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Open Journal of Immunology 2017年第1期7卷 1-17页

作者： Satoru Hamada Andrea Caballero-Benitez Kate L. Duran anne m. stevens Thomas Spies Veronika Groh Clinical Research Division Fred Hutch Seattle WA USA Department of Pediatrics Ryukyus University Okinawa Prefecture Nishihara Japan Division of Rheumatology Department of Pediatrics University of Washington Medicine Seattle WA USA Center for Immunity and Immuno Therapies Seattle Children’s Research Institute Seattle WA USA

Abnormal NKG2D ligand expression has been implicated in the initiation and maintenance of various auto-inflammatory disorders including systemic lupus erythematosus (SLE). This study’s goal was to identify the cellular contexts providing NKG2D ligands for stimulation of the immunosuppressive NKG2D+CD4 T cell subset that has been implicated in modulating juvenile-onset SLE disease activity. Although previous observations with NKG2D+CD4 T cells in healthy individuals pointed towards peripheral B cell and myeloid cell compartments as possible sites of enhanced NKG2DL presence, we found no evidence for a disease-associated increase of NKG2DL-positivity among juvenile-onset SLE B cells and monocytes. However, juvenile-onset SLE patient plasma and matched urine samples were positive by ELISA for the soluble form of the NKG2D ligands mICA and mICB, suggesting that kidney and/or peripheral blood may constitute the NKG2DL positive microenvironments driving NKG2D+CD4 T cell population expansions in this disease.

关键词： NKG2D Ligands NKG2D+ CD4 T Cells Juvenile-Onset Systemic Lupus Erythematosus B Cells monocytes

Ovarian autoimmune disease： clinical concepts and anima models

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Cellular & molecular Immunology 2014年第6期11卷 510-521页

作者： Bryce D Warren William K Kinsey Lynda K mcGinnis Lane K Christenson Susmita Jasti anne m stevens Brian K Petroff margaret G Petroff Department of Anatomy and Cell Biology University of Kansas Medical Center Kansas City KS USA Department of molecular and Integrative Physiology University of Kansas Medical Center Kansas City KS USA Research Center for Immunity and I mmunotherapies Children's Hospital and Regional Medical Center and Division of Rheumatology Department of Pediatrics University of Washington Seattle WA USA Department of Internal medicine University of Kansas Medical Center Kansas City KS USA Present address: Department of Pathobiology and Diagnostic Investigation Michigan State University College of Veterinary Medicine East Lansing MI USA

The ovary is not an immunologically privileged organ, but a breakdown in tolerogenic mechanisms for ovary-specific antigens has disastrous consequences on fertility in women, and this is replicated in murine models of autoimmune disease. Isolated ovarian autoimmune disease is rare in women, likely due to the severity of the disease and the inability to transmit genetic information conferring the ovarian disease across generations. Nonetheless, autoimmune oophoritis is often observed in association with other autoimmune diseases, particularly autoimmune adrenal disease, and takes a toll on both society and individual health. Studies in mice have revealed at least two mechanisms that protect the ovary from autoimmune attack. These mechanisms include control of autoreactive T cells by thymus-derived regulatory T cells, as well as a role for the autoimmune regulator （AIRE）, a transcriptional regulator that induces expression of tissue-restricted antigens in medullary thymic epithelial cells during development of T cells. Although the latter mechanism is incompletely defined, it is well established that failure of either results in autoimmune-mediated targeting and depletion of ovarian follicles. In this review, we will address the clinical features and consequences of autoimmune-mediated ovarian infertility in women, as well as the possible mechanisms of disease as revealed by animal models.

关键词：不育家庭特征卵巢卵巢炎模型动物生育力胸腺胰岛素小鼠

Phosphorylation of the Pseudomonas Effector AvrPtoB by Arabidopsis SnRK2.8 Is Required for Bacterial Virulence

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molecular Plant 2020年第10期13卷 1513-1522页

作者： Lei Lei Danielle m.stevens Gitta Coaker Department of Plant Pathology University of CaliforniaDavisDavisCAUSA

A critical component controlling bacterial virulence is the delivery of pathogen effectors into plant cells during *** alter host metabolism and immunity for the benefit of *** effectors are phosphorylated by host kinases,and this posttranslational modification is important for their *** sought to identify host kinases involved in effector *** phosphorylated effector residues matched the proposed consensus motif for the plant calcium-dependent protein kinase(CDPK)and Snf1-related kinase(SnRK)*** conserved Pseudomonas effector AvrPtoB acts as an E3 ubiquitin ligase and promotes bacterial *** this study,we identified a member of the Arabidopsis SnRK family,SnRK2.8,which interacts with AvrPtoB in yeast and in *** showed that SnRK2.8 was required for AvrPtoB virulence functions,including facilitating bacterial colonization,suppression of callose deposition,and targeting the plant defense regulator NPR1 and analyses receptor *** spectrometry analysis revealed that AvrPtoB phosphorylation occurs at multiple serine residues in planta,with S258 phosphorylation significantly reduced in the snrk2.8 *** phospho-'null'mutants exhibited compromised virulence functions and were unable to suppress NPR1 accumulation,FLS2 accumulation,or inhibit FLS2-BAK1 complex formation upon flagellin *** together,these data identify a conserved plant kinase utilized by a pathogen effector to promote disease.

