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国际医学放射学杂志 2016年第6期 692-692页

作者： P.S.de oliveira-Szejnfeld D.Levine A.S.de oliveira melo m.m.R.Amorim A.G.m.Batista L.Chimelli 张莹 Inst of Biomedical Sciences and National Ctr for Structural Biology and Bioimaging Federal Univ of S?o Paulo

摘要目的整理巴西东北部IPESQ(Instituto de Pesquisa in Campina Grande State Paraiba)先天性寨卡病毒感染者相关影像表现,该地区先天性寨卡病毒感染尤其严重。方法从

关键词：畸形感染者放射科医师颅内钙化

发展型国家的行政能力建设:对智利和新加坡的比较研究

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国际行政科学评论（中文版） 2021年第2期87卷 11-30页

作者： m.沙姆斯·哈克何塞·A.庞皮姆·德·奥利维拉杜明鸣(译) 王秋蕾(审校) 新加坡国立大学政治学系巴西FGV(FGV EAESP和FGV EBAPE) 中国人事科学研究院不详

行政能力取决于国家的性质,行政系统是行政能力的组成部分。近年来,在东南亚和拉丁美洲又展开了关于公共行政在发展型国家中起到的作用的争论。对发展型国家的一个主要研究内容是其行政能力以及如何建设行政能力。由于历史、经济、政治... 详细信息

行政能力取决于国家的性质,行政系统是行政能力的组成部分。近年来,在东南亚和拉丁美洲又展开了关于公共行政在发展型国家中起到的作用的争论。对发展型国家的一个主要研究内容是其行政能力以及如何建设行政能力。由于历史、经济、政治和文化背景的不同,发展型国家的行政能力存在很大差异。本文比较了两个来自不同大洲的国家(新加坡和智利)的案例,讨论了发展型国家的形成,及其如何塑造行政系统和其提高行政能力的举措。本文还研究了这两个国家形成中的差异以及影响其行政能力的背景因素。文章最后做出总结,为进一步研究提供了一个分析框架,并提出了建立有效行政能力所需的政策。

关键词：行政能力智利背景差异发展型国家新加坡

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KIT是胰腺内分泌肿瘤的独立预后标记

临床与实验病理学杂志 2009年第6期25卷 634-634页

作者： Zhang L Smyrk T C oliveira A m( et al.) 郎志强(摘译) 不详烟台毓璜顶医院病理科烟台264000

单凭组织学特点预测胰腺内分泌肿瘤（PET）的预后比较困难，最可靠的依据是转移或临近器官受累。但对于有些PET，尤其是无功能性肿瘤是影像学检查偶然发现的，并没有转移或局部浸润的证据，就很难预测其临床行为。WHO分类使用肿瘤大小... 详细信息

单凭组织学特点预测胰腺内分泌肿瘤（PET）的预后比较困难，最可靠的依据是转移或临近器官受累。但对于有些PET，尤其是无功能性肿瘤是影像学检查偶然发现的，并没有转移或局部浸润的证据，就很难预测其临床行为。WHO分类使用肿瘤大小、血管浸润、核分裂计数和Ki-67指数作为预后标准。

关键词：胰腺内分泌肿瘤预后 KIT Ki-67指数无功能性肿瘤影像学检查 WHO分类核分裂计数

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Virulence Factor Profile of Staphylococcus aureus Isolated from Bovine milk from Brazil

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Food and Nutrition Sciences 2014年第15期5卷 1496-1505页

作者： Verena m.Santos Hellen B.martins Izadora S.Rezende maysa S.Barbosa Ewerton F.Andrade Simone G.Souza Guilherme B.Campos Pollianna S.oliveira Daniel S.Sousa Danilo C.C.Da Silva Aline T.Amorim Jorge Timenetsky mariluze P.Cruz Regiane Yatsuda Lucas m.marques Instituto multidisciplinar em Saúde Núcleo de Tecnologia em SaúdeUniversidade Federal da BahiaVitoria da ConquistaBrazil Instituto de Ciências Biomédicas Departamento de MicrobiologiaUniversidade de Sao PauloSao PauloBrazil

