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新东方英语(中学生) 2009年第3期 52-55页

作者： Astrid lindgren Elaine

阿斯特丽德.林格伦(Astrid lindgren,1907～2002)是瑞典著名的儿童文学大师。她创作的儿童文学作品深受世界各地人们的喜爱,她因此被誉为"童话外婆"。她善用讲故事的笔法、通

关键词：林格伦丹德尔卡尔松

Long-Term Monoacylglycerol Lipase Inhibitor Treatment Decelerates Pathological Changes in APP/PS1-21 Mice, but Behavioral Improvements Require Early-Stage Treatment Onset—Short Report

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World Journal of Neuroscience 2018年第2期8卷 157-170页

作者： Rea Pihlaja Noora lindgren Annamari Torittu Anniina Snellman Merja Haaparanta-Solin Juha O. Rinne PET Preclinical Laboratory Turku PET Centre University of Turku Turku Finland Medicity Research Laboratory University of Turku Turku Finland Turku PET Centre Turku University Hospital Turku Finland Department of Biochemistry University of Turku Turku Finland Division of Clinical Neurosciences Turku University Hospital Turku Finland

The arachidonic acid (AA) pathway produces several essential proinflammatory eicosanoids. However, in many neurodegenerative diseases, e.g. Alzheimer’s disease (AD), this pathway is chronically hyperactivated. In brain, primarily monoacylglycerol lipase (MAgL) hydrolyzes the endocannabinoid 2-arachidonoylglycerol to AA, which is further metabolized to generate many proinflammatory eicosanoids. MAgL inhibition, simultaneously reducing the level of eicosanoids and increasing those of neuroprotective endocannabinoids, has proved efficacious in some AD models, reducing neurotoxic β-amyloid (Aβ) levels and improving memory functions. Here, a MAgL inhibitor, JZL184 was chronically administered (16 mg/kg, i.p., 3 x/wk for 5 mo) for 1 - 1.5 mo and 7 - 8 mo old transgenic (Tg) and wild-type (WT) APP/PS1-21 mice modelling cerebral amyloidosis. According to immunohistochemistry, JZL184 significantly increased the expression levels of cannabinoid receptor 1 in older WT and younger Tg and WT mice, decreased cannabinoid receptor 2 and oligomeric Aβ in older and younger Tg mice and decreased microglia-specific marker Iba1 in younger Tg mice, compared to Tg mice treated with vehicle only. However, in the Morris Water Maze test, spatial memory functions improved significantly only in younger Tg and WT mice, compared to vehicle-treated littermates. These tentative results suggest that chronic, rather long-term MAgL inhibition can decelerate pathological changes in Tg APP/PS1-21 mice but it improves memory functions only when administered at an early stage of the

关键词： Alzheimer’s Disease Arachidonic Acid Pathway Cannabinoid Receptor Monoacylglycerol Lipase Neuroinflammation

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小飞人又飞了

小飞人又飞了

作者： A.·林格伦(A. lindgren)

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空气层流室护理实践及操作

国际护理学杂志 1985年第2期06卷 74-76页

作者： lindgren PS 朱淑婷

感染一直是粒细胞减少症死亡的主要原因。大部分急性白血病、恶性淋巴瘤、再生障碍性贫血患者,虽经抗癌及抗菌治疗,感染仍是并发症发生的原因。所以有效地防止感染在治疗中是很重要的。在空气层流室(以下简称层流室)中隔离,并口服不吸... 详细信息

感染一直是粒细胞减少症死亡的主要原因。大部分急性白血病、恶性淋巴瘤、再生障碍性贫血患者,虽经抗癌及抗菌治疗,感染仍是并发症发生的原因。所以有效地防止感染在治疗中是很重要的。在空气层流室(以下简称层流室)中隔离,并口服不吸收的抗生素以减少胃肠道污染,是防止感染的有效方法,败血症及严重局部感染可明显减少。层流室中环境的保持,需要护士细致而科学地管理,故了解及遵守严格的护理标准很重要,下述守则及操作是统一设置的无菌层流室环境高质景管理的基础。

关键词：层流室护士抗生素病人空气工业气体

Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients:a nationwide Danish cohort study

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Journal of geriatric Cardiology 2021年第11期18卷 897-907页

