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Green-light fundus autofluorescence in diabetic macular edema

International Journal of Ophthalmology(English edition) 2013年第1期6卷 75-80页

作者： Lukas Reznicek Simeon Dabov Christos Haritoglou anselm kampik Marcus Kernt Aljoscha S Neubauer Department of Ophthalmology Ludwig Maximilians University

AIM:To evaluate the role of central green-light fundus autofluorescence (FAF) in diabetic macular edema(DME). METHODS:A consecutive series of 92 study eyes with diabetic retinopathy were included. Out of those, 51 diabetic eyes had DME and were compared to 41 diabetic eyes without DME. In all subjects, green-light FAF images were obtained, quantified and classified into various FAF patterns. Cross-sectional optical coherence tomography (OCT) scans were obtained for evaluation of Inner/Outer segment (IS/OS) layer integrity, measurements of central RPE-IS/OS layer thickness as well as classification of DME into various subtypes. ·RESULTS:Meancentralgreen-lightFAFintensityofeyes with DME (1.289 ±0.140)log did not significantly differ from diabetic patients without DME (1.317 ±0.137)log. Most classifiable FAF patterns were seen in patients with cystoid DME. Mean central retinal thickness (CRT) of all study eyes with DME was (501.9±112.4)μm compared to (328.2±27.0)μm in diabetic patients without DME. Patients with DME had significantly more disrupted photoreceptor IS/OS layers than diabetic patients without DME (28/51 vs 5/41, P <0.001). Mean RPE-IS/OS thickness of patients with DME (60.7±14.1)μm was significantly (P<0.001) lower than in diabetic eyes without DME (73.5 ±9.4)μm. Correlation analysis revealed non-significant correlations of green-light FAF intensity and OCT parameters in all subtypes of DME. ·CONCLUSION:Our results indicate a poor correlation of central green-light FAF intensity with CRT, IS/OS layer integrity or RPE-IS/OS layer thickness in diabetic patients with or without DME and its various subtypes. Thus, central green-light FAF is not suitable for detection of retinal thickening in DME.

关键词： diabetic macular edema fundus autofluorescence optical coherence tomography

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Role of wide-field autofluorescence imaging and scanning laser ophthalmoscopy in differentiation of choroidal pigmented lesions

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International Journal of Ophthalmology(English edition) 2014年第4期7卷 697-703页

作者： Lukas Reznicek Carmen Stumpf Florian Seidensticker anselm kampik Aljoscha S Neubauer Marcus Kernt Department of Ophthalmology Ludwig Maximilians University Muenchen

·AIM:Toevaluatethe diagnostic properties of wide-field fundus autofluorescence(FAF) scanning laser ophthalmoscope(SLO) imaging for differentiating choroidal pigmented lesions.·METHODS: A consecutive series of 139 patients were included, 101 had established choroidal melanoma with13 untreated lesions and 98 treated with ***-eight had choroidal nevi. All patients underwent a full ophthalmological examination, undilated wide-field imaging, FAF and standardized US examination. FAF images and imaging characteristics from SLO were correlated with the structural findings in the two patient groups.·RESULTS: Mean FAF intensity of melanomas was significantly lower than the FAF of choroidal nevi. Only 1out of 38 included eyes with nevi touched the optic disc compared to 31 out of 101 eyes with melanomas. In 18 out of 101 melanomas subretinal fluid was seen at the pigmented lesion compared to none seen in eyes with confirmed choroidal nevi. In 'green laser separation', a trend towards more mixed FAF appearance of melanomas compared to nevi was observed. The mean maximal and minimal transverse and longitudinal diameters of melanomas were significantly higher than those of nevi.·CONCLUSION: Wide-field SLO and FAF imaging may be an appropriate non-invasive diagnostic screening tool to differentiate benign from malign pigmented choroidal lesions.

关键词： imaging autofluorescence scanning laser ophthalmoscopy choroidal lesion melanoma

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Correlation of leaking microaneurysms with retinal thickening in diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 269-271页

作者： Lukas Reznicek Marcus Kernt Christos Haritoglou Michael Ulbig anselm kampik Aljoscha S Neubauer Department of Ophthalmology Ludwig-Maximilians University

