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Single-chain variable fragment antibody constructs neutralize measles virus infection in vitro and in vivo

Cellular & Molecular Immunology 2021年第7期18卷 1835-1837页

作者： Cyrille Mathieu Marion Ferren Olivia Harder Francesca TBovier Tara CMarcink Camilla Predella Fabrizio Angius Jennifer Drew-Bear NValerio Dorrello Alex LGreninger anne moscona Stefan Niewiesk Branka Horvat Matteo Porotto Center for Host-Pathogen Interaction Columbia University Vagelos College of Physicians and SurgeonsNew YorkNYUSA Department of Pediatrics Columbia University Vagelos College of Physicians and SurgeonsNew YorkNYUSA CIRI Centre International de Recherche en InfectiologieTeam IBIVUniv LyonInsermU1111UniversitéClaude Bernard Lyon 1CNRSUMR5308ENS de LyonF-69007LyonFrance Department of Veterinary Biosciences College of Veterinary MedicineThe Ohio State UniversityColumbusOHUSA epartment of Experimental Medicine UniversitàVanvitelliCasertaItaly Department of Laboratory Medicine University of Washington School of MedicineSeattleWAUSA Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research CenterSeattleWAUSA Department of Microbiology&Immunology Columbia University Vagelos College of Physicians and SurgeonsNew YorkNYUSA Department of Physiology&Cellular Biophysics Columbia University Vagelos College of Physicians and SurgeonsNew YorkNYUSA

Despite the availability of an effective measles virus(MeV)vaccine and efforts to increase vaccine coverage by the WHO,UNICEF,and their partners,MeV has not been eradicated,and the estimated global measles death rose from 89,780 in 2016 to 207,500 in 2019.1 Because there is an effective measles vaccine,antiviral development for measles has not been prioritized,but recent outbreaks have highlighted the need for drugs to prevent transmission in unvaccinated populations and to protect and treat immunocompromised *** identified several neutralizing mouse monoclonal antibodies(mAbs)that target the MeV fusion(F)protein in its prefusion state2 and inhibit fusion and viral *** engineered a single-chain variable fragment(scFv)from the most potent anti-MeV F *** scFv retains the ability to inhibit fusion and prevents infection in vitro,and intranasal administration of the scFv antibody construct prevents infection in vivo.

关键词： neutral priori UNICEF

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