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A fully inkjet-printed disposable glucose sensor on paper

npj Flexible Electronics 2018年第1期2卷 263-270页

作者： Eloïse Bihar Shofarul Wustoni anna maria pappa Khaled N.Salama Derya Baran Sahika Inal Division of Biological and Environmental Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955Saudi Arabia Division of Physical Science and Engineering KAUST Solar CenterKAUSTThuwal 23955Saudi Arabia Department of Chemical Engineering and Biotechnology University of CambridgePhilippa Fawcett DriveCambridge CB30ASUK Division of Computer Electrical and Mathematical Sciences and EngineeringAdvanced Membranes and Porous Materials CenterKAUSTThuwal 23955Saudi Arabia

Inexpensive and easy-to-use diagnostic tools for fast health screening are imperative,especially in the developing world,where portability and affordability are a *** monitoring of metabolite levels can provide useful information regarding key metabolic activities of the body and detect the concomitant irregularities such as in the case of diabetes,a worldwide chronic ***,the majority of daily glucose monitoring tools rely on piercing the skin to draw *** pain and discomfort associated with finger pricking have created a global need to develop non-invasive,portable glucose *** this work,we develop a disposable analytical device which can measure physiologically relevant glucose concentrations in human saliva based on enzymatic electrochemical *** use inkjet-printing technology for the rapid and low-cost deposition of all the components of this glucose sensor,from the electronics to the biorecognition elements,on commercially available paper *** only electronic component of the sensor is the conducting polymer poly(3,4 ethylenedioxythiophene)doped with polystyrene sulfonate(PEDOT:PSS),while the biorecognition element comprises of the enzyme glucose oxidase coupled with an electron *** demonstrate that one month after its fabrication and storage in air-free environment,the sensor maintains its function with only minor performance *** fully printed,all-polymer biosensor with its ease of fabrication,accuracy,sensitivity and compatibility with easy-to-obtain biofluids such as saliva aids in the development of next generation low-cost,noninvasive,eco-friendly,and disposable diagnostic tools.

关键词： maintain sensor printing

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Organic transistor platform with integrated microfluidics for in-line multi-parametric in vitro cell monitoring

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Microsystems & Nanoengineering 2017年第1期3卷 184-195页

作者： Vincenzo F.Curto Bastien Marchiori Adel Hama anna-maria pappa Magali P.Ferro Marcel Braendlein Jonathan Rivnay Michel Fiocchi George G.Malliaras Marc Ramuz Róisín M.Owens Department of Bioelectronics Ecole Nationale Supérieure des MinesCMP-EMSEMOC880 Avenue de MimetGardanne 13541France Flexible Electronics Department Ecole Nationale Supérieure des Mines CMP-EMSEMOC880 Avenue de MimetGardanne 13541France Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA

Future drug discovery and toxicology testing could benefit significantly from more predictive and multi-parametric readouts from in vitro *** the recent advances in the field of microfluidics,and more recently organ-on-a-chip technology,there is still a high demand for real-time monitoring systems that can be readily embedded with *** addition,multi-parametric monitoring is essential to improve the predictive quality of the data used to inform clinical studies that *** we present a microfluidic platform integrated with in-line electronic sensors based on the organic electrochemical *** goals are twofold,first to generate a platform to host cells in a more physiologically relevant environment(using physiologically relevant fluid shear stress(FSS))and second to show efficient integration of multiple different methods for assessing cell morphology,differentiation,and *** include optical imaging,impedance monitoring,metabolite sensing,and a wound-healing *** illustrate the versatility of this multi-parametric monitoring in giving us increased confidence to validate the improved differentiation of cells toward a physiological profile under FSS,thus yielding more accurate data when used to assess the effect of drugs or ***,this platform will enable high-content screening for in vitro drug discovery and toxicology testing and bridges the existing gap in the integration of in-line sensors in microfluidic devices.

关键词： bioelectronics in-line sensors in vitro microfluidics

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