检索结果-南通市图书馆

同方期刊数据库

Mesogens with aggregation-induced emission properties: Materials with a bright future

在线全文

学校读者我要写书评

暂无评论

Aggregate

Aggregate 2022年第1期3卷 50-74页

作者： Jens Voskuhl Michael giese Faculty of Chemistry(Organic Chemistry)and CENIDE University of Duisburg EssenEssenGermany

Within the past two decades,chromophores,which show aggregation-induced emission(AIE),have gained considerable attention with respect to the development of luminescent liquid *** contrast to common luminogens,AIE emitters do not suffer from aggregation-caused quenching of the emission in the solid *** this review,we summarize the recent development in the field of AIE-active liquid crystals and show first model devices,which already prove the application potential of these ***,three different approaches are followed,to get access to luminescent liquid crystals––namely the synthetic approach yielding luminescent mesogens,the doping approach,and the supramolecular approach,which will be described and discussed in detail in this review.

关键词： aggregation-induced emission ﬂuorescence liquid crystals materials mesogens

Xom interacts with and stimulates transcriptional activity of LEFI/TCFs: implications for ventral cell fate determination during vertebrate embryogenesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cell Research 2007年第4期 345-356页

作者： Roger giese Boston USA Department of Pharmaceutical Sciences Northeastern University MA

LEF1/TCFs are high mobility group box-containing transcriptional factors mediating canonical Wnt/β-catenin sig-naling during early embryogenesis and tumorigenesis.β-Catenin forms a complex with LEF1/TCFs and transactivatesLEF1/TCF-mediated transcriptions during *** LEF-mediated transcription is also implicated inventralization,the underlying molecular mechanism is not well *** the vertebrate Xenopus Iaevis modelsystem,we found that Xom,which is a ventralizing homeobox protein with dual roles of transcriptional activation andrepression,forms a complex with LEF 1/TCF through its homeodomain and transactivates LEF 1/TCF-mediated transcrip-tion through its N-terminal transactivation domain(TAD).Our data show that Xom lacking the N-terminal TAD failsto transactivate ventral genes,such as BMP4 and Xom itself,but retains the ability to suppress transcriptional activationof dorsal gene promoters,such as the Goosecoid promoter,indicating that transactivation and repression are separablefunctions of *** has been postulated that Xom forms a positive re-enforcement loop with BMP4 to promote ventral-ization and to suppress dorsal gene *** with an essential role of Xom transactivation of LEF1/TCFsduring early embryogenesis,we found that expression of the dominant-negative Xom mutant that lacks the TAD fails tore-enforce the ventral signaling of BMP4 and causes a catastrophic effect during *** data suggest that thefunctional interaction of Xom and LEF 1/TCF-factors is essential for ventral cell fate determination and that LEF1/TCFfactors may function as a point of convergence to mediate the combined signaling of Wnt/β-catenin and BMP4/Xompathways during early embryogenesis.

关键词： Xom Vent Wnt BMP4 β-catenin LEF1/TCFs dorsoventral patterning

Control of secondary structure and morphology of peptide-guanidiniocarbonylpyrrole conjugates by variation of the chain length

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2020年第5期31卷 1239-1242页

作者： Xin Liu Kaiya Wang Marlen Externbrink Jochen Niemeyer Michael giese Xiao-Yu Hu School of Material Science&Engineering Nanjing University of Aeronautics&AstronauticsNanjing 210016China Qinghai Provincial Key Laboratory of Tibetan Medicine Research and Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau BiologyChinese Academy of SciencesXinin g 810008China College of Pharmacy Nantong UniversityNantong 226001China

Peptide amphiphiles with well-organized secondary structure are an important family of molecules that are known to assemble into a variety of *** this work,we present three guanidiniocarbonylpyrrole(GCP)containing peptide amphiphiles,which show versatile morphology and secondary structure changes as a result of different chain lengths and in different concentration *** random coil conformation,α-helix,andβ-sheet are obtained for peptide 1,peptide 2,and peptide 3,respectively under neutral aqueous ***,all peptide amphiphiles can aggregate to form nanoparticles at low ***,at high concentrations,peptide 1 selfassembles into left-ha nded twisted helical fibers,while longer bamboo-like mo rphology can be obse rved exclusively for peptide *** peptide 3,freshly prepared samples show uniform spherical morphology,whereas an obvious morphological transition from original nanoparticles to disordered fibers was realized after incubating for one *** fascinating morphology changes were determined by the combination of circular dichroism,dynamic light scattering,transmission electron microscopy,atomic force microscopy,and theoretical calculations.

