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Current perspective on amyloid aggregation accelerating properties of the artificial butter flavoring,diacetyl

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Neural Regeneration Research 2024年第10期19卷 2113-2114页

作者： Ashish p.Vartak Swati S.More Center for Drug Design College of PharmacyUniversity of MinnesotaMinneapolisMNUSA

The amyloid—what peptide can resist its entropic bliss?Without kinetic barricades and chaperones,most peptides would simply tumble down that *** amyloid-β(Aβ) peptides are understood to underlie the hallmark pathology of Alzheimer's disease(AD) and are considered one of the causative factors for neurodegeneration and cognitive *** affects critical connected structures within the brain that are responsible for memory,language,and social behavior.

关键词： amyloid Alzheimer Aβ

Intertype superconductivity evoked by the interplay of disorder and multiple bands

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Frontiers of physics 2024年第4期19卷 81-89页

作者： p.M.Marychev A.A.Shanenko A.V.Vagov HSE University 101000 MoscowRussia Center for Advanced Mesoscience and Nanotechnology MIPTDolgoprudny141700Russia

Nonmagnetic impurity scattering is known to shift up the Ginzburg-Landau parameter k of a *** this case,when the system is initially in type I,it can change its magnetic response,crossing the intertype domain with k~1 between the two standard superconductivity types and arriving at type *** the present work we demonstrate that the impact of disorder can be much more profound in the presence of the multiband structure of the charge carrier *** particular,when the band diffusivities differ from each other,the intertype domain tends to expand significantly,including points with k>>1 that belong to deep type-Ⅱ in conventional single-band *** finding sheds light on the nontrivial disorder effect and significantly complements earlier results on the enlargement of the intertype domain in clean multiband superconductors.

关键词： superconductivity disorder intertype superconductivity twoband model

Calibration of the DEM sliding friction and rolling friction parameters of a cohesionless bulk material

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particuology 2024年第9期92卷 126-139页

作者： Jonatan Marín pérez Tugrul Comlekci Yevgen Gorash Donald MacKenzie University of Strathclyde 75 Montrose StreetG11XJGlasgowUnited Kingdom

The discrete element method(DEM)has become a valuable tool for understanding the mechanical behaviour of granular assemblies,however,the accuracy of the DEM simulations depends on several interaction parameters such as the sliding friction and rolling friction ***,these parameters are estimated using bulk calibration approach(BCA)where the draw down test has been suggested as an effective way to approach these *** test provides up to four bulk criteria,the angle of repose,shear angle,mass flow rate and the mass loss which are used to narrow down the possible ***,there is still more research needed around it to fully understand how this methodology *** experimental and numerical study was carried out using the draw down test to assess the influence of different mass flow rates and particle shapes on DEM parameters for a cohesionless bulk *** is concluded that use of multi-sphere particles and three aperture sizes in the draw down test to calibrate the sliding and rolling friction parameters of a cohesionless bulk material can converge to a small feasible region in which a single combination of the friction coefficients can be *** calibrated sliding and rolling friction coefficients were validated using multi-sphere particles,where the maximum deviation was 5.9%from the experimental values.

关键词： Discrete element method Calibration Draw down Sliding friction Rolling friction particle shape

Efficacy evaluation of standardized Rheum rhaponticum root extract(ERr 731®)on symptoms of menopause:A systematic review and meta-analysis study

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Journal of Biomedical Research 2024年第3期38卷 278-286页

作者： Vishal p.Dubey Varun p.Sureja Dharmeshkumar B.Kheni Department of Scientific and Medical Affairs Sundyota Numandis Probioceuticals Pvt.Ltd.AhmedabadGujarat 380015India

Menopause is characterized by various physical,mental and emotional *** 731®is a standardized extract from Rheum rhaponticum root and has been clinically studied for its role in reducing menopausal *** current systematic review and meta-analysis aimed to evaluate the efficacy of ERr 731®supplementation in alleviating the severity of menopausal *** this review,we searched across three online databases up to March 2023,evaluated the quality of the included studies by the physiotherapy Evidence Database scale,and assessed the risk of bias by the Cochrane Risk of Bias *** then performed a metaanalysis using RevMan software to estimate the pooled mean difference(MD).The study protocol was registered in the prospective Register of Systematic Reviews(CRD42023416808).After screening and evaluation,we included four high-quality studies(a total of 390 participants;the ERr 731®group:193 participants;the control group:197 participants)in the *** results showed that ERr 731®supplementation significantly reduced the Menopause Rating Scale score(MD:–15.12;ppared with control *** analysis revealed no effect of individual studies on the overall pooled estimate or overall observed *** current review provides evidence that ERr 731®supplementation is effective in reducing menopause *** bias and high heterogeneity in the results warrant further clinical studies.

