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Axonal degeneration in the anterior insular cortex is associated with Alzheimer’s co-pathology in Parkinson’s disease and dementia with Lewy bodies

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Translational Neurodegeneration 2022年第1期11卷 129-147页

作者： Yasmine Y.Fathy Laura E.Jonkman John J.Bol Evelien Timmermans Allert J.Jonker annemieke J.M.Rozemuller Wilma D.J.van de Berg Amsterdam UMC Department of Anatomy and NeurosciencesSection Clinical Neuroanatomy and BiobankingAmsterdam NeuroscienceVrije University AmsterdamO|2 Life Sciences buildingDe Boelelaan 11081081 HZ Amster-damNetherlands Amsterdam Neuroscience Program NeurodegenerationAmsterdamthe Netherlands Amsterdam UMC Department of Pathol-ogyAmsterdam NeuroscienceVrije University AmsterdamDe BoelelaanAmsterdamNetherlands Department of Neurology Erasmus Medical CenterPostbus 20403000 CA RotterdamNetherlands.

Background:Axons,crucial for impulse transmission and cellular trafficking,are thought to be primary targets of neurodegeneration in Parkinson’s disease(PD)and dementia with Lewy bodies(DLB).Axonal degeneration occurs early,preceeding and exceeding neuronal loss,and contributes to the spread of pathology,yet is poorly described outside the nigrostriatal *** insula,a cortical brain hub,was recently discovered to be highly vulnerable to pathology and plays a role in cognitive deficits in PD and *** aim of this study was to evaluate morphological features as well as burden of proteinopathy and axonal degeneration in the anterior insular sub-regions in PD,PD with dementia(PDD),and ***:α-Synuclein,phosphorylated(p-)tau,and amyloid-βpathology load were evaluated in the anterior insular(agranular and dysgranular)subregions of post-mortem human brains(n=27).Axonal loss was evaluated using modified Bielschowsky silver staining and quantified using *** damage was comprehensively studied using immunofluorescent multi-labelling and 3D confocal laser-scanning ***:Compared to PD and PDD,DLB showed significantly higherα-synuclein and p-tau pathology load,argyrophilic grains,and more severe axonal loss,particularly in the anterior agranular ***,the dysgranular insula showed a significantly higher load of amyloid-βpathology and its axonal density correlated with cognitive performance.p-Tau contributed most to axonal loss in the DLB group,was highest in the anterior agranular insula and significantly correlated with CDR global scores for *** and myelin showed degenerative changes including swellings,demyelination,and detachment of the axon-myelin ***:Our results highlight the selective vulnerability of the anterior insular sub-regions to various converging pathologies,leading to impaired axonal integrity in PD,PDD and DLB,disrupting their functional properties and potentially con

关键词： α-Synuclein Insular subregions Axonal length density Alzheimer’s disease pathology Neurofilament Myelin

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The mRNA Binding Proteome of Proliferating and Differentiated Muscle Cells

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Genomics, Proteomics & Bioinformatics 2020年第4期18卷 384-396页

作者： Monika Hiller Miriam Geissler George Janssen Peter van Veelen annemieke Aartsma-Rus Pietro Spitali Department of Human Genetics Leiden University Medical CenterLeiden 2333 ZCthe Netherlands Center for Proteomics and Metabolomics Leiden University Medical CenterLeiden 2333 ZCthe Netherlands

Muscle formation is a coordinated process driven by extensive gene expression changes where single cells fuse together to form multinucleated muscle fibers. Newly synthesized m RNAs are then regulated by RNA binding proteins(RBPs), affecting post-transcriptional transcript metabolism. Here, we determined how large-scale gene expression changes affect the catalog of RBPs by studying proliferating and differentiated muscle cells in healthy and dystrophic conditions. Transcriptomic analysis showed that the expression of more than 7000 genes was affected during myogenesis. We identified 769 RBPs, of which 294 were muscle-specific and 49 were uniquely shared with cardiomyocytes. A subset of 32 RBPs(half of which were muscle-specific) was found to be preferentially associated with target mRNAs in either myoblasts(MBs) or myotubes(MTs). A large proportion of catalytic proteins were bound to mRNAs even though they lack classical RNA binding domains. Finally, we showed how the identification of cell-specific RBPs enabled the identification of biomarkers that can separate healthy individuals from dystrophic patients. Our data show how interactome data can shed light on new basic RNA biology as well as provide cell-specific data that can be used for diagnostic purposes.

