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Epidemiology of onchocerciasis-associated epilepsy in the Mbam and Sanaga river valleys of Cameroon:impact of more than 13 years of ivermectin

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Infectious Diseases of Poverty 2018年第1期7卷 1191-1201页

作者： Joseph Nelson Siewe Fodjo Godwin Tatah Earnest Njih Tabah Leonard Ngarka Leonard Njamnshi Nfor Samuel Eric Chokote Michel kMengnjo Fidele Dema Aurelien Tele Sitouok Grace Nkoro Felicien ENtone anne-cecile zoung-k.nyi bissek.cedric bchesnais Michel Boussinesq Robert Colebunders Alfred k.Njamnshi Global Health Institute University of AntwerpAntwerpBelgium Neurology Department YaoundeCentral HospitalYaoundeCameroon Neurology Department CH Saint-NazaireSaint-NazaireFrance Neuroscience Laboratory FMBSThe University of YaoundeIYaoundeCameroon Ministry of Public Health YaoundeCameroon Neurology Department CHU BrugmanBrusselsBelgium Yoko District Hospital YaoundeCameroon UMI 233 Institut de Recherche pour le Developpement(IRD)MontpellierFrance UniversiteMontpellier MontpellierFrance INSERM Unite1175 MontpellierFrance Brain Research Africa Initiative(BRAIN) YaoundeCameroon.

Background:A high epilepsy prevalence has been reported in several onchocerciasis-endemic villages along the Mbam and Sanaga river valleys in Cameroon,including Bilomo and *** sought to determine the prevalence of epilepsy in these two villages following more than 13 years of community-directed treatment with ivermectin(CDTI).Methods:Door-to-door surveys were performed on the entire resident population in the villages in August 2017 and January *** was diagnosed using a 2-step approach:administration of a standardized 5-item questionnaire followed by confirmation by a *** published diagnostic criteria for onchocerciasis-associated epilepsy(OAE)were ***16 serology was done for children aged 7-10 years to assess onchocerciasis *** were compared with previous data from these two ***:A total of 1525 individuals(1321 in Bilomo and 204 in kelleng)in 233 households were surveyed in both *** crude prevalence of epilepsy was 4.6%in Bilomo(2017)and 7.8%in kelleng(2018),including 12(15.6%of cases)persons with epilepsy(PWE)with nodding *** age and sex-standardized prevalence in kelleng decreased from 13.5%in 2004 to 9.3%in 2018(Pkelleng(P=0.112).Furthermore,47.6%of all tested children between 7 and 10 years had Ov16 ***:There is a decrease in epilepsy prevalence after 13 years and more of CDTI in both *** age-shift observed in PWE suggests that ivermectin may prevent OAE in younger ***16 seropositivity in children indicates ongoing onchocerciasis transmission possibly due to suboptimal control *** findings support the existence of OAE in Cameroon and highlight the need to strengthen onchocerciasis elimination programs.

关键词： Onchocerciasis Epilepsy Nodding syndrome Ov16 rapid diagnostic test Ivermectin Cameroon

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