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A database of modeled gridded dry deposition velocities for 45 gaseous species and three particle size ranges across North America

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Journal of Environmental Sciences 2023年第5期127卷 264-272页

作者： Leiming Zhang Zhuanshi He Zhiyong Wu anne marie macdonald Jeffrey R.Brook Shailesh Kharol Air Quality Research Division Science and Technology BranchEnvironment and Climate Change CanadaTorontoON M3H 5T4Canada Department of Chemical Engineering and Applied Chemistry University of TorontoTorontoON M5S 2E4Canada

The dry deposition process refers to the flux loss of an atmospheric pollutant due to uptake of the pollutant by the earth’s *** deposition flux of a chemical species is typically calculated as the product of its surface-layer concentration and its dry deposition velocity(V_(d)).Field measurement based V_(d) data are very scarce or do not exist for many chemical species considered in chemistry transport *** the present study,gaseous and particulate dry deposition schemes were applied to generate a database of hourly V_(d) for 45 gaseous species and three particle size ranges for two years(2016–2017)at a 15 kmby 15 km horizontal resolution across North *** V_(d) of the 45 gaseous species ranged from<0.001 to 4.6 cm/sec across the whole domain,with chemical species-dependentmedian(mean)values being in the range of 0.018–1.37 cm/sec(0.05–1.43 cm/sec).The spatial distributions of the two-year average V_(d) showed values higher than 1–3 cm/sec for those soluble and reactive species over certain land *** species have the highest V_(d) over water surfaces,while insoluble but reactive species have the highest V_(d) over *** V_(d) of PM_(2.5) across the whole domain ranged from 0.039 to 0.75 cm/sec with median(mean)value of 0.18(0.20)cm s^(−1),while the mean V_(d) for PM_(2.5)–10 is twice that of PM_(2.5).Uncertainties in the modeled V_(d) are typically on the order of a factor of 2.0 or larger,which needs to be considered when applying the dataset in other studies.

关键词： Air quality modeling Atmospheric pollutant Atmospheric deposition Dry deposition velocity Spatiotemporal distribution

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Optimization Management of Industrial Organizations Based on Performance Indicators

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World Journal of Engineering and Technology 2024年第1期12卷 185-199页

作者： anne marie Chana Bernabé Batchakui Blaise Ndangang Department of Computer Engineering National Advanced School of Engineering Yaoundé Cameroon

This paper proposes an intelligent management system (IMS) to help managers in their delicate and tedious task of exploiting the plethora of data (indicators) contained in management dashboards. This system is based on intelligent agents, ontologies and data mining. It is implemented by PASSI (Process for Agent Societies Specification and Implementation) methods for agent design and implementation, the Methodology for Knowledge Modeling and Hot-Winters for data prediction. Intelligent agents not only track indicators but also store the knowledge of managers within the company. Ontologies are used to manage the representation and presentation aspects of knowledge. Data mining makes it possible to: make the most of all available data;model the industrial process of data selection, exploration and modeling;and transform behaviors into predictive indicators. An instance of the IMS named SYGISS, currently in operation within a large brewery organization, allows us to observe very interesting results: the extraction of indicators is done in less than 5 minutes whereas manual extraction used to take 14 days;the generation of dashboards is instantaneous whereas it used to take 12 hours;the interpretation of indicators is instantaneous whereas it used to take a day;forecasts are possible and are done in less than 5 minutes whereas they did not exist with the old management. These important contributions help to optimize the management of this organization.

