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Immune phenotype in children with therapy-nave remitted and relapsed Crohn’s disease

World Journal of Gastroenterology 2010年第47期16卷 6001-6009页

作者： Aron Cseh Barna Vasarhelyi Kriszta Molnar Balazs Szalay Peter Svec Andras Treszl antal dezsofi Peter Laszlo Lakatos Andras Arato Tivadar Tulassay Gabor Veres Research Group for Pediatrics and Nephrology Semmelweis University Hungarian Academy of Sciences Department of Laboratory Medicine Semmelweis University First Department of Pediatrics Semmelweis University First Department of Medicine Semmelweis University

AIM: To characterize the prevalence of subpopulations of CD4+ cells along with that of major inhibitor or stimulator cell types in therapy-nave childhood Crohn's disease (CD) and to test whether abnormalities of immune phenotype are normalized with the improvement of clinical signs and symptoms of disease. METHODS: We enrolled 26 pediatric patients with CD. 14 therapy-nave CD children; of those, 10 children remitted on conventional therapy and formed the remission group. We also tested another group of 12 chil-dren who relapsed with conventional therapy and were given infliximab; and 15 healthy children who served as controls. The prevalence of Th1 and Th2, nave and memory, activated and regulatory T cells, along with the members of innate immunity such as natural killer (NK), NK-T, myeloid and plasmocytoid dendritic cells (DCs), monocytes and Toll-like receptor (TLR)-2 and TLR-4 expression were determined in peripheral blood samples. RESULTS: Children with therapy-nave CD and those in relapse showed a decrease in Th1 cell prevalence. Simultaneously, an increased prevalence of memory and activated lymphocytes along with that of DCs and monocytes was observed. In addition, the ratio of myeloid /plasmocytoid DCs and the prevalence of TLR-2 or TLR-4 positive DCs and monocytes were also higher in therapy-nave CD than in controls. The majority of alterations diminished in remitted CD irrespective of whether remission was obtained by conventional or biological therapy. CONCLUSION: The finding that immune phenotype is normalized in remission suggests a link between immune phenotype and disease activity in childhood CD. Our observations support the involvement of members of the adaptive and innate immune systems in childhood CD.

关键词： Crohn’s disease Dendritic cell Infliximab Lymphocyte Monocyte Regulatory T cell Relapse Remission Therapy-nave Toll-like receptor

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Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis

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World Journal of Gastroenterology 2017年第29期23卷 5412-5421页

作者： Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter antal-Szalmas Gary L Norman Zakera Shums Gabor Veres antal dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp Institute of Internal Medicine Department of Gastroenterology University of Debrecen Faculty of Medicine Department of Laboratory Medicine University of Debrecen Faculty of Medicine Debrecen Inova Diagnostics Inc.San Diego 1^st Department of Pediatrics Semmelweis University 1^st Department of Medicine University of Pecs Gastroenterology Department of Medicine Borsod-Abauj Zemplen County Hospital 1^st Department of Medicine Semmelweis University

AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) *** Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and e

关键词：主要 sclerosing 胆管炎毁坏障碍机能障碍肠的丰满的酸绑定的蛋白质 Anti-F-actin 抗体反麦胶蛋白质抗体

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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Dental evaluation is helpful in the differentiation of functional heartburn and gastroesophageal reflux disease

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世界胃肠病学杂志:英文版 2023年第31期29卷 4774-4782页

作者： Krisztina Helle Anna ZsófiaÁrok Georgina Ollé Márk antal András Rosztóczy Department of Internal Medicine Division of GastroenterologyUniversity of SzegedSzeged 6725Hungary Department of Operative and Esthetic Dentistry University of SzegedSzeged 6725Hungary

BACKGROUND Heartburn is identically the key symptom of both,gastroesophageal reflux disease(GERD)and functional heartburn(FHB),making the differential diagnosis *** manifestations of GERD can be easily examined;therefore,their exploration might be a cheap,widely available,and useful tool in the differentiation of GERD and *** To evaluate the prevalence of dental erosions(DE)and periodontal diseases(PD)in patients with heartburn and their association with GERD and *** A total of 116[M/F:51/65,mean age:54(17-80)years]consecutive patients with heartburn were enrolled for detailed esophageal function and orodental *** Dental disorders were detected in 89%(103/116).Patients with PD+DE had significantly more often pathologic reflux(90.0%vs 27.8%;P<0.05),higher esophagitis scores(1.8 vs 0.9;P<0.05),and a significantly different mean impedance curve(P=0.04)than those without any dental *** opposite approach established that patients with GERD had significantly higher prevalence of DE and PD,especially if both were present(28.9%vs 2.0%;P<0.01),more severe PD(1.5 vs 1.0;P<0.01),and longer history of heartburn(15 years vs 9 years;P<0.01)than those with *** The dental evaluation of patients with heartburn seems to be useful in the differential diagnosis of GERD and *** the studied parameters,the co-appearance of DE and PD seems to be the best predictor of GERD,whereas the absence of dental disorders was mostly observed in FHB.

