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Crimean-Congo hemorrhagic fever:Pathogenesis,transmission and public health challenges

World Journal of Virology 2025年第1期14卷 63-72页

作者： Sita kumari Karanam Kandra Nagvishnu Praveen kumar Uppala Sandhya Edhi Srinivasa Rao Varri Department of Pharmaceutical Biotechnology Maharajah’s College of PharmacyVizianagaram 535002Andhra PradeshIndia Department of Pharmacology Santhiram Medical College and General HospitalNandyal 518501Andhra PradeshIndia Department of Pharmacology Santhiram Medical College and General HospitalNandyal 518501Andhra PradeshIndia Department of Pharmaceutical AnalysisMaharajah's College of PharmacyVizianagaram 535002Andhra PradeshIndia

The dangerous Crimean-Congo hemorrhagic fever virus(CCHFV),an encapsulated negative-sense RNA virus of the family Nairoviridae,is transmitted from person to person via *** a case fatality rate between 10%to 40%,the most common ways that the disease may spread to humans are via tick bites or coming into touch with infected animals'blood or ***,the transfer of bodily fluids between individuals is another potential route of *** is a wide range of symptoms experienced by patients throughout each stage,from myalgia and fever to extreme bruising and excess *** management measures include minimising the spread of ticks from one species to another and from people to animals via the use of protective clothing,repellents,and proper animal *** order to prevent the spread of illness,healthcare workers must adhere to stringent *** the lack of an authorised vaccine,the main components of treatment now consist of preventative measures and supportive care,which may include the antiviral medicine *** still don't know very much about the virus's mechanisms,even though advances in molecular virology and animal models have improved our understanding of the pathogenesis of CCHFV.A critical need for vaccination that is both safe and effective,as well as for quick diagnosis and efficient treatments to lessen the disease's impact in areas where it is most *** steps towards lowering Crimean-Congo hemorrhagic fever mortality and morbidity rates were to anticipatethe future availability of immunoglobulin products.

关键词： Crimean-congo haemorrhagic fever Tick-borne illness Immunoglobulins Viral hemorrhagic fever Antiviral therapy

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Zero Trust Networks: Evolution and Application from Concept to Practice

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Computers, Materials & Continua 2025年第2期82卷 1593-1613页

作者： Yongjun Ren Zhiming Wang Pradip kumar Sharma Fayez Alqahtani Amr Tolba Jin Wang School of Computer Science School of Cyber Science and EngineeringEngineering Research Center of Digital ForensicsMinistry of EducationNanjing University of Information Science and TechnologyNanjing210044China Department of Computing Science University of AberdeenAberdeenAB243FXUK Software Engineering Department College of Computer and Information SciencesKing Saud UniversityRiyadh12372Saudi Arabia Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Sanya Institute of Hunan University of Science and Technology Sanya572024China

In the context of an increasingly severe cybersecurity landscape and the growing complexity of offensive and defen-sive techniques,Zero Trust Networks(ZTN)have emerged as a widely recognized *** Trust not only addresses the shortcomings of traditional perimeter security models but also consistently follows the fundamental principle of“never trust,always verify.”Initially proposed by John Cortez in 2010 and subsequently promoted by Google,the Zero Trust model has become a key approach to addressing the ever-growing security threats in complex network *** paper systematically compares the current mainstream cybersecurity models,thoroughly explores the advantages and limitations of the Zero Trust model,and provides an in-depth review of its components and key ***,it analyzes the latest research achievements in the application of Zero Trust technology across various fields,including network security,6G networks,the Internet of Things(IoT),and cloud computing,in the context of specific use *** paper also discusses the innovative contributions of the Zero Trust model in these fields,the challenges it faces,and proposes corresponding solutions and future research directions.

