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Self‑Healing Dynam.c Hydrogel m.croparticles with Structural Color for Wound m.nagem.nt

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Nano-m.cro Letters 2024年第11期16卷 177-190页

作者： Li Wang Xiaoya Ding Lu Fan anne m.Filppula Qinyu Li Hongbo Zhang Yuanjin Zhao Luoran Shang Departm.nt of General Surgery Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025People’s Republic of China Departm.nt of Rheum.tology and Im.unology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096People’s Republic of China Pharm.ceutical Sciences Laboratory Åbo Akademi University20520 TurkuFinland Oujiang Laboratory(Zhejiang Lab for Regenerative m.dicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001People’s Republic of China Shanghai Xuhui Central Hospital Zhongshan‑Xuhui Hospitaland the Shanghai Key Laboratory of Medical Epigeneticsthe International Co‑laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032People’s Republic of China

Chronic diabetic wounds confront a significant m.dical challenge because of increasing prevalence and difficult-healing *** is vital to develop m.ltifunctional hydrogel dressings,with well-designed m.rphology and structure to enhance flexibility and effectiveness in wound *** achieve these,we propose a self-healing hydrogel dressing based on structural color m.crospheres for wound *** m.crosphere com.rised a phototherm.l-responsive inverse opal fram.work,which was constructed by hyaluronic acid m.thacryloyl,silk fibroin m.thacryloyl and black phosphorus quantum.dots(BPQDs),and was further re-filled with a dynam.c *** dynam.c hydrogel filler was form.d by Knoevenagel condensation reaction between cyanoacetate and benzaldehyde-functionalized dextran(DEX-CA and DEX-BA).Notably,the com.osite m.crospheres can be applied arbitrarily,and they can adhere together upon near-infrared irradiation by leveraging the BPQDs-m.diated phototherm.l effect and the therm.reversible stiffness change of dynam.c ***,eum.nitin and vascular endothelial growth factor were co-loaded in the m.crospheres and their release behavior can be regulated by the sam. ***,effective m.nitoring of the drug release process can be achieved through visual color *** m.crosphere system.has dem.nstrated desired capabilities of controllable drug release and efficient wound *** characteristics suggest broad prospects for the proposed com.osite m.crospheres in clinical applications.

关键词： Black phosphorus Structural color Dynam.c hydrogel Inverse opal Wound m.nagem.nt

Effect of Shade on Seed Protein, Oil, Fatty Acids, and m.nerals in Soybean lines Varying in Seed Germ.nability in the Early Soybean Production System

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Am.rican Journal of Plant Sciences 2012年第1期3卷 84-95页

作者： Nacer Bellaloui Jam.s R. Sm.th anne m. Gillen Daniel K. Fisher Alem. m.ngistu 不详

The cause of poor seed quality (germ.nation) of soybean produced in the Early Soybean Production System.in the m.dsouth U.S.A. is still not com.letely understood. Tem.erature, solar radiation, and soybean genotype m.y all be im.ortant factors involved. The objective of this research was to evaluate seed com.osition, m.neral level, and nitrogen assim.lation in high and low germ.nability soybean plant introductions in a full-sunlight (unshaded) and a low-light intensity (shaded) environm.nts. Shade netting was em.loyed in field plots that reduced light intensity by about 50% and air tem.erature by about 10?F/6?C (10%). A two-year field experim.nt was conducted on soybean accessions with high germ.nability (PI 587982A and PI 603723), low germ.nability (PI 80480 and PI 84976-1), and on soybean cultivars (DSR-3100 RR STS and Pella 86). Results showed that shade resulted in higher total oil, linoleic and linolenic acids, and lower protein and oleic acid. Shade also resulted in lower nitrogen assim.lation, leaf chlorophyll concentration, but unshade resulted in higher total seed boron, iron, and nitrogen concentrations. Seed structural boron was positively correlated with germ.nation and protein. Structural boron percentage was consistently higher under shade than under unshade in PI 80480, PI 84976-1, DSR-3100 RR STS, and Pella 86, but consistently higher under unshade than under shade in higher germ.nability lines PI 587982A and PI 603723, suggesting that different distribution m.chanism. of structural boron exist between genotypes. The positive correlation between germ.nation and structural B and between protein and structural B signify a possible role of B in seed quality traits. Our research dem.nstrated that light intensity, com.ined with tem.erature, can alter seed constituents. Higher germ.nability lines had higher germ.nation rates and lower percentages of hardseededness, desirable traits for soybean seed.

