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Fine-scale analysis of heavily invaded Italian freshwater fish assemblages

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Integrative Zoology 2017年第6期12卷 500-511页

作者： annamaria NOCITA Elena TRICARICO Sandro BERTOLINO Natural History Museum Section of Zoology“La Specola”University of FlorenceFirenzeItaly Department of Biology University of FlorenceFirenzeItaly Department of Agriculture Forest and Food SciencesGrugliascoItaly Department of Life Sciences and Systems Biology University of TurinTorinoItaly University of TurinItaly

Inland waters are highly vulnerable to the introduction and spread of non-native species,due to heavy human use of aquatic ecosystems and the natural linkages among streams and *** is particularly noticeable in freshwater fish *** better evaluate how these communities are affected by non-native species introductions,we conducted a fine-scale analysis of the changes in Italian freshwater fish assemblages after species *** this analysis,we collected information on fish species present in 44 *** present Italian freshwater fish fauna is composed of 48 native and 41 established introduced species,while a further 15 introduced species have been reported but are not yet considered *** changes in the fish assemblages mostly took place in the past 2 centuries and have increased recently,with nearly 60%of the species introduced in the past 3 *** number of species introduced per basin ranged from 0 to 35(mean 10.85±7.77 species/basin),and in 10 basins the number of species introduced is now equal to or even higher than the number of native *** the past,introduced species mainly originated from America,but over the past three decades,an increase of introductions from other parts of Europe and Asia has been *** results show that basins already rich in native species tend to become even richer as a consequence of the establishment of introduced *** confirms the trend toward a biotic homogenization of ecosystems even at a local scale,due to an increase in the human-mediated spread of generalist species.

关键词： biological invasions Ichthyofauna Italy non-native species species introductions

Ultra-subwavelength phase-sensitive Fano-imaging of localized photonic modes

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Light(Science & Applications) 2015年第1期4卷 223-230页

作者： Niccolo Caselli Francesca Intonti Federico la China Francesco Riboli annamaria Gerardino Wei Bao Alexander Weber Bargioni Lianhe Li Edmund H Linfield Francesco Pagliano Andrea Fiore Massimo Gurioli European laboratory for Nonlinear Spectroscopy via Nello Carrara 150019Sesto Fiorentino(FI)Italy Department of Physics University of Florencevia Sansone 150019 Sesto Fiorentino(FI)Italy Department of Physics University of Trentovia Sommarive 1438123Povo(TN)Italy Institute of Photonics and Nanotechnology CNR00156 RomaItaly Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA School of Electronic and Electrical Engineering University of LeedsLeeds LS29JTUK COBRA Research Institute Eindhoven University of Technology5600 MB EindhovenThe Netherlands

Photonic and plasmonic devices rely on nanoscale control of the local density of optical states(LDOS)in dielectric and metallic *** tremendous progress in designing and tailoring the electric LDOS of nano-resonators requires an investigation tool that is able to access the detailed features of the optical localized resonant modes with deep-subwavelength spatial *** scenario has motivated the development of different nanoscale imaging ***,we prove that a technique involving the combination of scanning near-field optical microscopy with resonant scattering spectroscopy enables imaging the electric LDOS in nano-resonators with outstanding spatial resolution(λ/19)by means of a pure optical method based on light *** this technique,we investigate the properties of photonic crystal nanocavities,demonstrating that the resonant modes appear as characteristic Fano line shapes,which arise from ***,by monitoring the spatial variation of the Fano line shape,we locally measure the phase modulation of the resonant modes without the need of external heterodyne *** novel,deep-subwavelength imaging method allows us to access both the intensity and the phase modulation of localized electric ***,this technique could be implemented on any type of platform,being particularly appealing for those based on non-optically active material,such as silicon,glass,polymers,or metals.

