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Human pluripotent stem cell-derived extracellular vesicles:From now to the future

World Journal of Stem Cells 2023年第5期15卷 453-465页

作者： Bruno Moises de Matos Marco Augusto Stimamiglio Alejandro Correa anny waloski robert Stem Cells Basic Biology Laboratory Carlos Chagas InstituteCuritiba 81350010ParanáBrazil

Extracellular vesicles(EVs)are nanometric particles that enclose cell-derived bioactive molecules in a lipid bilayer and serve as intercellular communication ***,in various biological contexts,EVs are reported to engage in immune modulation,senescence,and cell proliferation and ***,EVs could be key elements for potential off-the-shelf cell-free *** has been studied regarding EVs derived from human pluripotent stem cells(hPSC-EVs),even though hPSCs offer good opportunities for induction of tissue regeneration and unlimited proliferative *** this review article,we provide an overview of studies using hPSC-EVs,focusing on identifying the conditions in which the cells are cultivated for the isolation of EVs,how they are characterized,and applications already *** topics reported in this article highlight the incipient status of the studies in the field and the significance of hPSC-EVs’prospective applications as PSC-derived cell-free therapy products.

关键词： Pluripotent stem cells Extracellular vesicles Exosome Cell-free therapy

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Influence of donor age on the differentiation and division capacity of human adipose-derived stem cells

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World Journal of Stem Cells 2020年第12期12卷 1640-1651页

作者： Cintia DS Horinouchi María Julia Barisón anny W robert Crisciele Kuligovski Alessandra M Aguiar BrunoDallagiovanna Stem Cells Basic Biology Laboratory Instituto Carlos ChagasCuritiba 81350010ParanáBrazil

BACKGROUND Human adipose-derived stromal/stem cells(hASCs)are one of the most useful types of mesenchymal stromal/stem cells,which are adult multipotent cells with great therapeutic potential for the treatment of several ***,for successful clinical application,it is critical that high-quality cells can be *** factors seem to be able to influence cell quality and performance,especially factors related to donors’intrinsic characteristics,such as ***,there is no consensus regarding this characteristic,and there is conflicting information in the *** To investigate the growth kinetics and differentiation potential of adipose-derived stem cells isolated from the lipoaspirates of elderly and young *** hASCs were harvested from liposuctioned adipose tissue obtained from female donors(aged 20-70 years).Cells were distributed into two groups according to age range:old hASCs(oASCs,≥55 years,n=9)and young hASCs(yASCs,≤35 years,n=9).For each group,immunophenotypic characterization was performed by flow *** doubling time was assessed over seven *** adipogenic potential evaluation,lipid deposits were assessed after 7 d,14 d and 21 d of adipogenic *** potential was verified by analyzing cell mineralization after 14 d,21 d and 28 d of osteogenic *** expression of PPARγ2,CEBPA and Runx2 were detected by quantitative reverse transcription polymerase chain *** hASCs were successfully obtained,cultured,and grouped according to their age:yASCs(26.33±4.66 years old)and oASCs(64.78±4.58 years old).After maintenance of the cells in culture,there were no differences in morphology between cells from the young and old ***,both groups showed classical immunophenotypic characteristics of mesenchymal stem/stromal *** average doubling time indicated that yASCs(4.09±0.94 d)did not significantly differ from oASCs(4.19±1.29 d).Concerning differentiation pot

关键词： Adipose-derived stem cells Stem cells Adipogenesis Osteogenesis Cell differentiation Donor age

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终身监禁——铁墙内仍存的一线希望

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疯狂英语（口语版） 2015年第3期 11-16页

作者： anny

他，年少轻狂，犯了错，入了牢，也许终生都要在铁窗下度过，却仍在心中留着一线重见天日的希望;她，是人们眼中嫁错郎的苦命女人，却始终对他不离不弃，她说：“两个人结了婚，就是永远。”他的坚持，让他在狱中重拾自我：她的坚守，... 详细信息

他，年少轻狂，犯了错，入了牢，也许终生都要在铁窗下度过，却仍在心中留着一线重见天日的希望;她，是人们眼中嫁错郎的苦命女人，却始终对他不离不弃，她说：“两个人结了婚，就是永远。”他的坚持，让他在狱中重拾自我：她的坚守，给他和孩子们撑起了一片天……生命的旅程中不可能总上演喜剧，多一份战胜困难的信仰，多一份坚韧的守候，也许，幸福就在不远处。

关键词：监禁终身铁孩子

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A Literature Review—Khaya senegalensis, Anacardium ouestL., Cassia sieberianaDC., Pterocarpus erinaceus, Diospyros mespiliformis, Ocimum gratissimum, Manihot esculenta, Vernonia amygdalinaDelile, Pseudocedrela kotschyiand Daniellia oliveriPossess Properties for Managing Infectious Diarrhea

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Advances in Bioscience and Biotechnology 2020年第10期11卷 457-473页

作者： Victorien Dougnon Edna Hounsa Hornel Koudokpon Brice Boris Legba Kafayath Fabiyi Kevin Sintondji anny Afaton Merveille Akouta Jean robert Klotoe Honoré Bankole Lamine Baba-Moussa Jacques Dougnon Research Unit in Applied Microbiology and Pharmacology of Natural Substances Research Laboratory in Applied Biology Polytechnic School of Abomey-Calavi University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Biology and Molecular Typing in Microbiology Faculty of Science and Technology University of Abomey-Calavi Abomey-Calavi Benin

The rise in antimicrobial resistance increases researchers’ interest in medicinal plants used for traditional treatment of infectious diseases. The study is based on ten (10) medicinal plants mostly cited in the treatment of diarrhea in West Africa: Khaya senegalensis, Anacardium ouest L., Cassia sieberiana DC., Pterocarpus erinaceus, Diospyros mespiliformis, Ocimum gratissimum, Manihot esculenta, Vernonia amygdalina Delile, Pseudocedrela kotschyi, Daniellia oliveri. The objective is to make a review on ethnopharmacological, pharmacological, toxicological and chemical data that enhance these medicinal plants in the fight against diarrheal infections. Spec

关键词： Infectious Diarrhea West Africa Medicinal Plants

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