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Chrononutrition in traditional European medicine-ideal meal timing for car.iometabolic health promotion

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Journal of integrative Medicine 2024年第2期22卷 115-125页

作者： Nora Selena Eber.i Ludivine Colas anne Gimalac Department of Traditional European Medicine Navi Institute of Research in Integrative HealthEcole Professionnelle Superieure de NaturopathieCentre Andre Henzelin1066 EpalingesSwitzerland

Meal timing plays a crucial role for car.iometabolic health,given the circadian regulation of car.iometabolic ***,to the best of our knowledge,no concept of meal timing exists in traditional European medicine(TEM).Therefore,in this narrative review,we aim to define the optimal time slot for energy intake and optimal energy distribution throughout the day in a context of TEM and explore further *** reviewing literature published between 2002 and 2022,we found that optimal timing for energy intake may be between 06:00 and 09:00,12:00 and 14:00,and between 15:00 and18:00,with high energy breakfast,medium energy lunch and low energy dinner and possibly further adjustments accor.ing to one’s chronotype and ***,timing and distribution of energy intake may serve as a novel therapeutic strategy to optimize coction,a concept describing digestion and metabolism in TEM.

关键词： Circadian rhythm Chrononutrition Naturopathy Traditional European medicine Metabolic syndrome Meal timing

A numerical model to simulate the transient frictional viscoelastic sliding contact

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Friction 2024年第2期12卷 319-339页

作者： Dongze WANG Gregory de BOEr anne NEViLLE Ali GHANBArZADEH School of Mechanical Engineering University of LeedsLeeds LS29JTUK

Sliding motion has always been one of the major concerns when it comes to the analysis of viscoelastic contact problems.A new model simulating the transient sliding contact of smooth viscoelastic surfaces is developed in this *** taking the dry contact friction and the coupling between shear tractions and normal pressure into account,the effect of the early par.ial slip period,which is often neglected in the study of viscoelastic sliding contact problems,is investigated *** with solutions based on the frictionless assumption,the steady-state pressure profile is found to be slightly different under the effect of the par.ial slip regime,including a lower peak pressure and the shift of the contacting region in the direction opposite to the sliding ***,the time required for the viscoelastic contact to reach its steady state is delayed owing to the par.ial slip period preceding the global sliding motion.

关键词： contact mechanics frictional sliding viscoelasticity viscoelastic friction

Templated synthesis of transition metal phosphide electrocatalysts for oxygen and hydrogen evolution reactions

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Journal of Energy Chemistry 2024年第2期89卷 646-669,I0014页

作者： rose anne Acedera Alicia Theresse Dumlao DJ Donn Matienzo Maricor Divinagracia Julie anne del rosario Paraggua Po-Ya Abel Chuang Joey Ocon Laboratory of Electrochemical Engineering(LEE) Department of Chemical EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines Mechanical Engineering University of CaliforniaMercedCA 95343USA Energy Engineering Program College of EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines

Transition metal phosphides(TMPs)have been regarded as alternative hydrogen evolution reaction(HEr)and oxygen evolution reaction(OEr)catalysts owing to their comparable activity to those of noble metal-based *** have been produced in various morphologies,including hollow and porous nanostructures,which are features deemed desirable for electrocatalytic *** synthesis routes are often responsible for such *** paper reviews the latest advances and existing challenges in the synthesis of TMP-based OEr and HEr catalysts through templated methods.A comprehensive review of the structure-property-performance of TMP-based HEr and OEr catalysts prepared using different templates is *** discussion proceeds accor.ing to application,first by HEr and further divided among the types of templates used-from hard templates,sacrificial templates,and soft templates to the emer.ing dynamic hydrogen bubble *** catalysts are then reviewed and grouped accor.ing to their ***,prospective research directions for the synthesis of hollow and porous TMP-based catalysts,such as improvements on both activity and stability of TMPs,design of environmentally benign templates and processes,and analysis of the reaction mechanism through advanced material characterization techniques and theoretical calculations,are suggested.

关键词： OEr HEr Transition metal phosphide Templated synthesis Electrocatalysts

Assessing gully erosion and rehabilitation using multi temporal LiDAr DEMs:Case study from the Great Bar.ier reef catchments,Australia

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international Soil and Water Conservation research 2024年第1期12卷 184-199页

作者： Sana khan rebecca Bartley anne kinsey-Henderson Aaron Hawdon The Commonwealth Scientific and industrial research Organisation(CSirO) Environment1 James Cook DrDouglas4814Australia The Commonwealth Scientific and industrial research Organisation(CSirO) EnvironmentGPO Box 2583BrisbaneQLD4001Australia