This study investigates the biofilm formation, presence and distribution of virulence genes and the capacity to induce an inflammatory response in strains of Staphylococcus aureus isolated from milk samples in Bahia, Brazil. A total of 132 samples of raw milk were collected from four dairy farms (designated A to D) located in southwestern Bahia, in the municipality of Vitória da Conquista, from October/2009 to September/2010. After processing of the samples, 94 (71.2%) S. aureus isolates were obtained. These strains were subjected to the antibiogram method mIC (minimum Inhibitory Concentration). As for the pathogenicity, tests were performedin vitrobiofilm formation induced by glucose. moreover, we performed PCR for their virulence genes: sea (enterotoxin A), seb (B), sec (C), pvl (Panton-Valentine Leukocidin), clfA (Clumping Factor A) and spa (protein A) and analysis of cytokine induction in the inflammatory response of J774 macrophages by exocellular lipoteichoic acid. No isolates were resistant to oxacillin and vancomycin. In biofilm production, 5.31% (5/94) isolates did not produce biofilm, 5.31% (5/94) of the samples were poor producers, 15.96% (15/94) strains were moderate producers, 18.09% (17/94) were producers and 55.32% (55/94) of isolates were strong biofilm producers. One (1.06%) isolate expressed the seb gene, one (1.06%) sec, 18 (19.2%) cflA and 44 (46.8%) had spa. There was no expression of sea and pvl between isolates analyzed. The analysis of cytokine induction in the inflammatory response did not show statistical difference in the levels of IL-6, TNF-α and IL-10 induction. However, there was statistical difference in IL-1 induction between isolates from different farms. Thus, it appears that the results obtained in this study show significant effects for the region studied, since it is an important dairy region, hence the need for further studies, with the intent of attracting funding that contributes to improving prevention and control in both dai

关键词： milk Staphylococcus aureus Resistance Virulence Factors

Feasibility of Prototyping the Jominy Test device: Corroborating for Studies and Preliminary Results of the Heating and Data Acquisition Subsystems

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Journal of materials Science and Chemical Engineering 2021年第3期9卷 23-38页

作者： Giulliano A. S. Boaventura Ramon O. B. Santos Renann P. Gama Regina E. S. Cabette mariana F. B. motta Cesar A. Botura Adriano C. m. Rosa Any m. Rosa Wilson F. muniz Carlos D. Jaeger Luiz F. F. Honorato Thiago A. Bimestre Edward P. I. Silva Beatriz Santos Livya V. m. oliveira Theresa C. G. Venuto Henrique C. Sampaio Samuel F. V. Silva Izabela F. L. Calazans Felipe A. Santos Fagner C. F. Santos Fernando H. A. oliveira department mechanical Engineering Salesian University Center of Sao Paulo (UNISAL) S&#227 o Paulo Brazil department management and Business State College of Technology (FATEC) S&#227 o Paulo Brazil department mathematics International University Center (UNINTER) S&#227 o Paulo Brazil

This work contributed to a detailed study on a better understanding of the Jominy test, adopted a proportion of study to create the Jominy test device, exhibited favorable conceptions for the development of a prototype of the device, covering the four aspects of the project, being they: test device, test body heating system, test automation and instrumentation using embedded electronics and financial analysis for the elaboration of this project in Brazil. It was possible to observe in the results that the system is efficient, simple and functional, it was possible to obtain the first test carried out in the controlled environment the temperature data in degrees centigrade, the recorded data were automatically launched in microsoft Excel by the PLX DAQ software, making the acquisition of the data. In the matter of preparing the test device, the drawings are presented in the 3D modeling software, cost tables of the materials used for assembly in Brazil. In terms of the heating system, a heating system was adopted that uses electromagnetic induction, the cost of materials related to the heating system design was also presented. Another relevant factor that contributes to the research and improvement of the prototype is the municipality, located in the Paraiba Valley region, located in the state of São Paulo, consisting of a fertile and relevant scenario of regional, national, international and multinational statistics, thus concluding the effectiveness for the mainly metallurgical industries. The results obtained were satisfactory and consistent, when they were created for the Jominy test device with the ability to submit small pieces for testing and mainly essential in the didactic point of view for a higher education institution of engineering and technology.

