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Role of immunotherapy in downsizing hepatocellular carcinoma prior to liver transplantation

World Journal of Transplantation 2022年第11期12卷 331-346页

作者： Konstantinos Ouranos anthi chatziioannou Ioannis Goulis Emmanouil Sinakos 4th Medical Department Hippokratio HospitalAristotle University of ThessalonikiThessaloniki 54642Greece

Hepatocellular carcinoma(HCC)is an aggressive primary liver neoplasm that,according to tumor stage,can be treated with resection,transplantation,locoregional treatment options,or systemic *** interventions only in early-stage disease can offer complete tumor regression,systemic therapy in advanced disease can significantly prolong overall survival,according to published clinical *** emergence of immunotherapy in the field of cancer therapy has had a positive impact on patients with HCC,resulting in atezolizumab–bevacizumab currently being the first-line option for treatment of advanced *** light of this,application of immunotherapy in the preoperative process could increase the number of patients fulfilling the criteria for liver transplantation(LT).Implementation of this approach is faced with challenges regarding the safety of immunotherapy and the possibly increased risk of rejection in the perioperative *** reports and clinical trials assessing the safety profile and effectiveness of neoadjuvant immunotherapy,highlight important aspects regarding this newly evolving approach to HCC *** studies need to be conducted in order to reach a consensus regarding the optimal way to administer immunotherapy prior to *** this review,we summarize the role,safety profile and future considerations regarding the use of neoadjuvant immunotherapy prior to LT in patients with HCC.

关键词： Hepatocellular carcinoma Immunotherapy Tumor downsizing Liver transplantation Neoadjuvant Rejection

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Liver Imaging Reporting and Data System criteria for the diagnosis of hepatocellular carcinoma in clinical practice: A pictorial minireview

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World Journal of Gastroenterology 2022年第32期28卷 4540-4556页

作者： Christina Liava Emmanouil Sinakos Elissavet Papadopoulou Lamprini Giannakopoulou Stamatia Potsi Anestis Moumtzouoglou anthi chatziioannou Loukas Stergioulas Lydia Kalogeropoulou Ioannis Dedes Evangelos Akriviadis Danai Chourmouzi 4^(th)Department of Internal Medicine Hippokratio HospitalAristotle University of ThessalonikiThessaloniki 54642Greece Department of Radiology Interbalkan Medical CenterThessaloniki 57001Greece

Hepatocellular carcinoma(HCC)is the sixth most common *** main risk factors associated with HCC development include hepatitis B virus,hepatitis C virus,alcohol consumption,aflatoxin B1,and nonalcoholic fatty liver ***,hepatocarcinogenesis is a complex multistep *** factors lead to hepatocyte malignant transformation and HCC *** and surveillance of HCC can be made with the use of liver ultrasound(US)every 6 ***,the sensitivity of this imaging method to detect HCC in a cirrhotic liver is limited,due to the abnormal liver *** tomography(CT)and magnetic resonance imaging(MRI)are considered to be most useful tools for at-risk patients or patients with inadequate *** biopsy is still used for diagnosis and prognosis of HCC in specific nodules that cannot be definitely characterized as HCC by *** the American College of Radiology designed the Liver Imaging Reporting and Data System(LI-RADS),which is a comprehensive system for standardized interpretation of CT and MRI liver examinations that was first proposed in *** 2018,it was integrated into the American Association for the Study of Liver Diseases guidance statement for ***-RADS is designed to ensure high sensitivity,precise categorization,and high positive predictive value for the diagnosis of HCC and is applied to“highrisk populations”according to specific *** importantly LI-RADS criteria achieved international collaboration and consensus among liver experts around the world on the best practices for caring for patients with or at risk for HCC.

关键词： Hepatocellular carcinoma Hepatocarcinogenesis Computed tomography Magnetic resonance imaging Liver Imaging Reporting and Data System

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