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Efficient inhibition of SARS-CoV-2 emerging EG.5,EG.5.1 and BA.2.86 variants by fusion inhibitor HY3000 peptide

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hLife 2024年第1期2卷 43-46页

作者： Lili Wu anqi zheng Yangming Tang Xiaoyun Wang Yue Gao Wenwen Lei Guizhen Wu Qihui Wang George Fu Gao CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina University of the Chinese Academy of Sciences BeijingChina Hybio Pharmaceutical Co. Ltd.GuangdongChina College of Life Science Hebei UniversityHebeiChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to pose a significant threat to the world,as it continually evolves and gives rise to multiple variants and ***,the Omicron EG.5 linage,which was first detected in Indonesia on 17 February 2023,has raised concerns due to its increased prevalence and extended immune escape properties,according to the risk analysis by the World Health Organization(WHO)[1].As of 3 October 2023,EG.5 and its sub-linages have been reported in 83 countries with shared 49,008 genome sequences in GISAID database(https://***/hcov19-variants/).EG.5 has become the dominant strain in the United States according to Centers for Disease Control and Prevention(CDC),accounting for 29.4%of SARS-CoV-2 infections(https://***/covid-data-tracker/#variant-proportions).

关键词： acute respiratory variants

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空间指纹测量特征双精简下的室内定位算法

仪器仪表学报 2023年第10期44卷 80-89页

作者：郑安琪秦宁宁江南大学物联网技术应用教育部工程研究中心无锡214122

针对空间结构阻隔、信号弱穿透力等因素导致的参考点和接入点定位匹配冗余问题,提出一种“水平精简参考点,垂直精简接入点”的空间双精简定位算法。首先以最强接收信号的高阶统计信息替代传统均值表征各参考点,并结合小区域融合和边界... 详细信息

针对空间结构阻隔、信号弱穿透力等因素导致的参考点和接入点定位匹配冗余问题,提出一种“水平精简参考点,垂直精简接入点”的空间双精简定位算法。首先以最强接收信号的高阶统计信息替代传统均值表征各参考点,并结合小区域融合和边界参考点共享的处理方式,实现目标空间模糊聚类,以此弱化边缘绝对判别的不良影响;其次基于该降维子空间,综合衡量各接入点的空间区分度和覆盖可靠性,为各子空间筛选出高识别价值、高稳定性的精简接入点集合;最后通过判断最强接收信号信源执行一级区域判别,并利用WKNN算法实现二级位置估计。经实际路演测试,所提水平精简策略聚类规整也更符合场景结构约束,垂直精简策略较传统接入点选配算法平均定位精度至少提升17%,并在参考点1 m×1 m的分布密度条件下,滤除了约4.5 m以上的大定位误差。

关键词：室内定位指纹定位模糊聚类接入点筛选

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A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery

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Science China(Life Sciences) 2023年第10期66卷 2201-2213页

作者： Lili Wu anqi zheng Yangming Tang Yan Chai Jiantao Chen Lin Cheng Yu Hu Jing Qu Wenwen Lei William Jun Liu Guizhen Wu Shaogui Zeng Hang Yang Qihui Wang George Fu Gao CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of the Chinese Academy of Sciences Beijing 100049China Hybio Pharmaceutical Co. Ltd.Shenzhen 518109China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalShenzhen 518112China School of Life Sciences University of Science and Technology of ChinaHefei 230026China Shenzhen Center for Disease Control and Prevention Shenzhen 518055China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China CAS Key Laboratory of Special Pathogens and Biosafety Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Hubei Jiangxia Laboratory Wuhan 430299China Chinese Center for Disease Control and Prevention(China CDC) Beijing 102206China

Coronaviruses(Co Vs)have brought serious threats to humans,particularly severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),which continually evolves into multiple *** variants,especially Omicron,reportedly escape therapeutic antibodies and vaccines,indicating an urgent need for new antivirals with pan-SARS-Co V-2 inhibitory *** previously reported that a peptide fusion inhibitor,P3,targeting heptad repeated-1(HR1)of SARS-Co V-2 spike(S)protein,could inhibit viral ***,we further designed multiple derivatives of the P3 based on structural analysis and found that one derivative,the P315V3,showed the most efficient antiviral activity against SARS-Co V-2 variants and several other sarbecoviruses,as well as other human-Co Vs(HCo Vs).P315V3 also exhibited effective prophylactic efficacy against the SARS-Co V-2 Delta and Omicron variants in mice via intranasal *** results suggest that P315V3,which is in PhaseⅡclinical trial,is promising for further development as a nasal pan-SARS-Co V-2 or pan-Co Vs inhibitor to prevent or treat CoV diseases.

