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Structure,ligands,and roles of GPR126/ADGRG6 in the development and diseases

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Genes & Diseases 2024年第1期11卷 294-305页

作者： Qi Li anran huo Mengqi Li Jiali Wang Qiao Yin Lumiao Chen Xin Chu Yuan Qin Yuwan Qi Yang Li Hengxiang Cui Qifei Cong Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases Soochow UniversitySuzhouJiangsu215123China Department of Neurology and Clinical Research Center of Neurological Disease The Second Affliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Nephrology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Emergency Center The Second Affiliated Hospital of Nantong UniversityNantongJiangsu226001China Department of Neurology Huzhou Central HospitalThe Affiliated Huzhou HospitalZhejiang University School of MedicineHuzhouZhejiang 313000China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China

Adhesion G protein-coupled receptors(aGPCRs)are the second largest diverse group within the GPCR superfamily,which play critical roles in many physiological and patho-logical processes through cell-cell and cell-extracellular matrix *** adhesion GPCR Adgrg6,also known as GPR126,is one of the better-characterized ***126 was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and *** studies have extended our understanding of GPR126-mediated roles during develop-ment and in human *** this review,we highlighted these recent advances in GPR126 in expression profile,molecular structure,ligand-receptor interactions,and associated physiological and pathological functions in development and diseases.

关键词： Adhesion G protein-coupled receptor Function GPR126/Adgrg6 Ligand Structure

Diversity and ecological assembly process of aerobic anoxygenic phototrophic bacteria in a low irradiation area,Three Gorges Reservoir

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Journal of Environmental Sciences 2024年第9期143卷 116-125页

作者： Lixin huo anran Ma Hong Liu Xingzu Wang Cheng Song Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China Chongqing School University of Chinese Academy of SciencesCollege of Resources and EnvironmentChongqing 400714China Key Laboratory of Reservoir Aquatic Environment Chinese Academy of SciencesChongqing 400714China University of Chinese Academy of Sciences Beijing 100049China

Aerobic anoxygenic phototrophic bacteria(AAPB)are significant bacterial groups in aquatic ecosystems,known for their rapid growth and photoheterotrophic ***,the distribution and ecological assembly process of AAPB in low irradiation freshwater basins remain unclear,warranting further *** this study,we present the diversity,abundance,spatial variations,ecological process,and community interaction of AAPB in sediment of Three Gorges Reservoir(TGR)under low *** findings demonstrate the dominant genera of AAPB community that exist in the TGR area also are appeared in different waters,with some regional ***,the concentration of pufM gene,an indicator for AAPB,maintains a consistently high numerical level ranging from(2.21±0.44)×10^(4)to(9.98±0.30)×10^(7)gene copies/*** solar irradiation is suggested as the major factor affecting AAPB,it remains unclear whether and how AAPB differ between regions due to varying solar irradiation *** results show spatial differences between total bacteria and AAPB communities,with significant differences observed only in *** and environmental factor contributed less than 10%to the spatial difference of community,with sediment type and environmental factors being the key factors influencing microbial community *** stochastic process plays a dominant role in the aggregation and replacement of AAPB communities,among which the most contribution is dispersal *** AAPB network,Yoonia and Gemmobacter are the hubs for *** results valuable insights into the AAPB communities in TGR with low irradiation.

关键词： Three Gorges Reservoir(TGR) Aerobic anoxygenic phototrophic bacteria(AAPB) Bacterial community Null model Community assembly

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B10细胞在自身免疫性疾病中的研究进展

细胞与分子免疫学杂志 2022年第9期38卷 853-857页

作者：刘帅代安然孟露露周勇李明德霍星星安徽中医药大学第一附属医院临床研究实验中心安徽合肥230031

调节性B细胞(Breg)是一群具有负向免疫调节作用的B细胞,可产生负向调节细胞因子,如白细胞介素10(IL-10)、转化生长因子β(TGF-β),或以细胞间接触等方式参与免疫调节,抑制炎性反应。B10细胞是一类可产生IL-10的Breg,参与多种自身免疫性... 详细信息

调节性B细胞(Breg)是一群具有负向免疫调节作用的B细胞,可产生负向调节细胞因子,如白细胞介素10(IL-10)、转化生长因子β(TGF-β),或以细胞间接触等方式参与免疫调节,抑制炎性反应。B10细胞是一类可产生IL-10的Breg,参与多种自身免疫性疾病的发生发展过程。我们总结了B10细胞的起源、免疫机制以及B10细胞在类风湿性关节炎、炎症性肠病、干燥综合症等自身免疫性疾病中的作用以及调控机制,在治疗自身免疫性疾病的相关应用尝试,并探讨了B10细胞作为治疗自身免疫性疾病的新方法的可行性。

关键词： B10细胞白细胞介素10(IL-10) 免疫抑制综述

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苍术在温病组方中的配伍规律分析

山东中医药大学学报 2022年第5期46卷 604-609页

作者：刘朴霖宋安然阎兆君山东中医药大学山东济南250355 山东中医药大学附属医院山东济南250014

目的:探究温病学古方中苍术相关药对、药组及其配伍规律。方法:以明清时期及近代温病相关著作中收载的温病方剂为主要来源,整理含有苍术的方剂并建立数据库,运用频次分析和关联规则分析挖掘苍术在温病治疗组方中的核心药对、药组及其配... 详细信息

目的:探究温病学古方中苍术相关药对、药组及其配伍规律。方法:以明清时期及近代温病相关著作中收载的温病方剂为主要来源,整理含有苍术的方剂并建立数据库,运用频次分析和关联规则分析挖掘苍术在温病治疗组方中的核心药对、药组及其配伍规律。结果:收集温病方剂1547首,其中44首含有苍术,与苍术配伍频次较高的中药有甘草、藿香、陈皮、厚朴、茯苓、羌活、防风、滑石、生姜等;归类分析药性后发现苍术配伍药物以解表药频次最高,清热药次之;苍术+藿香、苍术+陈皮、苍术+厚朴为高支持度药对,苍术+藿香+陈皮、苍术+藿香+厚朴+陈皮为高支持度药组。结论:苍术在温病组方中具有重要配伍意义,可对温病过程中与寒、湿相关的肺、脾、胃、肠等证候发挥治疗作用。

关键词：数据挖掘苍术温病寒湿湿邪配伍规律药对药组