关键词： nanocavity nanophotonics near-field phase retrieval resonant-scattering

Neural Network Approach for Estimating the Hole Damage in Drilling Process of Reactive Powder Concrete （RPC）

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材料科学与工程（中英文版） 2011年第3期5卷 304-313页

作者： annamaria Gisario Alberto Boschetto Francesco Veniali Department of Mechanics and Aeronautics University of Rome ＂La Sapienza＂ Eudossiana 18 00184 Rome Italy

High Resolution Mass Spectrometry for the Recognition and Structural Characterization of a New Antimicrobial Compound

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Pharmacology & Pharmacy 2018年第5期9卷 135-148页

作者： Lù cia Carrano annamaria Naggi Elena Urso Fondazione Istituto Insubrico Ricerca per la Vita Gerenzano Italy Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni Milan Italy

Identification of novel specialized metabolites or bioactive compounds represents the main objective in the research field of natural product leads and drug discovery. Mass spectrometry (MS) provides a central tool to expedite and make more efficient the discovery and isolation phases, while minimizing the waste of resources on rediscovery of known compounds. MS contributes acutely to elucidation and identification of numerous species because it allows molecular mass and structural features determination. In particular, identification of the elemental composition of a precursor ion of interest by accurate mass measurement and investigation of dissociative processes undergone by the molecule, represent a worthy methodology to access the structure assignment. The aim of this study was to discover and identify novel antibacterial drugs from microbial source in a jungle of already known compounds. The focus of this paper is on the analytical strategy that permitted the disclosure of a new compound, otherwise confused with other substances. Emphasis is placed on the interpretation of the ESI-MS/MS fragmentation pattern that combined with high resolution mass determination, allowed step by step to properly deduce the exact molecular formula of an unknown component with a molecular weight higher than 1500 Daltons.

关键词： Antibiotic Development Antibiotic Discovery High Resolution Mass Spectrometry Molecular Formula MS/MS Fragmentation FT ICR MS

CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not

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Cellular & Molecular Immunology 2015年第4期12卷 474-482页

作者： MariaNeve Polimeno[1 7] CaterinaIerano[1 7] CrescenzoD'Alterio NunziaSimona Losito MariaNapolitano LuigiPortella Giosu #x000E8 Scognamiglio FabianaTatangelo annamaria Trotta StevenCurley SusanCostantini RaffaeleLiuzzi FrancescoIzzo Oncological Immunology Istituto Nazionale per lo Studio e la Cura dei Tumori &#x0201C Fondazione Giovanni Pascale” -IRCCS-ITALIA Naples ItalyPathology Unit Istituto Nazionale per lo Studio e la Cura dei Tumori &#x0201C Fondazione Giovanni Pascale” -IRCCS-ITALIA Naples ItalyHepato-Biliary Surgery Unit Istituto Nazionale per lo Studio e la Cura dei Tumori &#x0201C Fondazione Giovanni Pascale” -IRCCS-ITALIA Naples ItalyInstitute of Biostructure and Bioimaging (IBB) of the Italian National Research Council Naples ItalyCorrespondence: Dr S Scala Oncological Immunology Istituto Nazionale per lo Studio e la Cura dei Tumori &#x0201C Fondazione Giovanni Pascale” -IRCCS-ITALIA Via M. Semmola 52 80131 Naples Italy. E-mail: scalaste@*** s.scala@istitutotumori.na.it

Hepatocellular carcinoma （HCC） is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expression was analyzed by immunohistochemistry in 86 HCC patients （training cohort） and validated in 42 unrelated HCC patients （validation cohort）. CXCR4 levels were low in 22.1% of patients, intermediate in 30.2%, and high in 47.7%, whereas CXCR7 levels were low in 9.3% of patients, intermediate in 44.2% and high in 46.5% of the patients in the training cohort. When correlated to patient outcome, only CXCR4 affected overall survival （P=-O.03）. CXCR4-CXCL12-CXCR7 mRNA levels were examined in 33/86 patients. Interestingly, the common CXCR4-CXCR7 ligand CXCL12 was expressed at significantly lower levels in tumor tissues compared to adjacent normal liver （P=0.032）. The expression and function of CXCR4 and CXCR7 was also analyzed in several human HCC cell lines. CXCR4 was expressed in Huh7, Hep3B, SNU398, SNU449 and SNU475 cells, whereas CXCR7 was expressed in HepG2, Huh7, SNU449 and SNU475 cells. Huh7, SNU449 and SNU475 cells migrated toward CXCL12, and this migration was inhibited by AMD3 lO0/anti-CXCR4 and by CCX771/anti-CXCR7. Moreover, SNU449 and Huh7 cells exhibited matrix invasion in the presence of CXCL12 and CXCL11, a ligand exclusive to CXCR7. In conclusion, CXCR4 affects the prognosis of HCC patients but CXCR7 does not. Therefore, the CXCR4-CXCL12-CXCR7 axis plays a role in the interaction of HCC with the surrounding normal tissue and represents a suitable therapeutic target.

