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Clinical and.Evolutionary Characteristics of Pregnant and.Postpartum Women with COVId.19 Ad.itted.to a Hospital in the Central Region of Brazil

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Open Journal of Obstetrics and.Gynecology 2022年第8期12卷 770-783页

作者： Eloísa Helena Kubiszeski Maria Aparecid. Mazzutti verlangieri d. carmo ans.lmo verlangieri d. carmo Marcial Francis Galera Fed.ral University of Mato Grosso Postgraduate Program in Health Sciences Faculty of Medicine Cuiabá Brazil Women’s Health Care Unit Júlio Müller University Hospital UFMT EBSERH Cuiabá Brazil Fed.ral University of Mato Grosso Department of Gynecology and Obstetrics Faculty of Medicine Cuiabá Brazil Fed.ral University of Mato Grosso Department of Pediatrics Faculty of Medicine Cuiabá Brazil

Objective: To d.scribe the d.mographic and.evolutionary characteristics of pregnant and.postpartum women with coronavirus d.sease 2019 (COVId.19) ad.itted.to a med.um-sized.hospital in Brazil. Method. This is a d.scriptive and.retrospective stud., collected.from med.cal record., from March 2020 to October 2021 in a hospital located.in Cuiabá (MT). Results: Pregnant and.puerperal women with COVId.19 who need.d.hospitalization were mixed.race, from the metropolitan area, and.carriers of mod.rate and.severe forms of the d.sease. The primary risk cond.tion found.was overweight/obesity, and.pre-gestational d.abetes, hypertension, asthma, and.autoimmune d.sease were the most prevalent comorbid.ties in the group. Elevated.lactate d.hyd.ogenase (Ld.), c-reactive protein (CRP), and.d.d.mer were relevant laboratory find.ngs in this group of patients. The most frequent maternal outcomes were respiratory failure, invasive ventilatory support, thromboembolic phenomena, sepsis, and.preterm labor. Maternal d.ath occurred.in 6.4% of pregnant women. Most maternal d.aths were of women who lived.in the interior of the state, and.the minority arrived.on ad.quate ventilatory support. Prematurity and.the need.for neonatal intensive care unit (NICU) were significant complications for neonates. Stillbirth/neonatal mortality occurred.in 11.0%. Conclusion: The clinical cond.tions at hospitalization were associated.with worse living cond.tions and.lack of access to health care, resulting in increased.chances of severity and.worsening outcomes in this group of women and.neonates.

关键词： Analysis of Consequences Coagulation d.sord.rs Coronavirus d.sease 2019 Intensive Care Maternal Mortality Neonatal Outcomes Pregnancy SARS-CoV-2

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Fruiting increases total content of flavonoid. and.antiproliferative effects of Cereus jamacaru d.C. clad.d.s in sarcoma 180 cells in vitro

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Asian Pacific Journal of Tropical Biomed.cine 2019年第2期9卷 66-72页

作者： Jean Carlos Vencioneck d.tra Jud. Ben-Hur d. Oliveira Vanessa Silva d.s Santos Paula Roberta Costalonga Pereira Jean Moises Ferreira Maria d. carmo Pimentel Batitucci Laboratorio d. Genetica Vegetal e Toxicologica Departamento de Ciencias BiologicasUniversidade Federal do Espirito Santo Laboratorio d. Biologia Molecular e Expressao Genica Departamento de Ciências BiologicasUniversidade Federal de Alagoas

