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Neurocognitive Disorders in Patients with HIV Infection with Virologic Suppression for More than 10 Years

World Journal of AIDS 2017年第1期7卷 59-66页

作者： André Filipe dos Santos-Silva Joana Margarida Almeida Alves Isabel ramos Maria del Cármen Piñ eiro-Calvo Cláudia Sousa Maria do Rosário Serrã o antónio Carlos Eugénio Megre Sarmento Infectious Diseases Department S&atilde o Joã o Hospital Centre Oporto Portugal Faculty of Medicine of the University of Oporto Oporto Portugal Psychiatry and Mental Health Department S&atilde o Joã o Hospital Centre Oporto Portugal Neurology Department S&atilde o Joã o Hospital Centre Oporto Portugal

Background: HIV-associated neurocognitive disorder (HAND) may appear in patients with viral and immunological response to treatment and remain unnoticed during the initial stage of the infection. The goal of this study is to evaluate the development and/or progression of HAND in patients with undetectable viral load for more than ten years. Methods: We included adult HIV-infected patients who were under antiretroviral treatment and had undetectable plasma viral load for more than ten years (blips were included). These patients had already been subjected to neurocognitive evaluation five years previously. Demographic, clinical and analytical data were analysed. For the neurocognitive evaluation, the WAIS-III subtests (digit symbol coding and symbol search), trail making test (TMT) A and B, Stroop test and categorical verbal fluency (animals) tests were used. SPSS??version 22.0 for Windows was used for statistical analysis. Results: In this re-evaluation, performed 4.76 (±1.82) years after the first one, 9 (36%) patients showed deficits in processing speed (WAIS-III and TMT A), 8 (32%) executive function (TMT B and Stroop) and 12 (48%) verbal fluency. There were significant statistical differences between the past and current executive function tests (p = 0.029 and p = 0.01), highlighting worsening of deficits. No differences were found for the other tests. No association was found between deficit progression and the studied variables. Conclusions: Although not generally noticed on regular appointments, in this small population, worsening of executive function deficits (mental flexibility and divided attention) was found. Classical risk factors for HAND did not appear to interfere in its progression. Speed of information processing and categorical verbal fluency remained stable.

关键词： HIV HAND Dementia Impairment

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Nanomechanical hydrodynamic force sensing using suspended microfluidic channels

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微系统与纳米工程(英文) 2023年第3期9卷 95-102页

作者： Alberto Martín-Pérez Daniel ramos Optomechanics Lab Instituto de Ciencia de Materiales de Madrid(ICMMCSIC)3 Sor Juana Inés de la Cruz(Madrid)E-28049 MadridSpain

Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic ***,there is currently no available technique that enables the direct measurement and tracking of these hydrodynamic forces acting on a flowing *** this work,we introduce a novel method for the direct measurement of the hydrodynamic force actuating on an in-flow particle based on the analysis of the induced resonance changes of suspended microchannel resonators(SMRs).This hydrodynamic force sensitivity depends on the device used;therefore,we considered the geometry and materials to advance this dependency on the SMR resonance frequency.

关键词： hydrodynamic applying flow

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Robust and conductive hydrogel based on mussel adhesive chemistry for remote monitoring of body signals

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Friction 2022年第1期10卷 80-93页

作者： Weijun LI Hao LIU Yuanyuan MI Miaoran ZHANG Jinmiao SHI Ming ZHAO Melvin A.ramos Travis Shihao HU Jianxiong LI Meng XU Quan XU State Key Laboratory of Heavy Oil Processing.Beijing Key Laboratory of Biogas Upgrading Utilization Harvard SEAS-C UPB Joint L aboratory on Petroleum ScienceChina University of PetroleumBeijing 102249China Department of Mechanical Engineering.California State University Los AngelesCA 90032USA Department of Orthopedics General Hospital of Chinese People's Liberat ion Army Beijing 100853China

