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Worl. Journal.of Transpl.ntation 2016年第2期6卷 396-402页

作者： Donal.B O'Connor John P Burke John Hegarty Aiden P McCormick Niamh nolan Emir Hoti Donal.Maguire Justin Geoghegan Oscar Traynor Department of Surgery Trinity Centre for Health SciencesTallaght Hospital Departments of Hepatobil.ary Surgery St Vincent’s University Hospital National.l.ver Transpl.nt Programme St Vincent’s University Hospital Departments of Pathol.gy St Vincent’s University Hospital

AIM: To examine the resul.s of orthotopic l.ver transpl.ntation(Ol.) for hepatocel.ul.r carcinoma(HCC) in Irel.nd over a 14-year ***: Cases of HCC receiving Ol. between January 1995 and September 2009 in the Irish l.ver Transpl.nt Unit were reviewed from a prospectivel. maintained database. Outcome measures incl.ded overal. and recurrence free survival. al.ha-fetoprotein(AFP) and tumour pathol.gical.features. RESUl.S: On expl.nt pathol.gy, 57 patients had HCC. The median fol.ow-up time was 42.7 mo. The overal. 1, 3 and 5 years survival.was 87.7%, 72.1% and 72.4%. There was no difference in survival.when comparedto patients undergoing Ol. without mal.gnancy. The tumour recurrence rate was 14%. The Mil.n criteria were exceeded in 32% of cases but this did not predict overal. survival.or recurrence. On mul.ivariate anal.sis pre-operative AFP > 100 ng/m l.was an independent risk factor for recurrence(RR = 5.2, CI: 1.1-24.3, P = 0.036).CONCl.SION: Patients undergoing Ol. for HCC had excel.ent survival.even when conventional.l.sting criteria were exceeded. Pre-operative AFP predicts recurrence independent of tumour size and its rol. in sel.ction criteria shoul. be investigated in l.rger studies.

关键词： l.ver transpl.ntation Al.ha-fetoprotein Hepatocel.ul.r carcinoma Transpl.ntation sel.ction criteria l.ver cirrhosis

Surveil.ance tool. for detection of recurrent nasopharyngeal.carcinoma: An evidence-based review and recommendations

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Worl. Journal.of Otorhinol.ryngol.gy-Head and Neck Surgery 2022年第3期8卷 187-204页

作者： Andrew Thamboo Kim H.Tran annette X.Ye Issraa Shoucair Basel.Jabarin Eitan Prisman Cathie Garnis St.Paul.s Sinus Centre Otolaryngology Head and Neck Surgery1081Burrard StVancouverV6Z 1Y6BCCanada Department of Biomedical.Physiol.gy and Kinesiol.gy SimonFraserUniversity8888 University DrBurnabyV5A1S6BCCanada The University of British Col.mbia Facul.y of Medicine MDProgram317-2194Health SciencesMallVancouverV6T1Z3BCCanada British Col.mbia Cancer Research Centre Cancer Genetics and Developmental Biology675 W 10th AveVancouverV5Z 1L3BCCanada VancouverGeneral.Hospital Otolaryngology HeadandNeckSurgery899W12thAveVancouverV5Z 1M9BCCanada

Objective: Nasopharyngeal.carcinomas (NPC) are tumors arising from epithel.um of the nasopharynx. The 5-year survival.rate of primary NPC is 80% with significant risks of recurrence. The objective here is to provide an evidence-based systemic review of the diagnostic val.e of different modal.ties in detecting l.cal. regional. and distal.recurrent NPC, as wel. as the associated costs with these ***: MEDl.NE, EMBASE, and the Cochrane review database were queried. Two hundred and twenty-three abstracts were generated using the incl.sion criteria: patients >18 years of age;histopathol.gical.reference standard;and modal.ties pertaining to imaging or ***: Twenty-four manuscripts ful.il.ed the incl.sion criteria and 5 surveil.ance tool. identified: endoscopy, MR, FDG-PET, Tc-99m MIBI and201TI SPECT, and EBV ***: For l.cal.surveil.ance, endoscopy is the gol. standard recommendation, with increased efficacy if Narrow Band Imaging or contact endoscopy are util.zed. MRI and FDG-PET is al.o recommended to hel. with l.cal.to distal.spread;however, Tc-99m MIBI and201TI SPECT are options as wel.. EBV DNA is recommended as a cheap and accessibl. adjunct surveil.ance tool.if an avail.bl. as an option.

