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Ischemic colitis with small-vessel occlusion,simultaneous total colectomy and liver transplantation:A case report

World Journal of Transplantation 2025年第2期15卷 337-343页

作者： Leonardo Yuri Kasputis Zanini Fabiana Roberto Lima Michel Ribeiro Fernandes Paola Sofia Espinoza Alvarez Marcello de Souza Silva antônio paulo ramos martins filho Tomazo antonio Prince Franzini Lucas Souto Nacif Department of Surgery Federal University of São PauloSão Paulo 04023-062Brazil Department of Liver and Gastrointestinal Transplant Hospital 9 de JulhoSão Paulo 01409-002Brazil Department of Pathology University of São Paulo School of MedicineSão Paulo 05403-900Brazil Department of Surgical Pathology Hospital 9 de JulhoSão Paulo 01409-002Brazil Department of Gastrointestinal Endoscopy Unit Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-010Brazil Department of Endoscopy Hospital 9 de JulhoSão Paulo 01409-002Brazil

BACKGROUND The colon is the hollow viscera that proportionally has the lowest vascular supply and is more predisposed to ischemic *** the context of end-stage liver disease,various components may explain this group's greater predisposition to colonic ischemic ***,portal hypertension generates a process of coagulopathy,impairing local *** case report describes a case of ischemic colitis with small-vessel occlusion found during liver transplantation in a patient with decompensated end-stage liver *** SUMMARY A 64-year-old man with liver cirrhosis due to non-alcoholic steatohepatitis and hepatocellular *** patient underwent liver transplantation due to hepatic *** donor was a 53-year-old man who had died of a hemorrhagic *** examination revealed diffuse ischemic colitis with significant distention and *** to the condition of the colon,a subtotal colectomy was *** transplantation with warm ischemia time of 35 minutes,cold ischemia of 6 hours 30 minutes and total ischemia time of 7 hours 5 *** patient improved clinically with oral tract function and physiotherapy,but unfortunately,he developed a bloodstream infection,a new septic shock and died six months after *** Simultaneous total colectomy and orthotopic liver transplantation represent a rare *** events have a high mortality rate in the general population and are particularly important in cirrhotic patients.

关键词： Ischemic colitis Liver transplantation End-stage liver disease Acute-on-chronic liver failure Case report

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Axillary recurrence after intramammary sentinel lymph nodes metastases with capsular extravasation

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Journal of Cancer Metastasis and Treatment 2019年第1期4卷 13-17页

作者： paulo R.De Alcantara filho Stephania martins Bezerra Breast Surgery Department Hospital Sirio-LibanesSao Paulo 01308-050Brazil Pathology Department ACCamargo Cancer CenterSao Paulo 01509-010Brazil

Axillary recurrence is a rare event in patients treated with sentinel lymph node biopsy alone with the majority occurring in the first 5 years after surgery. Intramammary lymph node (IMLN) can be the primary sites of metastasis and sentinel lymph nodes, but the clinical significance, including prognosis and therapeutic approach is yet unclear, even more with capsular extravasation. IMLN metastases are strongly correlated with axillary lymph nodes involvement and therefore a guide for further surgical management of the axillary nodes.

关键词： Breast cancer sentinel lymph node lymph node dissection metastasis locoregional neoplasm recurrence

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Effectiveness of rotavirus vaccines against rotavirus infection and hospitalization in Latin America: systematic review and metaanalysis

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Infectious Diseases of Poverty 2016年第1期5卷 764-775页

作者： Victor S.Santos Daniella P.Marques paulo R.S.martins-filho Luis E.Cuevas Ricardo Q.Gurgel Postgraduate Program in Health Sciences Federal University of SergipeRua Cláudio Batista s/nAracajuSergipe Zip code:49060-108Brazil Department of Medicine Federal University of SergipeAracajuSergipeBrazil Investigative Pathology Laboratory Federal University of SergipeAracajuSergipeBrazil Liverpool School of Tropical Medicine LiverpoolUK