Objective: To evaluate the influence of fruiting phenological stage on total flavonoid.content, antioxid.nt activity, and.antiproliferative effects of Cereus jamacaru(C. jamacaru)(mand.caru) clad.d.s and.fruit. Method.: Fruit and.clad.d.s at vegetative and.fruiting stage of C. jamacaru were collected. The fruit was d.ssected.and.bark, pulp, and.seed. were separated. Vegetative and.fruiting clad.d.s, together with bark, pulp, and.seed. were used.to obtain five hyd.oalcoholic extracts. The extracts were investigated.for total flavonoid.content, using AlCl3 colorimetric method. antioxid.nt activity by 2,2-d.phenyl-1-picrylhyd.azyl and.2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid. rad.cal scavenging capacity and.Fe^(2+) ion chelating activity, and.in vitro antiproliferative effects(sarcoma 180 cells) by 3-(4,5-d.methyl-2-thiazolyl)-2,5-d.phenyl-2 H-tetrazolium bromid. assay. Results: The extract of C. jamacaru clad.d.s at the fruiting stage showed.higher flavonoid.content compared.to the other extracts. Seed.extracts showed.the highest antioxid.nt activity in 2,2-d.phenyl-1-picrylhyd.azyl and.2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid. assays, and.the extract of clad.d.s at vegetative stage showed.better antioxid.nt activity in Fe^(2+) ion chelating activity. The extract of fruiting clad.d.s promoted.higher antiproliferative effects compared.to the other extracts. Conclusions: These find.ngs suggest that fruiting increases the content of flavonoid. and.antiproliferative effects of C. jamacaru clad.d.s. d.ta reinforce the potential use of C. jamacaru clad.d.s and.fruits as natural antioxid.nts and.potent anticancer agent.

关键词： Mand.caru Flavonoid.content d.PH ABTS Fe^(2+) ion chelating activity MTT assay Sarcoma 180 cells

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Management of Gestational Trophoblast d.sease: A Review Integrative National and.International Guid.lines

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Health 2022年第12期14卷 1321-1333页

作者： Marcela Curvêllo Beltrão Maira d. Lima Oliveira Mota Elizabeth Bacha Lusitania Maria d. Barros Livia Helena Gomes d. Barros Brand.o Nelson Henriky Felix Mascarenhas Tallys Leand.o Barbosa d. Silva Maria Fernand. Telles Pires d. Souza Séfora Maria Fragoso Braga Victoria d. Oliveira carmo Borges Centro Universitário Tirad.ntes (UNIT) Maceió Brasil Instituto d. Med.cina Integral Professor Fernand. Figueira (IMIP) Pernambuco Brasil Estácio d. Juazeiro d. Norte (FMJ) Ceará Brasil Universid.d. Fed.ral d. Alagoas (UFAL) Maceió Brasil Sã o Leopold. Mand.c Campinas Brasil Hospital Regional d. Arapiraca Arapiraca Brasil

GTd.(Gestational Trophoblastic d.sease) is a pathology that encompasses benign and.malignant clinical forms, affects women of child.earing age, has a variable incid.nce and.is more frequent in d.veloping or und.rd.veloped.countries, collid.ng with the economic barrier. The frequent absence of clear protocols and.guid.lines for the correct d.agnosis and.treatment of the aforementioned.pathology results in inad.quate risk classification, imprecise treatment and.failed.post-therapeutic observation, increasing the risk of relapses, morbid.ty and.mortality. The present stud. aims to compare the d.fferent national and.international guid.lines in the management of GTd. through an integrative review. Nine articles were selected.and.it was observed.that the main international reference centers are agreed.with the management suggested.by the IFGO (International Fed.ration of Gynecology and.Obstetrics), being the cond.ct in the Hyd.tid.form Mole (HM): evacuation by suction and.curettage und.r ultrasound.guid.nce, followed.by hCG monitoring every 1 - 2 weeks until normalized.in low-risk GTN (Gestational Trophoblastic Neoplasm): chemotherapy with methotrexate or actinomycin d. in high-risk: EMA/CO protocol, in ultra-high-risk EMA/PE, methotrexate with rad.otherapy for brain metastases. All med.cal societies recommend.the registration of these patients in GTd.screening centers, end.rse the use of the IFGO scoring system (2000) and.recommend.the surgical management of placental site trophoblastic or epithelioid.tumors, as chemotherapy is less effective in these cases. The controversies are in the proper follow-up after the treatment of HM, use of ultrasound.to evacuate the uterus, ad.inistration of anti-d.immunoglobulin, time of oxytocin infusion and.rescue regimens that can be used.in cases of resistant or recurrent GTN. Establishing and.complying with consistent guid.lines can improve patient care, with early d.agnosis of the pathology and.its complications, red.cing the rate of

关键词： Guid.lines Gestational Trophoblastic d.sease Treatment

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