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Utilization of molecular genetic approaches for colorectal cancer screening

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World Journal of Gastroenterology 2024年第46期30卷 4950-4957页

作者： Marina A Emelyanova anna Y Ikonnikova Center for Precision Genome Editing and Genetic Technologies for Biomedicine Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscow 119991Russia

The feasibility of population screening for colorectal cancer has been demonstrated in several *** of these studies have considered individual characteristics,diagnostic approaches,epidemiological data,and socioeconomic *** this article,we comment on an editorial by Metaxas et al published in the recent issue of the *** authors emphasized the need to raise public awareness through health education programs and the possibility of using easily accessible non-invasive screening ***,we focus on non-invasive molecular genetic approaches that can aid in colorectal cancer *** the one hand,we highlighted the use of tumor DNA/RNA markers directly for screening and,on the other hand,underline the use of polygenic risk assessment and hereditary predisposition to select individuals for more thorough cancer screening.

关键词： Colorectal cancer Cancer screening Non-invasive screening Liquid biopsy Polygenic risk score

variation of Ⅰ–Ⅴ characteristics due to process parameters as base for modeling the component variability for LDD MOSFET devices

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第2期9卷 103-114页

作者： Roberto Marani anna Gina Perr Consiglio Nazionale delle Ricerche Istituto di Studi sui Sistemi Intelligenti per l’Automazione(ISSIA) Bari 70125Italy Electronic Devices Laboratory Department of Electrical and Information Engineering Polytechnic University of Bari 70125 Italy

In this paper,we present the effect of process parameters variations on Ⅰ-Ⅴ characteristics of LDD MOSFETs through a simulation study,applying also to any submicron *** particular,we examine the effect of variation of ionic implantation for different channel doping involved in MOSFET *** last,we examine a linear Ⅰ-Ⅴ model to simulate more adequately the effects of variation of the process parameters as correction to the base model.

关键词： LDD MOSFET drain engineering device simulations.

Risk modeling of femoral neck fracture based on geometric parameters of the proximal epiphysis

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World Journal of Orthopedics 2022年第8期13卷 733-743页

作者： anna D Shitova Olga N Kovaleva anna v Olsufieva Inchekhanum A Gadzhimuradova Dmitry D Zubkov Mikhail O Kniazev Tatyana S Zharikova Yury O Zharikov International School“Medicine of the Future” I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991MoscowRussia Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 125009MoscowRussia Department of Biomedical Disciplines of the Faculty of Medicine Nonstate Educational Private Institution of Higher Education"Moscow Financial and Industrial University“Synergy”Moscow 125190MoscowRussia Institute of Clinical Medicine I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991MoscowRussia

BACKGROUND Fractures of the proximal femur epiphysis are problematic for state health care because they are associated with severe medical and social problems and high morbidity and mortality *** To model the potential risk of hip fracture via femur geometric *** Seventy educational cadaveric femurs from people aged 14 to 80 years,10 X-ray images from the records of the Human Anatomy Department and 10 X-ray images from the Department of Traumatology,Orthopedics and Disaster Surgery of Sechenov University,were *** parameters of the fractured bone were measured using images captured with a Canon d60 *** projection values of the proximal epiphysis of the cadaveric femurs and geometric parameters of the bones shown in the X-ray images were measured with Autodesk software(AutoCAD 2018).Analysis of the video frames showing bone rotation reveal that the greater trochanter can be inscribed in a parallelepiped,where one of the faces is parallel to the plane of view in the frontal standard projection and is *** angle of bone rotation obtained by turning the cube corresponded to the angle measured with the second *** reliable method of calculating the rotation of the bone relative to the anterior projection was employed in subsequent *** geometric parameters of the femur were measured using X-ray images according to the proposed *** The geometric parameters of 70 femurs were analyzed,and correlation coefficients were *** measurement results were compared with those reported by other *** potential influence of femur geometry on force distribution in the proximal epiphysis of the femur was described,and a 2-dimensional model of the femur epiphysis associated with minimal neck fracture risk was *** assessment of the geometric parameters of the femoral epiphysis indicated the greatest risk of a varus fracture of the neck if the angle of the minimal resistance zone(AMRZ)

