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Bacterial direct-fed microbials fail to reduce methane emissions in primiparous lactating dairy cows

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Journal of Animal Science and Biotechnology 2019年第3期10卷 802-810页

作者： Jeyamalar Jeyanathan Cecile Martin Maguy Eugene anne Ferlay Milka popova Diego p.Morgavi Universite Clermont Auvergne INRAVetAgro SupUMR 1213 HerbivoresF-63122 Saint-Genes-ChampanelleFrance Laboratory for Animal Nutrition and Animal product Quality Faculty of Bioscience EngineeringGhent UniversityCoupure Links 6539000 GhentBelgium

Direct-fed microbials(DFM) are considered as a promising technique to improve animal productivity without affecting animal health or harming the *** potential of three bacterial DFM to reduce methane(CH4)emissions,modulate ruminal fermentation,milk production and composition of primiparous dairy cows was examined in this *** previous reports have shown that DFM respond differently to different diets,two contrasting diets were used in this *** lactating primiparous cows were randomly divided into two groups that were fed a corn silage-based,high-starch diet(HSD) or a grass silage-based,high-fiber diet(HFD).Cows in each dietary group were randomly assigned to four treatments in a 4 × 4 Latin square *** bacterial DFM used were selected for their proven CH4-reducing effect in *** included control(without DFM) and 3 DFM treatments: propionibacterium freudenreichii 53-W(2.9 × 10^10 colony forming units(CFU)/cow per day),Lactobacillus pentosus D31(3.6 × 10^11 CFU/cow per day) and Lactobacillus bulgaricus D1(4.6 × 10^10 CFU/cow per day).Each experimental period included 4 weeks of treatment and 1 week of wash-out,with measures performed in the fourth week of the treatment *** CH4 emissions were measured during 3 consecutive days using respiration *** samples were collected for ruminal fermentation parameters and quantitative microbial *** samples were collected for composition *** weight of cows were recorded at the end of each treatment *** of diet,no mitigating effect of DFM was observed on CH4 emissions in dairy *** contrast,propionibacterium increased CH4 intensity by 27%(g CH4/kg milk) in cows fed *** was no effect of DFM on other fermentation parameters and on bacterial,archaeal and protozoal ***,the effect of DFM on milk fatty acid composition was *** and *** DFM tended to increase body weight gain with ***

关键词： Bacterial direct-fed microbial Dairy cow Methane Milk fatty acid

Effectiveness and safety of apixaban and rivaroxaban vs warfarin in patients with atrial fibrillation and chronic kidney disease

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World Journal of Nephrology 2023年第5期12卷 132-146页

作者： Sylvie perreault Laurie-anne Boivin proulx Aurélie Lenglet Ziad A Massy Marc Dorais Faculty of pharmacy University of MontrealQuebecMontreal H3C3J7Canada Department of Cardiology Faculty of MedicineUniversity of Ottawa Heart InstituteOntarioOttawa K1Y4W7Canada Department of pharmacy Amiens-Picardie Hospital University CenterAmiens 80000France Faculty of pharmacy MP3CV LaboratoryUR7545University of Picardie Jules VerneAmiens 80000France Division of Nephrology University of Paris Ouest-Versailles-Saint-Quentin-en-Yvelines(UVSQ)VillejuifFrance.AP-HP Ambroise-ParéHospitalBoulogne Billancourt/Paris 92104France StatSciences inc. Notre-Dame-de-l’Île-PerrotQuebecMontreal J7W 3K8Canada

BACKGROUND Randomized controlled trials(RCTs)of direct oral anticoagulants(DOACs)included a low proportion of atrial fibrillation(AF)patients with chronic kidney disease(CKD),and suggested that DOACs are safe and effective in patients with mild-to-moderate *** a metanalysis of RCTs and observational studies,DOACs were associated with better efficacy(vs warfarin)in early CKD and had similar efficacy and safety profiles in patients with stages iV-V *** few studies have provided data on the safety and effectiveness of each DOAC vs warfarin in patients with stage iii *** effectiveness and safety of DOACs in those patients are still subject to *** To assess and compare the effectiveness and safety of apixaban and rivaroxaban vs warfarin in this patient *** A cohort of patients with an inpatient or outpatient code for AF and stage iii CKD who were newly prescribed apixaban and rivaroxaban was created using the administrative databases from the Quebec province of Canada between 2013 and *** primary effectiveness outcome was a composite of ischemic stroke,systemic embolism,and death,whereas the primary safety outcome was a composite of major bleeding within a year of DOAC vs warfarin *** groups were compared in an under-treatment analysis using inverse probability of treatment weighting and Cox proportional *** A total of 8899 included patients filled out a new oral anticoagulation therapy claim;3335 for warfarin and 5564 for *** with warfarin,15 mg and 20 mg rivaroxaban presented a similar effectiveness and safety composite *** 5.0 mg was associated with a lower effectiveness composite risk[Hazard ratio(HR)0.76;95%confidence interval(Ci):0.65-0.88]and a similar safety risk(HR 0.94;95%Ci:0.66-1.35).Apixaban 2.5 mg was associated with a similar effectiveness composite(HR 1.00;95%Ci:0.79-1.26)and a lower safety risk(HR 0.65;95%Ci:***,apixaban 5.0 mg was associated with a bet

