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In vitro effects of polyphenols on colorectal cancer cells

World Journal of Gastrointestinal Oncology 2014年第8期6卷 289-300页

作者： Barbara Pampaloni Gaia Palmini Carmelo Mavilia Roberto Zonefrati annalisa tanini Maria Luisa Brand Department of Surgery and Translational Medicine University of Florence Florence 50139 Italy

AIM:To investigate the effects of quercetin and genistein on colon cancer cell proliferation and their estrogen receptorβ(ERβ)***:Colon cancer cells were stably transfected with a mammalian expression vector to overexpress ERβ(HCT8-β8-expressing cells)or a control vector(HCT8-pSV2neo-expressing cells).The proliferation of these cells was examined after treatment with quercetin or genistein(5-100μmol/L),or 10 nmol/L17β-estradiol(17β-E2).Cell viability was examined by acridine orange staining following treatments for 48 or144 *** of quercetin and genistein on ERβtranscriptional transactivation were examined by luciferase activity in HCT8-β8-expressing cells transiently transfected with a pEREtkLUC reporter *** addition,the regulation of ERβtranscription by phytoestrogens and 17β-E2 was examined by quantitative polymerase chain ***:Proliferation of HCT8-β8-expressing cells was not reduced low doses(5μmol/L)of quercetin and genistein,while it was reduced at 25-50μmol/L with an effect similar to 10 nmol/L 17β-*** with doses of phytoestrogens≥75μmol/L completely blocked cell growth and reduced overall cell counts,however no effects at any dose were observed in HCT8-pSV2neoexpressing *** results were supported by viability staining that revealed acridine orange-stained lysosomes with high doses or extended treatment *** and quercetin(50μmol/L)significantly increased ER-responsive luciferase activity similar to 10nmol/L 17β-E2(P<0.05).Furthermore,genistein and quercetin(50μmol/L),as well as 10 nmol/L 17β-E2significantly increased ERβmRNA levels in HCT8-β8-expressing cells(P<0.05).In addition,treatment of HCT8-pSV2neo-expressing cells with 50μmol/L quercetin or 10 nmol/L 17β-E2 significantly increased ERβmRNA levels compared to untreated controls(P<0.05),though the absolute levels were much lower than in HCT8-β8-expressing ***:The antitumorigenic effects of the phytoestrogenic compounds querc

关键词： Estrogen receptor HCT8-β8 cells HCT8pSV2neo Quercetin Genistein

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Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: A case report and a review of literature

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World Journal of Gastroenterology 2006年第32期12卷 5234-5236页

作者： Chiara Riviello Ilaria tanini Greta Cipriani Pietro Pantaleo Carlo Nozzoli Alberto Poma Viligiardi Riccardo Andrea Valeri Second Division of General and Vascular Surgery Careggi Hospital FlorenceItaly Department of Internal Medicine Oncologic Day-Hospital University of Florence Italy Second Division of Internal Medicine Careggi Hospital FlorenceItaly

Renal cell carcinoma （RCC） is the most common renal tumor, accounting for 2%-3% of all malignancies. Though RCC is known to spread hematogenously, isolated RCC metastasis to the stomach is a rare event. In this article, we describe the clinical course of a patient who developed a pancreatic recurrence of RCC and 1 year later a gastric recurrence of RCC treated 10 years ago with a resection and interleukin-2 （IL-2）. Accumulating evidence indicates that metastatic involvement of the pancreas and stomach should be suspected in any patient with a history of RCC who presents with gastrointestinal symptoms even 10 years after RCC resection and immunotherapy.

关键词： Renal cell carcinoma Stomach metastasis Interleukin-2 treatment

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Osteopathy and Emergency: A Model of Osteopathic Treatment Aimed at Managing the Post-Traumatic Stress—Brief and Useful Guide—Part 2

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Health 2018年第7期10卷 1597-1608页

作者： Luca Collebrusco Simone Fabri Antonio Furfaro Ilaria tanini Rita Lombardini Andrea Rizza Paolo Zavarella Rehabilitation Unit National Health Service of Umbria Perugia Italy Research Department CROMON EDUCAM School Rome Italy Department of Medicine University of Perugia Perugia Italy

This work aims to describe a well standardized therapeutic path in reference to the article “Osteopathy and Emergency: A Model of Osteopathic Treatment Aimed at Managing the Post-Traumatic Stress—Part 1 in the form of a practical guide for manual therapist, Open Journal of Therapy and Rehabilitation, Vol. 10, No. 7, July 2018, https://***/10.4236/health.2018.107074”. The osteopathic manipulative treatment (OMT) approach we propose can be complementary to the psychological therapy in use today, and consists of ten standardized techniques directed to the anatomical structures more involved in the stress answer. This protocol was designed to improve and sustain the management of subjects exposed to extraordinary exogenous stress or post-traumatic stress disorder patients (PTSD).

关键词： Post-Traumatic Stress Disorder Osteopathic Manipulative Treatment Visceral Osteopathic Osteopathy Cranial Field Myofascial and Musculoskeletal Techniques

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