Millions of dollars are being spent on gully rehabilitation to help reduce excess fine sediment delivery to the Great Bar.ier reef(GBr).There is an urgent need for.i)prioritisation of active gullies for rehabilitation and(ii)the development of methodologies to inform the effectiveness of *** this study we analyse DEMs of Difference derived from 0.5 m resolution 2-3 year.interval multi-temporal LiDAr data collected pre and post rehabilitation at three variable gully morphologies in the Burdekin *** analysis indicates that the highest annual average fine sediment erosion rates for the untreated control gullies occur at the linear gully(53.38 t ha^(-1)y^(-1))followed by linear-alluvial gully(34.24 t ha^(-1)y^(-1))and least at the alluvial gully(14.41 t ha^(-1)y^(-1)).The propor.ional loss or export of fine sediment from the gullies in their un-treated condition ranges from∼68 to 90%of what is eroded,and when the gullies are treated the propor.ion of fine sediment that is retained in the gully propor.ional to what is eroded increases to∼60%at all *** pre-treatment baseline erosion rates,and additional post treatment LiDAr captures,it is difficult to quantify the treatment *** results offer.insights in the erosion mechanisms within different geomorphic gully morphologies and rehabilitation effects in these erosional *** study provides crucial knowledge of gully dynamics that can be coupled with other lines of evidence for better prioritisation of rehabilitation in the GBr catchments.

关键词： Digital elevation models (dis)connectivity restoration Geomorphic change detection Geomorphic effectiveness GiS

Perspectives for delivery of therapeutics by extravasation of biodegradable microspheres in the br.in

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Neural regeneration research 2024年第5期19卷 969-970页

作者： anne-Eva van der Wijk Ed VanBavel Amsterdam UMC location Univer.ity of Amsterdam Department of Biomedical Engineering and PhysicsAmsterdamThe Netherlands Amsterdam Neuroscience Neurovascular Disorders ProgramAmsterdamThe Netherlands Amsterdam Car.iovascular Sciences Microcirculation ProgramAmsterdamThe Netherlands

Development of therapeutics for br.in diseases has remained challenging,in par.icular due to the difficulty of passing the blood-br.in *** a result,the current arsenal of therapeutics targeting the br.in is limited to small,lipid-soluble drugs and there is a lack of options for treating neuroblastomas,Alzheimer’s disease,and many other devastating *** the advances in strategies for crossing the blood-br.in bar.ier such as the use of nanopar.icles(Hersh et al.,2022;Duan et al.,2023),such delivery systems have not yet reached clinical ***,novel platforms for the transport of therapeutics across the blood-br.in bar.ier remain highly *** specifically holds for large molecules such as monoclonal antibodies and recombinant proteins,as well as nucleotide-based therapeutics and cell *** efforts in this field are increasing exponentially,with thousands of publications in the last few years.

关键词： therapeutics holds spite

Probiotics: Shaping the gut immunological responses

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World Journal of Gastroenterology 2024年第15期30卷 2096-2108页

作者： Eirini Filidou Leonidas kandilogiannakis anne Shrewsbury George kolios katerina kotzampassi Faculty of Medicine Laboratory of PharmacologyDemocritus University of ThraceAlexandroupolis 68100Greece Department of Surgery Aristotle University of ThessalonikiThessaloniki 54636Greece

Probiotics are live microorganisms exer.ing beneficial effects on the host’s health when administered in adequate *** the most popular and adequately studied probiotics are bacteria from the families Lactobacillaceae,Bifidobacteriaceae and *** of them have been shown,both in vitro and in vivo studies of intestinal inflammation models,to provide favorable results by means of improving the gut microbiota composition,promoting the wound healing process and shaping the immunological *** intestinal conditions,such as inflammatory bowel diseases(iBD),are characterized by an imbalance in microbiota composition,with decreased diver.ity,and by relapsing and per.isting inflammation,which may lead to mucosal *** the results of the clinical studies investigating the effect of probiotics on patients with iBD are still controver.ial,it is without doubt that these microorganisms and their metabolites,now named postbiotics,have a positive influence on both the host’s microbiota and the immune system,and ultimately alter the topical tissue *** influence is achieved through three axes:(1)By dis-placement of potential pathogens via competitive exclusion;(2)by offering protection to the host through the secretion of various defensive mediators;and(3)by supplying the host with essential *** will analyze and discuss almost all the in vitro and in vivo studies of the past 2 years dealing with the possible favorable effects of certain probiotic genus on gut immunological responses,highlighting which species are the most beneficial against intestinal inflammation.