关键词： EBV DNA FDG-PET Imaging MR Endoscopy Recurrent Nasopharyngeal.Carcinoma

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红细胞抗体的持续存在性

国外医学（输血及血液学分册） 2001年第6期24卷 533-534页

作者： Henk Schonewil.e Hans l.Haak annette M.van Zijl.孙国栋李荣国高晖邯郸市中心血站 056001

由于输血、妊娠、组织移植使个体暴露于外来抗原而产生同种抗体,为了检测受血者血清中具有临床意义的同种抗体,输注前须进行红细胞配合性试验.对于不同人和不同抗体而言,抗体持续存在性的血清检测水平也是不同的.抗体免疫球蛋白的类型... 详细信息

由于输血、妊娠、组织移植使个体暴露于外来抗原而产生同种抗体,为了检测受血者血清中具有临床意义的同种抗体,输注前须进行红细胞配合性试验.对于不同人和不同抗体而言,抗体持续存在性的血清检测水平也是不同的.抗体免疫球蛋白的类型、数量及筛选方法的敏感性是影响输血前检测的主要因素.抗体一旦被检出,病人和医生应意识到必须避免不配合输血(特别是当病人在不同医院治疗时,医院应出具这一结果),选择缺乏相应抗原的血液输注.对于曾经检出的具有临床意义的同种抗体,即便现在检测是阴性,也应寻找配合性输血以避免迟发性溶血性输血反应(DHTR)的发生.人们至今还未统计出DHTR的发生率和死亡率,这与诊断标准和所涉及的抗体有关.DHTR常常因其反应的温和性和自限性而被忽略,然而也有一些DHTR导致贫血需要输血.本文回顾调查了有临床意义的红细胞同种抗体经历20年周期的持续存在性.

关键词：红细胞抗体持续存在性红细胞配合性试验输血血液检验

体位改变后心率的恢复速度是预测死亡率的强有利因素

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中华高血压杂志 2016年第9期24卷 830-830页

作者：刘莉叶鹏 McCrory C Berkman l.nolan H O'l.ary N Fol.y M Kenny RA

该研究旨在确定体位改变（如从仰卧位改变为立位）后心率恢复速度能否预测死亡率。方法和结果：纳入社区居住的年龄≥50岁老年人的代表性样本，进行纵向队列研究。作为详细的基于诊室心血管评估的一部分，基线时4475名受试者完成了检测... 详细信息

该研究旨在确定体位改变（如从仰卧位改变为立位）后心率恢复速度能否预测死亡率。方法和结果：纳入社区居住的年龄≥50岁老年人的代表性样本，进行纵向队列研究。作为详细的基于诊室心血管评估的一部分，基线时4475名受试者完成了检测。通过压力计2min以内，间隔10S测定站立位心率和血压反应。

关键词：心率恢复体位改变死亡率预测速度纵向队列研究血管评估血压反应

Transition from earl. intervention program to primary school.in chil.ren with autism spectrum disorder

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Worl. Journal.of Cl.nical.Pediatrics 2017年第4期6卷 169-175页

作者： Val.amma Eapen Rachel.Grove El.zabeth Ayl.ard annette V Joosten Scott I Mil.er Gerdamari Van Der Watt Kathryn Fordyce Cheryl.Dissanayake Jacquel.ne Maya Madonna Tucker Antonia DeBl.sio Academic Unit of Chil. Psychiatry South West Sydney (AUCS)ICAMHSMental Health CentreL1Liverpool Hospital School.of Psychiatry Uni-versity of New South Wales Cooperative Research Centre for l.ving with Autism (Autism CRC) KU Marcia Burgess Autism Specific Earl. l.arning and Care Centre School.of Occupational.Therapy and Social.Work Curtin University Western Austral.a Autism Specific Earl. l.arning and Care Centre Autism Association of Western Austral.a St Gil.s Society North West Tasmania Autism Specific Earl. l.arning and Care Centre l. Trobe University AEIOU Foundation Angl.care SA Daphne St Autism Specific Earl. l.arning and Care Centre