关键词： menopause Rheum rhaponticum hot flashes systematic review

On the analytical solution of transient friction in channel flows

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1447-1466页

作者： F.J.GARCíA-GARCíA p.FARINAS-ALVARINO Department of Naval&Industrial Engineering Polytechnic School of EngineeringUniversity of A CorunaCampus Industrial de FerrolFerrol 15403A CorunaSpain Integraciones Técnicas de Seguridad S.A.Pol.Ind.Espiritu SantoC/Nobel15Cambre 15650A CorunaSpain

The transient friction in channel mean flows is the sum of two contributions,i.e.,the underlying laminar flow(ULF)and the purely turbulent component(pTC),and the contributions are analyzed separately by theoretical *** is found that,the transient friction may be higher or remarkably lower than that in equal-Reynolds number steady-state *** universal time constant for plane-parallel laminar flows is reported,and the role of the time constant in a turbulent mean flow is *** is shown that the time constant is related to the turbulence's frozen ***,a study of the logarithmic layer during the transient flow is accomplished,which shows that the logarithmic layer is destroyed.

关键词： transient friction transient flow unsteady channel flow

Mechanisms behind the environmental sensitivity of carbon fiber reinforced polytetrafluoroethylene(pTFE)

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Friction 2024年第5期12卷 997-1015页

作者： pontus JOHANSSON p.MARKLUND M.BJORLING Y.SHI Division of Machine Element LuleåUniversity of TechnologyLuleåSE-97187Sweden

Carbon fiber reinforced polytetrafluoroethylene (CF/pTFE) composites are known for their exceptional tribological performance when sliding against steel or cast iron in inert gas environments. Compared to experiments in humid air, about an order of magnitude lower wear rate and several times lower coefficient of friction have been reported for tests conducted in dry nitrogen and hydrogen. Moreover, trace moisture has been shown to affect the friction and wear significantly of this tribosystem, although a possible effect of oxygen cannot be ruled out due to uncertainties regarding the oxygen concentrations. While several studies have pointed out the environmental sensitivity of CF/pTFE, the understanding of the underlying mechanisms are very limited. The objective of this research is to investigate the individual and combined effect of oxygen and moisture on the tribological behavior of CF/pTFE sliding against steel. Additionally, this study aims to elucidate the underlying mechanisms that govern the environmental sensitivity of the system. Climate-controlled three-pin-on-disc experiments were conducted in nitrogen atmospheres at various concentrations of oxygen and moisture. The tribological results clearly demonstrate that both moisture and oxygen contribute to increased friction and wear. However, the adverse effect was much more pronounced for oxygen than moisture. A qualitative method was developed to estimate the tribofilm coverage on the CF/pTFE surface. Results showed strong correlation between high coverage of strongly adhered tribofilm and low wear rate. Moreover, a loosely adhered tribofilm was observed on top of the CF/pTFE surface in presence of moisture. FTIR analysis indicated that the loosely adhered tribofilm found in the moisture-enriched environment contained a significant amount of adsorbed water, which may explain the lower coefficient of friction in presence of moisture compared to oxygen. The adsorbed water in the loosely adhered tribofilm coul

关键词： polymer composite tribofilm tribochemistry atmosphere

Biocompatible Biphasic Iontronics Enable Neuron-Like Ionic Signal Transmission

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Research 2024年第3期2024卷 795-796页

作者： Xiaoyi Wang Aleksandar p.Ivanov Joshua B.Edel Department of Chemistry Imperial College LondonMolecular Sciences Research HubLondon W12 OBZUK

Biocompatible connections between external artificial devices and living organisms show promise for future neuroprosthetics and *** study in Science by Zhao and colleagues introduces a cascade-heterogated biphasic gel(HBG)iontronic device,which facilitates electronic-to-multi-ionic signal transduction for abiotic–biotic *** by neuron signaling,the HBG device demonstrated its biocompatibility by regulating neural activity in biological tissue,paving the way for wearable and implantable devices,including brain–computer interfaces.

