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Altered pattern of tumor necrosis factor-alpha production in peripheral blood monocytes from Crohn's disease

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World Journal of Gastroenterology 2016年第41期22卷 9117-9126页

作者： Claudia Loganes Alessia Pin Samuele Naviglio Martina Girardelli anna monica bianco Stefano Martelossi Alberto Tommasini Elisa Piscianz Department of Medicine Surgery and Health Sciences University of Trieste Department of Pediatrics Institute for Maternal and Child Health IRCCS "Burlo Garofolo"

AIM To evaluate the inflammatory state in Crohn's disease(CD) patients and correlate it with genetic background and microbial *** By means of flow cytometry, production of tumor necrosis factor-alpha(TNF-α) was measured in peripheral blood monocytes from patients suffering from CD, ulcerative colitis(UC) and in healthy subjects after stimulation of the NOD2 and TLR pathways. CD patients were genotyped for the three most common NOD2 variants(R702W, G908 R and L1007Pfs*2) and basal production of TNF-α was correlated to NOD2 genotype. Also, production of TNF-α was correlated to plasmatic levels of LPS Binding Protein(LBP), soluble(s) CD14 and to the activity state of the *** The patients with CD were characterized by a significantly higher monocyte basal expression of TNF-αcompared with healthy subjects and UC patients, and after stimulation with Pam3CSK4(ligand of TLR2/1) and MDP-L18(ligand of NOD2) this difference was maintained, while other microbial stimuli(LPS, ligand of TLR4 and Poly I:C, ligand of TLR3) induced massive activation in CD monocytes as well as in UC and in healthy control cells. There was no significant difference in the production of TNF- α between patients who carried CD-associated heterozygous or homozygous variants in NOD2 and patients with wild type NOD2 genotype. Although serum LBP levels have been shown to correlate positively with the state of activity of the disease, TNF-α production did not show a clear correlation with either LBP or s CD14 levels in plasma. Moreover, no clear correlation was seen between TNF-α production and activity indices in either CD or *** Peripheral monocytes from CD express higher basal and stimulated TNF-α than controls, regardless of NOD2 genotype and without a clear correlation with disease activity.

关键词： Crohn’s disease Ulcerative colitis Tumor necrosis factor-α NOD2 variants Toll like receptors Dysbiosis Activity index LPS-binding protein

Fever tree revisited:From malaria to autoinflammatory diseases

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World Journal of Clinical Pediatrics 2015年第4期4卷 106-112页

作者： Serena Pastore Josef Vuch anna monica bianco Andrea Taddio Alberto Tommasini Department of Pediatrics Institute for Maternal and Child HealthIRCCS Burlo Garofolo Department of Medical Surgical and Health Sciences University of Trieste Department of Laboratory Institute for Maternal and Child HealthIRCCS Burlo Garofolo

Over the centuries the idea of recurrent fevers has mainly been associated with malaria, but many other fevers, such as typhoid and diphtheria were cause for concern. It is only in recent times, with the more severe forms of fever from infectious origin becoming less frequent or a cause for worry that we started noticing recurrent fevers without any clear infectious cause, being described as having a pathogenesis of autoinflammatory nature. The use of molecular examinations in many cases can allow a diagnosis where the cause is monogenic. In other cases, however the pathogenesis is likely to be multifactorial and the diagnostic-therapeutic approach is strictly clinical. The old fever tree paradigm developed to describe fevers caused by malaria has been revisited here to describe today's periodic fevers from the periodic fever adenitis pharyngitis aphthae syndrome to the more rare autoinflammatory diseases. This model may allow us to place cases that are yet to be identified which are likely to be of multifactorial origin.