关键词： Zero trust cybersecurity software-defined perimeter micro-segmentation internet of things

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Intricacies during pregnancy with gestational diabetes mellitus

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World Journal of Clinical Cases 2025年第1期13卷 62-64页

作者： Richa Rattan Rimesh Pal Parul Chawla Gupta Arvind kumar Morya Ripunjay Prasad Department of Endocrinology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology RP Eye InstituteDelhi 110001India

The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus(GDM)development using advanced proteomic techniques,such as Isobaric tags for relative and absolute quantitation isobaric tags for relative and absolute quantitation and liquid chromatography-mass spectrometry liquid chromatography-mass *** analysis revealed 47 differentially expressed proteins in the GDM group,with retinol-binding protein 4 and angiopoietin-like 8 showing significantly elevated serum levels compared to *** these findings are promising,the study is limited by its small sample size(n=4 per group)and lacks essential details on the reproducibility and reliability of the protein quantification methods ***,the absence of experimental validation weakens the interpretation of the protein-protein interaction network identified through bioinformatics *** study's focus on second-trimester biomarkers raises concerns about whether this is a sufficiently early period to implement preventive interventions for *** GDM risk during the first trimester or pre-conceptional period may offer more clinical *** its limitations,the study presents valuable insights into potential GDM biomarkers,but larger,well-validated studies are needed to establish their predictive utility and generalizability.

关键词： Gestational diabetes mellitus Biomarkers Differentially expressed proteins Retinol-binding protein 4 Angiopoietin-like 8 Proteomics Lifestyle interventions Early prediction

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Alcohol and alcoholism associated neurological disorders:Current updates in a global perspective and recent recommendations

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World Journal of Experimental Medicine 2025年第1期15卷 24-40页

作者： Prashanti Sahu Henu kumar Verma LVKS Bhaskar Department of Zoology GGU BilaspurBilaspur 495009ChhattīsgarhIndia Department of Lung Health and Immunity Helmholtz Zentrum MunichMunich 85764BayrenGermany Department of Zoology Guru Ghasidas VishwavidyalayaBilaspur 495001ChhattīsgarhIndia

Alcohol use disorder(AUD)is a medical condition that impairs a person's ability to stop or manage their drinking in the face of negative social,occupational,or health *** is defined by the National Institute on Alcohol Abuse and Alcoholism as a"severe problem".The central nervous system is the primary target of alcohol's adverse *** is crucial to identify various neurological disorders associated with AUD,including alcohol withdrawal syndrome,Wernicke-Korsakoff syndrome,Marchiafava-Bignami disease,dementia,and *** gain a better understanding of the neurological environment of alcoholism and to shed light on the role of various neurotransmitters in the phenomenon of alcoholism.A comprehensive search of online databases,including PubMed,EMBASE,Web of Science,and Google Scholar,was conducted to identify relevant *** neurotransmitters(dopamine,gammaaminobutyric acid,serotonin,and glutamate)have been linked to alcoholism due to a brain *** appears to be a complex genetic disorder,with variations in many genes influencing *** of these genes have been identified,including two alcohol metabolism genes,alcohol dehydrogenase 1B gene and aldehyde dehydrogenase 2 gene,which have the most potent known effects on the risk of *** degeneration and demyelination in people with AUD may be caused by neuronal damage,nutrient deficiencies,and blood brain barrier dysfunction;however,the underlying mechanism is *** review will provide a detailed overview of the neurobiology of alcohol addiction,followed by recent studies published in the genetics of alcohol addiction,molecular mechanism and detailed information on the various acute and chronic neurological manifestations of alcoholism for the Future research.

