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Evolutionary consequences of deception： Complexity and informational content of colony signature are favored by social parasitism

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Current Zoology 2014年第1期60卷 137-148页

作者： Maria Cristina LORENZI Laura AZZANI anne-Genevieve BAGNRRES Department of Life Sciences and Systems Biology University of Turin via Accademia Albertina 13 10123 Torino Italy I.R.B.I. - UMR CNRS 7261 - Universit6 de Tours Facult6 des Sciences Parc Grandmont 37200 Tours France

Nestmate recognition codes show remarkable chemical complexity, involving multiple biochemical pathways. This complexity provides the opportunity to evaluate the ecological and social conditions that favor the evolution of complex signaling. We investigated how the chemical signatures of three populations of the social paper wasp Polistes biglumis differed in terms of concentration of hydrocarbons, proportions of branched hydrocarbons and overall variation. We tested whether the variation in chemical signatures among populations could be explained by the prevalence of social parasites or whether this was just an effect of local abiotic conditions which influenced the composition of the hydrocarbon cuticular layer. We studied the chemical signa- ture in three populations in which obligate social parasites differed in the selection pressures they imposed on host populations. Within each population, we restricted our analyses to non-parasitized hosts, to avoid potential short-term effects of parasite pres- ence on the host chemical signatures. We found that host colonies in parasitized populations had more diverse profiles than the parasite-free population. Moreover, the overall concentration of hydrocarbons and the relative proportion of branched hydrocar- bons were larger in the parasitized populations, relative to the non-parasitized one. This is to our knowledge the first evidence in favour of the hypothesis that different traits in the host chemical signatures as a whole undergo evolutionary changes resulting from directional or balancing selection imposed by social parasites. We conclude that obligate social parasites act as ＇engines of diversity＇ on host chemical signatures and operate in favor of a geographic mosaic of diverging communication codes

关键词： Polistes Brood parasitism Cipher Nestmate recognition Hydrocarbons Geographic mosaic Crozier's paradox

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Macrophage polarization in nerve injury： do Schwann cells play a role？

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Neural Regeneration Research 2016年第1期11卷 53-57页

作者： Jo anne Stratton Prajay T.Shah Department of Clinical Neurosciences University of Calgary Calgary Canada Hotchkiss Brain Institute Calgary Canada Department of Comparative Biology and Experimental Medicine University of Calgary Calgary Canada

In response to peripheral nerve injury, the inflammatory response is almost entirely comprised of infiltrating macrophages. Macrophages are a highly plastic, heterogenic immune cell, playing an indispensable role in peripheral nerve injury, clearing debris and regulating the microenvironment to allow for efficient regeneration. There are several cells within the microenvironment that likely interact with macrophages to support their function – most notably the Schwann cell, the glial cell of the peripheral nervous system. Schwann cells express several ligands that are known to interact with receptors expressed by macrophages, yet the effects of Schwann cells in regulating macrophage phenotype remains largely unexplored. This review discusses macrophages in peripheral nerve injury and how Schwann cells may regulate their behavior.

关键词： nerve macrophage traumatic injury Schwann cells polarization

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Wetting of pure aluminium on graphite,SiC and Al_2O_3 in aluminium filtration

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Transactions of Nonferrous Metals Society of China 2012年第8期22卷 1930-1938页

作者：包萨日娜唐恺 anne KVITHYLD Thorvald ENGH Merete TANGSTAD Department of Materials Science and Engineering Norwegian University of Science and TechnologyNO-7491TrondheimNorway SINTEF Materials and Chemistry NO-7465TrondheimNorway

The wettability of pure aluminium on filter materials and on inclusions is believed to be an important factor affecting the filtration of aluminium. The contact angles of molten aluminium on alumina, SiC and graphite were measured under 10-8 bar high vacuum in the temperature range of 1000-1300 °C. To describe the wetting behaviour of the Al on ceramic at lower temperatures used in filtration and casting aluminium, a semi-empirical calculation was employed. The calculated contact angles at 700 °C were around 97° for alumina, 92° for vitreous graphite, 126° for single- and poly-crystal graphite, and 79° for single crystal SiC, respectively. This indicates that aluminium does not wet alumina or graphite （or Al4C3） around the casting temperature, but wets SiC at this temperature. Thus a priming height is required for aluminium to infiltrate an alumina filter. Increasing temperature can also improve the wettability of Al on ceramic.