关键词： Tempering Jominy Test Data Acquisition Heating

melt Infiltration Ability and microstructural Evolution of Fe40Al/TiC Composites System

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Melt Infiltration Ability and Microstructural Evolution of F...

Relationship between mollicutes and spontaneous abortion:An epidemiological analysis

第十届国际制造工程与管理会议

作者： mingxia Gao, F J oliveira, Yi Pan, J L Baptista, J m Vieira (1. department of materials Science and Engineering, Zhejiang University, Hangzhou 310027, China-, 2. department of Ceramics and Glass Engineering/CICECO, University of Aveiro, Portugal)

Pressureless melt infiltration is an economic route for preparation of high-density ceramic/melt composites. In this study, the Fe40Al iron aluminide intermetallic, a low cost material of excellent oxidation and corrosion resistance, was used as binder for fabricating Fe40Al/TiC composites by pressureless melt infiltration. The wetting ability of liquid Fe40Al in porous TiC preform was studied by in-situ monitoring the melting and infiltration process. The infiltration ability was investigated by observing the distance of liquid Fe40Al intrusion in porous TiC pre-forms at different infiltration temperatures and times by using optical microscope. Porous TiC per-forms with density of 60% - 88%TD (theoretical density), prepared under pre-defined sintering temperature cycles, were used for fabricating Fe40Al/TiC composites in the range of 12% - 40% metal content by volume. Almost full dense Fe40Al/TiC composites were successfully fabricated by this technique. Liquid Fe40Al exhibited excellent infiltration ability, the distance of complete intrusion of liquid Fe40Al in the TiC sintered pre-form with density of 88%TD was over 7 mm after 5 min at the infiltration temperature of 1 450 ℃.microstructural observation by SEm and TEm also showed that liquid Fe40Al filled the very narrow gaps among TiC particles, the interfaces of TiC particles and Fe40Al plastic ligaments being metallurgical bonded. TEm revealed that high density of dislocations formed in Fe40Al ligaments during solidification, which favor the mechanical properties. Ti decomposed from TiC particles and dissolved into Fe40Al during infiltration. According to the compositional analysis of TEm-EDS, the concentration of Ti in Fe40Al ranges at 1at% - 4at% depending on composite fabricating conditions and the distance from the measuring point to the closest TiC particles. XRD analysis indicated that the composites were composed of two phases, the original TiC and Fe0.4Al0.6 intermetallic. No new phase formed during in

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World Journal of Obstetrics and Gynecology 2021年第1期10卷 1-15页

作者： maria Tânia Silva oliveira Caline Novais Teixeira oliveira Lucas Santana Coelho da Silva Hellen Braga martins oliveira Raquel Sousa Freire Lucas miranda marques maria Luísa Cordeiro Santos Fabrício Freirede melo Cláudio Lima Souza márcio Vasconcelos oliveira Instituto multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Universidade Estadual Santa Cruz Universidade Estadual Santa CruzIlhéus 45662900BahiaBrazil

BACKGROUND Abortion is of great importance in public health,as it is among the main causes of maternal morbidity and *** addition to sociodemographic-and lifestylerelated factors,studies have associated infections of the genital tract with higher rates of ***,the exacerbated presence and rise of mollicutes in the genitourinary tract may be related to higher rates of *** To perform an epidemiological analysis of women who had spontaneous abortions and placental colonization by mollicutes in a maternity *** This cross-sectional study involved the collection of data and biological material from women hospitalized due to spontaneous abortion or term *** sample consisted of 89 women who miscarried and 20 women who had full term *** collection was carried out in three stages:(1)Conducting research on the information and clinical data in medical records of patients hospitalized due to abortion;(2)Application of a semi-structured questionnaire to identify the patient's epidemiological profile and(3)Collection of placental *** samples were collected after the curettage procedure(abortion)and after placental expulsion(delivery),both performed by an *** identification in the fragments was performed by real-time polymerase chain *** this study,the following explanatory variables were considered:(1)Sociodemographic variables;(2)Variables related to access to health services;(3)Variables related to lifestyle;and(4)Variables related to sexual and reproductive health,all of which were used to perform descriptive,univariate and multivariate *** In the final model,placental colonization by mollicutes was independently associated with the variables age[odds ratio(OR)=7.55;CI:2.37-24.03]and menarche(OR=3.43;CI:1.03-11.44).In this investigation,the prevalence of mollicutes colonization by at least one of the following three species:mycoplasma hominis,Ureaplasma urealyti