关键词： RNA binding protein Interactome Duchenne muscular dystrophy Proteomics Skeletal muscle

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Vitamin D_(3) attenuates anxiety-like behavior in long-term ovariectomized rats with unpredictable mild stress

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BIOCELL 2019年第4期43卷 299-311页

作者： DENIS BARANENKO JULIA FEDOTOVA annemieke JOHANNA MARIA VAN DEN TOL International Research Centre“Biotechnologies of the Third Millennium” ITMO University9 Lomonosova Str.St.Petersburg191002Russia Laboratory of Neuroendocrinology I.P.Pavlov Institute of Physiology RASci.6 Emb.MakarovaSt.Petersburg199034Russia University of Lincoln School of Psychology Sarah Swift Building 3201Brayford PoolLincolnLN57AYUK.

The impact of various vitamin D3(VD3)doses(1.0,2.5,or 5 mg/kg,s.c.)in mitigating the negative consequences of chronic unpredictable mild stress(CUMS)was *** female rats with long-term estrogen deficiency were assessed using the sucrose preference test(SPT),the elevated plus-maze(EPM),the light/dark test(LDT),and the open-field test(OFT)to measure anhedonia-like and anxiety-like *** corticosterone(CS)and adrenocorticotrophic hormone(ACTH)concentrations in blood serum and the brain-derived neurotrophic factor(BDNF)expression in the hippocampus of long-term ovariectomized(OVX)rats were measured by ELISA kits and/or western *** with VD3(5.0 mg/kg),similarly to fluoxetine(10.0 mg/kg),significantly reduced the anhedonia profile in the SPT and anxiety-like behavior in the EPM and LDT,and CS and ACTH levels in blood *** also elevated BDNF levels in the hippocampus of long-term OVX/CUMS compared to OVX/CUMS/solvent ***,these findings suggest that VD3(5.0 mg/kg)administration might attenuate the anxiety-like profile in long-term OVX adult rats subjected to the *** might occur via activation of the BDNF signaling pathway in the hippocampus and via restoration of CS and ACTH levels in blood serum.

关键词： Anxiety BDNF Chronic unpredictable mild stress Long-term ovariectomy Vitamin D3

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Exposing hidden diversity by concordant genealogies and morphology—a study of the Lactifluus volemus(Russulales)species complex in Sikkim Himalaya(India)

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Fungal Diversity 2012年第4期55卷 171-194页

作者： Kobeke Van de Putte Jorinde Nuytinck Kanad Das annemieke verb.ken Research group Mycology Department of BiologyUniversity of GhentK.L.Ledeganckstraat 359000GhentBelgium Botanical Survey of India Sikkim Himalaya Regional CentreP.O.RajbhawanGangtok 737103 SikkimIndia

Although Sikkim belongs to one of the Global Biodiversity Hotspots,little is known about its ectomycorrhizal fungi,and even less about the main genera of Russulales,***,Lactifluus,Multifurca and *** a multilocus genealogical and morphological study,we aimed to document the diversity within Lactifluus volemus sensu lato of Sikkim *** compared nuclear ITS and LSU rDNA,nuclear rpb1 and rpb2 protein-coding,and mitochondrial atp6 protein-coding genealogies to determine species *** relationships were inferred from the combined *** and maximum likelihood single-locus genealogies are concordant and support recognition of six *** of these could be identified by unique morphological characteristics and are described as new species:***,*** and ***.