Background:Rotavirus was the leading cause of childhood diarrhoea-related hospitalisations and death before the introduction of rotavirus ***:We describe the effectiveness of rotavirus vaccines to prevent rotavirus infections and hospitalizations and the main rotavirus strains circulating before and after vaccine introduction through a systematic review and meta-analysis of studies published between 1990 and 2014.203 studies were included to estimate the proportion of infections due to rotavirus and 10 to assess the impact of the vaccines.41 of 46 studies in the post-vaccination period were used for meta-analysis of genotypes,20 to calculate VE against infection,eight for VE against hospitalisation and seven for VE against severe ***:24.3%(95%CI 22.1–26.5)and 16.1%(95%CI 13.2–19.3)of cases of diarrhoea were due to rotavirus before and after vaccine introduction,*** most prevalent G types after vaccine introduction were G2(51.6%,95%CI 38–65),G9(14.5%,95%CI 7–23)and G1(14.2%,95%CI 7–23);while the most prevalent P types were P[4](54.1%,95%CI 41–67)and P[8](33%,95%CI 22–46).G2P[4]was the most frequent genotype combination after vaccine *** was 53%(95%CI 46–60)against infection,73%(95%CI,66–78)against hospitalisation and 74%(95%CI,68.0–78.0)against severe *** in hospitalisations and mortality due to diarrhoea were observed in countries that adopted universal rotavirus ***:Rotavirus vaccines are effective in preventing rotavirus-diarrhoea in children in Latin *** vaccines were associated with changes in genotype distribution.

关键词： Rotavirus vaccines Rotavirus vaccine effectiveness Rotavirus genotype Meta-analysis Latin America

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How Growth Ability of Multidrug-Resistant Escherichia coli Is Affected by Abiotic Stress Factors

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Open Journal of Preventive Medicine 2014年第5期4卷 250-256页

作者： Lucinda Janete Bessa Vania Filipa Dias Angelo Mendes Paula martins-Costa Helena ramos paulo martins da Costa CIIMAR—Interdisciplinary Center for Marine and Environmental Research University of PortoPortoPortugal ICBAS—Institute Abel Salazar for the Biomedical Sciences University of PortoPortoPortugal FCUP—Faculty of Sciences University of PortoPortoPortugal Servico de Microbiologia Centro Hospitalar do PortoHospital Geral de Santo AntonioPortoPortugal

The ability of multidrug-resistant Escherichia coli to adapt and grow in a wide range of different environmental conditions may be crucial to the global spread of antimicrobial resistance. The aim of this study was to evaluate the survival ability of 54 multidrug-resistant E. coli strains, isolated from three different biotopes (clinical setting, gull intestine, river water) when subjected to variations in pH (from 3 to 11) and salinity (from 0.5% to 6% of NaCl) and to nutrient deprivation. The growth of each isolate as well as of a reference strain was assessed during 168 h in every varying condition. Slight variations in the growth ability under some abiotic stress factors were recorded among the isolates from the different biotopes. Multidrug-resistant isolates from gull feces were found to be the more tolerant to environmental abiotic changes, while isolates from river water were the less tolerant. In addition, it was notorious that the carriage of antimicrobial resistance has a clear fitness cost in comparison with the susceptible (reference) strain, highlighting the necessity of reducing the selective pressure exerted by antibiotics. This study underlines the ecological hardness of multidrug-resistant E. coli isolates with a consequent ability to reach and colonize new host and environments.

关键词： Escherichia coli Multidrug Resistance Nutrient Deprivation pH Salinity

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Terpinolene inhibits acute responses triggered by different inflammatory agents in vivo models of mouse

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Food Bioscience 2023年第3期53卷 3038-3046页

作者： Isis Oliveira Menezes Lucas Yure Santos da Silva Renata Torres Pessoa Andreza Guedes Barbosa ramos Francisco Assis Bezerra da Cunha Jaime Ribeiro-filho Anita Oliveira Brito Pereira Bezerra martins Henrique Douglas Melo Coutinho Irwin Rose Alencar de Menezes Laboratory of Pharmacology and Molecular Chemistry(LFQM) Biological Chemistry DepartmentRegional University of Cariri(URCA)Rua Coronel Antônio Luis 1161Pepper63105-000CratoCEBrazil Semi-arid Bioprospecting Laboratory(LABSEMA) Biological Chemistry DepartmentRegional University of Cariri(URCA)Rua Coronel Antônio Luis 1161Pepper63105-000CratoCEBrazil Research Laboratory in Genetics and Translational Hematology(LIGHT) Gonçalo Moniz Institute(IGM)Oswaldo Cruz Foundation(FIOCRUZ)Rua Waldemar Falcão121Candeal40296-710SalvadorBABrazil Gonçalo Moniz Institute–IGM Fiocruz-BASalvador40296-710BABrazil Department of Biological Chemistry Regional University of CaririAv.Cel.Antonio Luiz1161.PimentaCratoCE63105-000Brazil