AIM: To investigate the contribution of fluorescein angiographic leaking microaneurysms (leak-MA) versus non-leaking microaneurysms (non-leak-MA) to retinal thickening in diabetic ***: A consecutive series of 38 eyes from 24 patients with diabetic retinopathy was ***-MA and non-leak-MA in each eye were selected in pairs at corresponding topographic *** was defined by late phase fluorescein angiograms compared to early *** thickness was measured with Heidelberg Spectralis OCT topographically aligned on early phase angiograms at the MA site and within a 1 mm ***: In all eyes,significant retinal thickening at the site of leaking compared to non-leaking microaneurysms was observed (356±69μm vs 318±56μm,P <0.001),showing a mean increase in thickness in the areas of leak-MA vs non-leak-MA of 38±39μm (95% confidence interval 2551μm,P<0.001).All 1mm area measurements also showed significant (P<0.001) thickening of the leak-MA with average thickness of leak-MA vs non-leak-MA as 351±67μmvs 319±59μm;minimum thickness 311±62μm vs 284±60μm;maximum thickness 389±78μm vs 352±66μm;and retina volume 26.4±6.0mmvs 23.6±3.7mm3,***: Leaking of microaneurysms on fluorescein angiography appears to cause focal thickening of retina,which can be measured with high-resolution ***,targeting leaking microaneursyms in diabetic retinopathy has the potential to reduce retinal thickening.

关键词： diabetic retinopathy microaneurysm retinal thickness OCT

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糖尿病视网膜病变中微动脉瘤荧光素渗出与视网膜增厚的关系(英文)

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国际眼科杂志 2011年第7期11卷 1137-1139页

作者： Lukas Reznicek Marcus Kernt Christos Haritoglou Michael Ulbig anselm kampik Aljoscha S Neubauer Ludwig-Maximilians大学眼科

目的:观察糖尿病视网膜病变患者血管荧光素造影微动脉瘤处渗出与视网膜增厚的关系。方法:选取糖尿病视网膜病变患者24例38眼,首次及末次血管荧光素造影检查确定是否存在微动脉瘤荧光素渗出。根据毛细血管闭塞区的位置选取微动脉瘤荧光... 详细信息

目的:观察糖尿病视网膜病变患者血管荧光素造影微动脉瘤处渗出与视网膜增厚的关系。方法:选取糖尿病视网膜病变患者24例38眼,首次及末次血管荧光素造影检查确定是否存在微动脉瘤荧光素渗出。根据毛细血管闭塞区的位置选取微动脉瘤荧光素渗出与未渗出各1眼配对进行对比。在微动脉瘤和直径为1mm区域使用光学相干断层成像术(OCT)测量视网膜厚度。结果:微动脉瘤荧光素渗出眼视网膜厚度明显高于未渗出眼(356±69μmvs318±56μm,P<0.001),渗出眼平均增长厚度高于未渗出眼(95%的可信区间为25～51μm,P<0.001).在直径为1mm区域,渗出眼视网膜厚度和平均增长厚度均明显高于未渗出眼(351±67μmvs319±59μm;最小值311±62μmvs284±60μm;最大值389±78μmvs352±66μm)。结论:血管荧光素造影显示微动脉瘤荧光素渗出可以增加视网膜厚度,并运用高分辨率OCT测量。因此,对糖尿病视网膜病变患者早期诊断微动脉瘤荧光素是否渗出可以抑制视网膜增厚。

关键词：糖尿病视网膜病变微动脉瘤视网膜厚度 OCT

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细菌性角膜炎微生物学分析作为指导治疗的依据

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德国医学 2000年第3期17卷 180-182页

作者： Stephen J.Frhlich Herminia MiodeKaspar Thomas Grasbon Caroline Mhring Volker Klauβ anselm kampik 杨红 Universitts-Augenklinik Mathildenstraβe.8 D-80336 München Germany 同济医科大学附属同济医院

与睑缘炎和结膜炎相比,细菌性角膜炎是一种较少见的感染,但它又是一个最严重的疾病,因为该病可以在短时间内出现戏剧性的病程并向眼的深部进展而威胁整个眼球。生理上有不同的机制阻止角膜的炎症:其一是眼睑的自然反射以对眼睛进行一定... 详细信息

与睑缘炎和结膜炎相比,细菌性角膜炎是一种较少见的感染,但它又是一个最严重的疾病,因为该病可以在短时间内出现戏剧性的病程并向眼的深部进展而威胁整个眼球。生理上有不同的机制阻止角膜的炎症:其一是眼睑的自然反射以对眼睛进行一定的清洁;

关键词：细菌性角膜炎微生物学诊断治疗

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脉冲电崩刀（PEAK-fc）切开视网膜组织

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美国医学会眼科杂志（中文版） 2006年第4期18卷 248-248页

作者： Siegfried G. Priglinger Christos Haritoglou Daniel V. Palanker Claudia S. Alge Arnd Gandorfer anselm kampik 陈慧瑾（译）

目的：评价用于精细切割的最新版脉冲电崩刀（PEAK—fc；Carl Zeiss Meditec，Jena,Germany）对视网膜进行无牵拉切开的有效性和准确性。

关键词：视网膜组织切开 Zeiss 有效性脉冲电崩刀

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