关键词： Arabidopsis Pseudomonas syringae effector AvrPtoB kinase SnRK2.8

NEXT NEAREST NEIGHBOR EFFECT ON TETRAHEDRAL FERROUS AND OCTAHEDRAL FERRIC IRON IN CHROmITE

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Science China Chemistry 1986年第8期29卷 889-896页

作者：李哲,J.G.stevens Institute of Geology Academia Sinica Beijing mssbauer Effect Data Center University of North Carolina Asheville U. S. A.

Four chromites have been studied by using mssbauer spectroscopy. Of the spectra of four chromites studied, three spectra aro fitted to three or four Fe2+doublets in the tetrahedral A sites and one or two Fe3+doublets in the tetrahedral A sites and octahedral B sites. The fourth spectrum is fitted to one Fe3+doublet in the A sites and two Fe3+doublets in tho B sites. Constant isomer shifts of approximately 0.9 mm/s for Fe2+ions in the A sites and 0.3 mm/s for Fe3+ions in the B sites as well as gradual changing quadrupole splitting for both of the A sites and the B sites are obtained. The binomial distributions in the B sites are ealeulated. Next nearest neighbor effect is used to explain the multiple doublets caused by Fe2+ions in the A sites in the spectra of chromites Ⅰ, Ⅱ, Ⅲ and by Fe3+ions in the B sites in the spectrum of chromite Ⅳ.

关键词： tetrahedral octahedral fitted NEXT neighbor explain nearest splitting fourth umber

Acute Kidney Injury in Patients with Cirrhosis

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Journal of Clinical and Translational Hepatology 2015年第3期3卷 195-204页

作者： Kirk B.Russ Todd m stevens Ashwani K.Singal Department of Internal medicine UAB Birmingham AL USA Department of Anatomic Pathology UAB Birmingham AL USA Division of Gastroenterology and Hepatology UAB Birmingham AL USA

Acute kidney injury (AKI) occurs commonly in patients with advanced cirrhosis and negatively impacts pre-and posttransplant *** changes that occur in patients with decompensated cirrhosis with ascites,place these patients at high risk of *** most common causes of AKI in cirrhosis include prerenal injury,acute tubular necrosis (ATN),and the hepatorenal syndrome (HRS),accounting for more than 80% of AKI in this *** between these causes is particularly important for prognostication and *** of Type 1 HRS with vasoconstrictors and albumin improves short term survival and renal function in some patients while awaiting liver *** with HRS who fail to respond to medical therapy or those with severe renal failure of other etiology may require renal replacement *** liver kidney transplant (SLK) is needed in many of these patients to improve their post-transplant ***,the criteria to select patients who would benefit from SLK transplantation are based on consensus and lack strong evidence to support *** this regard,novel serum and/or urinary biomarkers such as neutrophil gelatinase-associated lipocalin,interleukins-6 and 18,kidney injury molecule-1,fatty acid binding protein,and endothelin-1 are emerging with a potential for accurately differentiating common causes of *** studies are needed on the use of these biomarkers to predict accurately renal function recovery after liver transplantation alone in order to optimize personalized use of SLK.

关键词： Acute kidney injury Cirrhosis Liver transplantation SLK

Characterizing the patient experience during neoadjuvant therapy for pancreatic ductal adenocarcinoma:A qualitative study

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1175-1186页

作者： Lena stevens Zachary J Brown Ryan Zeh Christina monsour Sharla Wells-Di Gregorio Heena Santry Aslam m Ejaz Timothy michael Pawlik Jordan m Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of General Surgery University of Pittsburgh Medical CenterPittsburghPA 15213United States Department of Psychiatry Center for Palliative CareThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUND Neoadjuvant therapy(NT)has increasingly been utilized for patients with localized pancreatic ductal adenocarcinoma(PDAC).It is the recommended approach for borderline resectable(BR)and locally advanced(LA)cancers and an increasingly utilized option for potentially resectable(PR)*** its increased use,little research has focused on patient-centered metrics among patients undergoing NT,including patient experiences,preferences,and recommendations.A better understanding of all aspects of the patient experience during NT may identify opportunities to design interventions aimed at improving quality of life;it may also facilitate the completion of NT and receipt of surgery,ultimately optimizing long-term *** To understand the experience of patients initiating and receiving NT to identify opportunities to improve neoadjuvant cancer care *** Semi-structured interviews of patients with localized PDAC during NT were conducted to explore their experience initiating and receiving *** took place between August 2020 and October *** to the descriptive nature of the research,questions were open *** were conducted over the phone,audio recorded and then *** interviews were coded by two independent researchers using NVivo 12,iteratively identifying themes until thematic saturation was *** integrative approach to qualitative analysis was used,utilizing both inductive and deductive *** A total of 12 patients with localized PDAC were *** with BR(n=7),PR(n=2),and LA(n=3)cancers participated in the *** patients indicated that choosing NT was the doctor’s recommendation,while most reported not being familiar with the concept of NT(n=11)and that NT was presented as the only option(n=8).Five themes describing the patient experience emerged:physical symptoms,emotional symptoms,coping mechanisms,access to care,and life *** most commonly cited recommendation for