There is a high demand for hydrogels with multifunctional performance(a combination of adhesive,mechanical,and electrical properties)in biological,tissue engineering,robotics,and smart device ***,a majority of existing hydrogels are relatively rigid and brittle,with limited stretchability;this hinders their application in the emerging field of flexible *** this study,cheap and abundant potato residues were used with polyacrylamide(PAM)to fabricate a multifunctional hydrogel,and chitosan was used for the design of a three-dimentional(3D)network-structured *** as-prepared hydrogels exhibited excellent stretchability,with an extension exceeding 900%and a recovery degree of over 99%.Due to the combination of physical and chemical cross-linking properties and the introduction of dopamine,the designed hydrogel exhibits a remarkable self-healing ability(80%mechanical recovery in 2 h),high tensile strength(0.75 MPa),and ultra-stretchability(900%).The resultant products offer superior properties compared to those of previously reported tough and self-healing hydrogels for wound *** and potato residues were used as scaffold materials for the hydrogels with excellent mechanical *** addition,in vitro experiments show that these hydrogels feature excellent antibacterial properties,effectively hindering the reproduction of ***,the ternary hydrogel can act as a strain sensor with high sensitivity and a gauge factor of *** proposed strategy is expected to serve as a reference for the development of green and recyclable conductive polymers to fabricate *** proposed hydrogel can also act as a suitable strain sensor for bio-friendly devices such as smart wearable electronic devices and/or for health monitoring.

关键词： properties hydrogel conductive

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Pd-TiO_(2)/C催化剂中TiO_(2)对直接碱性燃料电池中丙三醇氧化的影响

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燃料化学学报 2022年第4期50卷 474-483页

作者： Viviane Santos Pereira Júlio Nandenha Andrezza ramos Almir Oliveira Neto Instituto de Pesquisas Energéticas e Nucleares-IPEN-CNEN/SP Centro de Células a Combustível e Hidrogênio-CECCO Cidade UniversitáriaSão Paulo-SP 05508-000Brasil

以Vulcan XC-72炭为载体,采用硼氢化钠还原法制备了Pd-TiO_(2)/C电催化剂用于直接丙三醇燃料电池阳极材料,并用能量色散谱(EDX)、X射线衍射(XRD)、透射电子显微镜(TEM)、循环伏安法(CV)、计时电流法(I-t)和全反射-傅里叶变换红外光谱(AT... 详细信息

以Vulcan XC-72炭为载体,采用硼氢化钠还原法制备了Pd-TiO_(2)/C电催化剂用于直接丙三醇燃料电池阳极材料,并用能量色散谱(EDX)、X射线衍射(XRD)、透射电子显微镜(TEM)、循环伏安法(CV)、计时电流法(I-t)和全反射-傅里叶变换红外光谱(ATR-FTIR)对催化剂进行了表征。EDX结果表明,Pd-TiO_(2)/C中Pd和Ti含量接近名义原子比。Pd-TiO_(2)的X射线衍射结果表明,Pd具有面心立方fcc结构,同时TiO_(2)展现出四方结构的锐钛矿相的峰特征。TEM图像显示Pd和TiO_(2)纳米颗粒在碳载体中分布均匀并存在一些簇状区域,纳米颗粒大小为7.0-8.0 nm。循环伏安显示在1 mol/L KOH电解液中催化剂Pd-TiO_(2)/C在约-0.7 V vs Ag/AgCl有明显的析氢行为和电容增加现象,表明催化剂在TiO_(2)修饰后活性明显增加。通过循环伏安对碱性体系的丙三醇电催化氧化表明,Pd-TiO_(2)/C(70∶30)显示了非常好的催化活性:起始氧化电位也变得更负达到-0.4V vs Ag/AgCl,氧化电流达到14.91 mA/cm,优于Pd-TiO_(2)/C(90∶10)的9.37 mA/cm和Pd-TiO_(2)/C(50∶50)的4.88 mA/cm,明显高于Pd/C和TiO_(2)/C的1.88和0.55 mA/cm。I-t实验表明1000 s之前Pd-TiO_(2)/C展现出最高的电流密度,但在1000 s后电流密度有一定程度的下降,表明催化剂的催化活性很高但长期稳定性方面需要进一步提升。在碱性直接丙三醇燃料电池中进行的实验表明,所制备的Pd-TiO_(2)/C(50∶50)、Pd-TiO_(2)/C(70∶30)和Pd-TiO_(2)/C(90∶10)对甘油的电化学氧化性能均优于Pd/C电催化剂,其中,Pd-TiO_(2)/C(70∶30)的催化活性最好:开路电压达到817 mV,最大功率密度达到12.5mW/cm,高于Pd-TiO_(2)/C(50∶50)的12.4mW/cm、Pd-TiO_(2)/C(90∶10)的7.9mW/cm、Pd/C的3.7mW/cm以及TiO_(2)/C的2.25 mW/cm,这表明,TiO_(2)对Pd/C催化剂有很好的促进作用,这种协同效应可以归因为TiO_(2)对Pd的电子效应和双功能机理,同时Pd和TiO_(2)比例为70∶30时,其催化性能达到最优。ATR-FTIR结果表明,反应后所有Pd-TiO_(2)/C电催化剂表面均有甘油醛、羟丙酮酸、甲酸等高附加值产物生成,为直接丙三醇燃料电池电-化学品联产提供一定的依据。