关键词： Gastroesophageal reflux disease Gastric acid Heartburn Differential diagnosis Epidemiology Oral manifestations Prevalence Risk factors Dental erosion Periodontal diseases

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Relationships among group delay,energy storage,and loss in dispersive dielectric mirrors

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Chinese Optics Letters 2012年第5期10卷 75-78页

作者： Péter Gyula antal Róbert Szipcs Research Institute for Solid State Physics and Optics P.O.Box 49H-1525 BudapestHungary

We show that absorbed and stored electromagnetic energy are proportional to the reflection group delay in highly reflective dispersive dielectric mirrors over the high-reflectivity band. Our theoretical considerations are verified by numerical simulations performed on different dielectric mirror structures. The revealed pro- portionality between group delay and absorbed energy sets constraint on the application of ultrabroadband and/or dispersive dielectric mirrors in broadband or widely tunable, high-power laser systems.

关键词： Relationships among group delay,energy storage,and loss in dispersive dielectric mirrors high

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Reversibility of visual field defects through induction of brain plasticity: vision restoration, recovery and rehabilitation using alternating current stimulation

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Neural Regeneration Research 2020年第10期15卷 1799-1806页

作者： Bernhard A.Sabel Ying Gao Andrea antal Institute of Medical Psychology Medical FacultyOtto-von-Guericke University of MagdeburgMagdeburgGermany Center for Behavioral and Brain Sciences(CBBS) MagdeburgGermany Sabel Vision Restoration Center MagdeburgGermany Department of Clinical Neurophysiology University Medical Center GottingenGottingenGermany

For decades visual field defects were considered irreversible because it was thought that in the visual system the regeneration potential of the neuronal tissues is ***,there is always some potential for partial recovery of the visual field defect that can be achieved through induction of *** refers to the ability of the brain to change its own functional architecture by modulating synaptic *** is maintained throughout life and just as neurological rehabilitation can improve motor coordination,visual field defects in glaucoma,diabetic retinopathy or optic neuropathy can be improved by inducing *** ophthalmology many new treatment paradigms have been tested that can induce neuroplastic changes,including non-invasive alternating current *** with alternating current stimulation(e.g.,30 minutes,daily for 10 days using transorbital electrodes and^10 Hz)activates the entire retina and parts of the *** and functional magnetic resonance imaging studies revealed local activation of the visual cortex,global reorganization of functional brain networks,and enhanced blood flow,which together activate neurons and their *** future of low vision is optimistic because vision loss is indeed,partially reversible.

关键词： alternating current stimulation glaucoma low vision optic nerve rehabilitation recovery stress vision vision restoration therapy visual field

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Ionic Elastomers for Electric Actuators and Sensors

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Engineering 2021年第5期7卷 581-602页

作者： Chenrun Feng C.P.Hemantha Rajapaksha antal Jákli Materials Science Graduate Program Kent State UniversityKentOH 44242USA Advanced Materials and Liquid Crystal Institute Kent State UniversityKentOH 44242USA Department of Physics Kent State UniversityKentOH 44242USA

In the past decades,ion conductive polymers and elastomers have drawn worldwide attention for their advanced functions in batteries,electroactive soft robotics,and *** ionic elastomers with dispersed soft ionic moieties such as ionic liquids have gained remarkable attention as soft sensors,in applications such as the wearable devices that are often called electric skins.A considerable amount of research has been done on ionic-elastomer-based strain,pressure,and shear sensors;however,to the best of our knowledge,this research has not yet been *** this review,we summarize the materials and performance properties of engineered ionic elastomer actuators and ***,we review three classes of ionic elastomer actuators—namely,ionic polymer metal composites,ionic conducting polymers,and ionic polymer/carbon nanocomposites—and provide perspectives for future actuators,such as adaptive four-dimensional(4D)printed systems and ionic liquid crystal elastomers(iLCEs).Next,we review the state of the art of ionic elastomeric strain and pressure *** also discuss future wearable strain sensors for biomechanical applications and sports performance ***,we present the preliminary results of iLCE sensors based on flexoelectric signals and their amplification by integrating them with organic electrochemical transistors.