关键词： Performance Indicator Intelligent Agent Data Mining Intelligent Management System Enterprise Management

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Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir anne Skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna marie Juhl Kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

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Amniotic Band Syndrome at the Van Norman Clinic in Burundi: A Case Series

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Surgical Science 2024年第3期15卷 118-124页

作者： Alice Ndayishimiye Hélène Bukuru Déogratias Niyungeko anne marie Nikuze Sylvestre Bazikamwe Jean Claude Mbonicura Gilbert Ndayizeye Department of Pediatrics Kamenge University Hospital Center Bujumbura Burundi Department of Obstetrics and Gynecology Kamenge University Hospital Center Bujumbura Burundi General Surgery Department Kamenge University Hospital Center Bujumbura Burundi Orthopaedy Department Kamenge University Hospital Center Bujumbura Burundi

Amniotic band syndrome is an acquired embryo-fetopathy. It is rare and is characterized by malformations mainly affecting the limbs but also the skull, face and thoraco-abdominal axis. Its etiopathogenesis remains poorly understood. Its diagnosis is essentially clinical and is classically based on the existence of signs such as furrows, amputations and pseudosyndactyly. To show the importance of antenatal diagnosis in resource-limited countries, we report the case of two newborns, one premature at 31 weeks and the other at term, in whom amniotic band syndrome was discovered incidentally at birth. It involved an amputation of the right leg for both cases. The premature baby was born in a context of neonatal sepsis and will succumb to the latter while the 2nd case was released from the hospital alive. Imaging examinations to search for probable congenital malformations could only be carried out for the 2nd case and no accessible congenital malformation had been identified. And as management of the disease, only psychological support to the parents was provided for the 2 cases. The antenatal discovery of a case of amniotic band syndrome in countries with low technical capacity such as Burundi should push clinicians to think in time about treatment options.

关键词： Amniotic Band Syndrome Embryo-Fetopathies Antenatal Diagnosis Limbs

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Epidemiological, Clinical Progress Aspects of Congenital Heart Disease with Neonatal Revelation at the Mother-Child Hospital of Bingerville (HME) Concerning 98 Cases from January 2021 to December 2022 (Côte d’Ivoire)

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Open Journal of Pediatrics 2024年第1期14卷 89-100页

作者： Adja Evelyne Akaffou-Gbery Richard Azagoh-Kouadio anne-Lise Laetitia Mobio Jean-Jacques Yao Atteby Serenah marie Janice N’vrah Anoh Kouassi Raoul Yao Department of Paediatrics and Neonatology H&#244pital Mère-Enfant de Bingerville (HME) Bingerville C&#244te d’Ivoire Department of Medical Pediatrics and Specialties CHU de Angré Abidjan C&#244te d’Ivoire

Introduction The distribution of congenital heart disease (CHD) in sub-Saharan Africa is highly imprecise and varies from one region to another due to the inequality of diagnostic facilities. The aim of this study was to determine the in-hospital prevalence of congenital heart disease in children at the Mother-Child hospital of Bingerville (HME) by specifying the diagnostic, therapeutic and evolutionary aspects. Materials and methods We conducted a retrospective, descriptive, cross-sectional study at HME of Bingerville from January 2021 to December 2022. All newborns with congenital heart disease confirmed by echocardiography were included in the study. Results Of 656 admissions to the neonatology department over the study period, congenital heart disease accounted for 14.9% (98/656) of cases. In our series, 76.7% were diagnosed before the 1st week of life, with a mean chronological age of 5.18 days and extremes of 0 and 46 days. There were as many male patients (50%) as female (50%), i.e. a sex ratio of 1. These newborns were premature in 60.2% of cases, with a mean and median gestational age of 34 weeks’ amenorrhea. Most were left-right shunts (90.8%). Persistent ductus arteriosus (PDA) (48.9%) predominated, followed by atrial septal defect (38.7%), ventricular septal defect (13.3%), common trunk artery (CTA) (3.1%) and open septal pulmonary atresia (OSPA) (1%) as the primary cyanogenic heart disease. Pulmonary arterial hypertension (PAH) (50%) was primary in 38.8% and secondary (61.2%). The mortality rate was 30.6%, and all CTA patients died (100%), with a significant statistical relationship (p = 0.027). Progression under treatment was marked by clinical stabilization (68/98) in 69.4% of cases. Conclusion: Congenital heart disease is relatively common at the Bingerville HME. Access to echocardiography should be facilitated in neonatology departments for rapid diagnosis and optimal management of congenital heart disease in newborns.