关键词： miscarriage Epidemiology mollicutes Primary prevention

In silico evidence of Remdesivir action in blood coagulation cascade modulation in COVID-19 treatment

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World Journal of Biological Chemistry 2023年第4期14卷 72-83页

作者： Luis Gustavo Pagliarin Lucca miketen de oliveira Valentina Nunes Fontoura dos Anjos Cristiano de Bem Torquato de Souza Gabrielle Caroline Peiter Cinthia Façanha Wendel Anderson Dillmann Groto Fabrício Freire de melo Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil Programa multicêntrico de Pós-graduação em Bioquímica e Biologia molecular-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Instituto multidisciplinar em Saúde-Campus Anísio Teixeira Universidade Federal da BahiaVitória da Conquista 45.029-094BahiaBrazil

BACKGROUND Coronavirus disease 2019(COVID-19)has demonstrated several clinical manifestations which include not only respiratory system issues but also liver,kidney,and other organ *** of these abnormalities is coagulopathies,including thrombosis and disseminated intravascular *** of this,the administration of low molecular weight heparin is required for patients that need to be *** addition,Remdesivir is an antiviral that was used against middle East Acute Respiratory Syndrome,Ebola,Acute Respiratory Syndrome,and other diseases,showing satisfactory results on ***,there is evidence suggesting that this medication can provide a better prognosis for patients with *** To investigate in silico the interaction between Remdesivir and clotting factors,pursuing a possibility of using it as *** In this in silico study,the 3D structures of angiotensin-converting enzyme 2(ACE2),Factor I(fibrinogen),Factor II(prothrombin),Factor III(thromboplastin),Factor V(proaccelerin),Factor VII(proconvertin),Factor VIII(antihemophilic factor A),Factor IX(antihemophilic factor B),Factor X(Stuart-Prower factor),and Factor XI(precursor of thromboplastin(these structures are technically called receptors)were selected from the Protein Data *** structures of the antivirals Remdesivir and Osetalmivir(these structures are called ligands)were selected from the PubChem database,while the structure of Atazanavir was selected from the ZINC *** software AutoDock Tools(ADT)was used to prepare the receptors for molecular ***,peptides,water molecules,and other ones were removed from each ligand,and then,hydrogen atoms were added to the *** grid box was delimited and calculated using the same software ADT.A physiological environment with pH 7.4 is needed to make the ligands interact with the receptors,and still the software marvin sketch®(ChemAxon®)was used to forecast the protonation *** perform m

关键词： Clotting factors Coagulating blood cascade COVID-19 treatment Remdesivir SARS-CoV-2

编辑寄语建设促进发展的行政能力:当前局限与未来前景

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国际行政科学评论（中文版） 2021年第2期 1-10页

作者： m.沙姆斯·哈克 m.拉梅什何塞·A.庞皮姆·德·奥利维拉亚历山大·德·雅维拉·戈米德何天纯(译) 王秋蕾(审校) 新加坡国立大学政治科学学院联合国教科文组织新加坡国际大学巴西圣保罗企业管理学院巴西教育、发展与研究所不详

一、引言学界一向有关于国家能力跨学科研究的传统,在政治科学和政治社会学领域尤甚(Cingolani,2013,2018)。近年来,这一概念更多转向国家能力的行政维度,即行政能力,并被广泛运用于公共行政和政策研究中(El-Taliawi and Van der Wal,20... 详细信息

一、引言学界一向有关于国家能力跨学科研究的传统,在政治科学和政治社会学领域尤甚(Cingolani,2013,2018)。近年来,这一概念更多转向国家能力的行政维度,即行政能力,并被广泛运用于公共行政和政策研究中(El-Taliawi and Van der Wal,2019)。就其对经济增长、工业发展、政策实施和国家整体发展的必要性而言,行政能力的实践重要性尤为显著(Cingolani,2013;El-Taliawi and Van der Wal,2019)。

关键词：公共行政未来前景社会学领域编辑寄语广泛运用跨学科研究 Van

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