关键词： Soft robots Ionic electroactive elastomer Ionic elastomer sensor Programmable deformation Liquid crystal elastomer

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Budesonide induces complete remission in autoimmune hepatitis

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World Journal of Gastroenterology 2006年第9期12卷 1362-1366页

作者： antal Csepregi Christoph R(o|¨)cken Gerhard Treiber Peter Malfertheiner Department of Gastroenterology Hepatology and Infectious DiseasesOtto-von-Guericke UniversityLeipziger Str 4439120 MagdeburgGermany Institute of Pathology Otto-von-Guericke University Leipziger Str 4439120 MagdeburgGermany

瞄准：泼尼松和 azathioprine 为自体免疫的肝炎(AIH ) 代表标准疗法。然而，仅仅， 65% 病人进入完全的组织学的宽恕。最近， budesonide (芽) 被报导是一种有希望的选择。在这研究，我们在 AIH 估计了芽的功效和安全。方法：十八个病... 详细信息

瞄准：泼尼松和 azathioprine 为自体免疫的肝炎(AIH ) 代表标准疗法。然而，仅仅， 65% 病人进入完全的组织学的宽恕。最近， budesonide (芽) 被报导是一种有希望的选择。在这研究，我们在 AIH 估计了芽的功效和安全。方法：十八个病人(12 个女人， 6 个男人；吝啬的年龄 45.4+/-21 年) 与芽(Budenofalk ) 与 AIH 被对待在上面三次每日、跟随的 3 mg 为至少 24 ***，病人们也有主要胆汁性肝硬变(n=5 ) 或主要致硬化的胆管炎(n=2 ) 的特征。先进的肝纤维变性或肝硬化在 6 个病人是在场的。结果：十五(83%) 病人们有完全的临床、生物化学的宽恕。十个病人，与尖锐肝炎包括五，作为首要的治疗被给芽，哪个七进入宽恕。三个病人，二与肝肝硬化，没改善。有第二线的治疗的所有病人经历了长期的宽恕。组织学的宽恕也在三个病人被看见。临床上相关的导致芽的副作用与肝肝硬化(n=4 ) 仅仅在病人被记录。结论：芽在在我们有 *** 效果的病人的多数的宽恕正式就职是有效的，治疗失败主要与肝肝硬化在病人被观察。

关键词：布地缩松自身免疫肝炎病理机制治疗

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The mutual interaction between the host spinal cord and grafted undifferentiated stem cells fosters the production of a lesion-induced secretome

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Neural Regeneration Research 2020年第10期15卷 1844-1845页

作者： Krisztián Pajer Tamás Bellák antal Nógrádi Department of Anatomy Histology and Embryology Faculty of Medicine University of Szeged

Pathophysiology of spinal cord injury:Injury to the spinal cord results in loss of gray and white matter i.e.,it produces a segmental spinal cord lesion and,as a consequence leads to a fatal loss of motor,sensory and autonomic *** cord injuries in humans and other mammals are not followed by the replacement of lost neurons and oligodendrocytes and regrowth of injured axons,instead they lead to permanent,fatal and incurable functional *** primary physical injury is followed by a cascade of tissue-decaying events,called secondary injury,which leads to ischemia,vascular disruption,neuroinflammation,excitotoxicity,demyelination and death of neurons and glial cells(Silva et al.,2014;Figure 1A).The direct mechanical disruption of the vasculature results in the increased permeability of the blood-spinal cord *** to the leakiness of blood-spinal cord barrier and production of cytokines by activated microglia,a number of various immune cells(T lymphocytes,neutrophils and monocytes)invade the injury *** macrophages generate a set of inflammatory cytokines such as tumor necrosis factor-α,interleukin(IL)-1α,IL-1β,and IL-6,which may further augment the secondary events(Ahuja et al.,2017).In addition,a number of other disruptive processes contribute to the heterogeneous and time-sensitive pathophysiology of spinal cord injury.

关键词： mutual Figure injuries

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Black locust(Robinia pseudoacacia L.)as a multi-purpose tree species in Hungary and Romania:a review

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Journal of Forestry Research 2018年第6期29卷 1449-1463页

作者： Valeriu-Norocel Nicolescu Cornelia Hernea Beatrix Bakti Zsolt Keseru Borbála antal Károly Rédei Faculty of Silviculture and Forest Engineering Transylvania University of BrassovSirul Beethoven no.1500123 BrasovRomania Faculty of Horticulture and Forestry Banat’s University of Agricultural Sciences and Veterinary Medicine“King Michael I of Romania”from Timi.oaraCalea Aradului 119300645 TimisoaraRomania Department of Plantation Forestry National Agricultural Research and Innovation Centre Forest Research InstituteFarkasszigetPu¨spo¨klada′ny 4150Hungary Hungarian Horticultural Propagation Material Non-profit Ltd. Sa′rva′rBudapestHungary

Black locust(Robinia pseudoacacia L.) was the first North-American tree species imported to Europe at the beginning of the seventeenth century. It is commonly planted worldwide because of its adaptability to environmental stresses, its valuable wood, easy propagation, frequent and abundant seed production, excellent coppicing,high seedling survival, and relatively high wood yield. In Europe, Romania and Hungary have the most highly-developed black locust growing techniques and *** a result of increasing interest in black locust in many countries, this review aims to provide a comprehensive overview of state-of-the-art site requirements, propagation, improvement and management(including growth and yield as well as use in energy plantations).

关键词： Robinia pseudoacacia Site requirements Selection Propagation Silviculture

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