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World Journal of Gastroenterology 2009年第2期15卷 226-230页

作者： anne f van rijn Paul fockens Peter D Siersema Bas Oldenburg Department of Gastroenterology and Hepatology Academic Medical Center University of Amsterdam Amsterdam 1105AZ The Netherlands Department of Gastroenterology and Hepatology University Medical Centre Utrecht Utrecht 3584CX The Netherlands

AIM: To study adherence to the widely accepted surveillance guidelines for patients with long-standing colitis in the Netherlands. METHODS: A questionnaire was sent to all 244 gastroenterologists in the Netherlands. RESULTS: The response rate was 63%. Of all gastroenterologists, 95% performed endoscopic surveillance in ulcerative colitis (UC) patients and 65% in patients with Crohn's colitis. The American Gastroenterological Association (AGA) guidelines were followed by 27%, while 27% and 46% followed their local hospital protocol or no specific protocol, respectively. The surveillance was correctly initiated in cases of pancolitis by 53%, and in cases of left-sided colitis by 44% of the gastroenterologists. Although guidelines recommend 4 biopsies every 10 cm, less than 30 biopsies per colonoscopy were taken by 73% of the responders. Only 31%, 68% and 58% of the gastroenterologists referred patients for colectomy when low-grade dysplasia, high-grade dysplasia (HGD) or Dysplasia Associated Lesion or Mass (DALM) was present, respectively. CONCLUSION: Most Dutch gastroenterologists performendoscopic surveillance without following international recommended guidelines. This practice potentially leads to a decreased sensitivity for dysplasia, rendering screening for colorectal cancer in this population highly ineffective.

关键词： Colorectal cancer Crohn's disease Dysplasia Guidelines Surveillance Ulcerative colitis

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World Journal of Gastroenterology 2012年第38期18卷 5397-5403页

作者： Sietze T van Turenhout Leo GM van Rossum frank A Oort Robert Jf Laheij anne f van rijn Jochim S Terhaar sive Droste Paul fockens René WM van der Hulst anneke A Bouman Jan BMJ Jansen Gerrit A Meijer Evelien Dekker Chris JJ Mulder Department of Gastroenterology and Hepatology VU University Medical Center1081 HV Amsterdam The Netherlands Department of Epidemiology Biostatistics and HTA Radboud University Nijmegen Medical Center6500 HB Nijmegen The Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center6500 HB Nijmegen The Netherlands Department of Gastroenterology and Hepatology Academic Medical Center1105 AZ Amsterdam The Netherlands Department of Gastroenterology and Hepatology Kennemer Gasthuis 2035 RC Haarlem The Netherlands Clinical Chemistry VU University Medical Center 1081 HV Amsterdam The Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center 6500 HB Nijmegen The Netherlands Department of Pathology VU University Medical Center 1081 HV Amsterdam The Netherlands Department of Gastroenterology and Hepatology Academic Medical Center 1105 AZ Amsterdam The Netherlands Department of Gastroenterology and Hepatology VU University Medical Center 1081 HV Amsterdam The Netherlands

AIM: To improve the interpretation of fecal immunochemical test (fIT) results in colorectal cancer (CRC) cases from screening and referral cohorts. METHODS: In this comparative observational study, two prospective cohorts of CRC cases were compared. The first cohort was obtained from 10 322 average risk subjects invited for CRC screening with fIT, of which, only subjects with a positive fIT were referred for colonoscopy. The second cohort was obtained from 3637 subjects scheduled for elective colonoscopy with a positive fIT result. The same fIT and positivity threshold (OC sensor; ≥ 50 ng/mL) was used in both cohorts. Colonoscopy was performed in all referral subjects and in fIT positive screening subjects. All CRC cases were selected from both cohorts. Outcome measurements were mean fIT results and fIT scores per tissue tumor stage (T stage). RESULTS: One hundred and eighteen patients with CRC were included in the present study: 28 cases obtained from the screening cohort (64% male; mean age 65 years, SD 6.5) and 90 cases obtained from the referral cohort (58% male; mean age 69 years, SD 9.8). The mean fIT results found were higher in the referral cohort (829 ± 302 ng/mLvs 613 ± 368 ng/mL,P = 0.02). Tissue tumor stage (T stage) distribution was dif-ferent between both populations [screening population: 13 (46%) T1, eight (29%) T2, six (21%) T3, one (4%) T4 carcinoma; referral population: 12 (13%) T1, 22 (24%) T2, 52 (58%) T3, four (4%) T4 carcinoma], and higher T stage was significantly associated with higher fIT results (P ficant difference in mean fIT results was observed (screening vs referral: T1 498 ± 382 ng/mL vs 725 ± 374 ng/mL, P = 0.22; T2 787 ± 303 ng/mL vs 794 ± 341 ng/mL, P = 0.79; T3 563 ± 368 ng/mLvs 870 ± 258 ng/mL,P = 0.13; T4 not available). After correction for T stage in logistic regression analysis, no significant differences in mean fIT results were observed between both types of cohorts (P = 0.10). CONCLUSION