关键词： Atrial fibrillation Chronic kidney disease Direct oral anticoagulant Effectiveness Safety Warfarin

春大麦对作物轮作、保护耕作和杂草管理强度的反应

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麦类作物 1998年第3期18卷 55-58页

作者： anne Legere 夏晓慧

在Ｑｕｅｂｅｃ中部和东部，对采取保护耕作措施的限制包括春季冷湿、生长季节短暂和的降雨方式多变。本研究目的在于确定保护耕作措施对Ｑｕｅｂｅｃ地区谷类作物种植制度的适合性。检测了在Ｋａｍｏｕｒａｓｋａ粘壤土和Ｓａｉｎｔ－... 详细信息

在Ｑｕｅｂｅｃ中部和东部，对采取保护耕作措施的限制包括春季冷湿、生长季节短暂和的降雨方式多变。本研究目的在于确定保护耕作措施对Ｑｕｅｂｅｃ地区谷类作物种植制度的适合性。检测了在Ｋａｍｏｕｒａｓｋａ粘壤土和Ｓａｉｎｔ－Ａｎｄｒｅ重沙壤土上作物（春大麦）单作、春大麦－红三叶草轮作、耕作和杂草管理强度对中耕作物和杂草群体、干重的影响以及对籽粒产量和产量因素的影响。在粘壤点免耕中，中度杂草管理有利于作物建成、生长和获得籽粒产量，与犁耕（ＭＰ）处理相近。在５年中，免耕（ＮＴ）的籽粒产量平均为２８７７ｋｇ·ｈｍ－２，与之相对照的ＭＰ和ＣＰ（凿耕）分别为２８７０和２２６０ｋｇ·ｈｍ－２。籽粒产量不仅一致，而且轮作（３０１４ｋｇ·ｈｍ－２）高于单作（２３２２ｋｇ·ｈｍ－２）。在沙壤点作物建成、生长和产量对减少作物和杂草管理强度具有负反应。沙壤点的ＣＰ和ＮＴ处理中，大麦植株建成和杂草控制在单作中不如轮作中成功。免耕籽粒产量平均比ＣＰ低７％，比ＭＰ低２９％。

关键词：春大麦轮作保护耕作杂草管理

癫痫:从儿童至成年的医疗过渡——来自安大略省癫痫执行工作组的建议

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癫痫杂志 2018年第4期4卷 362-373页

作者： Danielle M.Andrade anne S.Bassett Eduard Bercovici Borlot F Bui E Camfield p Clozza GQ Cohen E Gofine T Graves L Greenaway J Guttman B Guttman-Slater M Hassan A Henze M Kaufman M Lawless B Lee H Lindzon L Lomax LB McAndrews mp Menna-Dack D Minassian BA Mulligan J Nabbout R Nejm T Secco M Sellers L Shapiro M Slegr M Smith R Szatmari p Tao L Vogt A Whiting S Carter Snead O 3rd 刘旭熊维希慕洁

从儿童到成人的医疗保健系统的转变对许多患有癫痫的年轻人及其家庭来说是一个挑战。最近,加拿大安大略省卫生部和长期医疗部门成立了一个过渡工作组(Transition working group,TWG),为安大略省癫痫患者的过渡提出建议。在此对这项工作... 详细信息

从儿童到成人的医疗保健系统的转变对许多患有癫痫的年轻人及其家庭来说是一个挑战。最近,加拿大安大略省卫生部和长期医疗部门成立了一个过渡工作组(Transition working group,TWG),为安大略省癫痫患者的过渡提出建议。在此对这项工作做出总结。TWG包括儿科和成人癫痫病专家、精神科医生和来自学术界和社区的家庭医生,从事儿童和成人癫痫项目的社区医师、护士和社会工作者,以及青少年内科医师、律师、职业治疗师、社区癫痫机构的代表、癫痫患者和患者父母。该小组主要解决3个领域的问题:(1)癫痫的诊断和管理;(2)癫痫患者心理健康和社会心理需求;(3)癫痫患者经济、社会和法律支持。目前虽然还没有对过渡方案的结果进行系统研究,但TWG能早期识别处于过渡失败风险的青少年,在实际过渡之前即应协调儿童和成人神经科医师以及其他专家。过渡期是重新思考诊断和重复诊断检测(特别是基因检测,现有技术较多年前可发现更多病因)的理想时期。在转至成人医疗系统后部分筛查应重复。文章提出的7个步骤可以促进过渡,从而有助于为青少年癫痫患者转出儿童保健系统提供持续且合理的医疗服务。

关键词：癫痫过渡青少年青年遗传学出院方案过渡准备问卷