关键词： CXCR4 CXCR7 CXCL12 hepatocellular carcinoma prognosis

Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis

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World Journal of Gastroenterology 2013年第46期19卷 8659-8670页

作者： Martina Galatola Erasmo Miele Caterina Strisciuglio Lorella Paparo Daniela Rega Paolo Delrio Francesca Duraturo Massimo Martinelli Giovanni Battista Rossi annamaria Staiano Paola Izzo Marina De Rosa Department of Molecular Medicine and Medical Biotechnology and CEINGE Biotecnologie Avanzate University of Naples"FedericoⅡ" Department of Translational Medical Sciences Section of PediatricsUniversity of Naples"FedericoⅡ" Colorectal Surgical Oncology-Abdominal Oncology Department Istituto Nazionale per lo studio e la cura dei tumori"Fondazione Giovanni Pascale"IRCCS-80131 NaplesItaly Endoscopy Unit Istituto Nazionale per lo studio e la cura dei tumori"Fondazione Giovanni Pascale"IRCCS-80131 NaplesItaly

AIM: To investigated the molecular cause of very early-onset ulcerative colitis (UC) in an 18-mo-old affected child.

关键词： Inflammatory bowel disease, Ulcerative colitis, Interleukin 10 receptors, Tumour necrosis factor α receptors, Beta catenin

Pancreatic neuroendocrine tumor with hypoglycemia and elevated insulin-like growth factor II:a case report

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 345-347页

作者： Roberta Modica Antonella Di Sarno annamaria Colao Antongiulio Faggiano Department of Clinical Medicine and Surgery Federico II University80131 NaplesItaly UOC of Oncology A.O.Dei ColliMonaldi Unit80131 NaplesItaly Thyroid and Parathyroid Surgery Unit Istituto Nazionale per lo studio e la cura dei tumori“Fondazione G.Pascale”-IRCCS80131 NaplesItaly

Pancreatic neuroendocrine tumors(pNETs)can be associated with different clinical *** is the most common functioning pNET characterized by hypoglycemia and *** authors report a case of a man presenting with hypoglycemia and biochemical features of insulinoma.A pancreatic lesion was found and growth hormone(GH)deficiency was also diagnosed associated with an empty sella present on the pituitary magnetic resonance *** disappearance of hypoglycemia and normalization of GH secretion after surgical resection of the pancreatic lesion,revealed a rare pNET secreting insulin-like growth factor II.

关键词： Pancreatic neuroendocrine tumor insulinoma hypoglycemia insulin-like growth factor II

How to Reduce Unnecessary Invasive Angiograms When Patients Are Initially Evaluated by Coronary Computed Tomography?

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Advances in Computed Tomography 2013年第1期2卷 13-19页

作者： Edouard Cheneau Bruno Vahdat Noemie Resseguier laurent Bernard annamaria Molon Roch Giorgi Dimitri Panagides Service de Cardiologie Clinique BouchardMarseilleFrance Service de Sante Publique et d’Information Medicale Hopital de la TimoneMarseilleFrance