关键词： Newborn Congenital Heart Disease Côte d’Ivoire

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Matrix Roots and Embedding Conditions for Three-State Discrete-Time Markov Chains with Complex Eigenvalues

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Communications in Mathematics and Statistics 2022年第3期10卷 435-450页

作者： marie-anne Guerry Department of Business Technology and Operations Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium

The present paper examines matrix root properties and embedding conditions for discrete-time Markov chains with three states and a transition matrix having complex *** as well as sufficient conditions for the existence of an m-th stochastic root of the transition matrix are *** roots are expressed in analytical form based on the spectral decomposition of the transition matrix,and properties of these matrix roots are proved.

关键词： Markov chain Embedding problem Matrix root Complex eigenvalues

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Marine Oxygen Isotope Stage(MIS)-6 Glacial Advances on the Tibetan Plateau More Extensive than during MIS-2 due to More Abundant Precipitation

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Acta Geologica Sinica(English Edition) 2022年第5期96卷 1484-1494页

作者： marie-Luce CHEVALIER WANG Shiguang anne REPLUMAZ LI Haibing Key Laboratory of Deep-Earth Dynamics of Ministry of Natural Resources Institute of GeologyCAGSBeijing 100037China Jiangsu Donghai Crustal Activity in Deep Holes of the Continental Scientific Drilling National Observation and Research Station LianyungangJiangsu 222300China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China National Institute of Natural Hazards MEMCBeijing 100037China ISTerre UniversitéGrenoble AlpesCNRSGrenoble 38610France

Numerous studies dated glacial deposits within the Himalayan-Tibetan *** most focus on young deposits,i.e.,younger than the Last Glacial Maximum(LGM or Marine oxygen Isotope Stage(MIS)-2,~20 ka),older moraines such as those from MIS-6(~130–191 ka)are much harder to date and interpret due to the less well-preserved nature of their surfaces and boulders,as well as their scattered and continuous age distribution due to long-lived erosion since ***,we dated with~(10)Be,two imbricated moraines near Yadong in southern Tibet,as MIS-2 and 6,showing that the most extensive,smooth surfaces were abandoned during *** published data from 54 MIS-6 moraines on the Tibetan Plateau reveals that they exist in most regions,dry or *** are particularly well-preserved(sharp crests)in eastern and northern Tibet,while in southern and central Tibet,their crests are rounded to *** both MIS-2 and 6 were equally cold,and because MIS-6 moraines are much more extensive than those from the LGM,we conclude that MIS-6 glacial advances were controlled by more abundant precipitation than during *** would be consistent with the peak in Asian monsoon during MIS-6,revealed by sediments from the South China Sea.

关键词： Yadong rift southern Tibet cosmogenic isotopes Quaternary paleo-precipitation moraine morphology Indian monsoon

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Intrauterine insemination with donor sperm:only the number of motile spermatozoa inseminated influences both pregnancy and live-birth rates

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Asian Journal of Andrology 2022年第3期24卷 287-293页

作者： marie Cardey-Lefort Berengere Ducrocq Audrey Uk Helen Behal anne-Laure Barbotin Geoffroy Robin Reproductive Biology Institute Lille University HospitalLille F-59037France Lille University Lille University HospitalULR 2694-METRICSLille F-59000France Endocrine Gynecology and Reproductive Medicine Unit Lille University HospitalLille F-59037France

Intrauterine insemination with donor sperm(IUI-D)is an assisted reproductive technology(ART)offered to couples with definitive male infertility or risk of genetic disease ***,we sought to evaluate our practice in IUI-D and identify factors that influenced the success *** performed a retrospective,single-center study of all IUI-D procedures performed at Lille University Medical Center(Lille,France)between January 1,2007,and December 31,*** and multivariate analyses with a mixed logistic model were used to identify factors associated with clinical pregnancies and live *** included 322 couples and 1179 IUI-D *** clinical pregnancy rate was 23.5%,and the live birth rate was 18.9%per *** a multivariate analysis,the women’s age was negatively associated with the live birth *** number of motile spermatozoa inseminated was the only factor associated with both clinical pregnancies and live births,with a chosen threshold of 0.75 *** clinical pregnancy and live birth rates were,respectively,17.3%and 13.0%below the number of motile spermatozoa inseminated threshold and 25.9%and 21.0%at or above the threshold(all P=0.005).The number of motile spermatozoa inseminated was the only factor that significantly influenced both pregnancies and live-birth rates after ***,below a threshold of 0.75 million motile spermatozoa inseminated,those rates were significantly *** of this number of motile spermatozoa inseminated threshold may help centers to allocate donations more effectively while maintaining reasonable waiting times for patients.