关键词： Fracture Proximal epiphysis of femur Risk Traumatology Hip neck Risk assessment scale

Meso-substituted cationic 3-and 4-N-Pyridylporphyrins and their Zn(II)derivatives for antibacterial photodynamic therapy

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Journal of Innovative Optical Health Sciences 2022年第1期15卷 1-16页

作者： Aram G.Gyulkhandanyan Marina H.Paronyan anna G.Gyulkhandanyan Karapet R.Ghazaryan Marina v.Parkhats Boris M.Dzhagarov Maria v.Korchenova Ekaterina N.Lazareva Elena S.Tuchina Grigor v.Gyulkhandanyan valery v.Tuchin H.Buniatyan Institute of Biochemistry National Academy of Sciences of Armenia 5/1 Paruir Sevak Street Yerevan 0014Armenia INSERM U1204 Universite d'Evry vald'Essonne-Universite Paris-Saclay 1 Ruedu Pere JarlanBatiment Maupertuis91025Evry-CourcouronnesFrance B.I.Stepanov Institute of Physics National Academy of Sciences of Belarus 68-2 Nezavisimosti AvenueMinsk 220072Belarus Science Medical Center Saratov State University 83 Astrakhanskaya StreetSaratov 410012Russia Laboratory of Laser Molecular Imaging and Machine Learning(LMIML)National Research Tomsk State University 36 Lenin Avenue Tomsk 634050Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control Russian Academy of Sciences Saratov 410028Russia

Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy(APDT)is one of the most promising and innovative approaches for the destruction of pathogenic *** the photosensitizers(PSs),compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate *** of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in *** aim of this work was to determine and test the most e®ective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive *** was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria,including the methicillinresistant *** *** complexes of porphyrins are more phototoxic than metal-free porphyrin *** e®ectiveness of these Zn–metalloporphyrins on bacteria is consistent with the level of singlet oxygen *** was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors:the presence in the porphyrin macrocycle of a positive charge(+4),a central metal atom(Zn2þÞand hydrophobic peripheral functional groups as well as high values of quantum yields of singlet *** results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins cannd wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APDT.

关键词： Antibacterial photodynamic therapy cationic porphyrins/metalloporphyrins phototoxicity Zn-metalloporphyrins singlet oxygen quantum yield Gram negative and Gram positive bacteria S.aureus MRSA E.coli Salmonella typhimurium.

Hepatitis C virus-related lymphoproliferative disorders:An overview

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World Journal of Gastroenterology 2007年第17期13卷 2467-2478页

作者： anna Linda Zignego Carlo Giannini Clodoveo Ferri Department of Internal Medicine Center for Systemic Manifestations of Hepatitis Viruses (MASVE) and Center for Research Transfer and High Education DENOThe University of Florence Medical School Florence Italy Rheumatology Unit Department of Internal Medicine Medical School University of Modena and Reggio Emilia Modena Italy

Hepatitis C virus （HCv） is a global health problem affecting 3% of the world＇s population （about 180 million） and a cause of both hepatic and extrahepatic diseases. B-cell lymphoproUferative disorders, whose prototype is mixed cryoglobulinemia, represent the most closely related as well as the most investigated HCv- related extrahepatic disorder. The association between extrahepatic （lymphoma） as well as hepatic malignancies （hepatocellular carcinoma） has justified the inclusion of HCv among human cancer viruses. HCv-associated manifestations also include porphyria cutanea tarda, lichen planus, nephropathies, thyreopathies, sicca syndrome, idiopathic pulmonary fibrosis, diabetes, chronic polyarthritis, sexual dysfunctions, cardiopathy/ atherosclerosis, and psychopathological disorders. A pathogenetic link between HCv virus and some lymphoproliferative disorders was confirmed by their responsiveness to antiviral therapy, which is now considered the first choice treatment. The aim of the present paper is to provide an overview of extrahepatic manifestations of HCv infection with particular attention to B-cell lymphoproliferative disorders. Available pathogenetic hypotheses and suggestions about the most appropriate, currently available, therapeutic approaches will also be discussed.