关键词： Alcohol Alcoholism Neurotransmitter Neurological disorders Alcohol metabolism

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Practice patterns among ophthalmic surgeons in treating concomitant oculoplastic conditions in preoperative period:A questionnaire-based study

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World Journal of Clinical Cases 2025年第1期13卷 29-37页

作者： Bijnya Birajita Panda Chitaranjan Mishra Bhagabat Nayak Avik kumar Roy Logesh Balakrishnan Priyadarshini Mishra Department of Ophthalmology All India Institute of Medical SciencesBhubaneswar 751019OdishaIndia Department of Vitreo-Retina Trilochan NetralayaSambalpur 768004India Department of Glaucoma Services LV Prasad Eye InstituteBhubaneswar 751013India Department of Statistics Apollo HospitalsChennai 823104India

BACKGROUND Addressing oculoplastic conditions in the preoperative period ensures both the safety and functional success of any ophthalmic *** oculoplastic conditions,like nasolacrimal duct obstruction,have been extensively studied,whereas others,like eyelid malposition and thyroid eye disease,have received minimal or no *** To investigate the current practice patterns among ophthalmologists while treating concomitant oculoplastic conditions before any subspecialty ophthalmic *** A cross-sectional survey was disseminated among ophthalmologists all over *** survey included questions related to pre-operative evaluation,anaesthetic and surgical techniques preferred,post-operative care,the use of adjunctive therapies,and patient follow-up *** A total of 180 ophthalmologists responded to the *** practitioners(89%)felt that the ROPLAS test was sufficient during pre-operative evaluation before any subspecialty surgery was *** most common surgical techniques employed were lacrimal drainage procedures(Dacryocystorhinostomy)(63.3%),eyelid malposition repair(36.9%),and ptosis repair(58.7%).Post-operatively,47.7%of respondents emphasized that at least a 4-week gap should be maintained after lacrimal drainage procedures and eyelid ***-seven percent of ophthalmologists felt that topical anaesthetic procedures should be preferred while performing ocular surgeries in thyroid eye disease *** Approximately 50%of ophthalmologists handle prevalent oculoplastic issues themselves,seeking the expertise of an oculoplastic surgeon under particular *** ophthalmologists still favor using ROPLAS as a preliminary screening method before proceeding with cataract *** conditions and thyroid eye disease are not as commonly addressed before subspecialty procedures compared to issues like nasolacrimal duct obstruction and periocular infections.

关键词： Oculoplasty Ophthalmic plastic surgery Nasolacrimal duct obstruction Practice patterns Survey

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Comparative efficacy of hyperbaric bupivacaine vs hyperbaric ropivacaine in spinal anesthesia for cesarean section:A metaanalysis

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World Journal of Methodology 2025年第2期15卷 154-165页

作者： Rishi Anand Deb Sanjay Nag Roushan Patel Prashant Sharma Vamsi Krishna Uppalapati Umesh kumar Singh Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JhārkhandIndia

BACKGROUND Intrathecal bupivacaine is the traditional anesthetic drug used in spinal anesthesia for caesarean sections(CSs),but ropivacaine has emerged as a potential *** meta-analysis compares the efficacy and safety of intrathecal hyper-baric bupivacaine vs hyperbaric ropivacaine for cesarean *** To systematically evaluate and compare the efficacy and safety of intrathecal hyperbaric bupivacaine and hyperbaric ropivacaine for spinal anesthesia in *** A thorough search of electronic databases was carried out to find pertinent randomized controlled trials(RCTs)comparing intrathecal hyperbaric ropi-vacaine and hyperbaric bupivacaine during ***,Cochrane database,Google Scholar,and Scopus were searched,and papers from January 2000 to January 2024 were deemed eligible and filtered using predetermined inclusion and exclusion *** were assessed for methodological quality,and data were extracted for time to adequate anesthesia(sensory and motor blockade),duration of sensory and motor block,hemodynamic changes and side effect *** standardized mean difference with 95%CI was used for continuous *** variables were assessed using the Mantel-Haenszel test and the random effect model to compute the odds *** Total 8 RCTs were selected from a pool of 119 search results for *** meta-analysis evaluated pooled effect sizes and assessed heterogeneity among the *** primary objective was to compare key outcomes to identify any significant variances in efficacy and safety profiles between two local *** analysis revealed that the difference in the onset of sensory blockade between the two local anesthetics was statistically insignificant(P=0.1586).However,the onset of motor blockade appeared to be faster with bupivacaine(P=0.03589).Additionally,the regression of sensory and motor blockade occurred earlier in the ropivacaine ***,the duration of the first analgesic

