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Association between Fetal Heart Rate Monitoring during Labor and Neonatal Acidosis in Full-Term Newborns: A Retrospective Multicenter Cohort Study

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Open Journal of Obstetrics and Gynecology 2020年第9期10卷 1265-1278页

作者： anne-charlotte faivre Salma Tazi Jan Chrusciel Stéphane Sanchez Nathalie Bednarek René Gabriel Perrine Moussy Olivier Graesslin Department of Gynecology and Obstetrics Institute Alix de Champagne University Hospital Reims France Department of Medical Information Evaluation and Performance Centre Hospitalier Troyes Troyes France Neonatal Intensive Care Unit American Memorial Hospital Reims France

Introduction: Fetal heart rate monitoring during labor is used to study fetal well-being and predict neonatal acidosis of newborn. Fetal heart rate monitoring is analyzed by the obstetrical team and categorized according to the FIGO guidelines. An important limitation of this diagnostic tool is an inter- and intra-observer variability, leading to subjective cardiotocography interpretation and classification. Our objective was to study the association between the categories of fetal heart rate analysis (according to FIGO classification) and neonatal acidosis of full-term newborns. Study design: This is a multicenter retrospective cohort study conducted between 2014 and 2018 in the Grand-Est region. We searched and included retrospectively children hospitalized in a pediatric intensive care unit in one of the participating hospitals with an ICD-10 coding type “P91.6” corresponding to “Hypoxic Ischemic Encephalopathy”. Maternal, pregnancy, delivery, and newborn characteristics were collected and compared by univariate logistic regression with multiple imputation. Odds Ratio and 95% confidence intervals (CI) were calculated using the model and presented. Multiple imputation with m = 100 imputations was tested, using Rubin rules to combine the results. Results: 55 patients were included in the study. Fetal heart rate tracings classified in Category 3 as “pathological” according to FIGO guidelines were significantly associated with an increased risk of severe neonatal acidosis. Late decelerations and bradycardia during labor were associated with severe neonatal acidosis. Conclusion: Severe neonatal acidosis may be suspected b

关键词： Fetal Heart Rate Neonatal Acidosis Third Stage of Labor Newborn

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Trends in incidence and management of cancer of the ampulla of Vater

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World Journal of Gastroenterology 2014年第29期20卷 10144-10150页

作者： Florian Rostain Samia Hamza Antoine Drouillard Jean faivre anne-Marie Bouvier C?me Lepage Registre Bourguignon des Cancers Digestifs INSERM U866CHU de DijonFaculté de Médecine21079 Dijon CedexFrance

AIM: To provide trends in incidence, management and survival of cancer of the ampulla of Vater in a well-defined French population.

关键词： Cancer of the ampulla of Vater Incidence Survival Treatment Epidemiology

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Cyclin-dependent kinase inhibitors p21 and p27 function as critical regulators of liver regeneration following 90%hepatectomy in the rat

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World Journal of Hepatology 2020年第12期12卷 1198-1210页

作者： Nicolas Moniaux Laurence Lacaze Adelie Gothland Alice Deshayes Didier Samuel Jamila faivre INSERM U1193Paul-Brousse University HospitalHepatobiliary CentreVillejuif 94800France UniversitéParis-Saclay Facultéde Médecine Le KremlinBicêtre 94270France Department of Pôle de Biologie Médicale Laboratoire d’Onco-HématologieAssistance Publique-Hôpitaux de Paris(AP-HP)Paul-Brousse University HospitalVillejuif 94800France

BACKGROUND Liver reduction is the main curative treatment for primary liver cancer,but its use remains limited as liver regeneration requires a minimum of 30%functional *** To study the dynamics of the liver regeneration process and consequent behavior of cell cycle regulators in rats after extended hepatectomy(90%)and postoperative glucose *** Post-hepatectomy liver failure was triggered in 84 Wistar rats by reducing their liver mass by 90%.The animals received a post-operative glucose infusion and were randomly assigned to two groups:One to investigate the survival rate and the other for biochemical *** that underwent laparotomy or 70%hepatectomy were used as *** and liver samples were collected on postoperative days 1 to *** morphology,function,and regeneration were studied with histology,immunohistochemistry,and western *** Postoperative mortality after major resection reached 20%and 55%in the first 24 h and 48 h,respectively,with an overall total of 70%7 d after *** apparent signs of apoptotic cell death were detected in the extended hepatectomy rat livers,but hepatocytes displaying a clear cytoplasm and an accumulation of hyaline material testified to changes affecting their functional *** regeneration started properly,as early events initiating cell proliferation occurred within the first 3 h,and the G1 to S transition was detected in less than 12 ***,a rise in p27(Kip1)followed by p21(Waf1/Cip1)cell cycle inhibitor levels led to a delayed S phase progression and ***,liver regeneration in rats with a 90%hepatectomy was delayed by 24 h and associated with a delayed onset and lower peak magnitude of hepatocellular deoxyribonucleic acid *** This work highlights the critical importance of the cyclin/cyclin-dependent kinase inhibitors of the Cip/Kip family in regulating the liver regeneration timeline following extended hepatectomy.