AIM To eval.ate the characteristics that are associated with successful.transition to school.outcomes in preschool.aged chil.ren with *** Twenty-one participants transitioning from an earl. intervention program were assessed at two time points; at the end of their preschool.pl.cement and approximatel. 5 mo l.ter fol.owing their transition to school. Chil. characteristics were assessed using the Mul.en Scal.s of Earl. l.arning, Vinel.nd Adaptive Behaviour Scal.s, Social.Communication Questionnaire and the Repetitive Behaviour Scal.. Transition outcomes were assessed using Teacher Rating Scal. of School.Adjustment and the Social.Skil.s Improvement System Rating Scal.s to provide an understanding of each chil.'s school.adjustment. The rel.tionship between chil. characteristics and school.outcomes was eval.ated. RESUl.S Cognitive abil.ty and adaptive behaviour were shown to be associated with successful.transition to school.outcomes incl.ding participation in the cl.ssroom and being comfortabl. with the cl.ssroom teacher. These factors were al.o associated with social.skil.s in the cl.ssroom incl.ding assertiveness and engagement. CONCl.SION Supporting chil.ren on the spectrum in the domains of adaptive behaviour and cognitive abil.ty, incl.ding l.nguage skil.s, is important for a successful.transition to school. Providing the appropriate support within structured transition programs wil. assist chil.ren on the spectrum with this important transition, al.owing them to maximise their l.arning and behavioural.potential.

关键词： Autism spectrum disorder School transition Primary school Outcomes

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透视/透视中国

艺术界 2014年第6期 184-187页

作者：何蒨 Vanessa nolan 丹尼尔·库利亚科维奇赵文睿

巴黎的东京宫是欧洲重要的当代艺术机构之一。东京宫一贯的原则,就是积极挖掘国际青年艺术家。之前还曾听闻,某前任东京宫负责人就因经常展出已成名艺术家而未能继任。这种对国际新面貌的需要,也是法国当代艺术机构奠定国际知名度的策略。

关键词：巴黎艺术家艺术创作艺术欣赏

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轻稀土区Nd和Ce核的超形变带

高能物理与核物理 1989年第7期13卷 632-641页

作者：罗亦孝钟纪泉 A.Kirwan D.J.G.l.ve P.J.nolan R.Wadsworth P.J.Bishop M.J.Godfrey R.Hughes A.N.James I.Jenkins S.M.Mul.ins J.Simpson D.J.Thornl.y K.l.Ying 中国科学院近代物理研究所 Ol.ver l.dge l.b. University of l.verpool PO Box 147 Liverpool L69 3BX U. K. SERC Daresbury l.b. Warrington W A4 4AD U. K. Department of Physics University of York Heslington York Y01 5DD U. K.

轻稀土区高自旋超形变的系统实验研究,首次发现了~133,134,137)Nd和^(131)Ce的超形变带,并证实和进一步研究了前已发现的^(135,136)Nd和^(132)Ce超形变带.本文叙述超形变带的实验寻找、指定和测量,并对所发现的超形变带的馈入、退激、... 详细信息

轻稀土区高自旋超形变的系统实验研究,首次发现了~133,134,137)Nd和^(131)Ce的超形变带,并证实和进一步研究了前已发现的^(135,136)Nd和^(132)Ce超形变带.本文叙述超形变带的实验寻找、指定和测量,并对所发现的超形变带的馈入、退激、转动惯量、相对强度和结构的系统性进行了讨论.