关键词： Ropivacaine Bupivacaine Anesthesia Spinal Cesarean section Meta-analysis

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Crystal Structures, Optical, Electrical and Magnetic Properties of Ca0.9Sr0.1Mn1−xMoxO3 Perovskites for the Applications of Multifunctional Devices

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Journal of Applied Mathematics and Physics 2025年第1期13卷 61-86页

作者： Sanjana Afrin Tanvir Ahmed Mithum kumar Das Mohammad Majibur Rahman Mohammed Nazrul Islam Khan Mohammad J. Miah Department of Physics Comilla University Cumilla Bangladesh Department of EEE Bangladesh University of Business and Technology Dhaka Bangladesh Department of Environmental Sciences Jahangirnagar University Dhaka Bangladesh Materials Science Division Bangladesh Atomic Energy Commission Dhaka Bangladesh

The standard solid-state reaction method was employed to synthesize the polycrystalline Ca0.9Sr0.1Mn1−xMoxO3 (CSMMO with x = 0.00, 0.02, 0.04, 0.06, and 0.08) ceramics and each composition was sintered at 1300˚C for 4 hours. The crystal structure, microstructure, optical properties, electrical properties, complex initial permeability, and DC magnetization of the prepared compositions were carried out. The compound exhibited perovskite structure with the transformation of phase from orthorhombic symmetry for x = 0.00 to x = 0.04 samples into a tetragonal symmetry for the samples x = 0.06 and x = 0.08. The lattice constant was found to be enhanced with the doping of Mo concentration. The mean grain size was estimated in the micrometer, with values from 1.3045 to 3.0124 µm. Energy band gap (Eg) was determined for each composition and the magnitudes of Eg were lying between 1.85 - 4.00 eV. The Eg values firstly decreased with the doping content up to 2% and, then, increased for 4% to 6% Mo contents, where it again very slightly decreased for 8% Mo content. The lowest value of Eg was obtained for the x = 0.02 composition. The FTIR spectra revealed the existence of a metal oxide band in each of the prepared samples and supported the formation of a single-phase compound of synthesized material without any impurity, as confirmed by the XRD analysis. The electrical properties, such as resistivity and AC conductivity, were collected using the Impedance analyzer at room temperature. The resistivity and AC conductivity increased with the addition of dopant concentration. The frequency-dependent conductivity spectra showed three distinct regions. The complex initial permeability (μ′) was found to be enhanced with the addition of Mo and the highest value was noticed the 6% Mo dopant sample. On the other hand, the lowest loss factor was obtained for the samples x ≥ 0.06. The M-H hysteresis loops of various Ca0.9Sr0.1Mn1−xMoxO3 ceramics were measured both at room temperature (300 K

关键词： Perovskite Optical Band Gap Conductivity Permeability DC Magnetization

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跨境银行贷款币种选择的决定因素

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新金融 2025年第1期 68-74页

作者： Lorenz Emter Peter McQuade Swapan-kumar Pradhan Martin Schmitz 李丽丽周正铭欧洲中央银行

本文深入探讨了跨境银行借贷中货币选择的决定因素，如双边距离、与主要货币发行国的金融和贸易联系以及发行货币模式。以美元、欧元计价的跨境银行借贷高度集中在少数几个国家。英国在以欧元计价的国际贷款网络中处于核心地位，尽管有... 详细信息

本文深入探讨了跨境银行借贷中货币选择的决定因素，如双边距离、与主要货币发行国的金融和贸易联系以及发行货币模式。以美元、欧元计价的跨境银行借贷高度集中在少数几个国家。英国在以欧元计价的国际贷款网络中处于核心地位，尽管有初步迹象表明，自英国脱欧以来，英国在非银行贷款方面的作用有所减弱。离岸金融中心在美元贷款方面举足轻重，尤其是对开曼群岛非银行金融中介机构的贷款，这可能是监管和税收优化策略的结果。实证分析表明，与美元贷款相比，欧元贷款面临“距离约束”，这与贸易吸引力模型的预测一致。研究发现，欧元和美元贸易结算与银行贷款之间存在互补性。