关键词： Major hepatectomy Liver failure Liver regeneration Post-hepatectomy liver failure p21 p27

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Disease control with sunitinib in advanced intrahepatic cholangiocarcinoma resistant to gemcitabine-oxaliplatin chemotherapy

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World Journal of Hepatology 2015年第6期7卷 910-915页

作者： Chantal Dreyer Marie-Paule Sablin Mohamed Bouattour Cindy Neuzillet Maxime Ronot Safi Dokmak Jacques Belghiti Nathalie Guedj Valérie Paradis Eric Raymond Sandrine faivre Department of Medical Oncology Beaujon University Hospital (AP-HP-PRES Paris 7 Diderot) Department of Hepatology Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot) Department of Imaging Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot) Department of Biliary and Pancreatic Surgery Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot) Department of Pathology Beaujon University Hospital (AP-HP - PRES Paris 7 Diderot)

Advanced cholangiocarcinoma is associated with poor prognostic survival and has limited therapeutic options available at present. The importance of angiogenesis and expression of pro-angiogenic factors in intrahepatic forms of cholangiocarcinoma suggest that therapies targeting angiogenesis might be useful for the treatment of this disease. Here we report three cases of patients with advanced intrahepatic cholangiocarcinoma progressive after standard chemotherapy and treated with sunitinib 50 mg/d in 6-wk cycles of 4 wk on treatment followed by 2 wk off treatment(Schedule 4/2). In all three patients, sunitinib treatment was associated with a sustained disease control superior to 4 mo, patients achieving either a partial response or stable disease. A reduction in tumor size and density was observed in all cases, suggesting tumor necrosis as a result of sunitinib treatment in these patients. In addition, sunitinib was generally well tolerated and the occurrence of side effects was managed with standard medical interventions, as required. Our results suggest that sunitinib therapy maybe associated with favorable outcomes and tolerability in patients with advanced cholangiocarcinoma. Those observations contributed to launch a prospective phase Ⅱ multicenter trial investigating sunitinib in advanced intrahepatic cholangiocarcinoma(SUN-CK study; NCT01718327).

关键词： Biliary tract tumors Antiangiogenic therapy Hypodensity Tumor response Vascular endothelialgrowth factor receptor inhibitors Chemoresistance

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Intracellular biomineralization in bacteria

Intracellular biomineralization in bacteria

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中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： Wei Lin Karim Benzerara Damien faivre Yongxin Pan Biogeomagnetism Group Paleomagnetism and Geochronology LaboratoryKey Laboratory of Earth and Planetary PhysicsInstitute of Geology and GeophysicsChinese Academy of Sciences France-China Bio-Mineralization and Nano-Structures Laboratory Chinese Academy of Sciences Department of Biomaterials Max Planck Institute of Colloids and Interfaces

Microorganisms have populated the Earth for billions of years and their activities are important forces shaping our planetary environments through biogeochemical *** particular,microbial biomineralization that selectively take up environmental elements and deposit minerals either intracellularly or extracellularly is of great interest,because these processes play vital roles in the global cycles of numerous elements,such as Fe,Mn,Ca,As,O,S,and P,***,the products of

关键词： microbial biomineralization magnetotactic bacteria magnetosome magnetotaxis iron cycling biosignature ancient environment

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Evaluating Fecal Sieving Tool as an Indicator of Feed Valorization and the Impact of Feeding Strategy on Dairy Cow Performance under Farm Conditions

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Agricultural Sciences 2023年第10期14卷 1420-1435页

作者： Nizar Salah Héloïse Legendre Laurine faivre Maxime Briche Raphael Gourdon Valentin Nenov Phileo by Lesaffre Marcq-en-Baroeul France Huvepharma Flemish Region Antwerp Belgium

The objective of this study was to evaluate the use of a faeces sieving tool “Digescan” as an indicator of feed valorization, and to test the influence of feeding strategy on fecal particle size (PS) distribution and weight, milk performance and the possible association between them. Data from 95 trials were used. During each trial, two periods were identified: before and during live yeast probiotic (LYP) supplementation. The LYP used at 5 g/d/cow was Saccharomyces cerevisiae (CNCM I-4407, 1010 CFU/g, Actisaf® Sc47;Phileo by Lesaffre, France). Milk yield and composition were recorded. Fecal samples were taken at the end of each period and sieved with a set of two wire-mesh screens with pore sizes of 5 mm and 2 mm under running tap water. Yeast probiotic supplementation significantly reduced (P 5 mm was accompanied by 1.2 and 0.65 kg/d decrease in MY, 2.5 and 2 kg/d decrease in ECM and 3.2 and 2.6 kg/d in FCM before and during LYP supplementation, respectively. Fecal particle distribution appears to be a practicable tool to predict influences of feeding systems on feed valorization and performance in dairy cows. Live yeast increases dairy performance and decreases the quantity of fecal particles remaining in the two sieves after rinsing.