关键词： Peptide amphiphiles Secondary structures Supramolecular self-assembly Nanostructures pH-responsiveness

Highly Precise Corneal Surgery and All-Optical Histology with Femtosecond Lasers

在线全文

学校读者我要写书评

暂无评论

光学学报 2003年第S1期23卷 811-812页

作者： Leander Zickler Meng Han Guenter giese Josef FBille Frieder HLoesel University of Heidelberg Kirchhoff-Institute fuer PhysikIm Neuenheimer Feld 227D-69120HeidelbergGermany 20/10 Perfect Vision Optische Geraete GmbHAm Taubenfeld 21/1D-6912 Heidelberg Germany’Max-Planck-Institut fuer medizinische ForschungJahnstrasse 29D-69120HeidelbergGermany

We present an optimized femtosecond laser system for intrastromal tissue manipulation, application studies of commercial fs-LASIK procedures and results from the first successful demonstration of nonlinear (SHG) imagi... 详细信息

关键词： femtosecond laser

A 96-wells fluidic system for high-throughput screenings under laminar high wall shear stress conditions

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2023年第5期9卷 203-217页

作者： Catarina Gonçalves Fonseca Vânia Silvério David Barata Wolfgang giese Holger Gerhardt Susana Cardoso Claudio Areias Franco Instituto de Medicina Molecular João Lobo Antunes Faculdade de MedicinaUniversidade de LisboaLisboaPortugal INESC Microsistemas and Nanotecnologias INESC-MNLisboaPortugal Department of Physics Instituto Superior TécnicoUniversidade de LisboaLisboaPortugal Max Delbrück Center for Molecular Medicine BerlinGermany DZHK(German Centre for Cardiovascular Research) Partner Site BerlinBerlinGermany Charité–Universitätsmedizin Berlin BerlinGermany Universidade Católica Portuguesa Católica Medical SchoolCatólica Biomedical Research CentreLisbonPortugal

The ability of endothelial cells to respond to blood flow is fundamental for the correct formation and maintenance of a functional and hierarchically organized vascular *** flow responses,in particular related to high flow conditions,have been associated with atherosclerosis,stroke,arteriovenous malformations,and neurodegenerative ***,the molecular mechanisms involved in high flow response are still poorly ***,we described the development and validation of a 96-wells fluidic system,with interchangeable cell culture and fluidics,to perform high-throughput screenings under laminar high-flow *** demonstrated that endothelial cells in our newly developed 96-wells fluidic system respond to fluid flow-induced shear stress by aligning along the flow direction and increasing the levels of KLF2 and *** further demonstrate that our 96-wells fluidic system allows for efficient gene knock-down compatible with automated liquid handling for high-throughput screening ***,we propose that this modular 96-well fluidic system is an excellent platform to perform genome-wide and/or drug screenings to identify the molecular mechanisms involved in the responses of endothelial cells to high wall shear stress.

关键词： system laminar fluid

Different profiles of cytokine expression during mild and severe acute pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第15期16卷 1845-1853页

作者： Zilvinas Dambrauskas Nathalia giese Antanas Gulbinas Thomas giese Pascal O Berberat Juozas Pundzius Giedrius Barauskas Helmut Friess Laboratory for Research of Digestive System Institute for Biomedical ResearchEiveniu Str. 2 50009 Kaunas Lithuania Department of Surgery Kaunas University of MedicineEiveniu Str. 2 50009 Kaunas Lithuania Department of Surgery Heidelberg UniversityIm Neuenheimer Feld 110D-69120 Heidelberg Germany Institute for Immunology Heidelberg UniversityIm Neuenheimer Feld 305D-69120 Heidelberg Germany Department of Surgery University of Technology MunichIsmaninger Str. 2281675 Munich Germany Department of Surgery Kaunas University of MedicineEiveniu Str. 250009 Kaunas Lithuania

AIM:To study secretion patterns of proand anti-in-flammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral ***: We have conducted a prospective obser-vational study. One hundred and eight patients with a diagnosis of acute pancreatitis and onset of the disease within last 72 h were included in this study. The mRNA expression of 25 different types of cytokines in white blood cells was determined by quantitative real time polymerase chain reaction. Levels of 8 different cytokines in blood serum were measured by enzymelinked immunosorbent assay. Clinical data and cytokine expression results were subjected to statistical ***: Severe and necrotizing acute pancreatitis (AP) is characterized by the significant depletion of circulating lymphocytes. Severe acute pancreatitis is as-sociated with a typical systemic inflammatory response syndrome and over-expression of pro-inflammatory cy-tokines [interleukin (IL)-6, IL-8, macrophage migration inhibitory factor (MIF)]. Serum IL-6 and MIF concentra-tions are the best discriminators of severe and necrotiz-ing AP as well as possible fatal outcome during the early course of the disease. CONCLUSION: Deregulation of cellular immune sys-tem is a key event leading to severe and necrotizing AP. IL-6 and MIF could be used as early predictors of complications.

