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Effects of neoadjuvant chemotherapy vs chemoradiotherapy in the treatment of esophageal adenocarcinoma:A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第11期30卷 1621-1635页

作者： Armand Csontos Alíz Fazekas Lajos Szakó Nelli Farkas Csenge Papp Szilárd Ferenczi szabolcs Bellyei Péter Hegyi András Papp Department of Surgery University of PécsMedical SchoolClinical CenterPécs H-7624BaranyaHungary Institute of Bioanalysis University of PécsMedical SchoolPécs H-7624BaranyaHungary Institute for Translational Medicine University of PécsMedical SchoolPécs H-7624BaranyaHungary Department of Emergency Medicine Clinical CenterUniversity of PécsMedical SchoolPécs 7624BaranyaHungary Department of Oncotherapy University of PécsMedical SchoolClinical CenterPécs H-7624BaranyaHungary Centre for Translational Medicine Semmelweis UniversityBudapest 1085Hungary Institute of Pancreatic Diseases Semmelweis UniversityBudapest H-1083Hungary

BACKGROUND Neoadjuvant therapy is an essential modality for reducing the clinical stage of esophageal cancer;however,the superiority of neoadjuvant chemotherapy(nCT)or neoadjuvant chemoradiotherapy(nCRT)is ***,a discussion of these two modalities is *** To investigate the benefits and complications of neoadjuvant *** To address this concern,predefined criteria were established using the PICO *** independent authors performed comprehensive searches using predetermined *** analyses were performed to identify significant differences between *** publication bias was visualized using funnel *** quality of the data was evaluated using the Risk of Bias Tool 2(RoB2)and the GRADE *** Ten articles,including 1928 patients,were included for the *** difference was detected in pathological complete response(pCR)[P<0.001;odds ratio(OR):0.27;95%CI:0.16-0.46],30-d mortality(P=0.015;OR:0.4;95%CI:0.22-0.71)favoring the nCRT,and renal failure(P=0.039;OR:1.04;95%CI:0.66-1.64)favoring the *** significant differences were observed in terms of survival,local or distal recurrence,or other clinical or surgical *** result of RoB2 was moderate,and that of the GRADE approach was low or very low in almost all *** Although nCRT may have a higher pCR rate,it does not translate to greater long-term ***,nCRT is associated with higher 30-d mortality,although the specific cause for postoperative complications could not be *** the case of nCT,toxic side effects are suspected,which can reduce the quality of *** the quality of available studies,further randomized trials are required.

关键词： Neoadjuvant Chemotherapy Chemoradiotherapy Esophageal cancer Adenocarcinoma

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Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats

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World Journal of Gastroenterology 2006年第2期12卷 251-258页

作者： annamaria szabolcs Russel J Reiter Tamas Letoha Peter Hegyi Gabor Papai Ilona Varga Katalin Jarmay Jozsef Kaszaki Reka Sari Zoltan Rakonczay Jr Janos Lonovics Tamas Takacs st Department of Medicine University of SzegedHungary Department of Cellular and Structural Biology University of TexasHealth Science CentreSan AntonioTexasUnited States Institute of Chemistry University of SzegedHungary Biological Research Centre Hungarian Academy of SciencesSzegedHungary Biological Isotope Laboratory University of SzegedHungary Institute of Experimental Surgery University of SzegedHungary

瞄准：决定 melatonin 预告的处理的效果并且在 L 精氨酸(L-Arg ) 的严厉上处理以后在老鼠的导致的试验性的胰腺炎。方法：男 Wistar 老鼠(25 ) 被划分成五个组。那些在 1h 的间隔在组 A 收到了 3.2g/kg 体重 L-Arg i.p 的二注射。在组... 详细信息