关键词： Hepatitis C virus Extrahepatic manifestations Lymphoproliferative disorders Mixed cryoglobulinemia Lymphoma

Phylogeny of Brucella abortus strains isolated in the Russian Federation

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Asian Pacific Journal of Tropical Medicine 2021年第7期14卷 323-329页

作者： Dmitry A.Kovalev Dmitriy G.Ponomarenko Sergey v.Pisarenko Nikolay A.Shapakov anna A.Khachaturova Natalia S.Serdyuk Olga v.Bobrysheva Alexander N.Kulichenko Stavropol Research Anti-Plague Institute 355035StavropolRussian Federation

Objective: To study Brucella(B.) abortus strains isolated in the Russian Federation, in order to identify their detailed position in the phylogenetic structure of the species global population as well as to determine genetic relationships for isolates from different geographical ***: Based on Bayesian method, the whole genome singlenucleotide polymorphism(SNP) analysis of 258 B. abortus strains from different geographical areas of the world including 20 B. abortus strains isolated in Russia was carried out. Results: The core genome SNP analysis of the B. abortus isolates allowed describing the main genetic lineages. The Russian strains entered two separate clades, including the basal branch and the C1 branch that is widely spread in Eurasia. The data on the isolation time was used for the dating of phylogenetic tree, and also the estimated time frame for the B. abortus genotype diversification was determined. There were sets of specific SNPs identified, which defined each of the genotypes and ***: A significant genetic diversity of the brucellosis pathogen strains from Russia has been proven. The sets of unique specific SNPs described in our study may become one of the elements within a bio-informational analysis algorithm to be used for epidemiological study of brucellosis outbreaks, including those caused by new(atypical) genetic variants of B. abortus.

关键词： Brucella abortus Phylogeny Evolution Genome SNP

Hepatobiliary system and intestinal injury in new coronavirus infection(COvID-19):A retrospective study

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World Journal of Clinical Cases 2023年第10期11卷 2226-2236页

作者： Konstantin v Kozlov Konstantin v Zhdanov anna K Ratnikova vyacheslav A Ratnikov Artem v Tishkov vladimir Grinevich Yuriy A Kravchuk Panteley I Miklush Polina O Nikiforova vera v Gordienko Alexander F Popov Boris G Andryukov Department of Infectious Disease Military Medical Academy Named After SM.KirovSaint-Petersburg 194044Russia Department of Admission Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency"Saint-Petersburg 194291Russia Department of Roentgenology Federal State Budgetary Institution"North-West District Scientific and Clinical Center Named After LG.Sokolov Federal Medical and Biological Agency"Saint-Petersburg 194291Russia Department of Physics Mathematics and InformaticsFSBEI HE IP.Pavlov SPbSMU MOH RussiaSaint-Petersburg 197022Russia 2nd Department of Therapy(Advanced Medical Education) Military Medical Academy Named After SM.KirovSaint-Petersburg 194044Russia School of Medicine Far Eastern Federal UniversityVladivostok 690922Russia

BACKGROUND An important area of effective control of the coronavirus disease 19(COvID-19)pandemic is the study of the pathogenic features of severe acute respiratory syndrome coronavirus 2 infection,including those based on assessing the state of the intestinal microbiota and *** To study the clinical features of the new COvID-19 in patients with mild and moderate severity at the stage of hospitalization,to determine the role of hepatobiliary injury,intestinal permeability disorders,and changes in the qualitative and quantitative composition of the microbiota in the development of systemic inflammation in patients with *** The study was performed in 80 patients with COvID-19,with an average age of 45 years,19 of whom had mild disease,and 61 had moderate disease *** scope of the examination included traditional clinical,laboratory,biochemical,instrumental,and radiation studies,as well as original methods for studying microbiota and intestinal *** The clinical course of COvID-19 was studied,and the clinical and biochemical features,manifestations of systemic inflammation,and intestinal microbiome changes in patients with mild and moderate severity were *** permeability characteristics against the background of COvID-19 were evaluated by measuring levels of proinflammatory cytokines,insulin,faecal calprotectin,and *** This study highlights the role of intestinal permeability and microbiota as the main drivers of gastroenterological manifestations and increased COvID-19 severity.

