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Enhanced recovery after surgery in liver transplantation:Challenges and feasibility

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World Journal of Transplantation 2022年第7期12卷 195-203页

作者： Georgios Katsanos Konstantina-Eleni Karakasi Nikolaos Antoniadis Stella Vasileiadou Athanasios Kofinas Antonios Morsi-Yeroyannis Evangelia Michailidou Ioannis Goulis Emmanouil Sinakos Olga Giouleme Ilias Marios Oikonomou George Evlavis Georgios Tsakiris Eleni massa Eleni Mouloudi Georgios Tsoulfas Department of Transplantation Medical SchoolAristotle University of ThessalonikiHippokration General HospitalThessaloniki 54642Greece Intensive Care Unit National Health SystemHippokration General HospitalThessaloniki 54642Greece Fourth Department of Internal Medicine Hippokration General HospitalMedical School of Aristotle UniversityThessaloniki 54642Greece Second Propaedeutic Department of Internal Medicine Hippokratio General HospitalAristotle University ThessalonikiThessaloniki 54642Greece Nursing Department National Health SystemDepartment of TransplantationHippokration General HospitalThessaloniki 54642Greece

BACKGROUND Enhanced recovery after surgery(ERAS)started a revolution that changed age-old surgical stereotypical practices regarding the overall management of the surgical *** the last decade,ERAS has gained significant acceptance in the community of general surgery,in addition to several other surgical specialties,as the evidence of its advantages continues to *** of the last remaining fields,given its significant complexity and intricate nature,is liver transplantation(LT).AIM To investigate the existing efforts at implementing ERAS in *** We conducted a systematic review of the existing studies that evaluate ERAS in orthotopic LT,with a multimodal approach and focusing on measurable clinical primary endpoints,namely length of hospital *** All studies demonstrated a considerable decrease in length of hospital stay,with no readmission or negative impact of the ERAS protocol applied to the postoperative *** ERAS is a well-validated multimodal approach for almost all types of surgical procedures,and its future in selected LT patients seems promising,as the preliminary results advocate for the safety and efficacy of ERAS in the field of LT.

关键词： Enhanced recovery Enhanced recovery after surgery Recovery Liver transplantation Liver

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TGF－β家族及其受体组成

生命科学 1995年第2期7卷 32-35页

作者： massa.,J 张德胜中国科学院上海生物化学研究所

ＴＧＦ－β家族及其受体组成ＴｈｅＴＧＦ－βｆａｍｉｌｙａｎｄｉｔｓｃｏｍｐｏｓｉｔｅｒｅｃｅｐｔｏｒｓＪｏａｎ　Ｍａｓｓａｇｕｅ，ＬｉｌｉａｎａＡｔｔｉｓａｎｏａｎｄＪｅｆｆｒｅｙＬＷｒａｎａ￥／／张德胜译，曹惠婷校... 详细信息

ＴＧＦ－β家族及其受体组成ＴｈｅＴＧＦ－βｆａｍｉｌｙａｎｄｉｔｓｃｏｍｐｏｓｉｔｅｒｅｃｅｐｔｏｒｓＪｏａｎ　Ｍａｓｓａｇｕｅ，ＬｉｌｉａｎａＡｔｔｉｓａｎｏａｎｄＪｅｆｆｒｅｙＬＷｒａｎａ￥／／张德胜译，曹惠婷校阅（中国科学院上海生物化学研究所２...

关键词：转化生长因子β 受体细胞

Assessment of Environmental Cleaning Practices and the Impacts on Infection Prevention and Control in Selected Hospitals in Tanzania

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Journal of Environmental Protection 2022年第10期13卷 698-715页

作者： Honest Anicetus Samwel Manyele Michael Habtu Adolf Kiyunge Josephat Saria Robert Njee Linda Thadei Khalid massa Grace Elizabeth Saguti Zabulon Yoti Ministry of Health Community Development Gender Elderly and Children Dodoma Tanzania Department of Chemical and Mining Eng. University of Dar es Salaam Dar es Salaam Tanzania World Health Organization (WHO) Tanzania Dar es Salaam Tanzania Department of Environmental Studies The Open University of Tanzania Dar es Salaam Tanzani National Institute of Medical Research Dar es Salaam Tanzania National Council for Technical Education Dar es Salaam Tanzania