关键词： Acute pancreatitis Cytokines Prognostic factors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

气候变化对塔里木河来自天山的地表径流影响

冰川冻土 2008年第1期30卷 1-11页

作者：高前兆王润 Ernst giese 中国科学院寒区旱区环境与工程研究所甘肃兰州730000 中国科学院南京地理与湖泊所江苏南京210008 Center for International Development and Environment Research University of Giessen D-35390 Giessen Germany

塔里木河水资源主要来自天山南坡两条源流,选择西段阿克苏河和中段开都河-孔雀河作为研究区.1956—2003年研究河源山区气温呈持续升温且降水波动增加的趋势,其中1995—2003年升温强劲,升温速率高出48 a期间平均的3倍以上;降水自1986年... 详细信息

塔里木河水资源主要来自天山南坡两条源流,选择西段阿克苏河和中段开都河-孔雀河作为研究区.1956—2003年研究河源山区气温呈持续升温且降水波动增加的趋势,其中1995—2003年升温强劲,升温速率高出48 a期间平均的3倍以上;降水自1986年后持续增加,20世纪90年代较80年代增幅达18%,并显示出河源山区湿岛向塔里木盆地扩展.因高山缺少气象观测,出山径流过程变化可以综合反映中高山带的气候变化.塔里木河来自天山的地表径流在1986—2003年间持续增长,以冰川融水补给为主的库玛拉克河,1994年以来年径流量增加已在前期平均值基础上提升了一个台阶;开都河以降水径流补给为主,1986—2002年出现了观测记录以来的丰水期,并使1986年后博斯腾湖水位快速上升,恢复到1958年记录的最高水位以上.两河年径流变化趋势基本相似,但也显示有西、中段的气候变化局部差异,出现丰枯水期的不一致;然而,在近16 a升温过程中,年径流增长幅度和快慢相近.

关键词：气候变化降水与气温冰川融水与河川径流变化天山南坡塔里木河

在线全文

学校读者我要写书评

暂无评论

近期博斯腾湖水位变化及其原因分析

冰川冻土 2003年第1期25卷 60-64页

作者：王润 Ernst giese 高前兆中国科学院南京地理与湖泊研究所江苏南京210008 德国吉森大学国际发展和环境研究中心中国科学院寒区旱区环境与工程研究所甘肃兰州730000

新疆博斯腾湖 1987年以来湖泊水位的变化 (上升 )与主要补给河流开都河径流量的变化有直接关系 ,而这与发源于天山中段降水和高山冰雪融水的河流 ,受到气候变化影响很大有关 .全球变化研究结果显示 ,中亚干旱区是全球温度上升幅度较大... 详细信息

新疆博斯腾湖 1987年以来湖泊水位的变化 (上升 )与主要补给河流开都河径流量的变化有直接关系 ,而这与发源于天山中段降水和高山冰雪融水的河流 ,受到气候变化影响很大有关 .全球变化研究结果显示 ,中亚干旱区是全球温度上升幅度较大的地区 .当地的气象资料表明 ,过去 2 0a年平均温度明显升高的趋势 ,对水资源储量和补给来源影响深远 .

关键词：水位气候变化博斯腾湖气象资料降水温度冰雪融水

On the thermodynamics of aggregation toward phosphorescent metallomesogens:From electronic tuning to supramolecular design

在线全文

学校读者我要写书评

暂无评论

Aggregate

Aggregate 2024年第3期5卷 164-174页

作者： Matias E.Gutierrez Suburu Meik Blanke Leon Geerkens Alexander HeppIván Maisuls Jutta KöstersThorben Neumann Jens Voskuhl Michael giese Cristian A.Strassert Institut für Anorganische und Analytische Chemie Universität MünsterMünsterGermany CeNTech SoNCiMICUniversität MünsterMunsterGermany Organic Chemistry University of Duisburg-EssenEssenGermany

Two series with three Pt(II)complexes each(PtLPh-n,PtLFpy-n)bearing asymmet-ric tetradentate ligands as dianionic luminophores with variable alkyl chain lengths were ***,each ligand series is distinguished by one of its cyclomet-allating rings(phenyl vs.2,6-diﬂuoropyrid-3-yl).Steady-state and time-resolved photoluminescence spectroscopic studies in diluted solutions at room temperature and in glassy matrices at 77 K show that the emissive state is mainly centered on the invariantly electron-rich cyclometalated side while the second ring regulates the admixture of ligand-centered and metal-to-ligand charge-transfer ***,the radiative rates can be controlled,as indicated by quantum-mechanical calcula-tions,which also explain the temperature-dependent trend in the phosphorescence rate *** in condensed phases(single-crystal X-ray diffractometry,polarized optical microscopy,differential scanning calorimetry,steady-state and time-resolved photoluminescence micro(spectro)scopy)showed the development of a smectic A mesophase for theﬂuorinated species bearing the two longest alkyl *** magnetic resonance-based studies on the thermodynamics of aggre-gation in solution conﬁrm the marked enthalpic stabilization of aggregates mediated by the polar 2,6-diﬂuoropyrid-3-yl moiety(and to a lesser extent by dispersive forces between the alkyl chains).On the other hand,the negative entropy of aggregation is dominated by the restriction of degrees of freedom involving the peripheral alkyl moieties upon stacking,which becomes increasingly relevant for longer *** these factors control coupling,a crucial interaction for the design of Pt⋅⋅⋅Ptphotofunctional mesogens based on Pt(II)complexes.

关键词： aggregation metallomesogens organometallic synthesis phosphorescence photophysics supramolecu-lar chemistry