关键词： intrauterine insemination male infertility number of motile spermatozoa inseminated sperm donor

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Hereditary polyposis syndromes remain a challenging disease entity:Old dilemmas and new insights

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 1-8页

作者： Frederik Rønne Pachler Anna Byrjalsen John Gásdal Karstensen anne marie Jelsig Danish Polyposis Registry GastrounitCopenhagen University Hospital-Amager and Hvidovre HospitalHvidovre 2650Denmark Department of Clinical Genetics University Hospital of CopenhagenRigshospitaletCopenhagen 2100Denmark Department of Clinical Medicine University of CopenhagenHvidovre 2650Denmark

In this editorial we present an overview and insights of the management of hereditary polyposis *** primary focus was on familial adenomatous polyposis,juvenile polyposis syndrome and Peutz-Jegher *** testing has become increasingly available and is easier than ever to integrate into clinical ***,several genes have been added to the expanding list of genes associated with hereditary polyposis syndromes,allowing for precise diagnostics and tailored *** evaluation of patients with hereditary polyposis syndromes is paramount in the surveillance *** endoscopic procedures include both diagnostic procedures and surveillance as well as therapeutic *** for endoscopic procedures in the upper and lower gastrointestinal canal were *** is still a key component in the management of patients with hereditary polyposis *** increased cancer risk in these patients often render prophylactic procedures or intended curative procedures in the case of cancer *** interventions in the upper and lower gastrointestinal canal were described with relevant *** of chemopreventive medications is *** drugs have been investigated,including nonsteroidal anti-inflammatory *** has been demonstrated that cyclooxygenase-2 inhibitors may lower the number of *** medications are currently under investigation,but none have,to date,consistently been able to prevent development of disease.

关键词： Hereditary polyposis Familial adenomatous polyposis Juvenile polyposis syndrome Peutz-Jegher syndrome

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Expert group syndrome at high altitude

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Sports Medicine and Health Science 2022年第3期4卷 215-218页

作者： Jean-Paul Richalet marie-anne Magnan Alice Gavet Pierre Lafère UniversitéSorbonne Paris Nord Laboratoire Hypoxie et PoumonUMR INSERM U1272BobignyFrance Institut National des Sports de l’Expertise et de la PerformancePôle médicalParisFrance Hôpitaux universitaires de Genève Département de médecine aiguëUnitéde médecine subaquatique et hyperbareGenevaSwitzerland Hôpitaux du Mont-Blanc Soins de suite et réadaptationChamonixFrance Universitéde Bretagne Occidentale Laboratoire ORPHYEA 44324BrestFrance HauteÉcole Bruxelles-Brabant(HE2B) EnvironmentalOccupationalAgeing(Integrative)Physiology LaboratoryBrusselsBelgium

During a training session for the university diploma of Mountain medicine delivered by University Sorbonne Paris Nord for medical doctors,one of the participants developed signs of maladaptation to high altitude at 3600 m,the severity of which was incorrectly *** was sparingly given by the patient(an anesthetist)to several of his colleagues and no one was in charge to collect clinical data,take a history,and provide appropriate *** combination of the absence of designation of a supervising doctor and the difficulty of communicating with the patient led to a lack of coordinated management and to an evolution of the symptoms towards severe acute mountain ***,the very rapid management of the patient and a rapid helicopter evacuation,as soon as the symptoms worsened towards the onset of a suspected high altitude cerebral and/or pulmonary edema,allowed rapid resolution without ***,medical,psychological,and managerial factors led to this Expert Group Syndrome.

关键词： Acute mountain sickness High altitude cerebral edema Psychology Group management

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