关键词： asi Signal Neuron

System integration analysis of a zeolite 13x thermal energy storage

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Energy and Built Environment 2024年第4期5卷 568-579页

作者： S.De antonellis L.p.M.Colombo p.Castellazzi A.Rossetti L.Marocco politecnico di Milano Department of Energyvia Lambruschini 4Milan 20156Italy Ricerca sul Sistema Energetico-RSE S.p.A. Tecnologie di Generazione e Materialivia R.Rubattino 54Milan 20134Italy

Nowadays a major energy transition aimed at cutting CO 2 emissions has begun,with the ambitious goal of drasti-cally reducing the dependence on fossil fuels and promoting the use of renewable energy *** this context,energy storage systems play a key role in ensuring a stable,secure and time-aligned energy *** sorption thermal energy storages(TESs)can contribute to such transition,since they are simple and cheap devices able to provide a hot airflow with a high energy density and to store energy for long *** this work,open sorption TES systems operated with Zeolite13X are investigated with a focus on the integration in practical ***,the experimental analysis and modelling of the sole TES system is ***,the integration of the TES at system level is carried *** analysis evidences that a significant reduction of storage capac-ity occurs if air humidification is necessary before the adsorption process or afterwards to keep adequate indoor comfort conditions for the *** the exemplary case study considered,an energy density of 150 kWhm^(−3) can drop to 40 kWhm−3 in case of complete compensation of the adsorbed water through a *** paper provides useful guidelines for evaluating the performance of a TES integrated system in terms of specific energy and *** also identifies applications involving high latent loads(e.g.,swimming pools,locker rooms)or for which low relative air humidity is required(*** of vehicles to prevent condensation on windows)as particularly beneficial for using a TES system.

关键词： Energy storage Adsorption Zeolite System integration Numerical model

anthropogenic Influence on Decadal Changes in Concurrent Hot and Dry Events over China around the Mid-1990s

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Advances in Atmospheric Sciences 2024年第2期41卷 233-246页

作者： Qin SU Buwen DONG Fangxing TIAN Nicholas p.KLINGAMAN Yunnan Key Laboratory of Meteorological Disasters and Climate Resources in the Great Mekong Subregion Yunnan UniversityKunming 650500China Department of Atmospheric Sciences Yunnan UniversityKunming 650500China National Centre for Atmospheric Science Department of MeteorologyUniversity of ReadingReadingRG66BBUK Geofysisk Institut University of BergenBergen 5007Norway Citadel Investment Group Moor House120 London WallLondonRG66BBUK

The frequency and duration of observed concurrent hot and dry events(HDEs) over China during the growing season(April–September) exhibit significant decadal changes across the mid-1990s. These changes are characterized by increases in HDE frequency and duration over most of China, with relatively large increases over southeastern China(SEC), northern China(NC), and northeastern China(NEC). The frequency of HDEs averaged over China in the present day(pD,1994–2011) is double that in the early period(Ep, 1964–81);the duration of HDEs increases by 60%. Climate experiments with the Met Office Unified Model(MetUM-GOML2) are used to estimate the contributions of anthropogenic forcing to HDE decadal changes over China. anthropogenic forcing changes can explain 60%–70% of the observed decadal changes,suggesting an important anthropogenic influence on HDE changes over China across the mid-1990s. Single-forcing experiments indicate that the increase in greenhouse gas(GHG) concentrations dominates the simulated decadal changes,increasing the frequency and duration of HDEs throughout China. The change in anthropogenic aerosol(AA) emissions significantly decreases the frequency and duration of HDEs over SEC and NC, but the magnitude of the decrease is much smaller than the increase induced by GHGs. The changes in HDEs in response to anthropogenic forcing are mainly due to the response of climatological mean surface air temperatures. The contributions from changes in variability and changes in climatological mean soil moisture and evapotranspiration are relatively small. The physical processes associated with the response of HDEs to GHG and AA changes are also revealed.

关键词： concurrent hot and dry events decadal variation greenhouse gases aerosol emissions