关键词： SARS-CoV-2 peptide fusion inhibitor pan-coronavirus viral infection intranasal delivery

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模糊空间下双标签指纹定位算法

西安电子科技大学学报 2023年第2期50卷 81-91页

作者：郑安琪秦宁宁江南大学轻工过程先进控制教育部重点实验室江苏无锡214122

针对指纹定位中传统的空间划分方法所伴随的指纹点区归属识别困难和邻界匹配误判的问题,提出一种适用于区域中心识别和过渡双域判别的空间模糊划分方法,利用参考点类间距离与类内距离的差异度,衡量子区域边界的模糊度,保证实验场景定位... 详细信息

针对指纹定位中传统的空间划分方法所伴随的指纹点区归属识别困难和邻界匹配误判的问题,提出一种适用于区域中心识别和过渡双域判别的空间模糊划分方法,利用参考点类间距离与类内距离的差异度,衡量子区域边界的模糊度,保证实验场景定位开销最优化的同时,兼顾空间重叠划分优势,缓解子区域间绝对判别的负效应,提高定位匹配的泛化能力。在位置估计阶段,综合考虑参考点邻域间接收信号波动差异,将参考点与待定位点间信号域的距离度量转化为同源差异下的无量纲排序,并以修正后的多源排序均衡结果间接映射待定位点与参考点之间的相似度;此外,引入空间密度可达搜索强相关参考点集,结合信号域和空间域迭代约束参考点,实现目标近邻集的动态选择和集聚效应,有效克服环境变化与信号波动的干扰,提高定位方法的环境适应性。经路演下的实测数据对定位性能的评估,所提算法的定位精度优于同类区划分算法4.7%~11.8%,且在同全局匹配方法的比较中,平均定位误差最佳可降低0.422 m。

关键词：室内定位指纹定位模糊空间迭代约束

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宽频惯性基准谐振抑制陷波器参数优化方法

天津大学学报（自然科学与工程技术版） 2021年第8期54卷 852-860页

作者：李醒飞郑安琪拓卫晓周政天津大学精密测试技术及仪器国家重点实验室天津300072

宽频惯性基准(H-IRU)能够提供一束稳定于惯性空间的参考光束,作为捕获、跟踪与瞄准(ATP)系统视轴的惯性参考.根据H-IRU的弹簧-质量模型推导了系统的传递函数,并对系统的频响特性进行了辨识实验.为了抑制H-IRU柔性支撑结构引入的低频谐振... 详细信息

宽频惯性基准(H-IRU)能够提供一束稳定于惯性空间的参考光束,作为捕获、跟踪与瞄准(ATP)系统视轴的惯性参考.根据H-IRU的弹簧-质量模型推导了系统的传递函数,并对系统的频响特性进行了辨识实验.为了抑制H-IRU柔性支撑结构引入的低频谐振,提出了一种改进型陷波器.为了避免因陷波器参数设计不合理导致谐振抑制效果不理想或设计过程反复等情况的发生,提出了一种陷波器参数优化设计方法.以H-IRU系统模型幅频特性曲线最大幅值处的频率确定陷波中心频率,根据系统的直流增益与最大幅值之差确定陷波深度参数,以最小化加入陷波器后系统幅频曲线凸起为目标构造目标函数,对陷波器宽度参数进行快速寻优.将设计的陷波器串联入控制回路,结合不完全微分PID控制和噪声抑制扰动观测器设计了一种混合控制器作为H-IRU的位置环控制器.对串联陷波器后的H-IRU系统的开环及闭环频域特性进行了Matlab仿真,并利用扫频法和辨识法对其实验频域特性进行了测试.仿真和实验结果表明:采用参数优化方法设计的陷波器能够有效抑制系统27 Hz附近的低频机械谐振,结合闭环控制方法,可拓展系统闭环带宽至110 Hz.

关键词：宽频惯性基准谐振抑制陷波器参数优化

Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals

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National Science Review 2022年第9期9卷 166-177页

作者： Shihua Li Ruirui Yang Di Zhang Pu Han Zepeng Xu Qian Chen Runchu Zhao Xin Zhao Xiao Qu anqi zheng Liang Wang Linjie Li Yu Hu Rong Zhang Chao Su Sheng Niu Yanfang Zhang Jianxun Qi Kefang Liu Qihui Wang George F.Gao CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences College of Veterinary Medicine Shanxi Agricultural University Faculty of Health Sciences University of Macau Institute of Physical Science and Information Anhui University Center for Influenza Research and Early-Warning(CASCIRE) Chinese Academy of Sciences Savaid Medical School University of Chinese Academy of Sciences School of Life Sciences University of Science and Technology of China State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi University