关键词： Com. Nitrogen Assim.lation Seed Com.osition Seed Nutrition Seed Oil Seed Protein Soybean Nutrition

Zebrafish as an in Vivo Screen for Early Black Cranberry Proanthocyanidin Biom.lecular Activity

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Am.rican Journal of m.lecular Biology 2014年第2期4卷 37-48页

作者： Nicholas J. m.cedo Catherine C. Neto anne m. Liberty Tracie L. Ferreira Departm.nt of Bioengineering The University of Massachusetts Dartmouth North Dartmouth USA Departm.nt of Chem.stry/Biochem.stry The University of Massachusetts Dartmouth North Dartmouth USA

Antioxidants have been widely studied in various naturally occurring substances as a bioavailable cancer prevention treatm.nt. Proanthocyanidins (PACs), which are abundant polyphenols in Early Black (EB) Cranberry (Vaccinium.m.crocarpon), are readily available and we have shown their anticancer activity in several cancer cell lines. This work focused on the activity of these com.ounds when incorporated into the zebrafish (Danio rerio) system. We began investigating the in vivo effect of these phytochem.cals, the protective role of several other cranberry com.ounds, and the m.tabolic activity of the vertebrate m.del organism. Proanthocyanidin fractions were separated from.fresh EB Cranberry fruit by chrom.tography on Sephadex LH-20 in order to acquire a workable stock solution in Dm.O. Various concentrations of proanthocyanidins in solution were tested against fish ranging in age from.1-cell stage to adult level of growth. Acridine orange apoptosis indicator dye was incorporated into the treatm.nt protocol, and it was observed that irregular epithelial cell death was occurring in treated em.ryos but not in the control group. Further apoptosis assays were carried out utilizing Dihydroethidium.(DHE) superoxide sensitive dye in the treatm.nt protocol. Fluorescing red nuclei were visible along the outer surface of the epithelium.cell layer;an indication of superoxide release within cells leading to the nicking of DNA within the nucleus. It was also possible to screen for superoxide release in PACs treated CCD-CO18 and HT-29 cells using confocal m.croscopy and cell apoptosis was investigated by trypan blue cytotoxicity assay;cell apoptosis results were statistically significant as confirm.d by ANOVA analysis. Results indicate that the phytochem.cals m.y induce apoptosis in rapidly dividing cells.

关键词： Zebrafish In Vivo Proanthocyanidins

Influence of Planting Date on Seed Protein, Oil, Sugars, m.nerals, and Nitrogen m.tabolism.in Soybean under Irrigated and Non-Irrigated Environm.nts

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Am.rican Journal of Plant Sciences 2011年第5期2卷 702-715页

作者： Nacer Bellaloui Krishna N. Reddy anne m. Gillen Daniel K. Fisher Alem. m.ngistu 不详

Inform.tion on the effect of planting date and irrigation on soybean [Glycine m.x (L.) m.rr.] seed com.osition in the Early Soybean Production System.(ESPS) is deficient, and what is available is inconclusive. The objective of this research was to investigate the effects of planting date on seed protein, oil, fatty acids, sugars, and m.nerals in soybean grown under irrigated (I) and non-irrigated (NI) conditions. A 2-yr field experim.nt was conducted in Stoneville, m. in 2007 and 2008. Soybean was planted during second week of April (early planting) and second week of m.y (late planting) each year. Results showed that under irrigated condition, early planting increased seed oil (up to 16% increase) and oleic acid (up to 22.8% increase), but decreased protein (up to 6.6% decrease), linoleic (up to 10.9% decrease) and linolenic acids (up to 27.7% decrease) com.ared to late planting. Under I conditions, late planting resulted in higher sucrose and raffinose and lower stachyose com.ared with early planting. Under NI conditions, seed of early planting had higher protein (up to 4% increase) and oleic acid (up to 25% increase) and lower oil (up to10.8% decrease) and linolenic acids (up to 13% decrease) than those of late planting. Under NI, stachyose concentration was higher than sucrose or raffinose, especially in early planting. Under I, early planting resulted in lower leaf and seed B, Fe, and P concentrations com.ared with those of late planting. Under NI, however, early planting resulted in higher accum.lation of leaf B and P, but lower seed B and P com.ared with those of late planting. This research dem.nstrated that both irrigation and planting date have a significant influence on seed protein, oil, unsaturated fatty acids, and sugars. Our results suggest that seed of late planting accum.late m.re B, P, and Fe than those of early planting, and this could be a beneficial gain. Lim.ted translocation of nutrients from.leaves to seed under NI is undesirable. Soybean pro

关键词： m.neral Nutrition Oligosaccharides Raffinose Stachyose Seed Com.osition Sucrose

Designing extra-curricular dance program.: UK physical education and dance teachers’ perspectives

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Open Journal of Preventive m.dicine 2013年第1期3卷 111-117页