作者： Jesper Nielsen Kristian Hay Kragholm Sofie Brix Christensen Arne Johannessen Christian Torp-Pedersen Steen Buus Kristiansen Peter Karl Jacobsen Peter Steen Hansen Mogens Stig Djurhus Christoffer Polcwiartek Peter Søgaard Anna Margrethe Thøgersen Uffe Jakob Ortved gang Ole Dan Jørgensen Filip Lyng lindgren Sam Riahi Department of Cardiology Aalborg University HospitalDenmark Department of Cardiology Gentofte HospitalCopenhagen University HospitalDenmark Department of Clinical Research and Cardiology Nordsjaellands HospitalHillerødDenmark Department of Cardiology Skejby University HospitalDenmark Department of Cardiology RigshospitaletCopenhagen University HospitalDenmark Mølholm Clinic VejleDenmark Department of Cardiology Odense University hospitalDenmark Department of Cardiology Roskilde University HospitalDenmark Department of Thoracic Surgery Odense University HospitalDenmark AF-Study group Aalborg University Hospital Denmark Clinical Institute Aalborg UniversityDenmark

OBJECTIVES To investigate complications within 30-days following first-time ablation for atrial fibrillation(AF),including a composite of cardiac tamponade,hematoma requiring intervention,stroke or death,in patients≥75 years of age,compared to pa-tients aged 65−74 *** addition,one-year all-cause mortality and AF relapse were ***&RESULTS All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified us-ing Danish nationwide *** aged 65−74 years served as the reference group for patients≥75 *** of AF within one year was defined as cardioversion following a three-month blanking period,re-ablation or confirmed relapse within *** composite complication outcome did not differ between the two age groups,with 39/1554(2.8%)in patients 65−74 years of age,versus 5/199(2.5%)in older patients(adjusted HR=0.94),95%CI:0.37−2.39,P=0.896).Patients≥75 years or older had no increased hazard of death within 30 days after the procedure,with an incidence of 3/1554(0.2%)in younger pa-tients and 2/199(1.0%)in patients≥75 years of age(adjusted HR=4.71,95%CI:0.78−28.40,P=0.091).There was no difference in relapse of AF after one year between age groups(≥75 years adjusted HR=1.00,95%CI:0.78-1.26,P=0.969).CONCLUSION In patients≥75 years of age selected for catheter ablation for AF,the incidence of periprocedural complica-tions,as well as one-year freedom from AF showed no statistical difference,when compared to patients 65−74 years of age.

关键词： patients fibrillation atrial

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R.E.M.重出江湖

商业周刊（中文版） 2015年第1期 122-123页

作者： Hugo lindgren 赵萌萌

在推出上一张专辑多年后，上世纪90年代的偶像乐队R．E．M坚守初衷。

关键词：江湖重出 90年代

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一种诱捕小蠹虫的多重漏斗式诱捕器

浙江林业科技 1983年第4期 33-34+38页

作者： B.S.lindgren ,吴鸿

利用金属片、纱网和其它材料涂以粘性物质制成的诱捕器,已广泛应用于小蠹虫的研究和诱捕。这些诱捕器虽然有效,但花时赞工,且难以保养。为了设计出可替代的诱

关键词：诱捕器多重原型漏斗式性信息素性外激素

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Marketing

Marketing

1996年

作者： John H. lindgren Jr. Terence A. Shimp

来源：畅想之星图书光盘版（南... 评论

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表型选择与非约束联合指数选择的选择效率

表型选择与非约束联合指数选择的选择效率

中国遗传学会第七次代表大会暨学术讨论会

作者：李火根 Dag lindgren 南京林业大学森林资源与环境学院 Department of Forest genetics and Plant Physiology Swedish University of Agricultural SciencesS—901 83 UmeaSweden

植物育种的目标之一就是在保持一定的遗传多样性基础上最大限度地提高遗传增益,而这两者往往不可兼得,如何协调两者的关系是植物育种中需重点解决的问题。表型选择(Phenotypic selection)是仅依据个体的表现型而进行的选择,因而操作简... 详细信息

植物育种的目标之一就是在保持一定的遗传多样性基础上最大限度地提高遗传增益,而这两者往往不可兼得,如何协调两者的关系是植物育种中需重点解决的问题。表型选择(Phenotypic selection)是仅依据个体的表现型而进行的选择,因而操作简单且花费低廉,表型选择可保持较高的遗传多样性但遗传增益较低;联合指数选择(Combined index selection)综合考虑家系和个体的信息构件指数值,该指数值代表了个体的真正育种值(Breeding value)因而

关键词：遗传力遗传增益林氏有效群体大小选择效率

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淘气包艾米尔

淘气包艾米尔