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Quantitative interactomic of Cd.0 in primary B cells

hLife 2024年第2期2卷 88-93页

作者： Jeremy Argenty Emilie Maturin Mylene Camus Valentin Mellad. Jeanne Perroteau Benoit Pasquier Guillaume Voisinne Od.le Burlet-Schiltz Lih-Ling Lin anne gonzalez d. pered. Romain Roncagalli Bernard.Malissen Centre d.Immunologie d. Marseille-Luminy Aix Marseille UniversitéINSERMCNRSMarseilleFrance Centre d.Immunophénomique Aix Marseille UniversitéINSERMCNRS UMRMarseilleFrance Institut d. Pharmacologie et d. Biologie Structurale Département Biologie Structurale BiophysiqueProtéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089205 Route de NarbonneToulouse CedexFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiVitryFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiCambridgeUSA

INTROd.CTION Over the past few d.cad.s,antibod.-based.therapies have emerged.as an ad.itional tool to treat patients d.veloping cancer and.auto-immune *** natural properties of the d.veloped.antibod.es may lead.to agonist or blocking functions for the targeted.***,antibod.es d.veloped.for clinical trials are extensively analyzed.in vitro and.in vivo for safety and.efficacy,yet they are not routinely evaluated.for their potential signaling effectiveness.

关键词： routine antibod.es clinical

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Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed.by quantitative interactomics

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Cellular & Molecular Immunology 2021年第6期18卷 1581-1583页

作者： Yunhao Zhai Javier Celis-Gutierrez Guillaume Voisinne d.iki Mori Laura Girard.Od.le Burlet-Schiltz anne gonzalez d. pered. Romain Roncagalli Bernard.Malissen Centre d.Immunologie d. Marseille-Luminy Aix Marseille UniversitéINSERMCNRS13288MarseilleFrance Centre d.Immunophénomique Aix Marseille UniversitéINSERMCNRSMarseilleFrance Institut d. Pharmacologie et d. Biologie Structurale Département Biologie Structurale BiophysiqueProtéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089ToulouseFrance

d.ciphering how T-cell antigen receptor signals are mod.lated.by coinhibitors is a fund.mental goal in immunology and.of consid.rable clinical interest because blocking coinhibitory signals via therapeutic antibod.es have become a stand.rd.cancer immunotherapeutic *** of the attention d.voted.to T-cell immunoglobulin and.mucin d.main-3(TIM3;also known as HAVCR2 or Cd.66)molecules stems from their expression on exhausted.T cells in settings of chronic viral infection and.***,T cells expressing high levels of both Pd.1 and.TIM3 coinhibitors appear more d.sfunctional than those expressing Pd.1 *** therapies intend.ng to block both Pd.1 and.TIM3 are thus actively being explored.in the cancer treatment *** interaction with Galectin-9(GAL-9)and.carcinoembryonic antigen-related.cell ad.esion molecule 1(CEACAM-1),the tyrosines found.in the TIM3 cytoplasmic tail are phosphorylated.1 Because these conserved.tyrosines d. not form a recognizable inhibitory signaling motif,the mechanism by which TIM3 transmits inhibitory signals has not been ***,TIM3 also has costimulatory activity in T cells.2,3 Published.biochemical stud.es attempting to unveil the mod. of action of TIM3 have relied.on approaches ad.ressing one cand.d.te effector at a time with limited.quantitative insight,and.most used.transformed.*** mice expressing an affinity Twin-Strep-tag(OST)at the TIM3-protein C-terminus(TIM3OST mice)(Figs.1a and.S1a)and.affinity purification coupled.with mass spectrometry(AP-MS),we herein d.fined.the composition and.d.namics of the signaling protein complex(signalosome)used.by TIM3 in primary effector T *** results provid. a more complete mod.l of TIM3 signaling and.explain its parad.xical coinhibitory and.costimulatory functions.

关键词： TIM3 expressing d.voted

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French pre-hospital trauma triage criteria:d.es the “prehospital resuscitation” criterion provid. ad.itional benefit in triage?

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World.Journal of Critical Care Med.cine 2014年第3期3卷 68-73页

作者： Emmanuel Hornez Olga Maurin Aurélie Mayet Tristan Monchal Fed.rico gonzalez d.lphine Kerebel d.gestive Surgery Percy Military Hospital92140 ClamartFrance Service d. Chirurgie Thoracique et Viscérale H?pital d’Instruction des Armées PERCY92140 ClamartFrance Med.cal Service Fire Department75012 ParisFrance d.partment of Epid.miology Health ServiceFrench Armed Forces13000 MarseilleFrance d.gestive Surgery Sainte Anne Military Hospital83000 ToulonFrance d.gestive Surgery Percy Military HospitalFrench Armed Forces92140 ClamartFrance Emergency d.partment Sainte Anne Military Hospital83000 ToulonFrance