关键词： Screening population Referral cohort fecal immunochemical test Tumor stage distribution Colorectal cancer

Critical movement of large rocks in currents and waves

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International Journal of Sediment Research 2019年第4期34卷 387-398页

作者： L.C.van rijn LVR-Sediment Consultancy

Cobbles, boulders, and rocks often are used in a bed protection layer near a structure to protect the underlying sand bed against erosion by combined current and waves. The design of a bed protection layer consisting of loose rocks(rubble mound) requires knowledge of the stability and movement(as bed load) of very coarse materials. If some movement(or damage) is acceptable, the rock diameter can be designed to be smaller. This paper addresses the stability and movement of very coarse materials(cobbles, boulders, and rocks) based on the concept of the critical Shields mobility number. It is shown that the bed load transport of large cobbles, boulders, and rocks can be described by the equations of Meyer-Peter and Mueller(MPM) and Cheng. Both are valid for relatively small Shields mobility *** and general equations for the design of a bed protection layer(including some permissible damage)in conditions with a current with or without waves are proposed based on the Shields mobility parameter and the bed load transport equation of Cheng. Laboratory and field data of critical velocities for pebbles, cobbles, boulders, and rocks have been analyzed and compared to the computed results of the proposed equations. Practical applications are given to demonstrate the general applicability of the proposed equations.

关键词： Rock stability Bed protection Critical movement Bed load transport Rocks

Nanogels:A novel approach in antimicrobial delivery systems and antimicrobial coatings

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Bioactive Materials 2021年第10期6卷 3634-3657页

作者： Damla Keskin Guangyue Zu Abigail M.forson Lisa Tromp Jelmer Sjollema Patrick van rijn University of Groningen University Medical Center GroningenDepartment of Biomedical EngineeringW.J.Kolff InstituteAntonius Deusinglaan 19713 AVGroningenthe Netherlands

The implementation of nanotechnology to develop efficient antimicrobial systems has a significant impact on the prospects of the biomedical *** are soft polymeric particles with an internally cross-linked structure,which behave as hydrogels and can be reversibly hydrated/dehydrated(swollen/shrunken)by the dispersing solvent and external *** excellent properties,such as biocompatibility,colloidal stability,high water content,desirable mechanical properties,tunable chemical functionalities,and interior gel-like network for the incorporation of biomolecules,make them fascinating in the field of biological/biomedical *** this review,various approaches will be discussed and compared to the newly developed nanogel technology in terms of efficiency and applicability for determining their potential role in combating infections in the biomedical area including implant-associated infections.