关键词： Cryptic species Genealogical concordance Multilocus approach Phylogenetic species Russulaceae

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Digestive oncologist in the gastroenterology training curriculum

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World Journal of Gastroenterology 2011年第9期17卷 1109-1115页

作者： Chris Jacob Johan Mulder Marc Peeters annemieke Cats Anna Dahele Jochim Terhaar sive Droste Department of Gastroenterology and Hepatology VU University Medical Center Department of Oncology Antwerp University Hospital Antwerp Department of Gastroenterology and Hepatology Netherlands Cancer Institute

Until the late 1980s, gastroenterology (GE) was considered a subspecialty of Internal Medicine. Today, GE also incorporates Hepatology. However, Digestive Oncology training is poorly defined in the Hepatogastroenterology (HGE)-curriculum. Therefore, a Digestive Oncology curriculum should be developed and this document might be a starting point for such a curriculum. HGE-specialists are increasingly resisting the paradigm in which they play only a diagnostic and technical role in the management of digestive tumors. We suggest minimum endpoints in the standard HGE-curriculum for oncology, and recommend a focus year in the Netherlands for Digestive Oncology in the HGE-curriculum. To produce welltrained digestive oncologists, an advanced Digestive Oncology training program with specific qualifications in Digestive Oncology (2 years) has been developed. The schedule in Belgium includes a period of at least 6 mo to be spent in a medical oncology department. The goal ofthese programs remains the production of well-trained digestive oncologists. HGE specialists are part of the multidisciplinary oncological teams, and some have been administering chemotherapy in their countries for years. In this article, we provide a road map for the organization of a proper training in Digestive Oncology. We hope that the World Gastroenterology Organisation and other (inter)national societies will support the necessary certifications for this specific training in the HGE-curriculum.

关键词：消化系统肿瘤培训课程胃肠病学肿瘤学消化道肿瘤国家管理肿瘤组织附件

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Taxonomic revisionofthegenus Lactarius(Russulales,Basidiomycota)in Korea

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Fungal Diversity 2019年第2期95卷 275-335页

作者： Hyun Lee Komsit Wissitrassameewong Myung Soo Park annemieke verb.ken John Eimes Young Woon Lim School of Biological Sciences and Institute of Microbiology Seoul National University1 Gwanak-roGwanak-guSeoul 08826Korea Department of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium University College Sungkyunkwan University2066 SeoburoJangan-guSuwon 16419Korea

The genus Lactarius Pers.(Russulales)is a cosmopolitan group of Basidiomycota that forms ectomycorrhizal relationships primarily with both deciduous and coniferous *** the genus has been well-studied in Europe and North America,only fragmentary researches have been carried out on Asian *** particular,the distribution of Lactarius species in South Korea is poorly understood due to insufficient morphological descriptions and a lack of DNA sequence *** addition,the misuse of European and North American names has added to confusion regarding the taxonomy of Asian Lactarius *** this study,the diversity of Lactarius in South Korea was evaluated by employing both morphological and phylogenetic approaches.A multi-locus phylogenetic analysis of 729 Lactarius specimens collected between 1960 and 2017 was performed using the internal transcribed spacer(ITS)region,partial nuclear ribosomal large subunit(nrLSU),partial second largest subunit of RNA polymerase II(rpb2),and minichromosome maintenance complex component 7(mcm7).49 Lactarius species were identified in three Lactarius subgenera:***(17 spp.),***(22 spp.),and ***(10 spp.).Among them,28 Lactarius species were identified as new to science,while just 17 were previously described Lactarius *** of the taxa remain un-named due to paucity of materials.A key to Korean Lactarius species,molecular phylogenies,a summary of diversity,and detailed description are provided.

关键词： Intercontinental conspecificity mcm7 Milkcaps Multi-locus phylogeny Species delimitation

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Effects of land use on the fungal spore richness in small crater-lake basins of western Uganda

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Fungal Diversity 2012年第4期55卷 125-142页

作者： Vanessa Gelorini annemieke verb.ken Luc Lens Hilde Eggermont Bent Vad Odgaard Dirk Verschuren Limnology Unit Department of BiologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium Research Group Mycology Department of BiologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium Terrestrial Ecology Unit Department of BiologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium Royal Belgian Institute of Natural Sciences Freshwater BiologyVautierstraat 291000 BrusselsBelgium Department of Geosciences University of AarhusHoegh Guldbergsgade 2DK-8000 Aarhus CDenmark Research Unit Palaeontology Department of Geology and Soil SciencesGhent UniversityKrijgslaan 281/S89000 GhentBelgium

