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High Amounts of Halogenated Natural Products in Sperm Whales(Physeter macrocephalus)from Two Italian Regions in the Mediterranean Sea

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Environment & Health 2024年第4期2卷 233-242页

作者： Sina Schweizer Kristin Halder annika Schafer Jakob Hauns Letizia Marsili Sandro Mazzariol Maria Cristina Fossi Juan Muñoz-Arnanz Begoña Jiménez Walter Vetter Institute of Food Chemistry Department of Food Chemistry(170b)University of Hohenheim70599 StuttgartGermany European Union Reference Laboratory(EURL)for Halogenated POPs in Feed and Food 79114 FreiburgGermany Department of Environmental Earth and Physical SciencesUniversity of Siena53100 SienaItaly Department of Public Health Comparative Pathology and Veterinary HygieneUniversity of Padova35020 LegnaroItaly Department of Instrumental Analysis and Environmental Chemistry Institute of Organic Chemistry(IQOG-CSIC)28006 MadridSpain

Halogenated natural products(HNPs)are considered to be emerging contaminants whose environmental distribution and fate are only incompletely ***,several persistent and bioaccumulative HNP groups,together with manmade polychlorinated biphenyls(PCBs)and polybrominated diphenyl ethers(PBDEs),were quantified in the blubber of nine sperm whales(Physeter macrocephalus)stranded on the coast of the Mediterranean Sea in *** naturally occurring polybrominated hexahydroxanthene derivatives(PBHDs;sum of TetraBHD and TriBHD)were the most prominent substance class with up to 77,000 ng/g *** mean PBHD content(35,800 ng/g blubber)even exceeded the one of PCBs(28,400 ng/g blubber),although the region is known to be highly contaminated with manmade *** on mean values,Q1∼PBDEs>MeO-BDEs∼2,2′-diMeO-BB 80 and several other HNPs followed with decreasing *** blubber samples contained an abundant compound whose molecular formula(C_(16)H_(19)Br_(3)O_(2))was verified using high-resolution mass *** only plausible matching isomer was(2S,4′S,9R,9′S)-2,7-dibromo-4′-bromomethyl-1,1-dimethyl-2,3,4,4′,9,9′-9,9′-hexahydro-1H-xanthen-9-ol(OH-TriBHD),a hydroxylated secondary metabolite previously detected together with TriBHD and TetraBHD in a sponge known to be a natural producer of *** estimated mean amount of the presumed OH-TriBHD was 3000 ng/g blubber,which is unexpectedly high for hydroxylated compounds in the lipids of marine mammals.

关键词： Halogenated natural product naturally occurring polyhalogenated compound persistent organic pollutant sperm whale Italy polar metabolite

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CORE模型:引入高校质量管理体系的四部曲

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应用型高等教育研究 2019年第2期4卷 56-62页

作者： annika Boentert 陈颖(翻译) 明斯特应用科学大学德国明斯特48149 德国法院奥斯纳布吕克应用科学大学

CORE模型旨在帮助高校建立一个高校范围内的质量管理体系。它包含在不同层面需要应用的四个基本步骤:澄清目标、优化流程、反思结果、鼓励改进。教学和学习领域可以区分四个层面,即学校、院系、专业及具体的课程。阐述了如何使用该模型... 详细信息

CORE模型旨在帮助高校建立一个高校范围内的质量管理体系。它包含在不同层面需要应用的四个基本步骤:澄清目标、优化流程、反思结果、鼓励改进。教学和学习领域可以区分四个层面,即学校、院系、专业及具体的课程。阐述了如何使用该模型来对组织进行初始分析,以及如何构建一个学校的质量管理体系。这个模型由明斯特应用科学大学开发,在过去几年里,它已成功地应用于面向拉丁美洲和非洲一些大学展开的咨询项目。

关键词：高校质量管理战略管理质量文化质量保证

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Prefabricated flaps and neoangiogenesis initiated via venous grafts in arteriovenous Ioops

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Plastic and Aesthetic Research 2018年第9期5卷 30-39页