关键词：主导货币范式货币面值跨境银行吸引力

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Multilocular thymic cysts-a diagnostic challenge on computed tomography

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World Journal of Clinical Cases 2025年第3期13卷 61-65页

作者： Nirmal kumar Reddy Onteddu Naga Sai Rasagna Mareddy Sai Swarupa R Vulasala Jayabharath Onteddu Mayur Virarkar Department of Internal Medicine University of Florida College of MedicineJacksonvilleFL 32209United States Department of Diagnostic Radiology University of AlabamaBirminghamAL 35294United States Department of Diagnostic Radiology University of Florida College of MedicineJacksonvilleFL 32209United States Department of Public Health Sciences University of FloridaGainesvilleFL 32611United States

A recent case report provided a patient scenario,wherein,a 39-year-old male patient presented with occasional palpitations,headache,and *** of tumor markers did not show any abnormal ***,a computed tomography(CT)scan was undertaken,and its findings were affirmative of thymic ***,the postoperative histopathological assessment of the mass,after its resection,confirmed it as an anterior mediastinal multilocular thymic cyst(MTC),with concurrent acute upper respiratory tract infection and acute ***,this case report advocates the need for a preoperative histopathological examination with CT imaging to minimize the risk of confusing an MTC with a malignant thymic tumor.

关键词： Imaging findings Multilocular thymic cyst Histopathology Thymic cancer Mediastinal mass

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Effect of kidney transplantation on sexual dysfunction in patients with end stage renal disease:A systematic review

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World Journal of Nephrology 2025年第1期14卷 127-137页

作者： Jaydeep Jain Mahendra Singh Shashank kumar Om kumar Yadav Ankit Shettar Shiv Charan Navriya Deepak Prakash Bhirud Gautam Ram Choudhary Arjun Singh Sandhu Department of Urology All India Institute of Medical SciencesJodhpur 342008RājasthānIndia

BACKGROUND End-stage renal disease(ESRD)is associated with a multitude of physical,psychological,and social health challenges,including a profound impact on sexual and reproductive *** males with ESRD,erectile dysfunction(ED)is highly prevalent due to factors such as underlying comorbidities,including diabetes and hypertension,and the physiological effects of long-term *** transplantation(KTx)has been proposed as a potential intervention to mitigate the effects of ED by restoring renal function and improving hormonal ***,the evidence surrounding the effectiveness of KTx in improving sexual function,specifically erectile function(EF),remains *** systematic review and meta-analysis aim to evaluate the effects of KTx on sexual dysfunction(SexDys),particularly ED,in male ESRD *** To evaluate the benefits and potential harms of KTx compared to other forms of renal replacement therapy in improving EF in adult males with ESRD,assessed using the international index of EF(IIEF),to survey the prevalence of SexDys in this population,and to assess the correlation between various factors and SexDys through regression *** A systematic search of PubMed,EMBASE,Cochrane Library,Scopus,***,and Google Scholar was conducted,following the PRISMA 2020 *** and retrospective cohort studies,as well as cross-sectional studies assessing EF pre-and post-transplantation,were *** studies used validated tools such as the IIEF to measure ***-analyses were performed using a random-effects model to estimate standardized mean differences(SMD)and hazard ratios(HR)with 95%confidence intervals(CI).Heterogeneity was assessed using the I²statistic,and publication bias was evaluated with a funnel plot and the Egger’s *** A total of 2419 studies were identified,with 362 abstracts screened and 193 full-text articles ***,11 studies were included for qualitative analys

关键词： Kidney transplantation Sexual dysfunction Erectile dysfunction International index of erectile function Syste-matic review Meta analyses

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