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Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome

World journal of Gastroenterology 2010年第36期16卷 4532-4540页

作者： Erja Malinen Lotta Krogius-Kurikka janne Nikkil Airi Palva Anna Lyra anne jskelinen Teemu Rinttil Terttu Vilpponen-Salmela Atte johannes von Wright Department of Veterinary Biosciences Faculty of Veterinary MedicineUniversity of Helsinki00014 HelsinkiFinland Danisco Sweeteners Health and Nutrition02460 KantvikFinland Department of Clinical Nutrition Institute of Public Health and Clinical NutritionFaculty of Health SciencesUniversity of Eastern Finland70211 KuopioFinland Alimetrics Ltd. Koskelontie 19 B02920 EspooFinland Kuopio Harjula Hospital 70101 KuopioFinland Department of Biosciences University of Eastern Finland70211 KuopioFinland

AIM:To investigate the correlations between selfreported symptoms of irritable bowel syndrome(IBS) and the gastrointestinal(GI) microbiota ***:Fecal samples were collected from a total of 44 subjects diagnosed with *** symptoms were monitored with a validated inflammatory bowel disease questionnaire adjusted for IBS *** quantitative real-time polymerase chain reaction assays were applied to evaluate the GI microbiota *** and GI bacterial genera(Bifidobacterium,Lactobacillus and Veillonella),groups(Clostridium coccoides/Eubacterium rectale,Desulfovibrio desulfuricans) and distinct bacterial phylotypes [closest 16S rDNA sequence resemblance to species Bifidobacterium catenulatum,Clostridium cocleatum,Collinsella aerofaciens(***),Coprococcus eutactus(***),Ruminococcus torques and Streptococcus bovis ] with a suspected association with IBS were *** between quantities or presence/absence data of selected bacterial groups or phylotypes and various IBSrelated symptoms were ***:Associations were observed between subjects' self-reported symptoms and the presence or quantities of certain GI bacteria.A Ruminococcus torques(***)-like(94% similarity in 16S rRNA gene sequence) phylotype was associated with severity of bowel ***,among IBS subjects with *** 94% detected,the amounts of *** 88%,***-like and *** 97% phylotypes were significantly *** observations were also made concerning the effect of a subject's weight on GI microbiota with regard to *** like phylotype,Bifidobacterium *** Lactobacillus ***:Bacteria seemingly affecting the symptom scores are unlikely to be the underlying cause or cure of IBS,but they may serve as biomarkers of the condition.

关键词： Irritable bowel syndrome Self-reported symptoms Gastrointestinal microbiota Quantitative realtime polymerase chain reaction

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui jo anne Stratton G.R.Wayne Moore jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Surfactant protein A (SP-A) binds to phosphatidylserine and competes with annexin V binding on late apoptotic cells

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Protein & Cell 2010年第2期1卷 188-197页

作者： anne jäkel Kenneth B.M.Reid Howard Clark Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK MRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK University of Southampton MP 803 Level FSouth BlockSouthampton General HospitalSouthampton SO166YDUK

The role of surfactant protein A(SP-A)in the recognition and clearance of apoptotic cells is well established,but to date,it is still not clear which surface molecules of apoptotic cells are involved in the *** we present evidence that phosphatidylserine(PS)is a relevant binding molecule for human *** binding is Ca^(2+)-dependent and is not inhibited by mannose,suggesting that the sugar-binding site of the carbohydrate recognition domain(CRD)of SP-A is not *** cytometry studies on apoptotic jurkat cells revealed apparent inhibition of annexin V binding by increasing concentrations of SP-A in late apoptotic but not early apoptotic cells,and this was consistent for jurkat cells and *** these data,confocal microscopy results show a co-localisation of annexin V and SP-A in late apoptotic but not early apoptotic ***,we cannot conclude that this inhibition is exclusively due to the binding of SP-A to PS on the cell surface,as annexin V is not wholly specific for PS and SP-A also interacts with other phospholipids that might become exposed on the apoptotic cell surface.