Mycological tools to estimate the effects of diverse land-use practices on fungal diversity are scarce,because of poor knowledge of the taxonomic diversity of tropical fungi and their response to anthropogenic habitat ***,we investigate assemblages of fungal spores,recently deposited in the bottom sediments of 24 small crater lakes in western Uganda,to assess the relationship between the local richness of fungi and environmental variation in the crater basin along regional gradients of natural vegetation and land *** recovered~9500 fungal spore specimens,which could be attributed to 216 *** an information-theoretic approach based on the corrected Akaike Information Criterion(AICc),we determined the environmental factors which best explained variation in the diversity of fungal spores among three datasets:(i)the full set of 24 crater basins,(ii)the subset of 22 basins with freshwater lakes,and(iii)the subset of 17 basins partly or completely in agricultural use(cropland,fallow land,pasture and plantation).In these 17 human-impacted crater basins our results revealed a negative relationship between fungal spore richness and the areal fraction of basins in agricultural ***,this detrimental effect of land use on fungal spore richness was not apparent across the full set of both disturbed and(presently)undisturbed *** was due to large variation in fungal spore richness among the undisturbed basins covered either with forest or savannah vegetation,probably resulting from site-specific controls on fungal habitat diversity,such as climatic moisture balance and the composition of natural and/or secondary *** land-use effects on fungal spore diversity,as documented in this study,suggest that communities of tropical fungi progressively exposed to land-use practices are threatened by species ***,our study demonstrates the need to develop conservation strategies mitigating the impacts of agriculture on the biodiversity o

关键词： Fungal spores Richness Land use Lake basins Western Uganda

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The Australasian species of Lactarius subgenus Gerardii(Russulales)

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Fungal Diversity 2012年第1期52卷 141-167页

作者： Dirk Stubbe Huyen Than Le Xiang-Hua Wang Jorinde Nuytinck Kobeke Van de Putte annemieke verb.ken Department of Biology Ghent UniversityK.L.Ledeganckstraat 359000 GhentBelgium Section Mycology and Aerobiology Scientific Institute of Public HealthJuliette Wytmanstraat 141050 BrusselsBelgium Faculty of Environment Hanoi University of Natural Resources and Environment41A Street K1Cau DienTu LiemHanoiVietnam Kunming Institute of Botany Chinese Academy of SciencesLanhei Road 132#Kunming 650204People’s Republic of China Research Group Mycology Department of BiologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium

This paper provides an overview and identification key of the Australasian species of Lactarius ***.A molecular phylogeny based on the nuc DNA markers ITS,LSU and rpb2,combined with detailed morphological observations resulted in the delimitation of 12 strongly supported and morphologically recognizable *** new agaricoid species are described here:Lactarius hora,***,***,*** and *** agaricoid species belonging to *** are ***,***,*** and *** venosus is also considered as a member but could not be included in the molecular *** new pleurotoid species are discovered:*** and ***,both close relatives of ***,but each with distinct *** position within *** is supported in the phylogeny and by their microscopic *** study also confirms the existence of multiple cryptic species and species complexes for which species recognition or species delimitation remains problematic as is the case for the Australian species *** general,detailed macroscopic and microscopic observations are needed to identify species of ***.

关键词： Basidiomycota Lactifluus Plinthogalus Taxonomy Phylogeny Asia

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特殊医学用途配方食品——基于科学的法规

特殊医学用途配方食品——基于科学的法规

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优质乳品与婴幼儿健康：挑战和解决方案专题研讨会

作者： annemieke Tops 美赞臣营养公司

＜正＞～～

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Nonconformist Journalism:The Vrye Weekblad (Free Weekly Newspaper) as a form of Afrikaans resistance press in 1980s South Africa

Nonconformist Journalism:The Vrye Weekblad (Free Weekly News...

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2012 International Conference on Language,Medias and Culture（ICLMC 2012）

作者： annemieke Nel Masters Student Department of HistoryStellenbosch UniversitySouth Africa

Although The Vrye Weekblad was not the first nonconformist,alternative newspaper to grace the newspaper stands in South Africa,it was unique in its using Afrikaans-the 'language of the oppressor' as its main *** its short and turbulent life,it managed to change the image of Afrikaans,deliver superb journalism and contribute significantly to the progressive change that was taking place in 1980s South Africa.

关键词： nonconformist journalism,resistance press,apartheid,Afrikaans press

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