作者： Elias Polykandriotis Andreas Arkudas annika Weigand Aijia Cai Raymund E.Horch Department of Plastic and Hand Surgery University of Erlangen Medical CenterErlangen 91054Germany Department of Plastic and Hand Surgery Sana Hospital HofAcademic Teaching Hospital of Friedrich Alexander University Erlangen-Nurnberg FAUErlangen 95032Germany

New developments in regenerative medicine are bound to revolutionize the way we approach loss of function and form in human organisms. Especially in the field of reconstructive plastic surgery new biotechnologies find their way from bench to bed. Biofabrication is an evolving field that aims to combine natural biologic processes with bioartificial constructs with the scope of reconstituting tissue without having to rely on autotransplantation. In this brief review we present the concepts of intrinsic vs. extrinsic neovascularization and we discuss the use of neovascularization in three dimensional matrices. In a clinical context matrix flaps for application in reconstructive surgery can be fabricated this way.

关键词： Plastic surgery flap prefabrication tissue engineering arteriovenous loop venous graft neoangiogenesis

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FAIR Convergence Matrix:Optimizing the Reuse of Existing FAIR-Related Resources

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Data Intelligence 2020年第1期2卷 158-170,313页

作者： Hana Pergl Sustkova Kristina Maria Hettne Peter Wittenburg annika Jacobsen Tobias Kuhn Robert Pergl Jan Slifka Peter McQuilton Barbara Magagna Susanna-Assunta Sansone Markus Stocker Melanie Imming Larry Lannom Mark Musen Erik Schultes GO FAIR International Support and Coordination Office LeidenThe Netherlands Centre for Digital Scholarship Leiden University LibrariesLeidenThe Netherlands Max Planck Computing and Data Facility Gießenbachstraße 285748 GarchingGermany Leiden University Medical Center Leiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK Environment Agency Austria A-1090 ViennaAustria TIB Leibniz Information Centre for Science and Technology HannoverGermany SURF Utrecht 3511 EPThe Netherlands Corporation for National Research Initiatives(CNRI) RestonVirginia 20191USA Stanford Center for Biomedical Informatics Research StanfordCA 94305USA

The FAIR principles articulate the behaviors expected from digital artifacts that are Findable,Accessible,Interoperable and Reusable by machines and by *** by now widely accepted,the FAIR Principles by design do not explicitly consider actual implementation choices enabling FAIR *** different communities have their own,often well-established implementation preferences and priorities for data reuse,coordinating a broadly accepted,widely used FAIR implementation approach remains a global *** an effort to accelerate broad community convergence on FAIR implementation options,the GO FAIR community has launched the development of the FAIR Convergence *** Matrix is a platform that compiles for any community of practice,an inventory of their self-declared FAIR implementation choices and *** Convergence Matrix is itself a FAIR resource,openly available,and encourages voluntary participation by any self-identified community of practice(not only the GO FAIR Implementation Networks).Based on patterns of use and reuse of existing resources,the Convergence Matrix supports the transparent derivation of strategies that optimally coordinate convergence on standards and technologies in the emerging Internet of FAIR Data and Services.

关键词： FAIR Implementation Choices and Challenges Convergence FAIR Communities

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Investigation of <i>Yersinia enterocolitica</i>Bioserotype 4/O:3 Clusters in Finland, 2017-2018

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Advances in Infectious Diseases 2021年第2期11卷 185-195页

作者： Sari Huusko Saara Salmenlinna annika Pihlajasaari Saija Hallanvuo Jukka Ollgren Ruska Rimhanen-Finne Finnish Institute for Health and Welfare Helsinki Finland Finnish Food Authority Helsinki Finland