关键词： Nanogels Coatings Antibacterial activity Antifouling Biocompatibility

Use of incipient motion data for backward erosion piping models

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International Journal of Sediment Research 2019年第5期34卷 401-408页

作者： Vera M.van Beek Bryant A.Robbins Gijs J.C.M.Hoffmans Adam Bezuijen Leo C.van rijn Deltares U.S.Army Engineer Research and Development Center Ghent University Leovanrijn-Sediment-Consultancy

Backward erosion piping involves the gradual removal of granular material under the action of water flow from the foundation of a dam or levee, whereby shallow pipes are formed that grow in the direction opposite to the flow. This pipe-forming process can ultimately lead to failure of a water-retaining structure and is considered one of the most important failure mechanisms for dikes and levees in the Netherlands and the United States. Modeling of this mechanism requires the assessment of hydraulic conditions in the pipe, which are controlled by the particle equilibrium at the pipe wall. Since the pipe’s dimensions are controlled by the inflow to the pipe from the porous medium, the flow through the pipe is thought to be laminar for fine-to medium-grained sands. The literature provides data for incipient motion in laminar flow, which is reviewed here and complemented with data from backward erosion experiments. The experiments illustrate the applicability of the laminar incipient motion data to determine the erosion pipe dimensions and corresponding pipe hydraulics for fine-to medium-grained sands, for the purpose of backward erosion piping modeling.

关键词： Internal erosion Backward erosion piping Cylindrical test Incipient motion Dikes Levees

ESTUARINE AND COASTAL SEDIMENTATION PROBLEMS

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International Journal of Sediment Research 2005年第1期20卷 39-51页

作者： Leo C. van rijn Delft Hydraulics and University of Utrecht Prof. The Netherlands

This keynote lecture addresses engineering sedimentation problems in estuarine and coastal environments and practical solutions of these problems based on the results of field measurements, laboratory scale models and numerical models. The three most basic design rules are: (1) try to understand the physical system based on available field data; perform new field measurements if the existing field data set is not sufficient (do not reduce on the budget for field measurements); (2) try to estimate the morphological effects of engineering works based on simple methods (rules of thumb, simplified models, analogy models, i.e. comparison with similar cases elsewhere); and (3) use detailed models for fine-tuning and determination of uncertainties (sensitivity study trying to find the most influencial parameters). Engineering works should be designed in such a way that side effects (sand trapping, sand starvation, downdrift erosion) are minimum. furthermore, engineering works should be designed and constructed or built in harmony rather than in conflict with nature. This ‘building with nature’ approach requires a profound understanding of the sediment transport processes in morphological systems.

关键词： Sedimentation Sediment transport Morphological modelling

Applications of gene microarray and tissue microarray to histopathology

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Applications of gene microarray and tissue microarray to his...

Estimated impact of introduction of new diagnostic criteria for gestational diabetes mellitus

中华医学会病理学分会2007年学术年会暨第九届全国病理大会

作者： Matt van de rijn Professor of Pathology Department Stanford University School of Medicine MD PhD.

Gene expression profiling using gene microarrays is a powerful technique that allows the determination of expression levels for essentially all genes in the human genome in a single overnight *** technique has been used to discover new diagnostic markers for a variety of tumors,to find new prognostic markers that predict clinical outcome within a particular disease group,to identify new subtypes within specific disease

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World Journal of Diabetes 2021年第6期12卷 868-882页

作者： Leon de Wit Anna B Zijlmans Doortje Rademaker Christiana A Naaktgeboren J Hans DeVries Arie franx Rebecca C Painter Bas B van rijn Department of Obstetrics and Gynaecology University Medical Center UtrechtUtrecht 3584 EANetherlands Department of Obstetrics and Gynaecology Gelderse Vallei HospitalEde 6716 RPNetherlands Department of Obstetrics and Gynaecology Amsterdam University Medical Centers-Location AMCAmsterdam 1105 AZNetherlands Department of Obstetrics and Gynaecology Amsterdam University Medical Centers–Location AMCAmsterdam 1105 AZNetherlands Department of Endocrinology Amsterdam University Medical Centers–Location AMCAmsterdam 1105 AZNetherlands Department of Obstetrics and fetal Medicine Erasmus MC Sophia Children HospitalRotterdam 3015 GDNetherlands