The aim of this work was evaluate the effects of terpinolene on acute inflammatory responses in *** vivo preclinical research using different inflammatory agents to induce acute responses and evaluate the effects of terpinolene in orally treated *** acute inflammatory responses were induced by injecting phlogistic agents in the mice paw to observe the development of pain responses(formalin test)or edema(carrageenan,dextran,histamine,arachidonic acid,and prostaglandin).The antiedematogenic activity was also evaluated using a croton oil-induced ear edema ***,cotton pellet-induced granuloma was used to carry out a pre-liminary evaluation of terpinolene in a chronic inflammatory *** administered terpinolene(5,10,and 20 mg/mL)significantly inhibited ear edema development(by 33.82%,29.63%,and 33,30%,respectively).Following an oral administration,only the highest dose of the monoterpene(200 mg/kg)reduced the licking time of the formalin test in both phases 1(73.55%)and 2(96.61%).The carrageenan-induced edema signifi-cantly inhibited over time following the oral administration of terpinolene at 50 mg/kg(T1:47.74%,T2:54.67%,T3:48.63%,and T4:62.99%),100 mg/kg(T1:72.86%,T2:71.03%,T3:48.63%,and T4:57.83%),and 200 mg/kg(T1:43.22%,T2:34.11%,T3:36.47%,and T4:45.20%).On the other hand,only the dose of 200 (mg/kg)caused a significant reduction of the dextran-induced paw edema(T1:51.18%,T2:60%,T3:50.92%,and T4:65.15%).Regarding the participation of inflammatory pathways,the monoterpene(200 mg/kg,p.o.)had little impact on histamine-induced edema,while the edema induced by arachidonic acid was significantly reduced at all time-points(T1:37.04%,T2:24.32%,and T3:35.13%,and T4:35.53%),which was corroborated by the observation that the compound inhibited the response triggered by prostaglandin E2(PGE2),suggesting inter-ference with downstream signaling ***,terpinolene(200 mg/kg,p.o.)reduced both the weight(21.43%)and total protein content(36.21%)

关键词： Terpinolene antiedematogenic Inflammation In vivo study Inflammatory pathways

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Integrating species and successional classes for wood production in a mixed forest restoration system in a neotropical region

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Journal of Forestry Research 2021年第6期32卷 2313-2321页

作者： Ananias Francisco Dias Junior Ana Lucia martins Sodero Pincelli Ana Paula Camara da Silva Alison Moreira da Silva Natalia Dias de Souza Mario Tommasiello filho Jose Otavio Brito Wood and Forestry Science Department Federal University of EspIrito Santo(UFES)Av.Governador Lindemberg316JerOnimo Monteiro CityES 29550-000Brazil São paulo State School of Technology(FATEC/SP) Av.DiacOno Jair de Oliveira651PiracicabaSP 13414-141Brazil Forest Products Department Federal Rural University of Rio de Janeiro(UFRRJ)BR 465km 07SeropEdicaRJ 29890-000Brazil University of SAo paulo “Luiz de Queiroz”College of Agriculture(USP/ESALQ)Av.PAdua Dias11PiracicabaSP 13418-900Brazil

As forests in neotropical regions,particularly in developing countries,are devastated,interventions to restore biodiversity and its ecological functions are *** producers have thus been encouraged to grow trees for wood production as an economic *** objective of this study was to quantify the increment of wood density of four forest species from different successional classes of a mixed system of restoration in a neotropical forest in *** discs were sampled at breast height and analyzed radially by X-ray densitometry to obtain apparent density and basic *** trees each of a species from the pioneer,early and late secondary successional stages and of the dominant species in the climax *** radial profiles indicated increasing density from the pith to bark of trunks,except for some variations due to wood defects and *** density was 0.576 g cm^(-3),0.655 g cm^(-3),0.706 g cm^(-3)and 0.775 g cm^(-3),respectively,for Peltophorum dubium,Schinus terebinthifolius,Cariniana estrellensis and Hymenaea *** profiles indicated higher amplitudes in the apparent densities for slow-growing species.X-ray densitometry generated parameters such as minimum,average and maximum densities,and radial density *** parameters are important for understanding the ecological functional role of successional classes of the Atlantic Forest from the Neotropical region.