关键词： surfactant proteins phosphatidylserine apoptotic cells

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An Investigation of Freezing of Supercooled Water on Anti-Freeze Protein Modified Surfaces

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journal of Bionic Engineering 2013年第2期10卷 139-147页

作者： Thibaut V j Charpentier anne Neville Paul Millner Rob Hewson Ardian Morina Institute of Engineering Thermofluids Surfaces and Interfaces (iETSI) Mechanical Engineering University of Leeds LS2 9JT Leeds UK

This work investigates how functionalization of aluminium surfaces with natural type III Anti-Freeze Protein （AFP） affects the mechanism of heterogeneous ice nucleation. First the bulk ice nucleation properties of distilled water and aqueous solution of AFP were evaluated by differential scanning calorimetry. Then the modified surface was characterized by Secondary Ions Mass Spectroscopy （SIMS）, Fourier Transform InfraRed （FTIR） spectroscopy and contact angle measurement. Freezing experiments were then conducted in which water droplets underwent a slow controlled cooling. This study shows that compared to uncoated aluminium, the anti-freeze proteins functionalized surfaces exhibit a higher and narrower range of freezing temperature. It was found that these proteins that keep living organisms from freezing in cold environment act in the opposite way once immobilized on surfaces by promoting ice nucleation. Some suggestions regarding the mechanism of action of the observed phenomena were proposed based on the Classical Nucleation Theory （CNT）.

关键词： anti-freeze protein surface functionalization ice nucleation temperature ice-like monolayer

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Systemic inflammation in colorectal cancer: Underlying factors,effects, and prognostic significance

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World journal of Gastroenterology 2019年第31期25卷 4383-4404页

作者： anne E Tuomisto Markus j Makinen juha P Vayrynen Cancer and Translational Medicine Research Unit University of OuluOulu 90220Finland Department of Pathology Oulu University Hospital and Medical Research Center OuluOulu 90220Finland Department of Medical Oncology Dana-Farber Cancer Institute and Harvard Medical SchoolBostonMA 02115United States

Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-40%of colorectal cancer *** hallmarks of systemic inflammation include an increased production of proinflammatory cytokines and acute phase proteins that enter the *** the low-level systemic inflammation is often clinically silent,its consequences are many and may ultimately lead to chronic cancer-associated wasting,*** this review,we discuss the pathogenesis of cancer-related systemic inflammation,explore the role of systemic inflammation in promoting cancer growth,escaping antitumor defense,and shifting metabolic pathways,and how these changes are related to less favorable outcome.

关键词： Colorectal cancer Inflammation Prognosis Cytokine Chemokine C-reactive protein Glasgow prognostic score Cachexia Metastasis

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Intervention Research and Support Systems for People Affected by Cancer and Their Families:Results of a Descriptive Analysis

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Psycho-Oncologie 2023年第3期17卷 113-121页

作者： anne-Fleur Guillemin Iris Cervenka jérôme Foucaud Institut national du cancer(INCa) Boulogne-Billancourt92100France

Population health intervention research(PHIR)was initiated in the field of primary prevention by proposing a research paradigm focusing on intervention and the theory of *** intervention was coconstructed with the stakeholders as part of a global approach until its deployment in the local *** development of PHIR raises the question of its application to tertiary *** study proposes some initial thoughts on the similarities and specificities of PHIR projects-funded by the French National Cancer Institute(INCa)-of support systems for people affected by cancer and their families,which were based on a descriptive *** selected projects were obtained from the databases of PHIR projects funded from 2010 to 2021,which included 72 projects to which the inclusion and exclusion criteria were applied.A descriptive analysis was carried out for each project using the application files and the interim or final reports sent to INCa.A total of 30 projects were selected,half of which were in the public health *** all of the projects involved a university–hospital partnership,and one-third involved healthcare professionals and patients in the research *** involvement was classified into four types,which were linked to the supporting structure and the target *** main themes of the projects were quality of life and adapted physical activity,which were assessed in hospitals through randomized controlled trials targeting specific *** has revealed several specificities and similarities between support systems for people affected by cancer and their families developed in PHIR projects;however,these support systems vary widely,and PHIR in tertiary prevention can be conducted in several *** modeling of the systems is complicated;PHIR is evolving in its application and is the subject of research and evaluation.

关键词： Public policy funding research support systems partners patient involvement

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ESTIMATION AND UNCERTAINTY QUANTIFICATION FOR PIECEWISE SMOOTH SIGNAL RECOVERY

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journal of Computational Mathematics 2023年第2期41卷 246-262页

作者： Victor Churchill anne Gelb Department of Mathematics The Ohio State UniversityColumbusOHUSA Department of Mathematics Dartmouth CollegeHanoverNHUSA

This paper presents an application of the sparse Bayesian learning(SBL)algorithm to linear inverse problems with a high order total variation(HOTV)sparsity *** the problem of sparse signal recovery,SBL often produces more accurate estimates than maximum a posteriori estimates,including those that useℓ1 ***,rather than a single signal estimate,SBL yields a full posterior density estimate which can be used for uncertainty ***,SBL is only immediately applicable to problems having a direct sparsity prior,or to those that can be formed via *** paper demonstrates how a problem with an HOTV sparsity prior can be formulated via synthesis,and then utilizes *** expands the class of problems available to Bayesian learning to include,e.g.,inverse problems dealing with the recovery of piecewise smooth functions or signals from *** examples are provided to demonstrate how this new technique is effectively employed.