关键词： Novel coronavirus infection COvID-19 SARS-Cov-2 Zonulin Faecal calprotectin Microbiota

Tranexamic acid for the management of uterine fibroid tumors:A systematic review of the current evidence

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World Journal of Clinical Cases 2014年第12期2卷 893-898页

作者： Panagiotis Peitsidis anna Koukoulomati Department of Obstetrics and Gynecology Southend University Hospital Essex SS0 0RY United Kingdom Department of Obstetrics and Gynecology Iaso Maternity Hospital 17123 Athens Greece Department of Obstetrics and Gynecology Didymoteichon General Hospital 68300 Didymoteicho Greece

AIM: To conduct a detailed systematic review of the current evidence on the administration and efficacy of tranexamic acid in patients with menorrhagia due to uterine fibroids. METHODS: We conducted an electronic search on the following databases Pub Med and Medline(1950-2013);(1980-2013); Cochrane library(1993-2013). RESULTS: A total of 36 articles were retrieved after the initial electronic search. Careful assessment of the retrieved studies led to the final selection of 5 articles for inclusion in the review. CONCLUSION: Tranexamic acid may reduce blood loss perioperatively in myomectomies. It may reduce the menorrhagia in patients with fibroids, however a stratification of fibroids by size and location is required to define the responses. It is safe in general, with mild adverse effects observed in some cases. More studies with a double-blind randomized design and larger numbers of participants are necessary to reach more precise and safe conclusions.

关键词： Tranexamic acid Uterine fibroids Fibrinolysis Menorrhagia Myomectomy

Laetmonice iocasica ***.,a new polychaete species(Annelida:Aphroditidae)from seamounts in the tropical Western Pacific,with remarks on *** Grube,1877

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Journal of Oceanology and Limnology 2021年第5期39卷 1805-1816页

作者： Xuwen WU Pat HUTCHINGS anna MURRAY Kuidong XU Laboratory of Marine Organism Taxonomy and Phylogeny Shandong Province Key Laboratory of Experimental Marine BiologyInstitute of OceanologyCenter for Ocean Mega-ScienceChinese Academy of SciencesQingdao 266071China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Australian Museum Australian Museum Research InstituteSydney NSW 2000Australia Biological Sciences Macquarie UniversityNorth Ryde 2109Australia University of Chinese Academy of Sciences Beijing 100049China

Laetmonice Kinberg,1856 is a remarkable genus characterized by having harpoon notochaetae in the polychaete family *** describe a new species of Laetmonice,Laetmonice iocasica ***.,found from seamounts on the Caroline Ridge in the tropical Western *** new species is readily distinguished from congeners,particularly those distributed in the Indo-Pacific Ocean by possessing45 segments with 18 pairs of elytra,and the tuberculated harpoon notochaetae in the elytrigerous segments,which are replaced by tuberculated notochaetae without recurved fangs on segments 4 and *** iocasica *** closely related to *** Grube,1877,but differs in both morphology and the genetic distance of the mitochondrial cytochrome oxidase subunit I(COI)*** producta Grube,1877 contained five varieties reported in various marine areas,which have been raised to species ***,the records of *** from the Sagami B ay and Suruga B ay in Japan and in the south-eastern Australia remain obscure and probably represent a different *** data indicate that ***,which was originally described from Kerguelen Islands in the Southern Ocean and later commonly found on the Antarctic shelf,is probably distributed only at high latitudes of the Southern Hemisphere.

关键词： Polychaeta taxonomy biodiversity deep-sea