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npj Computational Materials 2022年第1期8卷 2076-2083页

作者： annick de b.cker Sandra Van Aert Christel Faes Ece Arslan Irmak Peter DNellist Lewys Jones EMAT University of AntwerpGroenenborgerlaan 1712020AntwerpBelgium NANOlab Center of Excellence University of AntwerpGroenenborgerlaan 1712020AntwerpBelgium I-bioStat Data Science InstituteHasselt UniversityHasseltBelgium department of Materials University of OxfordParks RoadOX13PHOxfordUK Advanced Microscopy Laboratory Centre for Research on Adaptive Nanostructures and Nanodevices(CRANN)Dublin 2Ireland School of Physics Trinity College DublinThe University of DublinDublin 2Ireland

We introduce a bayesian genetic algorithm for reconstructing atomic models of monotype crystalline nanoparticles from a single projection using Z-contrast *** number of atoms in a projected atomic column obtained from annular dark field scanning transmission electron microscopy images serves as an input for the initial three-dimensional *** algorithm minimizes the energy of the structure while utilizing a priori information about the finite precision of the atom-counting results and neighbor-mass *** results show promising prospects for obtaining reliable reconstructions of beam-sensitive nanoparticles during dynamical processes from images acquired with sufficiently low incident electron doses.

关键词： algorithm atomic utilizing

Exploring the Therapeutic Potential of Algae-based Sheet Masks in Skincare: A Comprehensive Study of Cosmetological benefits and Microbiome balanced Interactions

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Journal of Cosmetics, dermatological Sciences and Applications 2023年第4期13卷 277-301页

作者： Ciska Janssens-b.cker Karin Wiesweg Claudia Doberenz MedSkin Solutions Dr. Suwelack Billerbeck Germany

Research in dermatology is exploring bio-compatible materials like alginate and calcium sulphate for use in skincare products, such as facial sheet masks. Alginate (from seaweed) has wound healing and hydration properties, while calcium assists in maintaining skin balance and protection. In this study we explore the effects of an algae-calcium based sheet mask on skin. Materials and Methods: In-vitro studies investigated the purpose, process and effectiveness of an algae-calcium dry sheet mask (Algae Mask-MedSkin Solutions Dr. Suwelack). The mask is made from brown algae and undergoes a lyophilization and stabilization process to form its final structure. The mask’s properties were tested using scanning electron microscopy (SEM) and its performance was assessed on human skin biopsies. Various tests were performed, such as measuring the release of ionic constituents and concentration of calcium ions, and the fibroblast cell-activating effect. Clinical evaluations and skin microbiome assessment were conducted on healthy volunteers to assess the mask’s effect on the skin. Results and Conclusion: The study validates the benefits of macro algae-based sheet masks for skincare, with significant cosmetic effects and high tolerance due to its composition. Notably, the algae based mask releases substantial calcium ions, hydrates, minimizes skin roughness and wrinkles, regulates pH levels, and maintains skin microbiome diversity. It also decreases Corynebacterium species found on the skin, suggesting potential to modify skin microbiome. .

关键词： Algae Sheet Mask Calcium Skin Aging Hydration Microbiome Skin pH

SECOND-ORdeR CONVERGENCE PROPERTIES OF TRUST-REGION METHODS USING INCOMPLETE CURVATURE INFORMATION, WITH AN APPLICATION TO MULTIGRID OPTIMIZATION

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Journal of Computational Mathematics 2006年第6期24卷 676-692页

作者： Serge Gratton annick Sartenaer Philippe L. Toint CERFACS av. G. Coriolis Toulouse France department of Mathematics University of Namur 61 rue de Bruxelles B-5000 Namur Belgium

Convergence properties of trust-region methods for unconstrained nonconvex optimization is considered in the case where information on the objective function＇s local curvature is incomplete, in the sense that it may be restricted to a fixed set of ＂test directions＂ and may not be available at every iteration. It is shown that convergence to local ＂weak＂ minimizers can still be obtained under some additional but algorithmically realistic conditions. These theoretical results are then applied to recursive multigrid trust-region methods, which suggests a new class of algorithms with guaranteed second-order convergence properties.

关键词： Nonlinear optimization Convergence to local minimizers Multilevel problems.

