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Helicobacter pylori cagA,iceA and vacA genotypes in patients with gastric cancer in Taiwan

World Journal of Gastroenterology 2004年第17期10卷 2493-2497页

作者： Hwai-JengLin Chin-LinPerng Wen-ChingLo Chew-WunWu Guan-YingTseng annafen-yauli I-ChenSun Yueh-HsingOu DivisionofGastroenterology DepartmentofMedicineVGH-TAIPEITaiwanChina I-LanHospital DepartmentofhealthTaiwanChina ZhongxiaoMunicipalHospital TaipeiTaiwanChina DivisionofGeneralSurgery DepartmentofSurgeryVGH-TAIPEITaiwanChina Ton-YenGeneralHospital Hsin-ChnTaiwanChina DepartmentofPathology VGH-TAIPEITaiwanChina InstituteofBiotechnologyinMedicine SchoolofMedicalTechnologyandEngineeringandSchoolofMedicineNationalYang-MingUniversityTaiwanChina

AIM: Helicobacter pylori( H pylori) has been linked to chronic gastritis, peptic ulcer, gastric cancer and *** link of genotypes of Hpylorito gastric cancer remains controversial. The aim of this study was to investigate the Hpylori vacA alleles, cagA and iceA in patients with gastric cancer in ***: Patients with gastric cancer, peptic ulcer and chronic gastritis were enrolled in this study. We obtained biopsy specimens from the stomach at least 2 cm away from the tumor margin in patients with gastric cancer, and from the antrum of stomach in patients with peptic ulcer or chronic gastritis. DNA extraction and polymerase chain reaction were used to detect the presence or absence of cagA and to assess the polymorphism of vacA and ***: A total of 168 patients (gastric ulcer: 77, duodenal ulcer: 66, and chronic gastritis: 25) were found to have positive PCR results of the biopsy specimens from patients with peptic ulcer and chronic gastritis. We found positive cagA (139/168, 83%), m2 (84/168, 50%) and iceA1 (125/168,74%) strains in the majority of patients. In patients with gastric cancer, the vacA sla and slc subtypes were less commonly found than those in non-cancer patients (35/66 vs 127/168, P= 0.0001 for sla and 13/66 vs93/168, P<0.0001 for slc). In the middle region, the mlT strain in patients with gastric cancer was more than that of non-cancer patients(23/66 vs 33/168, P = 0.02).CONCLUSION: In Taiwan, H pylori with positive vacA sla,cagA and iceA1 strains are found in the majority of patients with gastric cancer or non-cancer patients. In patients with gastric cancer, the vacA s1a and slc subtypes are less and m1T is more than in patients with peptic ulcer and chronic gastritis.

关键词：哈比特属幽门菌 cagA1 iceA vacA 基因型胃癌肿瘤消化系统

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