To achieve Sustainable Development Goal (SDG) in healthcare facilities (HCFs,) the provision of water, sanitation, healthcare waste management, hand hygiene and environmental cleanliness services is crucial. Good WASH services in HCFs settings have the potential to reduce healthcare acquired infections (HAIs), increase trust and uptake of healthcare services, increase efficiency and improve staff morale. To address this, a National Assessment was carried out to ascertain environmental cleanliness condition of the healthcare facilities at all levels. The assessment of healthcare waste management in the facilities was conducted in all the 26 regions of Tanzania Mainland including districts and lower healthcare facilities. A standardized checklist and tools were used to assess and monitor various aspects related to healthcare waste management using open source software for data collection (ODK). Data were analyzed using SPSS computer software. It was observed that most of permanent staff (88%) in the Healthcare facilities had knowledge on hand hygiene, but the gap was observed to the waste handlers (12%) who were not equipped with the hand hygiene knowledge. About 89% of the hand washing stations were available at mortuary units, followed by 75% at main entrance and the lowest was 3% at waste zone areas of the healthcare facilities. Hand washing materials like soap were mainly found at theaters (64%) followed by mortuary (60%) and last at waste zones. The assessment concludes that handling of healthcare wastes is not practiced to the expectations, and there is a need to strengthen the situation. The findings provide evidence for those engaged in improving HCF conditions to develop evidence-based policies and efficient programs, enhance service delivery systems, and make better use of available resources.

关键词： Environmental Cleaning Infection Prevention Sanitation Hand Hygiene and Water Supplies

Morbidity and Mortality Related to Obstetrical Evacuations in a Country with Limited Resources: The Case of the Maternity Ward of the Prefectural Hospital of Coyah, Guinea

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Open Journal of Obstetrics and Gynecology 2021年第9期11卷 1140-1150页

作者： Mamadou Hady Diallo Ibrahima Sory Baldé Fatoumata Bamba Diallo Alpha Boubacar Barry massa Keita Emile Tinguiano Telly Sy Namory Keita University Department of Gynecology-Obstetrics Donka National Hospital Conakry Guinea University Department of Gynecology-Obstetrics Ignace Deen National Hospital Conakry Guinea Maternity Ward of the Prefectural Hospital of Coyah Coyah Guinea

Obstetric complications requiring evacuation are found all over the world with a high frequency in developing countries where they are responsible for high fetal-maternal morbidity and mortality. The objectives of this study were to calculate the frequency of obstetric evacuations in the maternity ward of the Coyah prefectural hospital, describe the socio-demographic characteristics of the evacuated patients, identify the main reasons for evacuation, determine the means of transport used and specify the maternal and fetal prognosis. Patients and Method: This was a prospective descriptive and analytical study conducted over a 6-month period (April 1-September 30, 2020) at the maternity ward of the Coyah prefectural hospital. All patients evacuated for complications of gravidopuerperium were included in the study. Results: We recorded 84 cases of obstetric evacuations out of a total of 2206 consultations, i.e. a frequency of 3.8%. The average age of the patients was 25.22 years with extremes of 15 and 45. Housewives (58.82%), nulliparous women (36.93%) and women with no education (64.29%) were the most numerous ones. No patient received medical transportation. More than half of the patients were evacuated by a nurse (51.21%). Hemorrhage in the last quarter was the main reason for evacuation. The average distance traveled by patients was 18.3 km with extremes of 12 and 68 km. The average transfer time was 63 min (1 h 3 minutes) with extremes of 20 min and 300 min (5 h). Maternal mortality was 5.95%. The perinatal mortality rate was 46.42%. No counter-referral was made. Conclusion:

关键词： Morbidity Mortality Obstetrical Evacuations Maternity Guinea

How to improve metastatic pancreatic ductal adenocarcinoma patients’selection:Between clinical trials and the real-world