关键词： High order total variation regularization Sparse Bayesian learning Analysis and synthesis Piecewise smooth function recovery

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GREEN ROOFING IN INDIANA: CASE STUDIES AND DESIGN NOTES

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journal of Green Building 2010年第3期5卷 50-68页

作者： anne Altor Tierra Verde Consulting

Green roof technology and implementation are taking root in North America at an accelerating *** recogni-tion of the benefits of green roofs and increasing interest in green infrastructure are leading to expansion of green roof tech-nologies that have been in use for decades in Europe and *** some regions have adopted the use of green roofs on a large scale,other areas are warming up to the concept more ***-scale implementation of green roofs has not yet occurred in Indiana,but a number of exemplary projects have been constructed,and there are signs that interest in the technology is increasing in the *** purpose of this article is to provide an overview of green roof technology,analyze selected green roofs in Indiana,explore trends in the state,and address issues for future development of green roof technol-ogy in the region.A variety of green roofs were investigated throughout the *** were held with individuals involved in each project to obtain technical and logistical details of green roof design,installation,and performance.

关键词： green roof technology green roof design and installation green roof maintenance and performance stormwater management modular versus loose laid systems energy efficiency

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Implementation of an in-house flow cytometric analysis of DNA fragmentation in spermatozoa

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Asian journal of Andrology 2020年第3期22卷 246-251页

作者： anne Sofie Rex Chunsen Wu jorn Aagaard jens Fedder Centre of Andrology and Fertility Clinic Odense University HospitalOdense 5000Denmark Aagaard Gynaecological Clinic Skejby 8200AarhusDenmark Research Unit of Gynaecology and Obstetrics Faculty of HealthUniversity of Southern DenmarkOdense 5000Denmark.

An increased amount of DNA fragme ntation in the spermatozoa(SDF)is linked to male in *** Sperm Chromati n Structure Assay(SCSA)is widely used for analysis of ***,the current software(SCSASoftR)linked to this assay is licensed and often located within larger diagnostic *** this study,we present a protocol for using other types of software than SCSASoftR to determine the SDF index(DFI)with clinical *** protocol is engineered after collect!ng and analyzing 254 samples from fertility patients and sperm donors over a 15-month *** is analyzed using a strict protocol where the spermatozoa are treated with a strong acid(pH 1.2)followed by acridine *** is determined by a standard flow cytometric software,FACSDiva *** of the outcome of the fertility treatment is included for 137 patients receiving either intrauterine inseminations(IUI)or timed coitus(TC).The results show that the chance of pregnancy decli nes as DFI in *** also found that the male DFI affects the chanee of pregnancy independent of the female *** have shown that a standard flow cytometric software can be used when determi ning a clinical releva nt *** findings are a sign ificant step toward impleme nting the an alysis as a part of the routi ne,in・house diag no sing of the male fertility patient and subseque ntly optimizing the treatme nt course of the couple with reduced human and financial costs.

关键词： DNA fragme ntation flow cytometry in-house an alysis in trauteri ne in semi natio n Sperm Chromati n Structure Assay spermatozoa

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Isoform-and cell-state-specific APOE homeostasis and function

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Neural Regeneration Research 2024年第11期19卷 2456-2466页

作者： Karina Lindner anne-Claude Gavin Department of Cell Physiology and Metabolism Faculty of MedicineUniversity of GenevaGenevaSwitzerland Diabetes Center Faculty of MedicineUniversity of GenevaGenevaSwitzerland

Apolipoprotein E is the major lipid transporter in the brain and an important player in neuron-astrocyte metabolic *** ensures the survival of neurons under stressful conditions and hyperactivity by nourishing and detoxifying *** E polymorphism,combined with environmental stresses and/or age-related alterations,influences the risk of developing late-onset Alzheimer’s *** this review,we discuss our current knowledge of how apolipoprotein E homeostasis,*** synthesis,secretion,degradation,and lipidation,is affected in Alzheimer’s disease.

关键词： Alzheimer’s disease apolipoprotein E autophagy cholesterol lipid detoxification lipid transport lysosomal failure metabolic impairment triacylglycerol

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