance for simulating complex cities than CA.

关键词： multi-agent systems, cellular automata, complex systems, cities, land use.

Discovery of transition rules for geographical cellular automata by using ant colony optimization

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Science China Earth Sciences 2007年第10期50卷 1578-1588页

作者： anthony Gar-On YEH Center of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

A new intelligent algorithm of geographical cellular automata (CA) based on ant colony optimization (ACO) is proposed in this paper. CA is capable of simulating the evolution of complex geographical phenomena, and the core of CA models is how to define transition rules. However, most of the transition rules are defined by mathematical equations, and are hence not explicit. When the study area is complicated, it is much more difficult to extract parameters for geographical CA. As a result, ACO is applied to geographical CA to automatically and intelligently obtain transition rules in this paper. The transition rules extracted by ACO are defined as logical expressions rather than implicit mathematical equations to describe the complex relationships of the nature, and easy for people to understand. The ACO-CA model was applied to simulating rural-urban land conversions in Guangzhou City, China, and appropriate simulation results were generated. Compared with See5.0 decision tree model, ACO-CA is more suitable to discovering transition rules for geographical CA.

关键词： ant colony optimization, CA, geographical simulation, artificial intelligence

Knowledge discovery for geographical cellular automata

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Science China Earth Sciences 2005年第10期48卷 1758-1767页

作者： anthony Gar-On Yeh Centre of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

This paper proposes a new method for geographical simulation by applying data mining techniques to cellular automata. CA has strong capabilities in simulating complex systems. The core of CA is how to define transition rules. There are no good methods for defining these transition rules. They are usually defined by using heuristic methods and thus subject to uncer-tainties. Mathematical equations are used to represent transition rules implicitly and have limita-tions in capturing complex relationships. This paper demonstrates that the explicit transition rules of CA can be automatically reconstructed through the rule induction procedure of data mining. The proposed method can reduce the influences of individual knowledge and preferences in de-fining transition rules and generate more reliable simulation results. It can efficiently discover knowledge from a vast volume of spatial data.

关键词： knowledge discovery, cellular automata, geographical simulation, geographical information systems.

Coronatine Alleviates Water Deficiency Stress on Winter Wheat Seedlings

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Journal of Integrative Plant Biology 2010年第7期52卷 616-625页

作者： anthony Egrinya Eneji State Key Laboratory of Plant Physiology and Biochemistry College of Agronomy and BiotechnologyChina Agricultural University

With the aim to determine whether coronatine （COR） alleviates drought stress on wheat, two winter wheat （Triticum aestivum L.） cultivars, ChangWu134 （drought-tolerant） and Shan253 （drought-sensitive） were studied under hydroponic conditions. Seedlings at the three-leaf stage were eultured in a Hoagland solution containing COR at 0.1 ~M for 24 h, and then exposed to 20% polyethylene glycol 6000 （PEG- 6000）. Under simulated drought （SD）, COR increased the dry weight of shoots and roots of the two cultivars significantly; the root/shoot ratio also increased by 30% for Shan253 and 40% for ChangWu134. Both cultivars treated with COR under SD （0.1COR-I-PEG） maintained significantly higher relative water content, photosynthesis, transpiration, intercellular concentration of CO2 and stomatal conductance in leaves than those not treated with PEG. Under drought, COR significantly decreased the relative conductivity and malondialdehyde production, and the loss of 1,1-diphenyl-2-picrylhydrazyl scavenging activity in leaves was significantly alleviated in COR-treated plants. The activity of peroxidase, catalase, glutathione reductase and ascorbate peroxidase were adversely affected by drought. Leaves of plants treated with COR under drought produced less abscisic acid （ABA） than those not treated. Thus, COR might alleviate drought effects on wheat by reducing active oxygen species production, activating antioxidant enzymes and changing the ABA level.

关键词： RWC Coronatine Alleviates Water Deficiency Stress on Winter Wheat Seedlings PEG Figure

Profile of anthony Trewavas

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Molecular Plant 2015年第3期8卷 345-351页

作者： anthony Trewavas Institute of Molecular Plant Science University of Edinburgh Mayfield Road Edinburgh EH9 3 JH UK

When asked to write on my experience in science and give some background, it sounded remarkably easy at first. In fact, it has proved very difficult. Apart from the short introduction below, I decided to write on four topics to which I have made a minor contribution. These are used to illustrate how I often fumbled my way through research and the ideas that I found fascinating. Investigation is never a direct path but a road full of obstacles.

关键词：胰岛素

Investigations on longwall mining subsidence impacts on Pennsylvania highway alignments

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International Journal of Mining Science and Technology 2020年第1期30卷 85-92页

作者： Emily Adelsohn anthony Iannacchione Robert Winn Civil and Environmental Engineering University of PittsburghPittsburghPA 15213USA

Over 600 longwall panels have been mined in Pennsylvania in the last 50 years. Of those 600 panels, 25 panels undermined interstates highways. Despite this quantity of panels, much is still unknown regarded the detailed effects of undermining highways. The Gateway Mine, the Emerald Mine, and the Cumberland Mine undermined I-79 with 17 panels in 1982–1989 and in 2003–2008, respectively;Mine 84 undermined I-70 with 4 panels in 1987–2000. Through the examination of the panels that undermined I-70 and I-79, it is possible to determine which factors have most impacted the highway alignments. In some locations, the highway intersects with panels at angles ranging from 45° to 80°;and at the others, it runs between two panels, which simulates the effect of gateroads on the subsidence. The panel width to overburden ratio varies between 0.64 and 1.7, meaning that the interstates were influenced by both subcritical and supercritical subsidence basins. The face advance rates and overburden depths also vary between the panels. Unfortunately, specific information detailing highway impacts associated with unique characteristics of the subsidence basins are limited. In this paper, using the profile function model and influence function model within the surface deformation prediction system(SDPS), the effects of overburden,panel size, and orientation of the road on the highway can be indirectly assessed.

关键词： Longwall mining Subsidence Coal Interstate damage