瞄准：决定 melatonin 预告的处理的效果并且在 L 精氨酸(L-Arg ) 的严厉上处理以后在老鼠的导致的试验性的胰腺炎。方法：男 Wistar 老鼠(25 ) 被划分成五个组。那些在 1h 的间隔在组 A 收到了 3.2g/kg 体重 L-Arg i.p 的二注射。在组麻省，老鼠与 50 mg/kg 体重 melatonin i.p 被对待在 L-Arg 管理以前的 30 min。在组 AM，在 L-Arg 被给以后，老鼠收到了 melatonin 1h 的一样的剂量。在组 M， melatonin 的单次量是以前描述了被管理。在组 C，对照动物收到了生理盐水注射 i.p 所有老鼠被给在第二 L-Arg 注射以后的 24 h。结果：引起严重引起坏死胰腺炎的 L-Arg 管理在浆液淀粉酶水平，胰腺的重量 / 身体重量比率(pw/bw ) ，胰腺的 IL-6 内容和 myeloperoxidase 由重要举起证实了活动，相对控制值。浆液淀粉酶水平的举起显著地在与仅仅与 L-Arg 注射的老鼠相比给 melatonin 追随者 L-Arg 的老鼠被减少。胰腺的抗氧化剂酶(Cu/Zn-superoxide 歧化酶(Cu/Zn-SOD ) 和过氧化氢酶(猫)) 的活动显著地被增加在胰腺炎以后的 24 h 感应。显著地在 L-Arg 之前给的 Melatonin 在独自与 L-Arg 对待的老鼠相对那减少了胰腺的猫活动。在肝， L-Arg 显著地每氧化水平，和谷胱甘肽过氧化物酶和 Cu/Zn-SOD 活动增加了类脂化合物，而 Mn 草皮活动作为与控制老鼠相比被减少。Melatonin 预告的处理阻止了这些变化。结论：Melatonin 是能在尖锐胰腺炎期间抵抗一些 L-Arg-induced 变化的一种抗氧化剂，并且可能因此在有尖锐引起坏死胰腺炎的病人的支持的治疗有用。

关键词：急性胰腺炎褪黑激素清除剂 L-精氨酸大鼠

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Prevalence and correlates of aggressive behavior in psychiatric inpatient populations

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World Journal of Psychiatry 2022年第1期12卷 1-23页

作者： Hunor Girasek Vanda Adél Nagy szabolcs Fekete Gabor S Ungvari Gábor Gazdag Department of Psychiatry and Psychiatric Rehabilitation Jahn Ferenc South Pest HospitalBudapest 1204Hungary Department of Psychiatry National Institute of Forensic PsychiatryBudapest 1108Hungary School of PhD Studies Semmelweis UniversityBudapest 1085Hungary Division of Psychiatry School of MedicineUniversity of Western AustraliaCrawley 6009Australia Section of Psychiatry University of Notre DameFremantle 6160Australia Department of Psychiatry and Psychotherapy Faculty of MedicineSemmelweis UniversityBudapest 1083Hungary

Aggressive behavior in patients with psychiatric disorders is attracting increasing research *** reason for this is that psychiatric patients are generally considered more likely to be aggressive,which raises a related question of whether diagnoses of psychiatric disorders predict the prevalence of aggressive *** aggression in psychiatric wards is crucial,because aggressive behavior not only endangers the safety of both patients and staff,but it also extends the hospitalization *** of aggressive behavior also need careful attention to ensure effective treatment *** literature review explores the relationship between aggressive behavior and psychiatric disorders and syndromes(dementia,psychoactive substance use,acute psychotic disorder,schizophrenia,bipolar affective disorder,major depressive disorder,obsessivecompulsive disorder,personality disorders and intellectual disability).The prevalence of aggressive behavior and its underlying risk factors,such as sex,age,comorbid psychiatric disorders,socioeconomic status,and history of aggressive behavior are discussed as these are the components that mostly contribute to the increased risk of aggressive *** tools commonly used to predict and detect aggressive behavior and to differentiate between different forms of aggressive behavior in both research and clinical practice are also *** aggression prevention programs can be developed based on the current findings of the correlates of aggressive behavior in psychiatric patients.