关键词： Recurrent fevers Malaria Autoinflammatory diseases Periodic fever adenitis pharyngytis aphthe syndrome History of medicine Interleukin-1 Genetics The fever tree

Neither hereditary periodic fever nor periodic fever, aphthae, pharingitis, adenitis: Undifferentiated periodic fever in a tertiary pediatric center

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World Journal of Clinical Pediatrics 2018年第1期7卷 49-55页

作者： Silvia De Pauli Sara Lega Serena Pastore Domenico Leonardo Grasso anna monica Rosaria bianco Giovanni Maria Severini Alberto Tommasini Andrea Taddio Department of Medicine Surgery and Health University of Trieste Institute for Maternal and Child Health IRCCS Burlo Garofolo

AIM To describe the frequency and clinical characteristics of patients with undifferentiated periodic fever(UPF) and to investigate whether a clinical classification of UPF based on the PRINTO-Eurofever score can help predicting the response to treatment and the outcome at *** Clinical and therapeutic information of patients with recurrent fever who presented at a single pediatric rheumatology center from January 2006 through April 2016 were retrospectively collected. Patients with a clinical suspicion of hereditary periodic fever(HPF) syndrome and patients with clinical picture of periodic fever, aphthae, pharingitis, adenitis(PFAPA) who were refractory to tonsillectomy underwent molecular analysis of five HPF-related genes: MEFV(NM_000243.2), MVK(NM_000431.3), TNFRSF1 A(NM_001065.3), NLRP3(NM_001079821.2), NLRP12(NM_001277126.1). All patients who had a negative genetic result were defined as UPF and further investigated. PRINTO-Eurofever score for clinical diagnosis of HPF was calculated in all cases. RESULTS Of the 221 patients evaluated for periodic fever, twelve subjects with a clinical picture of PFAPA who were refractory to tonsillectomy and 22 subjects with a clinical suspicion of HPF underwent genetic analysis. Twenty-three patients(10.4%) resulted negative and were classified as UPF. The median age at presentation of patients with UPF was 9.5 mo(IQR 4-24). Patients with UPF had a higher frequency of aphthae(52.2% vs 0%, P = 0.0026) and musculoskeletal pain(65.2% vs 18.2%, P = 0.0255) than patients with genetic confirmed HPF. Also, patients with UPF had a higher frequency of aphthous stomatitis(52.2% vs 10.7%, P < 0.0001), musculoskeletal pain(65.2% vs 8,0%, P < 0.0001), and abdominal pain(52.2% vs 4.8%, P < 0.0001) and a lower frequency of pharyngitis(56.6% vs 81.3%, P = 0.0127) compared with typical PFAPA in the same cohort. Twenty-one of 23 patients with UPF(91.3%) received steroids, being effective in 16; 13(56.2%) were given colchicine, w

关键词： Hereditary periodic fever syndromes Therapy Genetics Autoinflammatory diseases Undifferentiated periodic fever

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解压指南

健与美 2025年第1期 169-173页

作者： monica

不摧毁压力，就会被压力摧毁。如果你总是感觉充满压力——无论是内在的还是外在的，就不可能长期保持健康和健美。本文将帮助你从压力的奴隶，变成压力的老板。要怪就怪那些不断发送短信、提醒音和电子邮件给我们的智能手机，要怪就怪...

不摧毁压力，就会被压力摧毁。如果你总是感觉充满压力——无论是内在的还是外在的，就不可能长期保持健康和健美。本文将帮助你从压力的奴隶，变成压力的老板。要怪就怪那些不断发送短信、提醒音和电子邮件给我们的智能手机，要怪就怪拥挤的地铁、高速公路和大卖场吧，要怪就怪大萧条、全球变暖、网络泡沫，或者你手上那杯不便宜的拿铁咖啡吧。

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减量增效中级水平选手的最佳训练模式

健与美 2025年第1期 160-163页

作者： monica

本文是受到奥赛冠军多里安·耶茨在1983～1986年期间的训练计划的启发而产生的。对于自然健美运动员来说，最大的错误就是训练量太大。如果你目前的训练效果不尽人意，不妨试试下面的增肌策略，效果很可能比你以前采用的方法更好。

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On predicting and improving the quality of Volunteer Geographic Information projects

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International Journal of Digital Earth 2016年第2期9卷 134-155页

作者： Gloria Bordogna Paola Carrara Laura Criscuolo monica Pepe anna Rampini CNR IREANational Research Council of ItalyInstitute for Environmental Remote SensingMilanoItaly