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World Journal of Clinical Oncology 2022年第5期13卷 417-422页

作者： Andrea Pretta Dario Spanu Stefano Mariani Nicole Liscia Pina Ziranu Valeria Pusceddu Marco Puzzoni Elena massa Mario Scartozzi Eleonora Lai Medical Oncology Unit University Hospital and University of CagliariMonserrato 09042CagliariItaly Department of Oncology IRCCS San Raffaele Scientific Institute HospitalVita-Salute San Raffaele UniversityMilano 20121Italy

As underlined in the minireview by Blomstrand et al,given the poor prognosis and the paucity of data on a therapeutic sequence in pancreatic ductal adenocarcinoma(PDAC),additional randomized controlled trials and real-world evidence studies addressing current and novel regimens are *** real-world outcomes of first-line chemotherapy regimens such as FOLFIRINOX and gemcitabine/nab-paclitaxel are thoroughly reviewed and seem to be largely generalizable in a real-world *** second-line chemotherapy,the key question about the optimal sequence of regimens remains *** in this setting,it is therefore useful to encourage the implementation of clinical studies that may contribute to the scarcity of data available up to *** report our experience with a small group of patients treated with second-line liposomal irinotecan(nal-IRI)plus 5-fluorouracil and *** improve the treatment of patients affected by PDAC,it is useful to identify subgroups of patients who may benefit from target treatments(e.g.,BRCA mutant)and it is also important to focus on any prognostic factors that may affect the survival and treatment of these patients.

关键词： Metastatic pancreatic ductal adenocarcinoma Palliative chemotherapy Realworld data Molecular selection Biomarkers Second-line treatment

Hemorrhages in the First Trimester of Pregnancy: Etiological Aspect and Management at the Maternity Ward of the Ignace Deen National Hospital of the University Hospital of Conakry

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Open Journal of Obstetrics and Gynecology 2022年第8期12卷 719-730页

作者： Fatoumata Bamba Diallo Elhadj Mamoudou Bah massa Keita Mamadou Sanoussy Barry Abdoul Aziz Balde Mamadou Dian Balde Ibrahima Sory Balde Telly Sy University Department of Gynecology-Obstetrics Donka National Hospital Conakry Guinea University Department of Gynecology-Obstetrics Ignace Deen National Hospital Conakry Guinea

Aims: Hemorrhages in the first trimester of pregnancy constitute a public health problem in developing countries with maternal mortality which is still very high. This is the most common reason for consultation in early pregnancy. The objectives of this study were to describe the sociodemographic characteristics of the patients, identify the etiologies, describe the management and evaluate the maternal prognosis in patients presenting with hemorrhage in the first trimester of pregnancy. Methods: This was a descriptive-type prospective study lasting 12 months from January 1 to December 31, 2020, carried out at the maternity ward of Ignace Deen National Hospital. Results: During the study period, we recorded 163 cases of hemorrhage in the first trimester of pregnancy out of 5478 deliveries, i.e. a frequency of 2.97%. The main incriminated etiologies were spontaneous abortion (46.62%), ectopic pregnancy (28.22%), hydatidiform mole (16.56%), threatened abortion (5.52%) and pregnancy stopped (3.06%). The socio-demographic profile of the patients was that of a woman in the age group of 26 - 30 years (33.12%), married (79.14%), with secondary level (35.58%), exercising a liberal profession (36.19%) and nulliparous (60.12%). More than half of the patients came directly from home (57.66%) with metrorrhagia (44.78%) and abdominal pain (33.12%) as reasons for consultation. The gestational age between 7-11SA was more represented (82.82%). Manual intrauterine aspiration (58.89%) and salpingectomy (28.22%) were the most practiced therapeutic procedures. We transfused 10.42% of patients and 20.85% received medical treatment. The maternal prognosis was good in 47.87%. The main complications recorded were anemia (38.65%) and the state of shock (10.42%). Conclusion: Hemorrhages in the first trimester of pregnancy represent an important cause of maternal morbidity in developing countries. The improvement of the maternal prognosis would pass by the early consultation in front of any ca