关键词：丙三醇氧化 Pd-TiO_(2)电催化剂原位ATR-FTIR 循环伏安碱性燃料电池

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Nasal sill reconstruction with the Abbe flap after skin cancer resection:A case report

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Chinese Journal Of Plastic and Reconstructive Surgery 2023年第2期5卷 64-67页

作者： Renata Fernanda ramos Marcante Oona Tomiê Daronch Murilo Sgarbi Secanho Maria Madalena Silva Department of Plastic Surgery State University of Sao PauloBotucatuSao Paulo 18618-687Brazil

Local flaps are widely known as the best option for partial nasal reconstructions depending on donor tissue laxity,vascularization,and defect shape and *** nasolabial flap is used more often in the nasal *** larger defects,greater tissue mobilization with larger scars or free flaps is ***,the Abbe flap has been used for lip reconstruction in patients with cleft lip *** allows less retraction than other local flaps or skin grafts in patients with large defect sizes and great defect *** study reported on the application of the Abbe flap for nasal sill reconstruction on a 71-year-old female patient with nasal sill basal cell carcinoma who had undergone resection surgery with a posterior lip switch operation with satisfactory *** application of the Abbe flap could be considered in patients with multiple previous surgeries and at risk for necrosis.

关键词： Surgical flaps Myocutaneous flap Nose Nasal diseases Nasal defects Neoplasms Basal cell

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Parabolic Trough Collector and Central Receiver Coupled with Fresnel Lens:Experimental Tests

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International Journal of Automation and computing 2020年第4期17卷 572-587页

作者： Angelica Palacios Dario Amaya Olga ramos Universidad Militar Nueva Granada Bogota 110121Colombia

Renewable energies have a high impact on power energy production and reduction of environmental pollution worldwide,so high efforts have been made to improve renewable technologies and research about *** paper presents the thermal performance results obtained by simulation and experimental tests of a parabolic trough collector with central receiver coupled to Fresnel lens,under different configurations on the *** simulation method was computational fluid dynamics(CFD)analysis in SolidWorks(R)soft-ware tool,which works with Naiver-Stokes equations to converge on a *** tests were formed with all configurations proposed and three observations for each one,a total of 12 observations were performed in all *** a result,the best thermal performance in simulation was achieved with the Fresnel lens and black pipe collector,with a maximum temperature of 116℃under 1000 W/m^2 radiation,the same system achieved in experimental tests a maximum temperature of 96℃with a radiation of 983 W/m^2.

关键词： Solar collector parabolic trough collector Fresnel lens thermal conductivity solar power

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Astroglial heterogeneity:merely a neurobiological question? Or an opportunity for neuroprotection and regeneration after brain injury?

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Neural Regeneration Research 2016年第11期11卷 1739-1741页

作者： Alberto Javier ramos Laboratorio de Neuropatología Molecular Instituto de Biología Celular y Neurociencia "Prof.E.De Robertis" UBA-CONICETFacultad de MedicinaUniversidad de Buenos Aires

Pioneer studies by Ramon y Cajal in the early nineteenth century evidenced that astrocytes are a heterogeneous cell population. The initial division of the glial family proposed by Rudolf Albert von Kolliker and William Lloyd Andriezen that separated glia into two groups, fibrous glia and protoplasmic glia, was further refined by Ramon y Cajal,

关键词： Or an opportunity for neuroprotection and regeneration after brain injury

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Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer’s disease therapy

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Neural Regeneration Research 2020年第1期15卷 30-35页

作者： Alejandro Romero JoséMarco-Contelles Eva ramos Department of Pharmacology&Toxicology Faculty of Veterinary MedicineComplutense University of MadridMadridSpain Laboratory of Medicinal Chemistry Institute of General Organic Chemistry(CSIC)MadridSpain

There is no effective treatment to face Alzheimer’s disease *** molecules are a good approach against the multiple physiopathological events associated with its development and *** this context,N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine(ASS234)has been tested achieving promising ***234 has demonstrated to cross the blood-brain barrier in vivo,and a good in silico safety profile being less toxic than ***,ASS234 reversibly inhibits human acetyl-and butyryl-cholinesterase,and irreversibly inhibits human monoamine oxidase A and ***,this multitarget molecule has antioxidant and neuroprotective properties,and inhibitsΑβ1–42 andΑβ1–40 *** about the mechanism of action,several signaling pathways related to Alzheimer’s disease had been explored showing that ASS234 induces the wingless-type MMTV integration site(Wnt)family and several members of the heat shock proteins family and moreover counteracts neuroinflammatory and oxidative stress-related genes promoting the induction of several key antioxidant ***,in vivo experiments with ASS234 in C57BL/6J mice displayed its ability to reduce amyloid plaque burden and gliosis in the cortex and hippocampus,ameliorating scopolamine-induced learning *** we gather the information regarding ASS234 evaluated so far,showing its ability to face different targets,necessary to counteract a neurodegenerative disease as complex as the Alzheimer’s disease.