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has an extremely broad host range that includes hippopotami,which are phylogenetically closely related to *** cellular ACE2 receptor is one of the key determinants of the host ***,we found that from several marine mammals and hippopotami could efficiently bind to the receptor-binding domain(RBD) of both SARS-C oV and SARS-C oV-2 and facilitate the trans duction of SARS-C oV and SARS-C oV-2 pseudo viruses into ACE2-expressing *** further resolved the cryo-electron microscopy complex structures of the minke whale ACE2 and sea lion ACE2,respectively,bound to the RBDs,revealing that they have similar binding modes to human ACE2 when it comes to the SARS-C oV-2 RBD and SARS-C oV *** results indicate that marine mammals could potentially be new victims or virus carriers of SARS-C oV-2,which deserves further careful investigation and *** will provide an early warning for the prospective monitoring of marine mammals.

关键词： marine animals SARS-CoV-2 cross-species recognition cryo-EM structure

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高温渣罐车通过时隧道内的热传递

西南交通大学学报 1999年第3期34卷 325-330页

作者：巫锡勇王鹰郑安启西南交通大学土木工程学院铁道部第二勘察设计院

研究了高温渣罐车通过隧道时，因高温热源的传热影响而使隧道内温度场发生变化，隧道内动态热源的热传递问题，并结合实例计算出了隧道内的温度分布情况。

关键词：隧道热传递高温渣罐车通风

Mouse model for pangolin-origin coronavirus GX/P2V/2017 infection and cross-protection from COVID-19 ZF2001 subunit vaccine

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hLife 2023年第1期1卷 35-43页

作者： Xiao Qu Yunfei Jia Na Jia Huahao Fan anqi zheng Luoyuan Xia Zhenfei Wang Di Tian Sheng Niu Yu Hu Wenxia Tian Zhihai Chen Yigang Tong Yuwei Gao Wuchun Cao Qihui Wang George Fu Gao CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina College of Veterinary Medicine Shanxi Agricultural UniversityShanxiChina State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingChina Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and TechnologyBeijing University of Chemical TechnologyBeijingChina Savaid Medical School University of Chinese Academy of SciencesBeijingChina Center of Infectious Disease Beijing Ditan HospitalCapital Medical UniversityBeijingChina School of Life Sciences University of Science and Technology of ChinaAnhuiChina Institute of Military Veterinary Medicine Academy of Military Medical SciencesJilinChina

Many severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)–related coronaviruses have been discovered,constituting potential threats to human ***,it remains unclear whether the currently available vaccines are effective against these ***,we constructed a wild-type mouse model to evaluate pathogenicity of the SARS-CoV-2-related pangolin coronavirus GX/P2V/2017 and neutralization efficacy of the approved tandemrepeat SARS-CoV-2 spike receptor-binding domain(RBD)vaccine *** found that ZF2001-induced cross-reactive and cross-neutralizing antibodies against GX/P2V/2017,and the vaccination alleviated the pathological lung damage caused by GX/P2V/2017 in *** results indicate that RBD may work as a promising candidate for pan-coronavirus vaccine development.

关键词： ZF2001 pangolin-origin coronavirus mouse model vaccine protection

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基于信道排序的认知频谱分配算法

传感技术学报 2023年第10期36卷 1635-1642页

作者：蒋孜浩郑安琪秦宁宁江南大学轻工过程先进控制教育部重点实验室江苏无锡214122

针对认知传感网中均衡能耗的频谱分配问题,提出了一种适应信道的改进遗传算法(Adapt channel improved genetic algorithm,ACGA)进行频谱分配。为改良遗传算法中传统交叉方法运用于频谱分配问题时面临的交叉失效等问题,采用一种基于信... 详细信息

针对认知传感网中均衡能耗的频谱分配问题,提出了一种适应信道的改进遗传算法(Adapt channel improved genetic algorithm,ACGA)进行频谱分配。为改良遗传算法中传统交叉方法运用于频谱分配问题时面临的交叉失效等问题,采用一种基于信道排序的交叉方案,以信道排序的增益作为交叉的限制,并利用个体相似度进行交叉基因的选取。为增加遗传变异的可靠性,采用了一种混合变异方案,利用博弈对个体进行良性变异,同时组合传统变异以控制种群的整体进化方向。仿真实验表明,相比传统的遗传算法,所提算法有着良好的寻优能力,可以有效降低网络的周期能耗。

关键词：认知传感网频谱分配网络能耗遗传算法