关键词： Feces Sieving Yeast Probiotic Dairy Cow Milk Particle Size

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112例间质性肺病的超高分辨CT成像：光子计数CT的价值

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国际医学放射学杂志 2023年第5期 625-626页

作者： Y.Gaillandre A.Duhamel T.Flohr J.B.faivre S.Khung A.Hutt 胡中盟

摘要目的比较采用光子计数CT(PCCT)超高分辨（UHR）影像与采用能量整合探测器CT(EID-CT)高分辨（HR）CT的肺实质影像。方法 112例病情稳定的间质性肺疾病（ILD）病

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Building a cluster of NLR genes conferring resistance to pests and pathogens: the story of the Vat gene cluster in cucurbits

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Horticulture Research 2021年第1期8卷 899-910页

作者： Veronique Chovelon Rafael Feriche-Linares Guillaume Barreau Joel Chadoeuf Caroline Callot Veronique Gautier Marie-Christine Le Paslier Aurelie Berad Patricia faivre-Rampant Jacques Lagnel Nathalie Boissot INRAE GAFL84143 MontfavetFrance INRAE CNRGV31326 Castanet-TolosanFrance INRAE GDEC-Gentyane Plateform63000 Clermont-FerrandFrance Universite Paris-Saclay INRAEEPGV91000 Evry-CourcouronnesFrance

Most molecularly characterized plant resistance genes(R genes)belong to the nucleotide-binding-site-leucine-rich-repeat(NLR)receptor family and are prone to duplication and transposition with high sequence *** this family,the Vat gene in melon is one of the few R genes known for conferring resistance to insect,i.e.,Aphis gossypii,but it has been misassembled and/or mispredicted in the whole genomes of *** examined 14 genomic regions(about 400 kb)derived from long-read assemblies spanning Vat-related genes in Cucumis melo,Cucumis sativus,Citrullus lanatus,Benincasa hispida,Cucurbita argyrosperma,and Momordica *** built the phylogeny of those *** the paleohistory of the Vat gene cluster,we revealed a step by step process beginning from a common ancestry in cucurbits older than 50 *** highlighted Vat exclusively in the Cucumis genera,which diverged about 20 my *** then focused on melon,evaluating a minimum duplication rate of Vat in 80 wild and cultivated melon lines using generalist primers;our results suggested that duplication started before melon *** phylogeny of 44 Vat-CDS obtained from 21 melon lines revealed gain and loss of leucine-rich-repeat domains along ***,we revealed the high putative recognition scale offered in melon based on a combination of SNPs,number of leucine-rich-repeat domains within each homolog and number of homologs within each cluster that might jointly confer resistance to a large pest and pathogen *** on our findings,we propose possible avenues for breeding programs.

关键词： NLR cluster resistance

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结直肠癌肝转移的流行病学及处理

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医学信息（手术学分册） 2007年第9期20卷 853-853页

作者： Manfredi, Sylvain Lepage, Come Hatem, Cyril Coatmeur, Olivier faivre, Jean Bouvier, anne - Marie

目的／背景：基于人群水平对结直肠癌肝转移的流行病学及处理的认识还很少。这项基于人群的研究目的是报告同期或后期结直肠癌肝转移的发病率、治疗及预后。方法：本项研究的所有数据来自法国勃艮第人群癌症注册系统。结果：同期肝转移... 详细信息

目的／背景：基于人群水平对结直肠癌肝转移的流行病学及处理的认识还很少。这项基于人群的研究目的是报告同期或后期结直肠癌肝转移的发病率、治疗及预后。方法：本项研究的所有数据来自法国勃艮第人群癌症注册系统。结果：同期肝转移的发病率为14．5％，年龄标准化发病率为：男性7．6／100000、女性3．7／100000。5年累计肝转移率为14．5％，TNM分期Ⅰ期患者为3．7％，Ⅱ期为13．3％，Ⅲ期为30．4％（P〈0．001）。

关键词：结直肠癌肝转移流行病学标准化发病率同期肝转移 TNM分期人群转移率

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高时间分辨率及长螺距模式双源CT胸部血管成像:140例病人影像质量的评价

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国际医学放射学杂志 2010年第4期 397-398页

作者： N.Tacelli M.Remy-Jardin T.Flohr J.B.faivre V.Delannoy A.Duhamel 赵芳 Department of Thoracic Imaging Hospital CalmetteUniversity Centre of Lille (EA 2694)Boulevard Jules Leclercq59037 Lille cedexFrance

目的评价应用高时间分辨率及长螺距模式双源CT胸部血管成像的影像质量。方法分为2组,每组70人,行双源单能量胸部CT血管成像扫描。第1组时间分辨率为83ms,螺距为2;第2组

关键词：影像质量时间分辨率血管成像双源胸部躯干 CT

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