关键词： wettability contact angle aluminium alumina SiC graphite

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How virtual reality can help visualise and assess geohazards

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International Journal of Digital Earth 2019年第2期12卷 173-189页

作者： Hans-Balder Havenith Philippe Cerfontaine anne-Sophie Mreyen Georisk and Environment Department of GeologyUniversity of LiegeLiègeBelgium

Geohazard research requires extensive spatiotemporal understanding based on an adequate multi-scale representation of modelling *** most commonly applied representation basis for collected data is still the one of a 2D plane,typically a *** maps of spatial data can be visualised and processed by using Geographic Information *** is far less common to use 3D geomodels for the analysis and visualisation of spatial *** the visualisation of both spatial and temporal hazard components,there are no standardised *** claim that a full geohazard assessment is only possible inside a new type of geoscientific and technological environment that is at the same time multi-dimensional,spatiotemporal,integrated,fully interactive(tele-)immersive,and *** and subsurface processes are interacting at various scales that are difficult to be overviewed at *** Reality(VR)technology could provide an attractive solution to overcome the multi-dimensional and spatiotemporal *** review of geoscientific applications using VR technology developed by multiple teams around the world shows that some solutions have already been developed many years ago,but widespread use was not *** is clearly changing now and soon we will see if VR can contribute to a better understanding of geo-processes.

关键词： 4D geospace spatiotemporal analysis virtual environments immersive visualisation collaboration

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A robust test for growth hormone doping- present status and future prospects

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Asian Journal of Andrology 2008年第3期10卷 416-425页

作者： anne E. Nelson Ken K. Ho Pituitary Research Unit Garvan Institute of Medical Research Darlinghurst NSW 2010 Australia

Although doping with growth hormone （GH） is banned, there is anecdotal evidence that it is widely abused. GH is reportedly used often in combination with anabolic steroids at high doses for several months. Development of a robust test for GH has been challenging because recombinant human 22 kDa （22K） GH used in doping is indistinguishable analytically from endogenous GH and there are wide physiological fluctuations in circulating GH concentrations. One approach to GH testing is based on measurement of different circulating GH isoforms using immunoassays that differentiate between 22K and other GH isoforms. Administration of 22K GH results in a change in its abundance relative to other endogenous pituitary GH isoforms. The differential isoform method has been implemented; however, its utility is limited because of the short window of opportunity of detection. The second approach, which will extend the window of opportunity of detection, is based on the detection of increased levels of circulating GH-responsive proteins, such as insulin-like growth factor （IGF） axis and collagen peptides. Age and gender are the major determinants of variability for IGF-I and the collagen markers; therefore, a test based on these markers must take age into account for men and women. Extensive data is now available that validates the GH- responsive marker approach and implementation is now largely dependent on establishing an assured supply of standardized assays. Future directions will include more widespread implementation of both approaches by the World Anti-Doping Agency, possible use of other platforms for measurement and an athlete＇s passport to establish individual reference levels for biological parameters such as GH-responsive markers. Novel approaches include gene expression and proteomic profiling.

关键词： growth hormone doping athletes isoforms growth hormone-responsive markers

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How Properties that Distinguish Solids from Fluids and Constraints of Spherical Geometry Suppress Lower Mantle Convection

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Journal of Earth Science 2018年第1期29卷 1-20页

作者： anne M. Hofmeister Everett M. Criss Department of Earth and Planetary Sciences Washington University St. Louis MO 63130 USA Panasonic Avionics Corporation Lake Forest CA 92630 USA

The large magnitude of the dimensionless Rayleigh number （Ra-10^8） for Earth＇s -3 000 km thick mantle is considered evidence of whole mantle convection. However, the current formulation assumes behavior characteristic of gases and liquids and also assumes Cartesian geometry. Issues arising from neglecting physical properties unique to solids and ignoring the spherical shapes for planets include：（1） Planet radius must be incorporated into Ra, in addition to layer thickness, to conserve mass during radial displacements. （2） The vastly different rates for heat and mass diffusion in solids, which result from their decoupled transport mechanisms, promote stability. （3） Unlike liquids, sub- stantial stress is needed to deform solids, which independently promotes stability. （4） High interior compression stabilizes the mantle in additional minor ways. Therefore, representing conditions for convection in solid, self-gravitating spheroids, requires modifying formulae developed for bottom- heated fluids near ambient conditions under an invariant gravitational field. To derive stability criteria appropriate to solid spheres, we use dimensional analysis, and consider the effects of geometry, force competition, and microscopic behavior. We show that internal heating has been improperly ac- counted for in the Ra. We conclude that the lower mantle is stable for two independent reasons： heat diffusion far outpaces mass diffusion （creep） and yield strength of solids at high pressure exceeds the effective deviatoric stress. We discuss the role of partial melt in lubricating plate motion, and explain why the Ra is not applicable to the multi-component upper mantle. When conduction is insufficient to transport heat in the Earth, melt production and ascent are expected, not convection of solid rock.

关键词： plasticity diffusion mantle convection stability criteria dimensional analysis geometry.