关键词： X-ray densitometry Timber species of neotropical forest Successional classes of forest species Maintenance of forest restoration

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Uniformity of Precipitation and Radial Profile of the Super 10 Sprinkler at Different Operating Pressures

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Journal of Water Resource and Protection 2014年第11期6卷 951-960页

作者： paulo Eduardo S.martins Elcides R.da Silva Juan Gabriel C.L.Ruiz Gustavo R.Barbosa Jose Renato Zanini Marcilio V.martins filho Centro Universitário de Patos de Minas Patos de MinasBrazil Instituto Taquaritinguense de Ensino Superior TaquaritingaBrazil Sao paulo State University JaboticabalBrazil

The study aimed to evaluate the effect of operating parameters of the sprinkler Super 10, manufactured by NaanDanJain, with green, yellow and blue nozzles on the hydraulic characterization, so that this information can contribute to a better dimensioning of systems and management of irrigated areas. For the determination of UC and UD the radial method was used and with the aid of computer application CATCH 3D the overlapping of water slides with ten spacings was calculated. The results demonstrate that the mechanism used for the fractionation of the water jet of sprinkler Super 10 is efficient because it presented good uniformity of water distribution and low amplitude of precipitation. For high uniformity of distribution of water in the larger wetting radii, it is recommended to work with Super 10 sprinkler using the green nozzle, with a pressure of 40 mH2O and spacing between sprinklers and lateral lines 12 × 12 m.

关键词： Hydraulic Performance Uniformity Irrigation Water Distribution Profile

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Perturbations in the uterine luminal fluid composition are detrimental to pregnancy establishment in cattle

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Journal of Animal Science and Biotechnology 2019年第1期10卷 56-66页

作者： Thiago martins Guilherme Pugliesi Mariana Sponchiado Angela M.Gonella-Diaza Oscar A.Ojeda-Rojas Frederich D.Rodriguez Roney S.ramos Andrea C.Basso Mario Binelli Department of Animal Reproduction School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo Department of Nutrition and Animal Production School of Veterinary Medicine and Animal ScienceUniversity of Sao Paulo University Corporation of Huila ABS Global In Vitro Brasil Department of Animal Sciences University of Florida

Background: A major,unresolved issue is how the uterine microenvironment determines pregnancy success in *** implantation,conceptus development depends on the uterine secretome(i.e.,histotroph).Despite its pivotal role,little is known about the dynamics of histotroph synthesis and changes in composition throughout the early diestrus and the relevance to pregnancy *** hypothesize that disturbances on histotroph composition affect the establishment of *** was to disturb histotroph composition at early diestrus and verify the effects on:(Exp.1) timing to restore its composition; and(Exp.2) pregnancy rate after multiple-embryo *** cycle of multiparous Nelore cows were synchronized and estrus was considered d 0(D0) of the *** was through flushing each uterine horn with 30 m L of DMPBS and collecting the resulting uterine luminal flushing(ULF) on D1; D4; D7; D1 + D4 + *** group remained *** Exp.1,ULF was collected on D7.5 from all animals and used for quantification of total protein concentration and abundance of *** Exp.2,three in vitro-produced embryos were transferred to the uterine horn ipsilateral to the ovary containing the CL on D7.5 and pregnancy was checked on D25 by ***: In Exp.1,ULF collection on D4 or D7 increased(1.5-to 2.2-folds) the total protein concentration and albumin *** collection on D1 did not alter(P > 0.10) these *** Exp.2,ULF collected on D4 or D7 decreased pregnancy rates to approximately half of that measured in the remaining ***: Subtle perturbations imposed to the native intrauterine milieu,such as those caused by a single,low-volume collection of ULF,profoundly disturbs intrauterine composition and pregnancy *** least 4 d were necessary for the uterus to recover its composition and the functional capacity to carry post-implantation gestation.