关键词： Aggression Mental disorders Inpatients Prevalence Risk factors Risk assessment

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Network meta-analysis of randomized controlled trials on esophagectomies in esophageal cancer:The superiority of minimally invasive surgery

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World Journal of Gastroenterology 2022年第30期28卷 4201-4210页

作者： Lajos Szakó Dávid Németh Nelli Farkas szabolcs Kiss Réka Zsuzsa Domotor Marie Anne Engh Péter Hegyi Balint Eross András Papp Institute of Translational Medicine University of PécsMedical SchoolPécs 7624Hungary János Szentágothai Research Centre University of PécsMedical SchoolPécs 7624Hungary Institute for Translational Medicine University of PécsMedical SchoolPécs 7624Hungary of Bioanalysis University of PécsMedical SchoolPécs 7624Hungary Insittute of Translational Medicine University of PécsMedical SchoolPécs 7624Hungary Doctoral School of Clinical Medicine University of SzegedMedical SchoolSzeged 6720Hungary First Department of Medicine University of SzegedMedical SchoolSzeged 6725Hungary Institute of Translational Medicine University of PecsMedical SchoolPecs 7624Hungary Department of Surgery Clinical CenterUniversity of PécsMedical SchoolPécs 7624Hungary

BACKGROUND Previous meta-analyses,with many limitations,have described the beneficial nature of minimal invasive *** To compare all modalities of esophagectomies to each other from the results of randomized controlled trials(RCTs)in a network meta-analysis(NMA).METHODS We conducted a systematic search of the MEDLINE,EMBASE,Reference Citation Analysis(https://***/)and CENTRAL databases to identify RCTs according to the following population,intervention,control,outcome(commonly known as PICO):P:Patients with resectable esophageal cancer;I/C:Transthoracic,transhiatal,minimally invasive(thoracolaparoscopic),hybrid,and robot-assisted esophagectomy;O:Survival,total adverse events,adverse events in subgroups,length of hospital stay,and blood *** used the Bayesian approach and the random effects *** presented the geometry of the network,results with probabilistic statements,estimated intervention effects and their 95% confidence interval(CI),and the surface under the cumulative ranking curve to rank the *** We included 11 studies in our *** found a significant difference in postoperative pulmonary infection,which favored the minimally invasive intervention compared to transthoracic surgery(risk ratio 0.49;95%CI:0.23 to 0.99).The operation time was significantly shorter for the transhiatal approach compared to transthoracic surgery(mean difference-85 min;95%CI:-150 to-29),hybrid intervention(mean difference-98 min;95%CI:-190 to-9.4),minimally invasive technique(mean difference-130 min;95%CI:-210 to-50),and robot-assisted esophagectomy(mean difference-150 min;95%CI:-240 to-53).Other comparisons did not yield significant *** Based on our results,the implication of minimally invasive esophagectomy should be favored.

关键词： Surgery Esophageal cancer Esophagectomy Network meta-analysis Minimally invasive Laparoscopy

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Insufficient etiological workup of COVID-19-associated acute pancreatitis: A systematic review

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World Journal of Gastroenterology 2020年第40期26卷 6270-6278页

作者： Márk Félix Juhász Klementina Ocskay szabolcs Kiss Péter Hegyi Andrea Párniczky Institute for Translational Medicine University of PécsMedical SchoolPécs 7624Hungary Doctoral School of Clinical Medicine University of SzegedSzeged 6720Hungary Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7624Hungary Department of Pediatrics Heim Pál National Institute for PediatricsBudapest 1089Hungary

BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection, mostly causing respiratory symptoms, is also known to affect the gastrointestinal tract. Several case reports hypothesize that SARS-CoV-2 could be an etiological factor in acute pancreatitis(AP).AIM To assess all the available evidence in the literature relating to coronavirus disease 2019(COVID-19) and *** We performed a systematic review of the available literature on the topic. The systematic search was conducted on 15 May 2020 on MEDLINE, EMBASE, CENTRAL, Web of Science and Scopus with a search key using the terms "amylase," "lipase," "pancr*," "COVID-19" and synonyms. Due to the low quality and poor comparability of the studies, a meta-analysis was not *** Six case reports and two retrospective cohorts were included, containing data on eleven COVID-19 patients with AP. Five patients had AP according to the Atlanta classification. Other publications did not provide sufficient information on the diagnostic criteria. Most cases were considered SARS-CoV-2-induced, while several established etiological factors were not investigated. We were able to identify other possible causes in most of *** We strongly highlight the need for adherence to the guidelines during a diagnostic and etiological workup, which could alter therapy.

关键词： Pancreas COVID-19 Pancreatic involvement Pancreatitis Amylase Lipase

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Modification of tooth development by heat shock protein 60

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International Journal of Oral Science 2016年第1期8卷 24-31页

作者： Tamas Papp Angela Polyak Krisztina Papp Zoltan Meszar Roza Zakany Eva Meszar-Katona Paine Terdik Tiinde Chang Hwa Ham szabolcs Felszeghy Department of Anatomy Histologyand EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Scoliosis Research Institute Korea University Guro HospitalSeoul Department of Oral Anatomy Faculty of DentistryUniversity of DebrecenDebrecenHungary

several heat shock proteins have been investigated in relation to tooth development, no available information is available about the spatial and temporal expression pattern of heat shock protein 60 （Hsp 60）. To characterize Hsp 60 expression in the structures of the developing tooth germ, we used Western blotting, immunohistochemistry and in situ hybridization. Hsp 60 was present in high amounts in the inner and outer enamel epithelia, enamel knot （EK） and stratum intermedium （SI）. Hsp 60 also appeared in odontoblasts beginning in the bell stage. To obtain data on the possible effect of Hsp 60 on isolated lower incisors from mice, we performed in vitro culturing. To investigate the effect of exogenous Hsp 60 on the cell cycle during culturing, we used the 5-bromo-2- deoxyuridine （BrdU） incorporation test on dental cells. Exogenously administered Hsp 60 caused bluntness at the apical part of the 16.5-day-old tooth germs, but it did not influence the proliferation rate of dental cells. We identified the expression of Hsp 60 in the developing tooth germ, which was present in high concentrations in the inner and outer enamel epithelia, EK, SI and odontoblasts. High concentration of exogenous Hsp 60 can cause abnormal morphology of the tooth germ, but it did not influence the proliferation rate of the dental cells. Our results suggest that increased levels of Hsp 60 may cause abnormalities in the morphological development of the tooth germ and support the data on the significance of Hsp during the developmental processes.

关键词： enamel organ heat shock protein 60 inhibitor of κB kinase morphology mouse tooth development

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Novel, X-ray supported kinetic imaging of hidden-lifestyle arthropods

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Insect Science 2021年第1期28卷 281-284页

作者： Sandor Keszthelyi David Szollosi Lilia Strobe szabolcs Osvath Krisztian Szigeti Zsolt Pbnya Adam Csoka Tamas Donko Faculty of Agricultural and Environment Sciences Department of Plant Production and ProtectionInstitute of Plant ScienceKaposvar UniversityKaposvarHungary Kinepict Ltd. BudapestHungary Medicopus Nonprofit Ltd. KaposvarHungary

Dear Editor,There are several arthropods,which live and develop covertly in plant *** plant tissues surrounding them provide them with shelter during their vulnerable developing stage or ensure overwintering as well a... 详细信息

关键词： arthropod kinetic hidden

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Laboratory Experiments for Arsenic and Ammonium Removal The Combination of Breakpoint Chlorination and Iron（Ⅲ）-Coagulation

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Journal of Environmental Science and Engineering(A) 2012年第10期1卷 1165-1172页

作者： szabolcs Takó Dóra Laky Department of Sanitary and Environmental Engineering Budapest University of Technology and Economics Muegyetem rkp. 31111Budapest Hungary

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What does organelle-to-nucleus DNA transfer tell in the plant kingdom?

