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Journal of Geriatric Cardiology 2020年第9期17卷 574-579页

作者： Fritz Kather Miralem Hadzic Teresa Hehle Sarah Eichler Julia Klein Heinz Völler annett salzwedel Department of Rehabilitation Medicine University of PotsdamFaculty of Health Sciences BrandenburgGermany Klinik am See Rehabilitation Center for Internal MedicineRüdersdorfGermany

Malnutrition is described as a state of insufficient intake of energy,protein and other nutrients leading to changes in body composition(weight loss,reduced fat-free mass)as well as adverse functional and clinical outcomes.[1]Depending on the assessments and definition used,the prevalence in older patients ranges between 12%in communitydwelling adults to 60%of patients in geriatric care facilities.[2–5]Older populations are at high risk of nutritional deficiencies because of risk factors such as multimorbidity,polypharmacy,cognitive and physical decline,poor appetite,depressive syndromes and socioeconomic changes.[4,6].

关键词： Cardiac rehabilitation Malnutrition Octogenarians Test-retest reliability

Influence of short chain ceramides and lipophilic penetration enhancers on the nano-structure of stratum corneum model membranes studied using neutron diffraction

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 29-36页

作者： annett SCHROETER Tanja ENGELBRECHT Reinhard H. H. NEUBERT Institute of Pharmacy Martin Luther University Halle-Wittenberg D-06120 Halle/Saale Germany

Oriented stratum corneum model lipid membranes were used to study the influence of the short chain ceramides （CER）[NP] and [AP] as well as the impact of the lipophilic penetration enhancer molecules oleic acid （OA） and isopropyl myristate （IPM） on the lipid nanostrueture. The influence of the enhancer molecules were studied using specifically deuterated OA and IPM and neutron diffraction. 2H NMR spectroscopy was used to study the impact of the ceramides＇ degree of order within the stratum corneum model lipid membranes. It was found that CER[NP] forms two very stable phases with high resistance against temperature increase. Phase B showed unusual hydration behavior as no water uptake of this phase was observed. The 2H NMR spectroscopic measurements showed that CER[NP] based ternary model system had a higher state of lamellar order in comparison to CER[AP] based lipid matrix. The studies confirmed that the short chain ceramides, particularly CER[NP], have a very high impact on the integrity of the Stratum comeum lipid bilayers. The penetration enhancer OA has not influenced the repeat distance of the model membrane based on CER[AP], and was not able to induce a phase separation in the investigated lipid matrix. However, a disorder and a fluidisation of the model membranes were observed when OA was incorporated. IPM showed the same effect but two phases （assigned as phase A and B） appeared, when IPM was used as penetration enhancer and incorporated into the model membrane. Furthermore, two arrangements of IPM were identified in phase A using deuterated IPM. A model of the nanostructure of the Stratum corneum lipid membranes is presented.

关键词： nano-structure of the stratum corneum cer-amide penetration enhancer model membrane neutron diffraction 2H NMR spectroscopy

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High temperature characteristic of hydroxyapatite-titania

作者： (1982-)annett Sandra

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中国有色金属学会会刊：英文版 2005年第S3期15卷 443-446页

作者：汪涛张文彦 D.R.annett S.Sabine College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 210016 China Institute of Ceramic Materials Technische Universitt Bergakademie Freiberg Freiberg 09596 Germany Institute of Analytical Chemistry Technische Universitt Bergakademie Freiberg Freiberg 09596 Germany

In order to provide the kinetic mechanism for optimizing the quality of the hydroxyapatite （Ca 10（PO4）6-（OH）2, HA） coating on Ti-alloy orthopedic devices, the high temperature behavior of HA-titania （TiO2） composite specimen was investigated using XRD, FTIR and 31P MAS NMR methods. Thermal treatment of HA-TiO2 mixture powders leads to dehydroxylate and decompound of HA as well as chemical reaction between the two materials. Evidence for the initiation of the dehydroxylation of hydroxyapatite was found at 700℃ in air. The decomposition product of β-tricalcium phosphate was proven at 900℃ in air. Additionally, the formation of CaTiO3, derived from the chemical reaction between HA and titania at 900℃, was confirmed.

关键词： hydroxyapatite FT-IR spectroscopy NMR spectroscopy titania XRD

Zinc Fingers, TAL Effectors, or Cas9-Based DNA Binding Proteins： What＇s Best for Targeting Desired Genome Loci？

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Molecular Plant 2013年第5期6卷 1384-1387页

作者： annett Strauβ Thomas Lahaye Faculty of Biology Institute of Genetics Ludwig-Maximilians-University Munich Grolβhaderner Straβe 2-4 D-82152 Martinsried Germany

ZINC FINGER- AND TAL EFFECTOR- BASED DNA BINDING PROTEINSProgrammable DNA binding proteins （PDPs） that selectively bind user-defined nucleotide sequences can navigate protein domains to any desired target within the genome. Different functional domains can be fused to PDPs to achieve （1） acti- vation or repression of transcription, （2） nicking or cleavage of DNA, or （3） modification or removal of epigenetic marks at the targeted genome spot. Given their broad applicabil- ity, the development of highly specific, easy-to-use PDPs has been a holy grail of biotechnology since the determination of the 3-D structure of zinc fingers （ZFs） bound to DNA in 1991 （Pavletich and Pabo, 1991）. This structure suggested that tandemly arranged ZFs act as functionally independ- ent modules with each finger binding three bases. However, the combination of fingers with experimentally defined base specificities into arrays revealed that ZFs are not function- ally independent. Instead, they were found to behave in a context-dependent, and often unpredictable fashion requir- ing iterative cycles of selection to get ZF arrays with desired specificity （Joung and Sander, 2013）.