关键词： Probiotics Lactobacillaceae Bifidobacteriaceae Saccharomyces intestinal inflammation immune responses

Comparative Analysis of the Essential Oil of the Underground Organs of Valeriana spp. from Different Countries

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Phyton-international Journal of Experimental Botany 2024年第7期93卷 1365-1382页

作者： Ain raal Valer.ia kokitko Vira Odyntsova anne Orav Oleh koshovyi institute of Pharmacy University of TartuTartu50411Estonia Zaporizhzhia State Medical and Pharmaceutical Univer.ity Zaporizhzhia69035Ukraine institute of Chemistry Tallinn University of TechnologyTallinn12618Estonia National Univer.ity of Pharmacy Kharkiv61002Ukraine

Valeriana ofﬁcinalis *** a plant from the Caprifoliaceae family,which is widely distributed in various parts of the world,especially in Europe and *** species of Valeriana are distinguished by their ability to synthesize essen-tial oil,which has a powerful effect on the physiological and mental aspects of the human *** aim was to study the qualitative and quantitative composition of essential oil from valerian roots,collected in different coun-tries,using the gas chromatography method,and to establish marker compounds for valerian species.13 samples of commer.ial roots with r.izomes of ***ﬁcinalis from nine countries of the world and a sample of Valeriana pratensis and Valeriana stolonifera growing in Ukr.ine were selected for the *** essential oil was obtained from dried valerian roots by the distillation method described in the European *** deter.ine the component composition of the essential oils of the selected samples,the methods of gas chromatography with a mass spectrometric detector and capillary gas chromatography were *** commer.ial samples of ***ﬁci-nalis from different countries yielded 0.21%–1.03%of essential *** six of 13 samples contained essential oil in an amount that satisﬁes the requirement of the European Pharmacopoeia standard(not less than 4 mL/kg).150 compounds were identiﬁed in the essential oils of 13 samples of ***ﬁcinalis essential *** range and average content and coefﬁcients of variation of the identiﬁed compounds were *** principal com-pounds of ***ﬁcinalis essential oils were bornyl acetate(1.6%–27.1%),valeranone(0.5%–17.9%),valerenal(0%–14.7%),camphene(0%–14.6%),α-fenchene(0%–10.6%),and valerenic acid(0%–8.5%).The samples of *** and *** yielded rather high levels of essential oil(1.18%and 0.93%,respectively).Three chemotypes of ***ﬁcinalis samples were deter.ined-bornyl acetate/valerenal,valeranone,and isovaleric *** composition of the three essential

关键词： Valeriana ofﬁcinalis Valeriana pratensis Valeriana stolonifera volatile compounds terpenoids chemotype

An emer.ing terpolymeric nanopar.icle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid disper.ion beads:Experimental studies and molecular dynamics analysis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2669-2684页

作者： Jamie anne Lugtu-Pe Xuning Zhang Sako Mirzaie Hao Han r.Chang Nour AL-Mousawi kuan Chen Yongqiang Li Anil kane Daniel Bar-Shalom Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Thermo Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution ***,most new chemical entities exhibit poor water solubility,and hence are exempt from such *** combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,par.icularly within the dosage ***,we explored the potential of an emer.ing,non-leachable terpolymer nanopar.icle(TPN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid disper.ion(CrASD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)*** to conventional pore former,polyvinylpyrrolidone(PVP),TPN-containing membranes exhibited superior structural integrity,less crystal formation at the CrASD bead surface,and greater extent of celecoxib ***-atom molecular dynamics analyses revealed that in the presence of TPN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to *** work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CrASD.

关键词： Controlled release amorphous solid disper.ion Poorly soluble drug internal recrystallization Membrane-reservoir coated beads Molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer.interactions

A cross-sectional study of breastfed infants referred for tongue tie assessment and frenotomy in one Canadian health region

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Pediatric investigation 2024年第1期8卷 53-60页

作者： Tiffany A.Lee Jessica Bishop anne Drover William k.Midodzi Laurie k.Twells School of Pharmacy Memorial University of Newfoundland(MUN)St.John’sCanada Faculty of Medicine Memorial University of Newfoundland(MUN)St.John’sCanada

importance:Tongue tie(TT)is a condition that can cause infant feeding difficulties due to restricted tongue *** TT presents as a significant bar.ier to breastfeeding,a frenotomy may be *** accepted diagnostic criteria for TT are lacking and wide prevalence estimates are *** referral processes and a Frenotomy Assessment Tool were implemented in one Canadian health region to connect breastfeeding dyads with a provider for TT evaluation and ***:To deter.ine the propor.ion of babies with TT as well as the frequency of ***:This cross-sectional study included infants who initiated breastfeeding at birth and were referred for TT evaluation over a 14-month *** were collected retrospectively by chart review and analyzed using *** associated with frenotomy were examined using logistic ***:Two hundred and forty-one babies were ***-two percent(n=222)were diagnosed with TT and 66.0%(n=159)underwent *** the multivariate model,nipple pain/trauma,inability to latch,inability to elevate tongue,and dimpling of tongue on extension were associated with frenotomy(Preferrals in our region resulted in a diagnosis of TT;however,the number of referrals was lower than expected,and of these two-thirds underwent ***:TT is a relatively common finding among breastfed *** research should examine whether a simplified assessment tool containing the four.items associated with frenotomy in our multivariate model can identify breastfed infants with TT who require frenotomy.

关键词： Breastfeeding Nutrition Community health ser.ices Pediatrics