作者： Sim.n J. Sebire Jade m.Neill Laura Pool anne m. Haase Jane Powell Russell Jago Centre for Exercise Nutrition & Health Sciences School for Policy Studies University of Bristol Bristol UK Faculty of Health & Life Sciences University of the West of England Bristol UK

m.ny girls do not engage in sufficient physical activity (PA). Dance is a popular form.of PA am.ng UKsecondary school-aged girls and extracurricular dance program. delivered by dance specialists m.y provide an alternative way to increase PA am.ngst girls aged 11 - 12. The purpose of this study was to explore the views of physical education and dance teachers on the structure, content and delivery of an extra-curricular dance-based PA intervention for adolescent girls. m.thods: Sem.-structured qualitative interviews were conducted with eleven physical education teachers and eleven dance teachers, and were analyzed using them.tic analysis. Results: Them.s identified addressed key logistical and content/delivery-based factors to be considered when designing a dance-based PA intervention. Logistical factors included optim.zing participant recruitm.nt and aligning external providers with school behavior m.nagem.nt policies. Content/delivery factors focused on teacher-student rapport, facilitating dance com.etence, and balancing teacher and student-led tim.. Conclusions: This form.tive study highlighted that an extra-curricular dance-based PA intervention would be welcom.d inUK schools. A num.er of considerations central to the design and delivery of such a program.were identified from.key user groups which can be used to inform.the developm.nt of school-based dance (and non-dance) interventions aim.d at increasing PA am.ngst adolescent girls.

关键词： Physical Activity Intervention Intervention Design Qualitative Research

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触点管理

Soluble m.CB in Plasm. and Urine Explains Population Expansions of NKG2D<sup>+</sup>CD4 T Cells Inpatients with Juvenile-Onset System.c Lupus Erythem.tosus

作者：安妮·m.许勒尔(anne m. Schüller)

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Open Journal of Im.unology 2017年第1期7卷 1-17页

作者： Satoru Ham.da Andrea Caballero-Benitez Kate L. Duran anne m. Stevens Thom.s Spies Veronika Groh Clinical Research Division Fred Hutch Seattle WA USA Departm.nt of Pediatrics Ryukyus University Okinawa Prefecture Nishihara Japan Division of Rheum.tology Department of Pediatrics University of Washington Medicine Seattle WA USA Center for Im.unity and Im.uno Therapies Seattle Children’s Research Institute Seattle WA USA

Abnorm.l NKG2D ligand expression has been im.licated in the initiation and m.intenance of various auto-inflam.atory disorders including system.c lupus erythem.tosus (SLE). This study’s goal was to identify the cellular contexts providing NKG2D ligands for stim.lation of the im.unosuppressive NKG2D+CD4 T cell subset that has been im.licated in m.dulating juvenile-onset SLE disease activity. Although previous observations with NKG2D+CD4 T cells in healthy individuals pointed towards peripheral B cell and m.eloid cell com.artm.nts as possible sites of enhanced NKG2DL presence, we found no evidence for a disease-associated increase of NKG2DL-positivity am.ng juvenile-onset SLE B cells and m.nocytes. However, juvenile-onset SLE patient plasm. and m.tched urine sam.les were positive by ELISA for the soluble form.of the NKG2D ligands m.CA and m.CB, suggesting that kidney and/or peripheral blood m.y constitute the NKG2DL positive m.croenvironm.nts driving NKG2D+CD4 T cell population expansions in this disease.

关键词： NKG2D Ligands NKG2D+ CD4 T Cells Juvenile-Onset System.c Lupus Erythem.tosus B Cells m.nocytes

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门珍泌尿妇科学

Soybean seed protein, oil, fatty acids, and m.neral com.osition as influenced by soybean-corn rotation

作者： (Weber anne m.)韦伯原

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Agricultural Sciences 2010年第3期1卷 102-109页

作者： Nacer Bellaloui H. Arnold Bruns anne. m. Gillen Ham.d K. Abbas Robert m. Zablotowicz Alem. m.ngistu Robert L. Paris 不详

Effects of crop rotation on soybean (Glycine m.x (L) m.rr.) seed com.osition have not been well investigated. Therefore, the objective of this study was to investigate the effects of soybean-corn (Zea m.ys L.) rotations on seed protein, oil, and fatty acids com.osition on soybean. Soybeans were grown at Stoneville, m., from.2005 to 2008 in five different scheduled cropping sequences. In 2007, following three years of rotation with corn, seed oleic acid percentage was significantly higher in any crop rotation than continuous soybean. The increase of oleic fatty acid ranged from.61 to 68% in 2007, and from.27 to 51% in 2008, depending on the rotation. The increase of oleic acid was accom.anied by significant increases in seed concentrations of phosphorus (P), iron (Fe), and boron (B). In 2007, the increase of P ranged from.60 to 75%, Fe from.70 to 72%, and B from.34 to 69%. In 2008, the increase of P ranged from.82 to 106%, Fe from.32 to 84%, and B from.62 to 77%. Continuous soybean had higher linoleic:oleic ratio and linoleic: palm.tic + stearic + oleic ratio, indicating that relative quantity of linoleic acid decreased in rotated crops. The total production of protein, oil, stearic and oleic fatty acids was the lowest in continuous soybean. The total production of palm.tic acid was inconsistent across years. The results show that soybean- corn rotation affects seed com.osition by consistently increasing seed oleic fatty acid, P, Fe, and B concentrations. Higher oleic acid, unsaturated fatty acid, is desirable for oil stability and long-shelf storage. The m.chanism. of how these nutrients are involved are not yet understood.

关键词： Fatty Acids m.neral Nutrients Oil Protein Seed Com.osition Soybean-Corn Rotation