In December 2017, two suspected outbreaks of Yersinia enterocolitica 4/O:3 were notified in Finland. We analyzed the surveillance and outbreak investigation data and genotyped Y. enterocolitica strains in order to understand Y. enterocolitica epidemiology in Finland and to find out whether the notified outbreaks were related. A total of 13,344 Y. enterocolitica cases were reported in 1995-2018 to the National Infectious Diseases Register. The mean annual incidence ranged from 7.9 to 15.9/100,000 inhabitants. The highest incidence was observed in young adults (14/100,000). Incidence varied geographically. The incidence was higher in spring compared to other seasons. The most common pathogenic bioserotype was 4/O:3 but the information on bio/serotype was missing in 64% of the surveillance cases. For most of the cases, 87%, no travel history was reported. In the YE 4/O:3 outbreak investigation, whole genome sequencing was performed for isolates from 29/69 (42%) of the outbreak cases. The sequencing results showed that cases consisted of six independent clusters with 2 - 6 isolates in each cluster, and 5 sporadic isolates. No food item was found to be common to all of the clusters. In order to improve monitoring and facilitate the detection and investigation of Y. enterocolitica outbreaks, more comprehensive information on bio/serotype and on travel history is required in the surveillance.

关键词： Outbreak Whole Genome Sequencing Yersinia enterocolitica

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从零售物流到综合性物流

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现代制造 2023年第4期 53-55页

作者： annika Nolte 不详

Coop公司设在瑞士Oberbüren市的子公司Fust公司计划扩建自己的物流中心,使其物流能力翻倍并停止使用外部仓库。凭借SSI Schäfer公司整体性的物流解决方案,Fust公司已经充分准备好了增加产品种类和范围、提高产品的可用性以及灵活地适... 详细信息

Coop公司设在瑞士Oberbüren市的子公司Fust公司计划扩建自己的物流中心,使其物流能力翻倍并停止使用外部仓库。凭借SSI Schäfer公司整体性的物流解决方案,Fust公司已经充分准备好了增加产品种类和范围、提高产品的可用性以及灵活地适应新仓库的物资吞吐量。

关键词：物资吞吐量物流中心物流解决方案物流能力零售物流子公司仓库综合性物流

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Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence

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World Journal of Gastroenterology 2012年第33期18卷 4549-4556页

作者： Suvi Tuulia Avoranta Eija annika Korkeila Kari Juhani Syrjnen Seppo Olavi Pyrhnen Jari Toivo Tapio Sundstrm Department of Oncology and Radiotherapy University of Turku and Turku University Hospital FIN-20521 Turku Finland Department of Pathology University of Turku and Turku University Hospital FIN-20520 Turku Finland

AIM: To investigate the prognostic value of CD44 variant 6 (CD44v6), a membranous adhesion molecule, in rectal cancer. METHODS: Altogether, 210 rectal cancer samples from 214 patients treated with short-course radiotherapy (RT, n = 90), long-course (chemo) RT (n = 53) or surgery alone (n = 71) were studied with immunohistochemistry for CD44v6. The extent and intensity of membranous and cytoplasmic CD44v6 staining, and the intratumoral membranous staining pattern, were ***: Membranous CD44v6 expression was seen in 84% and cytoplasmic expression in 81% of the cases. In 59% of the tumors with membranous CD44v6 expression, the staining pattern in the invasive front was determined as "front-positive" and in 41% as "front-negative". The latter pattern was associated with narrower circumferential margin (P = 0.01), infiltrative growth pattern (P < 0.001), and shorter disease-free survival in univariate survival analysis (P = 0.022) when compared to the "front-positive" tumors. CONCLUSION: The lack of membranous CD44v6 in the rectal cancer invasive front could be used as a method to identify patients at increased risk for recurrent disease.

关键词： CD44 variant 6 Rectal cancer Invasive front Disease-free survival Disease-specific survival

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Towards the future of plastic surgery:from flaps to microsurgery and regenerative medicine and biofabrication?