关键词： Pancreatic ductal adenocarcinoma Neoadjuvant therapy Patient experience Patient-centered care Quality of life Qualitative research

Risk factors for liver disease among adults of mexican descent in the United States and mexico

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World Journal of Gastroenterology 2018年第37期24卷 4281-4290页

作者： Yvonne N Flores Zuo-Feng Zhang Roshan Bastani mei Leng Catherine m Crespi Paula Ramírez-Palacios Heather stevens Jorge Salmerón Unidad de Investigación Epidemiológica y en Servicios de Salud Delegación MorelosInstituto Mexicano del Seguro SocialCuernavacaMorelos 62000México UCLA Department of Health Policy and management and Kaiser Permanente Center for Health Equity Fielding School of Public HealthLos AngelesCA 90095United States UCLA Cancer Prevention and Control Research Center Fielding School of Public Health and Jonsson Comprehensive Cancer CenterLos AngelesCA 90095United States UCLA Division of General Internal medicine and Health Services Research Los AngelesCA 90095United States UCLA Department of Biostatistics Fielding School of Public HealthLos AngelesCA 90095United States University of Washington School of MedicineSeattleWA 98195United States Universidad Nacional Autónoma de méxico Academic Epidemiology Research UnitAvenida Universidad 3000Ciudad UniversitariaCoyoacánMexico City 04510México Centro de Investigación en Salud Poblacional Instituto Nacional de Salud PúblicaCuernavacaMorelos 62100México

AIm To compare the prevalence of chronic liver disease(CLD) risk factors in a representative sample of mexicanAmericans born in the United States(US) or mexico, to a sample of adults in *** Data for mexican-Americans in the US were obtained from the 1999-2014 National Health and Nutrition Examination Survey(NHANES), which includes persons of mexican origin living in the US(n = 4274). The NHANES sample was restricted to mexican-American participants who were 20 years and older, born in the US or mexico, not pregnant or breastfeeding, and with medical *** data in mexico were obtained from the 2004-2013 Health Worker Cohort Study in Cuernavaca, mexico(n =9485). The following known risk factors for liver disease/cancer were evaluated: elevated aminotransferase levels(elevated alanine aminotransferase was defined as > 40 IU/L for males and females; elevated aspartate aminotransferase was defined as > 40 IU/L for males and females), infection with hepatitis B or hepatitis C,metabolic syndrome, high total cholesterol, diabetes,obesity, abdominal obesity, and heavy alcohol use. The main independent variables for this study classified individuals by country of residence(i.e., mexico vs the US) and place of birth(i.e., US-born vs mexico-born).Regression analyses were used to investigate CLD risk *** After adjusting for socio-demographic characteristics,mexican-American males were more likely to be obese,diabetic, heavy/binge drinkers or have abdominal obesity than males in mexico. The adjusted multivariate results for females also indicate that mexican-American females were significantly more likely to be obese, diabetic, be heavy/binge drinkers or have abdominal obesity than mexican females. The prevalence ratios and prevalence differences mirror the multivariate analysis findings for the aforementioned risk factors, showing a greater risk among US-born as compared to mexico-born mexicanAmericans. CONCLUSION In this study, mexican-Americans i

关键词： Liver disease Risk factors Health disparities mexico mexican Americans Latinos

The antioxidant status in human population based on the concept of prakruthi in Ayurveda

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Asian Pacific Journal of Tropical medicine 2008年第4期1卷 40-43页

作者： madhukar mallya H Revathi P Shenoy Sreejith Ramakrishnan Linta Thampi Rashmi stevens m Sethukumar Kamath Anupama Nayak Anjali Rao Department of Biochemistry Kasturba Medical College and HospitalManipal-576104KarnatakaIndia Department of Ayurveda Kasturba Medical College and HospitalManipal-576104KarnatakaIndia Department of Biochemistry Kasturba medical College and Hospital Manipal-576104KarnatakaIndia