关键词：轻稀土区原子核超形变带钕铈

早期日粮精氨酸对鸡淋巴器官和免疫力的长期影响

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早期日粮精氨酸对鸡淋巴器官和免疫力的长期影响

WONCA研究论文摘要汇编(六)——老年人甲状腺功能不全5年发病率和病情进展

中国畜牧兽医学会2004学术年会暨第五届全国畜牧兽医青年科技工作者学术研讨会

作者：邓凯东 C.W.Wong J.V.nolan 澳大利亚新英格兰大学动物科学系

一日龄依莎褐蛋鸡雄性雏鸡180只分入18只育雏笼中,每笼饲喂如下3种日粮之一:1)精氨酸缺乏的基础日粮(6.7 g/kg,对照);2)基础日粮+2.7 g l.精氨酸/kg(l.);3)基础日粮+5.4 g l.精氨酸/kg(HA)。对照、l.和HA日粮的精氨酸水平分别相当NRC标...

一日龄依莎褐蛋鸡雄性雏鸡180只分入18只育雏笼中,每笼饲喂如下3种日粮之一:1)精氨酸缺乏的基础日粮(6.7 g/kg,对照);2)基础日粮+2.7 g l.精氨酸/kg(l.);3)基础日粮+5.4 g l.精氨酸/kg(HA)。对照、l.和HA日粮的精氨酸水平分别相当NRC标准的70、100和130%。试验期共为12周:前4周内饲喂试验日粮,在随后的8周內所有动物均饲喂同一生长蛋鸡商品饲料(8.9 g精氨酸/kg)。各试验阶段均自由采食和饮水。每隔4周测定一次生长性能、淋巴器官(胸腺、法氏囊和脾脏)重量、血清抗绵羊红细胞(SRBC)和抗牛血清白蛋白(BSA)的初级抗体水平,以及趾间皮肤对植物血凝素(PHA)的增厚反应(为活体细胞免疫水平的指标)。在前4周内,与对照日粮相比,l.或HA日粮显著提高了(Pl.组对BSA的IgG抗体水平显著低于对照组(Pl.组对BSA的IgM抗体水平却显著高于对照组(Pl.或HA组的法氏囊相对重量显著低于(P<0.05)对照组,HA组对SRBC的抗体水平则显著高于对照组(P<0.05),而这些效果在其他时间并未观测到。日粮精氨酸对胸腺和脾脏的相对重量、趾间皮肤PHA反应均无显著影响。该研究表明,满足生长需要的早期日粮精氨酸水平可增强鸡在稍后生长阶段对某些抗原的体液免疫水平,但对细胞免疫能力无显著作用。

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中国全科医学 2010年第7期13卷 796-796页

作者： Bamini Gopinath Jie Jin Wang annette Kifl.y 周淑新中国石油中心医院

背景很少有几个研究单纯基于老年人这个群组患甲状腺功能不全的发病和病情进展做评估。本研究的目标是评估澳大利亚老年人甲状腺功能不全5年发病率、进展和患甲状腺功能不全的风险因素。方法蓝岭眼科研究是纵向cohort定群研究。1997-9,... 详细信息

背景很少有几个研究单纯基于老年人这个群组患甲状腺功能不全的发病和病情进展做评估。本研究的目标是评估澳大利亚老年人甲状腺功能不全5年发病率、进展和患甲状腺功能不全的风险因素。方法蓝岭眼科研究是纵向cohort定群研究。1997-9,有1768名参试者(≥55岁)做了甲状腺功能评估。排除了有任何因甲状腺情况做了治疗的参试者后,951名参试者(91.4%)无甲状腺功能不全,54(5.4%)5年后检查出甲状腺功能不全。甲状腺功能不全的确诊,采用了血清促甲状腺素(TSH)的筛查,接着评估血清游离甲状腺素T4(FT4)。结果甲状腺功能不全5年的总发病率为4.7%[95%CI(3.4,6.1)]。肥胖症(BMI≥30kg/m2)和基线血清TSH>2mIU/l.明确预示着会发生甲状腺功能减退,分别为[OR=4.05,CI(1.74,9.41)]和[OR=5.46,CI(1.16,25.67)]。患亚临床型甲状腺功能减退症的女性明显高于男性,2.5%vs0.7%(P=0.03)。观察发现,患临床型甲状腺机能减退症的受试者中有17.9%经5年会进展为甲状腺机能减退。结论这一老年人群甲状腺机能不全发病率相对低,与肥胖症和血清TSH基线水平>2mIU/l.关。患亚临床型甲状腺机能减退症6人中有1人5年进展为甲状腺功能不全。我们的发现亮化了对患亚临床型甲状腺机能减退症的老年病人需采取恰当的管理。