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Plastic and Aesthetic Research 2017年第10期4卷 185-189页

作者： Raymund EHorch annika Weigand Harald Wajant Ran An Jia-Min Sun Andreas Arkudas Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine University Hospital ErlangenFriedrich-Alexander University Erlangen-Nuernberg FAU91054 ErlangenGermany Division of Molecular Internal Medicine Department of Internal Medicine IIUniversity Hospital WüzburgJulius-Maximilians-Universitat Wüzburg97070 WüzburgGermany Union Plastic and Aesthetic Hospital Huazhong University of Science and TechnologyWuhan Union HospitalWuhan430022HubeiChina

Plastic surgery is a specialty that is now worldwide recognized as its own academic discipline within the surgical community. The roots however are as old as 600 BC when in the Sushruta Ayurveda the reconstruction of a nose with a flap from the forehead was described. Plastic surgery is a problem solving discipline that meanwhile is an integral part within modern surgical concepts.

关键词： future surgery biofabrication

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食物消费模式及其对气候变化的影响——瑞典所消费的西红柿和胡萝卜生命周期中的温室气体排放

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人类环境杂志 1998年第7期27卷 528-533页

作者： annika Carlsson-Kanyama 胡莹瑞典斯德哥尔摩大学系统生态系

本文给出了瑞典所消费的胡萝卜和西红柿的生命周期评估结果,并就此进行了讨论。它们的生命周期可分为贮藏、从种植者到零售商之间的运输、田间生产以及化肥的生产和运输。产于瑞典及周边地区的胡萝卜的排放量最低,而西红柿则相反。胡萝... 详细信息

本文给出了瑞典所消费的胡萝卜和西红柿的生命周期评估结果,并就此进行了讨论。它们的生命周期可分为贮藏、从种植者到零售商之间的运输、田间生产以及化肥的生产和运输。产于瑞典及周边地区的胡萝卜的排放量最低,而西红柿则相反。胡萝卜的排放主要来自贮藏和运输过程中;而西红柿的排放主要来自种植过程中对温室加热时的燃料燃烧。本文对瑞典目前蔬菜消费过程中的全部温室气体的排放进行了评估,并与所假定的食物消费允许的环境空间做了比较。结论表明。目前的蔬菜生产消费方式是不可持续的。

关键词：气候变化食物消费模式西红柿温室气体排放

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Perinatal events and the risk of developing primary sclerosing cholangitis

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World Journal of Gastroenterology 2006年第37期12卷 6037-6040页

作者： annika Bergquist Scott M Montgomery Ulrika Lund Anders Ekbom Rolf Olsson Stefan Lindgren Hanne Prytz Rolf Hultcrarltz Ulrika Broomé Department of Gastroenterology and Hepatology Karolinska University Hospital Huddinge Karolinska Institute Stockholm Sweden Clinical Epidemiology Unit Department of Medicine Karolinska University Hospital Solna Karolinska Institute Stockholm Sweden Department of Medicine Sahlgrenska University Hospital Gothenburg Sweden Gastroenterology and Hepatology Division Department of Medicine University Hospital Malmoe Sweden Division of Gastroenterology and Hepatology University Hospital Lund Sweden Department of Gastroenterology and Hepatology Karolinska Institute and Hospital. Solna. Stockholm. Sweden 不详

AIM: To investigate whether perinatal events, intrauterine or postpartum, are associated with the development of primary sclerosing cholangitis (PSC) later in life. METHODS: Birth records from 97 patients with adult PSC in Sweden were reviewed. Information on perinatal events including medications and complications during pregnancy, gestation length, birth weight and length were collected. Two control children of the same sex were selected for each subject. Conditional multiple logistic regression was used to assess associations of the perinatal measures with development of PSC. RESULTS: No significant associations were found between gestational age, birth length, breastfeeding, and the majority of medical complications including infections or medication during pregnancy for the mothers or postpartum for the children. Vaginal bleeding and peripheral oedema showed associations with PSC, with matched odds ratios of 5.70 (95% CI, 1.13-28.83) and 2.28 (95% CI, 1.04-5.03), respectively. CONCLUSION: The associations of vaginal bleeding and oedema with subsequent PSC cannot readily beexplained, so our fi ndings do not strongly support the hypothesis of a signifi cant role of perinatal events as a risk for the development of PSC later in life.

关键词： Inflammatory bowel disease Perinatal factors Sclerosing cholangitis

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