Objective:In the Ayurvedic system of medicine,body constitution(prakruthi) is said to play a vital role in the disease process as well as in its *** radical toxicity is also involved in the etiopathogenesis of many ***,in the present study an attempt has been made to correlate the body constitution type and the antioxidant status of that ***:Healthy volunteers from manipal University Campus, South Karnataka,India were classified into three main human constitutions(prakruthi) and their possible combinations and their serum total antioxidant activity was ***:There was a significant negative correlation of the total antioxidant status with the pitta prakruthi whereas vata and kapha constitutions showed no significant correlation with the total antioxidant ***:Ayurveda classifies each individual based on his/her prakruthi into three categories of Doshas:Vata,Pitta and Kapha(collectively known as Tridoshas ). The three Doshas are fundamental regulatory principles responsible for maintaining organism functioning and manifesting those characteristics typifying each individual,that is,in equilibrium Tridoshas signify health and an imbalance leads to ***,in this study a significantly decreased antioxidant status in the Pitta group would render them more susceptible to damage by oxidative ***,we suggest that supplementation with antioxidants of herbal(Ayurvedic) origin to such a group would prove to be beneficial - opening up the arena for pharmacogenomics and customized antioxidant drug administration based on the prakruthi of an individual.

关键词： Ayurveda Antioxidant status Prakruthi Vata Pitta Kapha

Ternary Ni-Co-Fe oxyhydroxide oxygen evolution catalysts:Intrinsic activity trends,electrical conductivity,and electronic band structure

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Nano Research 2019年第9期12卷 2288-2295页

作者： michaela Burke stevens Lisa J. Enman Ester Hamal Korkus Jeremie Zaffran Christina D. m. Trang James Asbury matthew G. Kast maytal Caspary Toroker Shannon W. Boettcher Department of Chemistry & Biochemistry and the materials Science Institute University of OregonEugeneOR 97403USA Department of materials Science & Engineering and The Nancy & Stephen Grand Technion Energy Program Technion Israel Institute of TechnologyHaifa 3200003Israel

Nickel-,cobalt-,and iron-based(oxy)hydroxides comprise the most-commonly studied electrocatalysts for the oxygen-evolution reaction(OER)in alkaline solution.A fundamental understanding of composition-structure-activity relationships for mixed-metal Ni-Co and Ni-Co-Fe(oxy)hydroxides is important to guide the design of advanced OER *** we use cyclic voltammetry,chronopotentiometry,inductively-coupled plasma-optical emission spectroscopy,and in situ electrical conductivity measurements to characterize the properties and activity of various compositions of Ni-Co-Fe(oxy)hydroxides prepared by cathodic *** with previous studies,we find Fe is essential for the mixed-metal(oxy)hydroxides to achieve high OER *** the rigorous absence of Fe(achieved by using specially cleaned electrolytes),the most-active Ni-Co(oxy)hydroxide composition has an OER turn-over frequency only twice that ofpure Co(oxy)hydroxide,suggesting minimal synergism between the two *** addition of Co to Ni-Fe(oxy)hydroxides shifts the onset of electrical conductivity to lower potentials,but has little effect on the intrinsic OER activity,with the most-active Ni-Co-Fe(oxy)hydroxide having an OER turn-over frequency only -1.5 times that of the Ni-Fe(oxy)*** magnitudes of the electrical conductivities are similar for all the compositions ***-functional-theory-calculated projected density of states show a significant contribution of all chemical elements at the valence band edge of the mixed-metal oxyhydroxide electronic structure,demonstrating significant electronic hybridization between the *** calculations suggest the involvement of all the elements in modulating the electronic structure at putative Fe-based active sites that are probably located at edges or defects in the two-dimensional oxyhydroxide sheets.

关键词： electrocatalysis heterogeneous catalysis water electrolysis oxygen evolution density functional theory

metastatic recurrence to a solitary lymph node four years after hepatic lobectomy for primary hepatocellular carcinoma

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World Journal of Hepatology 2016年第23期8卷 994-998页

作者： michael L Caparelli Nathan J Roberts Timothy S Braverman Robert m stevens Edward R Broun Shyam Allamaneni Department of Surgery the Jewish Hospital Department of Pathology the Jewish Hospital Department of Radiology the Jewish Hospital Department of Oncology Hematology Care Inc.

This report describes a patient that developed recurrent metastatic hepatocellular carcinoma(HCC) to a suprapancreatic lymph node four years after being treated for primary HCC via complete left hepatectomy. metastatic HCC was proven by pathologic confirmation. The report addresses the role of surgical resection as a treatment modality for recurrent HCC to solitary lymph nodes. The role of biological chemotherapy as adjuvant treatment is also addressed.

关键词： Hepatocellular carcinoma Lymph node Recurrence metastatic Extrahepatic