关键词： Albumin Embryo Histotroph Protein

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LAND-USE INTENSIFICATION TRENDS IN THE RIO DE LA PLATA REGION OF SOUTH AMERICA:TOWARD SPECIALIZATION OR RECOUPLING CROP AND LIVESTOCK PRODUCTION

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Frontiers of Agricultural Science and Engineering 2021年第1期8卷 97-110页

作者： paulo César DE FACCIO CARVALHO Jean Víctor SAVIAN Tomas DELLA CHIESA William DE SOUZA filho JoséAlfredo TERRA Priscila PINTO Amanda POSSELT martins Sebastian VILLARINO Júlio Kuhn DA TRINDADE Pedro Arthur DE ALBUQUERQUE NUNES Gervasio PIÑEIRO Integrated Crop-Livestock Systems Research Group Federal University of Rio Grande do Sul7712 Bento Gonçalves AvenuePorto Alegre RS 91540-000Brazil Instituto Nacional de Investigación Agropecuaria(INIA) Estación Experimental INIA Treinta y TresRuta 8 km 281Treinta y TresUruguay Facultad de Agronomía Universidad de Buenos AiresIFEVA/CONICETArgentina Unidad Integrada Balcarce Facultad de Ciencias AgrariasUniversidad Nacional de Mar del Plata(UNMdP)Estación Experimental Agropecuaria Balcarce(INTA)Argentina Department of Agricultural Research and Diagnosis Secretariat of AgricultureLivestock and Rural Development of Rio Grande do Sul Facultad de Agronomía Universidad de la RepúblicaUruguay

The Rio de la Plata region comprises central Argentina,Uruguay,and southern *** agriculture developed around 1900 with recent decades being characterized by the advance of cropping areas over native *** specialized agriculture has decoupled crop and livestock production but has succeeded in intensifying ***,significant losses of ecosystem services have been ***,questions have been raised on the sustainability of this pathway.A glance at world regions that have experienced similar trends suggests that an urgent course correction is needed.A major concern has been the lack of diversity in regions with highly specialized agriculture,promoting renewed interest in integrated crop-livestock systems(ICLS),not only because ICLS are more diverse than specialized systems,but also because they are rare examples of reconciliation between agroecosystem intensification and environmental ***,this paper discusses alternatives to redesign multifunctional landscapes based on *** data provide evidence that recoupling crop and animal production increases the resilience of nutrient cycling functions and economic indicators to external stressors,enabling these systems to face climate-market uncertainty and reconcile food production with the provision of diverse ecosystem ***,these concepts are exemplified in case studies where this perspective has been successfully applied.

关键词： grazing integrated crop-livestock systems mixed crops-livestock Pampa

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Comparison between endoscopic sclerotherapy and band ligation for hemostasis of acute variceal bleeding

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World Journal of Gastrointestinal Endoscopy 2011年第5期3卷 95-100页

作者： Gustavo Oliveira Luz Fauze Maluf-filho Sérgio Eiji Matuguma Fábio Yuji Hondo Edson Ide Jeane martins Melo Spencer Cheng paulo Sakai Gastrointestinal Endoscopy Unit Hospital das ClínicasSo Paulo University Medical School

AIM:To compare band ligation(BL) with endoscopic sclerotherapy(SCL) in patients admitted to an emergency unit for esophageal variceal rupture. METHODS:A prospective,randomized,single-center study without crossover was *** endoscopic diagnosis of esophageal variceal rupture,patients were randomized into groups for SCL or BL *** was performed by ethanolamine oleate intravascular injection both above and below the rupture point,with a maximum volume of 20 *** BL patients,banding at the rupture point was attempted,followed by ligation of all variceal tissue of the distal *** outcomes for both groups were initial failure of bleeding control(5 d) ,early re-bleeding(5 d to 6 wk),and complications,including *** May 2005 to May 2007,100 patients with variceal bleeding were enrolled in thestudy:50 SCL and 50 BL *** differences between groups were observed across gender,age,ChildPugh status,presence of shock at admission,mean hemoglobin levels,and variceal size. RESULTS:No differences were found between groups for bleeding control,early re-bleeding rates,complications,or *** 6 wk,36(80%) SCL and 33(77 %) EBL patients were alive and free of bleeding.A statistically significant association between Child-Pugh status and mortality was found,with 16%mortality in Child A and B patients and 84%mortality in Child C patients(P<0.001) . CONCLUSION:Despite the limited number of patients included,our results suggest that SCL and BL are equally efficient for the control of acute variceal bleeding.

关键词： Portal hypertension Hemorrhage Esophageal varices Gastrointestinal endoscopy Ligation Sclerotherapy

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