Supported ZnO catalysts for the conversion of alkanes:About the metamorphosis of a heterogeneous catalyst

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Journal of Natural Gas Chemistry 2012年第5期21卷 581-594页

作者： S.Arndt b.Uysal A.berthold T.Otrebma Y.Aksu M.Driess R.Schomcker Technische Universitāt zu berlin Institut fūr ChemieStraβe des 17 Juni 12410623 BerlinGermany Akdeniz University Department of Chemistry07058 AntalyaTurkey Technische Universitāt zu berlin Institut fūr Werkstof fwissenschaftenHardenbergstr 4010623 BerlinGermany

ZnO could be a suitable catalyst for the oxidative conversion of CH4,C2H6 and ***,the main drawback is its thermal ***,ZnO supported on ZrO 2,TiO2,γ-Al2O and SiO2 was investigated for the oxidative dehydrogenation of propane and ethane,and the oxidative coupling of *** stability of the supported ZnO is partially improved,but ZnO reacts with the support material,forming new compounds （Zn-zirconates,-titanates,-aluminates and-silicates）,which already occurs below reaction *** might also be the case for many other heterogeneous catalysts.

关键词： oxidative dehydrogenation oxidative coupling of methane oxidative dehydrogenation of ethane oxidative dehydrogenation of propane ZnO

Subtraction hemiarthoplasty in basal joint arthritis: A case report

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World Journal of Orthopedics 2019年第8期10卷 304-309页

作者： Henrik Constantin b.cker Christina E Freibott Melvin Paul Rosenwasser department of Orthopedic Surgery New York Presbyterian/Columbia University Medical Center

bACKGROUND basal joint arthritis is a common disease which is especially present in postmenopausal women. A variety of procedures have been described once conservative treatment has failed. The purpose of our study is to present a novel surgical technique based on a clinical case with three-year follow-up which is highly effective, even after failure of previous procedures. CASE SUMMARY We present a case of a 39 year-old-woman who suffered from recurring, persistent, sharp left thumb pain for several years After two operative procedures, she presented again with intolerable, sharp pain over the trapeziometacarpal joint, and wished to proceed with a pain relieving procedure or arthroplasty. Intraoperatively, the articular surfaces appeared well, without any bare areas of bone or eburnation, resulting in the decision to perform a “subtraction hemiarthroplasty”. A shortening osteotomy of the os trapezium was performed by removing a slice of 8-9 mm bone, without damaging the joint cartilages. The osteotomy was stabilized using two screws, the ligament and capsular tissue was suture imbricated, and a cut down on the translation and a dorsal radial ligament reconstruction were performed. Three years after the final procedure, a long-term follow-up demonstrates excellent results, pain free with full range-of-motion. CONCLUSION Subtraction hemiarthroplasty with ligament tightening imbrication and reconstruction of the radial ligament led to excellent results in motion and pain.

关键词： basal joint Arthritis Trapeziometacarpal Subtraction hemiarthroplasty Carpometacarpal joint Thumb Case report

Pathogenesis of hepatitis b virus infection

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World Journal of Gastroenterology 2007年第1期13卷 82-90页

作者： Thomas F baumert Robert Thimme Fritz von Weizscker department of Medicine II University of Freiburg Freiburg Germany INSERM U748 Université Louis Pasteur Strasbourg France department of Medicine II University of Freiburg Freiburg Germany department of Medicine II University of Freiburg Freiburg Germany Schlosspark-Klinik Charité Humboldt University Berlin Germany

Infection with hepatitis b virus (HbV) leads to a wide spectrum of clinical presentations ranging from an asymptomatic carrier state to self-limited acute or fulminant hepatitis to chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma. Infection with HbV is one of the most common viral diseases affecting man. both viral factors as well as the host immune response have been implicated in the pathogenesis and clinical outcome of HbV infection. In this review, we will discuss the impact of virus-host interactions for the pathogenesis of HbV infection and liver disease. These interactions include the relevance of naturally occurring viral variants for clinical disease, the role of virus-induced apoptosis for HbV-induced liver cell injury and the impact of antiviral immune responses for outcome of infection.

关键词：发病机制乙型病毒肝炎治疗临床病毒感染

biomechanics of posterior shoulder instability-current knowledge and literature review

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World Journal of Orthopedics 2018年第11期9卷 245-254页

作者： Henrik Constantin b.cker Samuel E Galle Mauro Maniglio Melvin Paul Rosenwasser department of Orthopedic Surgery New York Presbyterian/Columbia University Medical Center department of Orthopedics HFR Cantonal Hospital of Fribourg

Posterior instability of the shoulder is a rare condition and represents about 10% of shoulder instability. It has become more frequently recognized in the last year,even though it is more difficult to diagnose than anterior shoulder instability. As this form of shoulder pathology is somewhat rare,biomechanical knowledge is limited. The purpose of our study was to perform an extensive literature search,including PubMed and Medline,and to give an overview of the current knowledge on the biomechanics of posterior shoulder instability. The Pub Med/Medline databases were utilized,and all articles related to posterior shoulder instability and biomechanics were included to form a comprehensive compilation of current knowledge. A total of 93 articles were deemed relevant according to our inclusion and exclusion criteria. As expected with any newly acknowledged pathology,biomechanical studies on posterior shoulder instability remain limited in the literature. Current biomechanical models are performed in a static manner,which limits their translation for explaining a dynamic pathology. Newer models should incorporate dynamic stabiliza-tion of both the rotator cuff and scapulothoracic joint. There is a current lack of knowledge with regards to the pathomechanism of posterior shoulder instability,with no consensus on appropriate treatment regimens. Further investigation is therefore required at both basic science and clinical levels.