What does organelle-to-nucleus DNA transfer tell in the plan...

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第十三届全国植物基因组学大会

作者： szabolcs Makai Javeed Hussain He Genetic Engineering International Cooperation Base of Chinese Ministry of Science and Technology Chinese National Center of Plant Gene Research(wuhan)Hust PartCollege of Life Science and TechnologyHuazhong University of Science & Technology(hust) Department of Plant Physiology and Molecular Biology Eotvos University He Genetic Engineering International Cooperation Base of Chinese Ministry of Science and Technology Chinese National Center of Plant Gene Research(wuhan)Hust PartCollege of Life Science and TechnologyHuazhong University of Science & TechnoIogy(hust)

Plastid and mitochondria of the eukaryotic cell are of endosymbiotic *** event stretches back some 2 billion years and brought about significant changes in the genomes of the host and the *** studies concluded the conquest of lands left different marks on plastid and mitochondria and also that the integration of mitochondria followed different paths for animals and *** the growing number of sequenced genomes it has become possible to examine organelle to

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Prophylactic transcatheter arterial embolization reduces rebleeding in non-variceal upper gastrointestinal bleeding: A meta-analysis

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World Journal of Gastroenterology 2021年第40期27卷 6985-6999页

作者： Eszter Boros Zoltán Sipos Péter Hegyi Brigitta Teutsch Levente Frim Szilárd Váncsa szabolcs Kiss FanniDembrovszky Eduard Oštarijaš Andrew Shawyer Bálint Erőss Institute for Translational Medicine University of PecsMedical SchoolPécs 7624Hungary First Department of Internal Medicine St.George University Teaching Hospital of County FejérSzékesfehérvár 8000Hungary Szentágothai Research Center University of PecsPécs 7624Hungary Doctoral School of Clinical Medicine University of SzegedSzeged 6720Hungary Department of Interventional Radiology University Hospitals Dorset NHS Foundation TrustBournemouth BH77DWUnited Kingdom

BACKGROUND Despite the improvement in the endoscopic hemostasis of non-variceal upper gastrointestinal bleeding(NVUGIB),rebleeding remains a major *** To assess the role of prophylactic transcatheter arterial embolization(PTAE)added to successful hemostatic treatment among NVUGIB *** We searched three databases from inception through October 19th,*** controlled trials(RCTs)and observational cohort studies were *** compared patients with NVUGIB receiving PTAE to those who did not get *** outcomes were rebleeding,mortality,reintervention,need for surgery and transfusion,length of hospital(LOH),and intensive care unit(ICU)*** the quantitative synthesis,odds ratios(ORs)and weighted mean differences(WMDs)were calculated with the random-effects model and interpreted with 95%confidence intervals(CIs).RESULTS We included a total of 3 RCTs and 9 observational studies with a total of 1329 patients,with 486 in the intervention *** was associated with lower odds of rebleeding(OR=0.48,95%CI:0.29–0.78).There was no difference in the 30-d mortality rates(OR=0.82,95%CI:0.39–1.72)between the PTAE and control *** who underwent PTAE treatment had a lower chance for reintervention(OR=0.48,95%CI:0.31–0.76)or rescue surgery(OR=0.35,95%CI:0.14–0.92).The LOH and ICU stay was shorter in the PTAE group,but the difference was non-significant[WMD=-3.77,95%CI:(-8.00)–0.45;WMD=-1.33,95%CI:(-2.84)–0.18,respectively].CONCLUSION PTAE is associated with lower odds of rebleeding and any reintervention in ***,further RCTs are needed to have a higher level of evidence.

关键词： Prophylactic transcatheter arterial embolization Non-variceal upper gastrointestinal bleeding Rebleeding Reintervention Meta-analysis Review

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