Purpose:When Coronary Computed Tomography (CCT) detects coronary obstruction, patients are regularly referred to invasive angiogram. With higher sensitivity than specificity, CCT might induce unnecessary angiograms (“false positive CCT”). We sought to determine the patients and CCT findings associated with false positive CCT. Methods: Patients were prospectively referred to CCT with a 64-slice CT scan for suspected CAD. Inclusion criteria were: 1) clinically suspected angina pectoris;or 2) suspected silent ischemia on resting EKG. Exclusion criteria were acute coronary syndrome and non sinus rhythm. Invasive coronary angiogram (ICA) was performed on the basis of CCT findings (stenosis >50%). Analysis was performed on a per patient basis. Results: Out of 702 patients, 228 had suspected significant stenosis by CCT and ICA was performed in 176 patients. Coronary stenosis >50% was not confirmed by ICA in 44 (25%). In multivariate analysis, we observed that atypical angina (OR 3.63,CI 1.43-9.66), silent ischemia (OR 5.11, CI 1.89-14.6) and number of suspected stenosed arteries by CCT (OR 1.81, CI 1.15-2.94) were independently predictive of false positive CCT (p Conclusions:Performing CCT for atypical angina or silent ischemia is associated with higher rate of unnecessary invasive coronary angiograms. We failed to identify lesions characteristics prone to be “false positive” of CCT.

关键词： Angina Coronary Disease Diagnosis CCT

Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study

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Food Science and Human Wellness 2024年第6期13卷 3536-3543页

作者： Mirco Vacca Eduardo Maria Sommella Marina Liso Giulio Verna Aurelia Scarano annamaria Sila Margherita Curlo Mauro Mastronardi Katia Petroni Chiara Tonelli Bruno Di Jeso Angelo Santino Vincenzo Vestuto Fabrizio Merciai Gianluigi Giannelli Pietro Campiglia Maria De Angelis Marcello Chieppa Francesco Maria Calabrese Department of Soil Plant and Food ScienceUniversity of Bari Aldo MoroBari 70126Italy Department of Pharmacy School of PharmacyUniversity of SalernoFisciano 84084Italy Functional Gastrointestinal Disorders Research Group National Institute of Gastroenterology IRCCS“S.de Bellis”Castellana Grotte 70013Italy Department of Medicine Digestive Health Research InstituteCase Western Reserve University School of MedicineCleveland 44106USA Unit of Lecce Institute of Sciences of Food Production C.N.R.Lecce 73100Italy Department of Biosciences University of MilanMilan 20133Italy Department of Biological and Environmental Sciences and Technologies University of SalentoLecce 73100Italy Department of Biological and Environmental Sciences and Technologies(DISTEBA) University of SalentoLecce 73100Italy

Nowadays,inflammatory bowel disease(IBD)-patient therapies are mainly based on corticosteroid,thiopurine,and immunomodulator *** with active disease,that do not respond to corticosteroid and/or thiopurine treatment,can switch to the usage of the chimeric monoclonal antibody infliximab(IFX).However,to date,no treatment appeared to be conclusive in lowering the incidence of IBD *** the aim to increase the effectiveness of IFX treatment,we combined it with an adjuvant purple corn supplementation enriched in ***-patients were enrolled before they underwent to the IFX-infusion,and they were allocated in 2 different study *** in the intervention-arm followed a dietary supplementation with purple corn water-soluble extract,whereas control patients had a daily consumption of red fruit tea.16S rDNA gene-sequencing and high-resolution mass-spectrometry metabo-lipidomics analyses were conducted on stool and sera samples,*** a result,the experimental intervention mainly affected the serum metabolome of IBD-patients by decreasing the concentration of specific *** on IBD patient annotated taxa,a significant decrease in lactobacillus and Bifi dobacterium relative abundances was *** far as it concerns the ulcerative colitis patient subset,the experimental intervention led to a decrease in Alistipes and Erysipelotrichaceae UCG-003 genus abundances and a concomitant Parabacteroides *** the contrary,after treatment,Crohn’s disease patients did not exhibit metataxonomics differences at the genus *** the end of the treatment that led to a reshaped microbiota community,the gathered data paves the way for the usage of a specifically designed probiotic supplementation as a valuable strategy for IBD-patients under IFX infusion.

关键词： Inflammatory bowel disease infliximab infusion Antioxidants Nutrigenomics Adjuvant therapy