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Evaluation of the Heat,Entropy,and Rotational Changes Produced by Gravitational Segregation during Core Formation

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Journal of Earth Science 2015年第1期26卷 124-133页

作者： anne M.Hofmeister Robert E.Criss Department of Earth and Planetary Sciences Washington University

Core formation by gravitational segregation allegedly released sufficient interior heat to melt the Earth. Analysis of the energetics, which compare gravitational potential energy （Ug） of a fictitious, homogeneous reference state to Earth＇s current layered configuration, needs updating to correct errors and omissions, and to accommodate recent findings：（1） An erroneous positive sign was used for Ug while maintaining the reference value of 0 at infinity, which results in an incorrect sign fur AUg, which is crucial in determining whether a process is endothermic or exothermic. （2） The value of Ug for Earth＇s initial state is uncertain. （3） Recent meteorite evidence indicates that core formation began before the Earth was full-sized, which severely limits AUg. （4） Inhomogeneous accretion additionally reduced AUg. （5） The potentially large effect of differential rotation between the core and the mantle was not accounted for. （6） Entropy changes associated with creating order were neglected. Accordingly, we revise values of Ug, evaluate uncertainties, and show that AUg was converted substantially to eonfigurational energy （TAS）. These considerations limit the large sources of primordial heat to impacts and radioactivity. Although these processes may play a role in core formation, their energies are independent of gravitational segregation, which produces order and rotational energy, not internal heat. Instead, gravitational segregation promotes planetary cooling mainly because it segregates lithophilic radioactive elements upward, increasing surface heat flux while shortening the distance over which radiogenic heat diffuses outwards.

关键词： core formation primordial heat configurational energy thermodynamics rotational energy.

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Integrate Omics Data and Molecular Dynamics Simulations toward Better Understanding of Human 14-3-3 Interactomes and Better Drugs for Cancer Therapy

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Journal of Genetics and Genomics 2015年第10期42卷 531-547页

作者： Jo anne J.Babula Jing-Yuan Liu Department of Pharmacology and Toxicology Indiana University School of Medicine Department of Computer and Information Science Indiana University Purdue University Indianapolis

The 14-3-3 protein family is among the most extensively studied, yet still largely mysterious protein families in mammals to date. As they are well recognized for their roles in apoptosis, cell cycle regulation, and proliferation in healthy cells, aberrant 14-3-3 expression has unsurprisingly emerged as instrumentalin the development of many cancers and in prognosis. Interestingly, while the seven known 14-3-3 isoforms in humans have many similar functions across cell types, evidence of isoform-specific functions and localization has been observed in both healthy and diseased cells The strikingly high similarity among 14-3-3 isoforms has made it difficult to delineate isoform-specific functions and for isoform-specific targeting. Here, we review our knowledge of 14-3-3 interactome（s） generated by high- throughput techniques, bioinformatics, structural genomics and chemical genornics and point out that integrating the information with molecular dynamics （MD） simulations may bring us new opportunity to the design of isoform-specific inhibitors, which can not only be used as powerful research tools for delineating distinct interactomes of individual 14-3-3 isoforms, but also can serve as potential new anti-cancer drugs that selectively target aberrant 14-3-3 isoform.

关键词： Interactome Chemical genomics Structural genomics Molecular dynamics simulation

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Identification of Arabidopsis MYB56 as a Nove Substrate for CRL3BPM E3 Ligases

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Molecular Plant 2015年第2期8卷 242-250页

作者： Liyuan Chen anne Bernhardt JooHyun Lee Hanjo Hellmann School of Biological Sciences Washington State University Abelson 435 Pullman WA 99164-4236 USA Present address: Plant Gene Expression Center UC Berkeley Albany CA 94710 USA present address: Robert Koch Institut 13353 Berlin Germany

Controlled stability of proteins is a highly efficient mechanism to direct diverse processes in living cells. A key regulatory system for protein stability is given by the ubiquitin proteasome pathway, which uses E3 ligases to mark specific proteins for degradation. In this work, MYB56 is identified as a novel target of a CULLIN3 （CUL3）-based E3 ligase. Its stability depends on the presence of MATH-BTB/POZ （BPM） proteins, which function as substrate adaptors to the E3 ligase. Genetic studies have indicated that MYB56 is a negative regulator of flowering, while BPMs positively affect this developmental program. The interaction between BPMs and MYB56 occurs at the promoter of FLOWERING LOCUS T （FT）, a key regulator in initiating flowering in Arabidopsis, and results in instability of MYB56. Overall the work establishes MYB transcription factors as substrates of BPM proteins, and provides novel information on components that participate in controlling flowering time in plants.

关键词： CUL3 BPM MYB transcription factor E3 ligase flowering

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Ependymal cells and multiple sclerosis: proposing a relationship

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Neural Regeneration Research 2020年第2期15卷 263-264页

作者： Dale Hatrock Nina Caporicci-nucci Jo anne Stratton The Montreal Neurological Institute McGill UniversityMontrealCanada Integrated Program in Neuroscience McGill UniversityMontrealCanada

Multiple sclerosis (MS) currently affects ~2.5 million people worldwide. MS is typically diagnosed in young adults and is usually not fatal, meaning people live long lives with MS. Affected individuals usually suffer from progressive physical and/or cognitive disability, often including fatigue (89.6%), depression (53.9%), memory loss (49.0%), motor or sensory dysfunction (76.4%, 70.4%) and urinary incontinence (50.8%).

关键词： multiple sclerosis relationship dysfunction

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