BACKGROUND Implementation of new diagnostic criteria for gestational diabetes mellitus(GDM)are still a subject of debate,mostly due to concerns regarding the effects on the number of women diagnosed with GDM and the risk profile of the women newly *** To estimate the impact of the World Health Organization(WHO)2013 criteria compared with the WHO 1999 criteria on the incidence of gestational diabetes mellitus as well as to determine the diagnostic accuracy for detecting adverse pregnancy *** We retrospectively analyzed a single center Dutch cohort of 3338 women undergoing a 75 g oral glucose tolerance test where the WHO 1999 criteria to diagnose GDM were clinically *** were categorized into four groups:non-GDM by both criteria,GDM by WHO 1999 only(excluded from GDM),GDM by WHO 2013 only(newly diagnosed)and GDM by both *** compared maternal characteristics,pregnancy outcomes and likelihood ratios for adverse pregnancy *** Retrospectively applying the WHO 2013 criteria increased the cohort incidence by 13.1%,from 19.3%to 32.4%.Discordant diagnoses occurred in 21.3%;4.1%would no longer be labelled as GDM,and 17.2%were newly *** to the non-GDM group,women newly diagnosed were older,had higher rates of obesity,higher diastolic blood pressure and higher rates of caesarean *** infants were more often delivered preterm,large-for-gestational-age and were at higher risk of a 5 min Apgar scorefrom GDM were older and had similar pregnancy outcomes compared to the non-GDM group,except for higher rates of shoulder dystocia(4.3%vs 1.3%,P=0.015).Positive likelihood ratios for adverse outcomes in all groups were generally low,ranging from 0.54 to *** Applying the WHO 2013 criteria would result in a substantial increase in GDM *** diagnosed women are at increased risk for pregnancy adverse *** risk,however,seems to be lower than those identified by the

关键词： Diagnostic criteria Gestational diabetes Glucose tolerance test Incidence Pregnancy outcome

Sensitive capacitive pressure sensors based on graphene membrane arrays

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Microsystems & Nanoengineering 2020年第1期6卷 176-184页

作者： Makars Siskins Martin Lee Dominique Wehenkel Richard van rijn Tijmen W.de Jong Johannes R.Renshof Berend C.Hopman Willemijn S.J.M.Peters Dejan Davidovikj Herre S.J.van der Zant Peter G.Steeneken Kavli Institute of Nanoscience Delft University of TechnologyLorentzweg 12628 CJ DelftThe Netherlands Applied Nanolayers B.V. Feldmannweg 172628 CT DelftThe Netherlands Department of Precision and Microsystems Engineering Delft University of TechnologyMekelweg 22628 CD DelftThe Netherlands

The high flexibility,impermeability and strength of graphene membranes are key properties that can enable the next generation of nanomechanical ***,for capacitive pressure sensors,the sensitivity offered by a single suspended graphene membrane is too small to compete with commercial ***,we realize highly sensitive capacitive pressure sensors consisting of arrays of nearly ten thousand small,freestanding double-layer graphene *** fabricate large arrays of small-diameter membranes using a procedure that maintains the superior material and mechanical properties of graphene,even after high-temperature *** sensors are readout using a low-cost battery-powered circuit board,with a responsivity of up to 47:8af Pa^(−1) mm^(−2),thereby outperforming the commercial sensors.

关键词： graphene arrays thereby

新型西欧联运快车(TEE)(巴黎-布鲁塞尔-阿姆斯特丹间)

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铁道车辆 1965年第6期 1-12页

作者： Jean Robert ,Willy van rijn ,李炳权

1934年西欧七国铁路成立了西欧联运快车(TEE)组织。初期选用了内燃牵引,在较低的牵引重量下最大速度为140公里/小时,有120个座位,并有可能增加到150个座位。1957年设计了略有不同而一般属于高标准的内燃牵引客车组,并已投入运用。不久以... 详细信息

1934年西欧七国铁路成立了西欧联运快车(TEE)组织。初期选用了内燃牵引,在较低的牵引重量下最大速度为140公里/小时,有120个座位,并有可能增加到150个座位。1957年设计了略有不同而一般属于高标准的内燃牵引客车组,并已投入运用。不久以后,瑞士联邦铁路开始研究多电流制的电气牵引客车组,以保证瑞士、法国和意大利之间增开新车次的需要。1961年4月,新车次开始通过这三个国家,车组的

关键词： TEE 走道座位交流发电机客室