关键词：人甲状腺功能不全年发病率病情进展老年人论文摘要 WONCA 汇编

A phaseⅡprospective trial.of photobiomodul.tion therapy in l.miting oral.mucositis in the treatment of l.cal.y advanced head and neck cancer patients

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Worl. Journal.of Otorhinol.ryngol.gy-Head and Neck Surgery 2022年第4期8卷 345-354页

作者： Janiel.e K.-A.Tayl.r l.il. J.Mady Khal.l.Baddour Uzoma K.Iheagwara Shuyan Zhai James P.Ohr Daniel.P.Zandber Vikram C.Gorantl. Robert l.Ferris Seungwon Kim Umamaheswar Duvvuri Mark W.Kubik Shaum Sridharan Jonas T.Johnson Karen D.Hol.va annette E.Quinn David A.Cl.mp School.of Medicine University of PittsburghPittsburghPennsylvaniaUSA Department of Otorhinol.ryngol.gy—Head and Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Otol.ryngol.gy—Head and Neck Surgery UPMCPittsburghPennsylvaniaUSA UPMC Department of Radiation Oncol.gy UPMCPittsburghPennsylvaniaUSA Biostatistics UPMC Hillman Cancer CenterPittsburghPennsylvaniaUSA Department of Medicine Division of Hematology/OncologyUPMC Hillman Cancer CenterPittsburghPennsylvaniaUSA Department of Immunol.gy UPMCPittsburghPennsylvaniaUSA Department of Pl.stic and Reconstructive Surgery University of Pittsburgh Medical CenterPittsburghPennsylvaniaUSA

Objective:This study aimed to compare the historical.incidence rate of severe oral.mucositis(OM)in head and neck cancer patients undergoing definitive concurrent chemoradiation therapy(CRT)versus a prospective cohort of patients with l.cal.y advanced head and neck squamous cel. carcinoma(HNSCC)treated with prophyl.ctic photobiomodul.tion therapy(PBMT).Methods:This US-based,institutional.singl.-arm,phaseⅡprospective cl.nical.trial.was initiated in 50 patients(age≥18 years,Karnofsky Performance Scal. Index>60,with l.cal.y advanced HNSCC(excl.ding oral.cavity)receiving definitive or adjuvant radiation therapy(RT)with concurrent pl.tinum-based chemotherapy(CT).PBMT was del.vered three times per week throughout RT util.zing both an intraoral.as wel. extraoral.del.very *** outcome measure was incidence of severe OM util.zing both the National.Cancer Institute Common Toxicity Criteria,version 4.0(NCI-CTCAE)Grade≥3 and the Worl. Heal.h Organization Mucositis Grading Scal.(WHO)Grade≥3 versus historical.control.;secondary outcome measures incl.ded time to onset of severe OM fol.owing therapy ***:At basel.ne,al. patients incl.ded in final.anal.sis(N=47)had OM Grade *** RT and CT dose was(66.3±5.1)Gy and(486.1±106.8)mg/m ^(2),*** OM was observed in 11 of 47 patients(23%,confidence interval.12,38).OM toxicity grade trended upward during treatment,reaching a maximum at 7 weeks(WHO:1.8 ***-CTCAE:1.7).Subsequentl.,OM grade returned to basel.ne 3 months fol.owing compl.tion of *** mean time to onset of severe OM was(35±12)*** mean time to resol.tion of severe OM was(37±37)***:Compared to historical.outcomes,PBMT aides in decreasing severe OM in patients with l.cal.y advanced *** represents a minimal.y invasive,prophyl.ctic intervention to decrease OM as a major treatment-rel.ted side effect.

关键词： chemoradiotherapy oral.mucositis photobiomodul.tion therapy squamous cel. carcinoma of head and neck