关键词： DNA结合蛋白基因组 TAL 锌指期望基础蛋白质结构域用户自定义

Phase selection-oriented mechanical properties tailoring forβ-type TiNbZrTaSi alloy fabricated by laser powder bed fusion

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Advanced Powder Materials

Advanced Powder Materials 2023年第3期2卷 77-87页

作者： Xuan Luo Tao Song Feng Wang Haizhou Lu Limei Kang Hongwei Ma Dongdong Li annett Gebert Chao Yang National Engineering Research Center of Near-net-shape Forming for Metallic Materials Guangdong Provincial Key Laboratory for Processing and Forming of Advanced Metallic MaterialsSouth China University of TechnologyGuangzhou 510640China State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China Institute for Complex Materials Leibniz Institute for Solid State and Materials Research Dresden01069DresdenGermany Guangzhou Railway Polytechnic Guangzhou 510430China

The morphology and distribution of silicides inα/αþβtype titanium alloys impress on their ***,the types of silicide precipitates and their formation mechanisms remain unclear inβ-type Ti–Nb–Zr–Ta *** this study,we report the precipitation behavior of silicides formed upon aging treatment of a laser powder bed fusion(LPBF)-fabricatedβ-type Ti–34.5Nb–6.9Zr–4.9Ta–1.4Si(wt%,TNZTS)*** further discuss their underlying formation mechanism and silicide selection-oriented mechanical properties tailoring for LPBF-fabricated TNZTS *** novel silicide precipitates were formed:a supersaturated Si–richβ–Ti matrix in the form of a network that can further transform into the(Ti,Zr)2Si(S2)phase with the increase of aging temperature;and a short,rod-like S2 precipitate adjacent to pre-existing dot-shaped *** former results from the aggregation of Si solute atoms towards to the dislocation walls/microbands and the subsequent precipitation reaction,while the latter arises from the considerable micro-strain around the phase boundary between the dotshaped S2 andβ-Ti owing to the large difference in their thermal expansion coefﬁ*** aging-treated TNZTS alloy exhibits a good combination of tensile strength(10835 MPa)and fracture strain(5.6%1.0%),which is attributed to precipitation strengthening,grain-boundary strengthening,and discontinuous intergranular silicide derived from phase *** obtained results provide a basis for the design and fabrication of biomedical Sicontainingβ-type Ti alloys with excellent mechanical properties.

关键词： Laser powder bed fusion β-type titanium alloys Silicide precipitates Microstructure Mechanical propertie

Clinical trial perspective for adult and juvenile Huntington's disease using genetically-engineered mesenchymal stem cells

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Neural Regeneration Research 2016年第5期11卷 702-705页

作者： Peter Deng Audrey Torrest Kari Pollock Heather Dahlenburg Geralyn annett Jan A.Nolta Kyle D.Fink Stem Cell Program and Institute for Regenerative Cures University of California Davis Health System

Progress to date from our group and others indicate that using genetically-engineered mesenchymal stem cells（MSC） to secrete brain-derived neurotrophic factor（BDNF） supports our plan to submit an Investigational New Drug application to the Food and Drug Administration for the future planned Phase 1 safety and tolerability trial of MSC/BDNF in patients with Huntington＇s disease（HD）. There are also potential applications of this approach beyond HD. Our biological delivery system for BDNF sets the precedent for adult stem cell therapy in the brain and could potentially be modified for other neurodegenerative disorders such as amyotrophic lateral sclerosis（ALS）, spinocerebellar ataxia（SCA）, Alzheimer＇s disease, and some forms of Parkinson＇s disease. The MSC/BDNF product could also be considered for studies of regeneration in traumatic brain injury, spinal cord and peripheral nerve injury. This work also provides a platform for our future gene editing studies, since we will again use MSCs to deliver the needed molecules into the central nervous system.

关键词： mesenchymal stem cells neurodegenerative disorders, Huntington's disease genetic engineering brain derived neurotrophic factor

Synthesis of Southern Corn Rootworm Pheromone from S-Citronellol and Its Field Evaluation

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Journal of Agricultural Chemistry and Environment 2016年第4期5卷 223-230页

作者： Thangaiah Subramanian Meiling Webb Ganga Bhagavathy annett Rozek Bheema Rao Paraselli Kamlesh R. Chauhan Invasive Insects Biocontrol & Behavior Laboratory USDA-ARS Beltsville USA Terramera Inc. Vancouver Canada Chemveda Life Sciences Inc. San Diego USA

Southern rootworm (Diabrotica undecimpunctata howardi) affects several plants such as soybean, sorghum, wheat, cucumber, alfalfa, cucurbits and it is most damaging to corn and peanuts. The pheromone based “attract and kill” strategy is one of the powerful ways to control pest population. To address our key objective of the practical utility of the synthetic pheromone, we have developed a simple synthetic strategy to produce gram scale southern corn rootworm pheromone in nine simple steps starting from S-Citronellol. The present strategy takes advantage of the existing chiral center of commercially available S-Citronellol. To get the basic carbon skeleton of the pheromone, the main step in the synthetic strategy is coupling of aliphatic units through Wittig reaction. The phosphonium salt from a non-functionalized aliphatic bromide followed by Wittig reaction improved the overall yield in the multistep synthesis of this pheromone. The large-scale production of pheromone enabled us to test it in the field.

关键词： Southern Corn Rootworm Pheromone Synthesis Wittig Reaction Diabrotica undecimpunctata howardi Field Attraction