关键词： AChE BuChE gene expression heat shock proteins inflammation in silico toxicology MAO A/B neuroprotection oxidative stress Wnt signaling

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Artisanal ceramic factories using wood combustion:A nanoparticles and human health study

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Geoscience Frontiers 2022年第1期13卷 488-497页

作者： Kátia Martinello James C.Hower Diana Pinto Carlos E.Schnorr Guilherme L.Dotto Marcos Leandro Silva Oliveira Claudete G.ramos Instituto Inanís Rua Felizardo FurtadoPorto AlegreBrazil Department of Civil and Environmental Universidad de la CostaCUCCalle 58#55–66BarranquillaAtlánticoColombia University of Kentucky Department of Earth&Environmental SciencesLexingtonKY 40506USA University of Kentucky Center for Applied Energy Research2540 Research Park DriveLexingtonKY 40511USA Centro de Estudos em Estresse Oxidativo-Departamento de Bioquímica-Instituto de Ciências Básicas da Saúde-Universidade Federal do Rio Grande do Sul(UFRGS) Porto AlegreRSBrazil Chemical Engineering Department Federal University of Santa MariaUFSMRoraima Avenue1000Santa MariaRS97105-900Brazil Departamento de Ingeniería Civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600–Santiago de Surco 1503Peru

The ceramics industry,resulting from developments of modern compounds,is a segment of great influence in worldwide *** ceramic factories based on wood combustion have significant risks for the creation and discharge of atmosphere nanoparticles(NPs)and ultra-fine particles(UFPs).At present,there is insufficient recognition on the influence of engineered-NPs on the atmosphere and *** improvements are indispensable to diminish contact with *** present study demonstrates the main NPs and UFPS present in an area of intense artisanal wood-combustion ceramic *** matter was sampled for morphological,chemical,and geochemical studies by sophisticated electron microbeam microscopy,X-Ray Diffraction,and Raman *** NPs configuration(10 nm)were produced around the studied artisanal ceramic *** study presents an indication of the recent information on population and work-related contact to NPs in the artisanal ceramic factories and their influence on health.

关键词： Ceramic manufacturing Nanoparticles Advanced characterization Multiple impacts

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An overview of resistance to chemotherapy in osteosarcoma and future perspectives

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Cancer Drug Resistance 2022年第3期5卷 762-793页

作者： Dorian Yarih Garcia-Ortega Sara Aileen Cabrera-Nieto Haydee Sarai Caro-Sanchez Marlid Cruz-ramos Cirugia Oncologica Instituto Nacional de Cancerologia(INCAN)Ciudad de Mexico 14080Mexico Posgrado en Ciencias Medicas Facultad de Ciencias de la SaludUniversidad AnahuacCiudad de Mexico 52786Mexico Departamento de Patologi Instituto Nacional de Cancerologia(INCAN)Ciudad de México 14080Mexico Catedras de Consejo Nacional de Ciencia y Tecnologia(CONACYT) Instituto Nacional de CancerologiaCiudad de Mexico 14080Mexico

Osteosarcoma(OS)is the most common type of bone *** the availability of multimodal treatment with surgery and chemotherapy,the clinical results remain *** main reason for the poor outcomes in patients with OS is the development of resistance to methotrexate,cisplatin,doxorubicin,and *** and cellular mechanisms associated with resistance to chemotherapy include DNA repair and cell-cycle alterations,enhanced drug efflux,increased detoxification,resistance to apoptosis,autophagy,tumor extracellular matrix,and *** versatility of cells to generate chemoresistance has motivated the use of anti-angiogenic therapy based on tyrosine kinase *** approach has shown that other therapies,along with standard chemotherapy,can improve responses to therapy in patients with ***,microRNAs may act as predictors of drug resistance in *** review provides insight into the molecular and cellular mechanisms involved in the development of resistance during the treatment of OS and discusses promising novel therapies(e.g.,afatinib and palbociclib)for overcoming resistance to chemotherapy in OS.

关键词： Osteosarcoma therapy resistance tyrosine kinase inhibitor tumoral extracellular microenvironment cell cycle

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