关键词： Posterior shoulder instability Anatomy Shoulder complex Scapula Humerus Glenohumeral

Assessing the Storage Root development of Cassava with a New Analysis Tool

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Plant Phenomics 2022年第1期4卷 43-57页

作者： Jens Wilhelm Tobias Wojciechowski Johannes A.Postma Dirk Jollet Kathrin Heinz Vera bockem Mark Muller-Linow Institute of Plant Sciences IBG-2Forschungszentrum Julich GmbH52425 JulichGermany Tesla Automation GmbH 54595 PrumGermany

Storage roots of cassava plants crops are one of the main providers of starch in many South American,African,and Asian *** varieties with high yields is crucial for growing and *** requires a better understanding of the dynamics of storage root formation,which is usually done by repeated manual evaluation of root types,diameters,and their distribution in excavated *** introduce a newly developed method that is capable to analyze the distribution of root diameters automatically,even if root systems display strong variations in root widths and clustering in high *** application study was conducted with cassava roots imaged in a video acquisition *** root diameter distribution was quantified automatically using an iterative ridge detection approach,which can cope with a wide span of root diameters and *** approach was validated with virtual root models of known geometries and then tested with a time-series of excavated root *** on the retrieved diameter classes,we show plausibly that the dynamics of root type formation can be monitored qualitatively and *** conclude that this new method reliably determines important phenotypic traits from storage root crop *** method is fast and robustly analyses complex root systems and thereby applicable in high-throughput phenotyping and future breeding.

关键词： crops roots Storage

Skin Anti-Aging benefits of a 2% Resveratrol Emulsion

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Journal of Cosmetics, dermatological Sciences and Applications 2021年第2期11卷 155-168页

作者： Anke Schulte to brinke Ciska Janssens-b.cker Martina Kerscher department of Clinical Affairs MedSkin Solutions Dr. Suwelack AG Billerbeck Germany dermatology at the Division of Cosmetic Science Department of Chemistry University of Hamburg Hamburg Germany

background: Young and intact skin is highly responsive. As skin ages, its responsiveness decreases. Production of structural components of the skin slows down and signs of skin aging appear. External influences like UV radiation and pollution contribute to signs of skin aging. They lead to an increased formation of so-called free radicals. bioactive antioxidant compounds, such as polyphenols, have beneficial effects on skin health by free radical scavenging. The purpose of this study was to evaluate the topical effects of new and highly concentrated resveratrol containing emulsion (Medskin Solutions Dr. Suwelack AG, 2% trans-resveratrol) on age-related alterations to the skin. Methods: A clinical observation study was performed on 20 subjects to observe the effects of a 2% resveratrol emulsion on typical signs of skin aging. Product was applied once daily for a period of 8 weeks in combination with a standardized treatment. Tested parameters were skin elasticity, skin barrier function, skin smoothness, skin thickness and density. Results: After 8 weeks of treatment, skin pH value is significantly lowered and skin barrier function improved. The value of skin elasticity (+5.3%), and skin density (+ 10.7%) had increased, while skin roughness (-6.4%) and skin dispensability (-45.9%) had diminished. Intensity of skin redness had decreased. Furthermore, expert and participant evaluations show satisfaction, especially with regard to skin smoothness and skin moisture. Conclusion: The resveratrol emulsion shows positive outcomes by supporting reduction of skin wrinkling and increasing skin firmness, as well as reducing skin redness, and is therefore an all-round anti-aging treatment.

关键词： Resveratrol Emulsion Skin Care Skin Aging

大型动物模型给予单剂量钆基对比剂后组织中钆的分布

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国际医学放射学杂志 2022年第1期 111-112页

作者： H.Richter P.b.cker L.F.Martin C.Dunker S.Fingerhut A.Xia 曹秋婷

摘要关于钆基对比剂（GbCA）注射后在大脑和其他器官中的沉积程度和临床重要性的科学讨论一直没有间断过。虽然大多数已发表的数据都集中在大脑钆沉积上，但对其他

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