Initiatives that rely upon the contributions of volunteers to reach a specific goal are growing more and more with the success of Web 2.0–interactive *** scientific projects are testing and exploiting volunteers’collaboration,but the quality of information obtained with this approach is often *** paper offers a rich overview of many scientific projects where geographic contributions are committed to volunteers,to the aim of defining strategies to improve information *** describing real examples of Volunteer Geographic Information(VGI),the contribution establishes a categorization based on the characteristics of the information,tasks,and scopes of the *** a discussion on the relationships of categories and VGI quality,the paper analyses techniques to improve the quality of volunteered information according to the moment of its assessment(i.e.,ex ante,ex post,or both with respect to information creation).The paper outlines the main limitations of the different approaches and indicates some guidelines for future developments.

关键词： Volunteered Geographic Information Citizen Science information quality quality improvement

Apaf1 inhibition promotes cell recovery From apoptosis

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Protein & Cell 2015年第11期6卷 833-843页

作者： anna Gortat monica Sancho Laura Mondragon Angel Messeguer Enrique Perez-Paya Mar Orzaez Laboratory of Peptide and Protein Chemistry Centro de Investigaci6n Principe Felipe 46012 Valencia Spain Department of Chemical and Biomolecular Nanotechnology Instituto Quimica Avanzada de CataluSa (CSIC) 08034 Barcelona Spain Instituto de Biomedicina de Valencia IBV-CSIC 46010 Valencia Spain

The protein apoptoUc protease activating factor I （Apafl） is the central component of the apoptosome, a multiprotein complex that activates procaspase-9 after cytochrome c release from the mitochondria in the intrinsic pathway of apoptosis. We have developed a vital method that allows fluorescence-activated cell sorting of cells at different stages of the apoptotic pathway and demonstrated that upon pharmacological inhibition of Apafl, cells recover from doxorubicinor hypoxia-induced early apoptosis to normal healthy cell. Inhibiting Apafl not only prevents procaspase-9 activation but delays massive mitochondrial damage allowing cell recovery.

关键词： Apaf1 Apaf1 inhibitors apoptosis,apoptosome autophagy cell recovery

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BIOCELL 2022年第12期46卷 2525-2530页

作者： monica SAVIO VALENTINA MINOIA PAOLA FULGHIERI LUCIA anna STIVALA VIRGINIE SOTTILE Department of Molecular Medicine University of PaviaPavia27100Italy

The nutraceutical resveratrol is associated with a range of biological effects,from antibiotic to antiinflammatory *** major axis of research has sought to harness its anti-tumour potential,with promising preclinical results and early clinical trials.A second strong interest relies on the anti-ageing effects ascribed to the compound and its application to stem cell *** is becoming clear however that these possible favourable effects are conditioned by a set concentration range not easily controllable in *** we evoke novel developments in the field that could lead to more reliable conditions for the translational use of resveratrol-based compounds.

关键词： Resveratrol Nutraceutical Cancer Cell Differentiation Dihydroxystilbene

Architecture, values and perception： Between rhetoric and reality

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Frontiers of Architectural Research 2018年第1期7卷 92-99页

作者： Lino bianco Department of Architecture and Urban Design Faculty for the Built Environment University of Malta Msida Malta

Throughout history, design values have always underlined a given architectural style. The manner architects and architectural critics distinguish between them varies from that of the public. In fact a style welt perceived by civil society was read as pathological by architectural academia. This paper examines the values and perceptions of contemporary architecture by architects and civil society. Through qualitative methodology, a project by each of the following leading contemporary architects - Renzo Piano, Norman Foster and Rem Koolhaas - was analyzed. The selected designs, all commissioned not more than a decade ago, vary in locations from Malta to Lebanon to India. The study concludes that design values and perceptions of architecture as read by members of the architectural profession do not tally with those of the public. The emphasis by architects is on the aesthetic whilst non-architects focus on the utilitarian dimension. Furthermore, the rhetorical language which architects use is not read as such by the public. The assessment of the public is based on the existential reality which they experience. The perception of civil society matters; it is at the core of architectural design values.

关键词： Architecture Design values Pefception Valletta Dharavi Beirut