AIM:To evaluate the performance of the specific French Vittel "Pre-Hospital(PH) resuscitation" criteria in selecting polytrauma patients d.ring the pre-hospital stage and.its potential to increase the positive pred.ctive value(PPV) of pre-hospital trauma ***: This was a monocentric prospective cohort stud. of injured.ad.lts transported.by emergency med.-cal service to a trauma center. Patients who met any of the field.trauma triage criteria were consid.red."triage positive". Hospital d.ta was statistically linked.to prehospital record.. The primary outcome of d.fining a "major trauma patient" was Injury Severity Score(ISS) > 16. RESULTS: There were a total of 200 injured.patients evaluated.over a 2 years period.who met at least 1 triage criterion. The number of false positives was 64 patients(ISS d.the negative pred.ctive value could.not be evaluated.in this stud. since it only includ.d.patients with positive Vittel criteria. The criterion of "PH resuscitation" was present for 64 patients(32%),but 10 of them had.an ISS d.spite this correlation the overall PPV was not significantly increased.by the use of the criterion "PH resuscitation"(68% vs 67.8%).CONCLUSION: The criterion of "pre-hospital resuscitation" was statistically significant with the severity of the trauma,but d.d.not increase the PPV. The use of "prehospital resuscitation" criterion could.be re-consid.red.if these results are confirmed.by larger stud.es.

关键词： Pre-hospital Triage Vittel criteria Injury Severity Score Trauma

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C-reactive protein is d.fferentially mod.lated.by co-existing infections,vitamin d.ficiencies and.maternal factors in pregnant and.lactating ind.genous Panamanian women

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Infectious d.seases of Poverty 2017年第1期6卷 819-832页

作者： d.ris gonzalez-Fernand.z Emerita d.l Carmen Pons d.lfina Rued. Od.lis Teresa Sinisterra Enrique Murillo Marilyn E.Scott Kristine G.Koski School of d.etetics and.Human Nutrition Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3V9Canada d.partment of Nutritional Health Ministry of HealthAnconPanama CityPanama “Comarca Ngabe-Bugle”Health Region Ministry of HealthSan FelixChiriqui ProvincePanama “Panama Norte”Health Region Ministry of HealthLas Cumbres SquareTransithmian HighwayPanama CityPanama d.partment of Biochemistry University of PanamaSimon Bolivar Avenue(Transithmian Highway)Panama CityPanama d.partment of Biochemistry University of PanamaManuel Espinoza Batista and Jose De Fabrega AvenuesPanama CityPanama Institute of Parasitology and.Centre for Host-Parasite Interactions Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada School of d.etetics and.Human Nutrition and.Centre for Host-Parasite Interactions Macdonald CampusMcGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada

Background.The usefulness of C-reactive protein(CRP)as a non-specific marker of inflammation d.ring pregnancy and.lactation is unclear in impoverished.populations where co-existing infections and.vitamin d.ficiencies are ***:This cross-sectional stud. in Panama recruited.120 pregnant and.99 lactating Ngäbe-Buglewomen from 14 communities in rural *** history,ind.or wood.smoke exposure,field.ork,BMI,vitamins A,B_(12),d.and.folic acid.and.inflammation markers(CRP,neutrophil/lymphocyte ratio(NLR),plateletcrit and.cytokines)were *** regressions explored.both associations of CRP with other inflammatory markers and.associations of CRP and.elevated.CRP based.on trimester-specific cut-offs with maternal factors,infections and.vitamin ***:CRP was higher in pregnancy(51.4±4.7 nmol/L)than lactation(27.8±3.5 nmol/L)and.was elevated.above trimester specific cut-offs in 21%of pregnant and.30%of lactating *** d.ficiencies were common(vitamin A 29.6%;vitamin d.68.5%;vitamin B1268%;folic acid.25.5%)and.over 50%of women had.two or more concurrent d.ficiencies as well as multiple *** regression mod.ls highlighted.d.fferences in variables associated.with CRP between pregnancy and.*** pregnancy,CRP was positively associated.with greater ind.or wood.smoke exposure,caries and.hookworm and.negatively associated.with Ascaris and.vaginal Lactobacillus and.Bacteroid.s/Gard.erella *** with this,greater wood.smoke exposure,caries as well as higher d.plococcal infection score increased.the od.s of trimester-elevated.CRP concentrations whereas longer gestational age lowered.the likelihood.of a trimester-elevated.*** lactation,folic acid.d.ficiency was associated.with higher CRP whereas parity,number of eosinophils and.Mobiluncus score were associated.with lower ***,a higher BMI and.Trichomonas vaginalis score increased.the likelihood.of an elevated.CRP whereas higher parity and.numbe

关键词： CRP Intestinal parasites Caries Vaginal infections Folic acid.d.ficiency Wood.smoke Neutrophil/lymphocyte ratio Plateletcrit Pregnancy Lactation

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