关键词： Pregnancy First Trimester Hemorrhage Etiologies Management Ignace Deen Guinea

Gynecological and Obstetrical Emergencies at the University Clinic of Gynecology-Obstetrics of the National Hospital Donka Guinea

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Open Journal of Obstetrics and Gynecology 2021年第12期11卷 1862-1874页

作者： Mamadou Hady Diallo Fatoumata Bamba Diallo massa Keita Djénabou Binta Baldé Alpha Boubacar Barry Ibrahima Sory Baldé Telly Sy Namory Keita University Department of Gynecology-Obstetrics National Hospital Donka Conakry Guinea University Department of Gynecology and Obstetrics National Hospital Ignace Deen Conakry Guinea

Gynecological and obstetrical emergencies are found all over the world, especially in developing countries where women pay a heavy price for giving birth. They can occur at any time during pregnancy and outside of pregnancy often in a socio-economic context. The objectives of this study were to describe the sociodemographic characteristics and the maternal and fetal prognosis of gynecological and obstetric emergencies. Patients and Methods: This was a descriptive cross-sectional study with prospective data collection, conducted at the University Clinic of Gynecology and Obstetrics of the Donka National Hospital between June 1 and September 30, 2015. It involved all patients admitted to our department in emergency for a gynecological or obstetrical complaint. Results: We collected 361 cases of gynecological and obstetrical emergencies out of a total of 1779 consultations, i.e. a frequency of 20.29%. Obstetrical emergencies were predominant with 91.41% and gynecological emergencies represented 8.59%. The average age of patients was 29.5 with extremes of 14 and 47. Nulliparous women were the most numerous (34.35%). More than half of the patients did not attend school (52.08%) and 56.70% were evacuees. Abdominopelvic pain and hemorrhage were the main reasons for consultation (54.29% and 49.58%). Admission diagnoses were dominated by acute fetal distress and hemorrhage in the last quarter of pregnancy (52.3% and 36.01%). The caesarean section rate was high (82.12%). Maternal and perinatal lethality rates were high (5.2% and 30.3%). Conclusion:

关键词： Gynecological Emergencies Obstetrical Donka Guinea

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关于普朗克辐射的热力学

大学物理 1991年第4期 46-46页

作者： Cormdo massa

Severe cyclophosphamide-related hyponatremia in a patient with acute glomerulonephritis

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World Journal of Nephrology 2017年第4期6卷 217-220页

作者： Pasquale Esposito Maria Valentina Domenech Nicoletta Serpieri Marta Calatroni Ilaria massa Alessandro Avella Edoardo La Porta Luca Estienne Elena Caramella Teresa Rampino Department of Nephrology Dialysis and TransplantationFondazione IRCCS Policlinico "San Matteo" and University of Pavia

Cyclophosphamide is frequently used to treat cancer,autoimmune and renal diseases,such as rapidly progressive *** side effects are well-known,including bone marrow depression,infections,alopecia,sterility,bladder malignancy and hemorrhagic ***,in some cases cyclophosphamide use has been related to the onset of hyponatremia,by development of a syndrome of inappropriate ***,severe hyponatremia has been previously reported in patients treated with high-dose or moderate-dose of intravenous cyclophosphamide,while only few cases have been reported in patients treated with low ***,we discuss a case of a syndrome of inappropriate antidiuresis followed to a single low-dose of intravenous cyclophosphamide in a patient with a histological diagnosis of acute glomerulonephritis,presenting as acute kidney *** cyclophosphamide administration(500 mg IV),while renal function gradually improved,the patient developed confusion and *** examinations showed serum sodium concentration dropped to 122 mmol per liter associated with an elevated urinary osmolality of 199 mO sm/kg,while common causes of acute hyponatremia were *** was successfully treated with water restriction and hypertonic saline solution infusion with the resolution of the electrolyte *** case,together with the previous ones already reported,highlights that electrolyte profile should be strictly monitored in patients undergoing cyclophosphamide therapy in order to early recognize the potentially lifethreatening complications of acute water retention.

关键词： Hyponatremia Cyclophosphamide Syndrome