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Prognosis Factors of Urinary Quality of Life in Parkinson Disease

Open Journal of Therapy and Rehabilitation 2024年第1期12卷 10-17页

作者： Ngor Side Diagne Sakhi Othman Ababacar Mamadou Gueye Marie Jeanne Sakho Fatou Dialo Mboup Amélie Ndeye Makarame Sy Papa Ndiouga Lo Ba Seydina Ousmane anna modji basse Maouly Fall Adjaratou Dieynaba Sow Moustapha Ndiaye Amadou Gallo Diop Physical Médicine and Rehabilitation Department Fann Teaching Hospital Dakar Senegal Neurology Department Pikine Hospital Dakar Senegal Physical Médicine and Rehabilitation Department Ibn Rochd Teaching Hospital Casablanca Morocco Physical Médicine and Rehabilitation Department Military Hospital Dakar Senegal Neurology Department Fann Teaching Hospital Dakar Senegal

Introduction: Quality of life in Parkinson disease is not necessary linked to motor symptoms. It’s correlated of overactive bladders and prostatic symptoms. Prognosis factors of urinary quality of life are unknown. Objectives: Our study aims to find prognosis factors of quality of life associated specifically of urinary disorders in PD. Patients and methods: We conducted a transversal, analytic and descriptive study in Physical Medicine, and Neurology departments, Fann Teaching Hospital, Dakar and included patients followed for treatment of PD. Urinary disorders, quality of life and functional autonomy were assessed respectively by Urinary Symptoms Profile (USP), Qualiven Short Form, Schwab and England Scale. Results: 38 patients presented PD, with a mean age of 60.89 ± 13.6 years and sex-ratio of 2.45. Mean duration of PD was 3.1 ± 2.9 years. Urinary disorders were found in 47.36% and dominated by incontinence (88.88%) and overactive bladders (88.88%) which were minor in more than 55%. Quality of life was impaired in 88.88% of cases. Minor forms (43.75%) were predominant and constraint dimension (50%) was the most severely altered. Prognosis factors for quality of life of urinary disorders were PD stages (0.046) and functional autonomy (0.042). Discussion and conclusion: Urinary disorders in PD are common, impaired quality of life, especially the constraint dimension, depends on stage of evolution of PD and functional autonomy of patients.

关键词： Urinary Quality of Life Parkinson Disease Dakar

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Guillain-Barré Syndrome (GBS) in Children, the Experience of Senegal

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Neuroscience & Medicine 2023年第1期14卷 1-8页

作者： anna modji basse Khalifa Ababacar Mbaye Adjaratou Dieynabou Sow Rokhaya Diagne Ahmadou Bamba Mbodji Mame Doyneck Dieng Marie Emilie Ndong Moustapha Ndiaye Ibrahima Pierre Ndiaye Neuroscience Clinic FANN National University Hospital Centre (NUHC) Dakar Senegal Albert Royer National Children’s Hospital Dakar Senegal

Introduction: GBS is a rare condition in children. The risk factors for GBS are present in Africa;however, the majority of studies reported are case series. The objective of our work was to evaluate the epidemiological, clinical, paraclinical, therapeutic and evolutionary profile of GBS cases. Material and Method: This was a prospective longitudinal study, lasting 24 months between November 2019 and November 2021. All patients aged 2 - 18 years diagnosed with GBS according to the Brighton criteria (level 2) were included in our study. Patients with incomplete or unexploitable records were excluded. Results: Over a 24-month period, 16 cases of GBS were collected. These included 12 boys (75%) and 4 girls (25%). The demyelinating form (ADIP) was found in 9 children (43.75%) and the axonal form in 7 patients (37.5%), 5 of whom had pure motor involvement (AMAN) and 2 with sensory-motor involvement (AMSAN). Corticosteroid therapy was more effective in treating pain and in demyelinating forms. Three deaths were noted and all had AMAN. Conclusion: GBS poses a management problem in our context of a country with limited resources. Corticosteroid therapy has been shown to be effective in the treatment of pain and demyelinating forms of the disease and should be considered for use in GBS.

关键词： GBS Child Senegal Corticotherapy

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Legal Conditions for Water Utilities Eco-innovation as Energy Smart Water Utilities

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Journal of Earth Science and Engineering 2013年第9期3卷 644-654页

作者： Ellen Margrethe basse Department of Law School of Business and Social Sciences Aarhus University DK 8000 Denmark

Welfare and green growth rest heavily on an appropriate supply of safe water, the provision of adequate sewerage, and on energy services. These services are interdependent, as water is an integral part of electric-power generation; it is used directly in hydroelectric generation, and it is used extensively for cooling and emissions scrubbing in thermoelectric generation. Energy is also an integrated part of water services, as satisfying water needs for supply, purification, distribution, and treatment of wastewater requires energy sources. Water and energy utilities are however regulated without a specific focus on the interdependency of the two sectors and the possibilities to ensure sustainable use of the resources and reduction of greenhouse gasses by a better coordination. The article explains the possibilities of sustainable consumption and production of energy in the water utilities. It highlights EU legal framework that makes coordination at national level possible, and it gives examples and concludes--on the obstacles for the water utilities＇ future as energy-smart utilities that exist at the national level in Denmark.

关键词： Resource efficiency energy smart technologies water utilities legislation

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^（99m）Tc－HMPAO－白细胞在探查骨关节感染中的临床应用

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中华核医学杂志 1995年第2期15卷 96-98页

作者：李彪 Barthe N basse-Cathalinal 上海第二医科大学附属瑞金医院核医学科法国波尔多第二大学附属ＰＥＬＬＥＧＲＩＮ医院核医学科

对２５例临床怀疑为骨关节感染的病人分别进行９９ｍＴｃ－亚甲基二膦酸（ＭＤＰ）骨显像和９９ｍＴｃ－６－甲基丙二胺肟（ＨＭＰＡＯ）－白细胞显像．结果表明：９９ｍＴｃ－ＭＤＰ骨显像在临床怀疑为感染的部位出现了异常的放射性浓... 详细信息

对２５例临床怀疑为骨关节感染的病人分别进行９９ｍＴｃ－亚甲基二膦酸（ＭＤＰ）骨显像和９９ｍＴｃ－６－甲基丙二胺肟（ＨＭＰＡＯ）－白细胞显像．结果表明：９９ｍＴｃ－ＭＤＰ骨显像在临床怀疑为感染的部位出现了异常的放射性浓聚区，其中３例在其他部位也出现了与骨折、无菌性坏死及类风湿性关节炎等有关的异常放射性浓聚区．９９ｍＴｃ－ＨＭＰＡＯ－白细胞显像１９例真阳性，４例真阴性，２例假阴性，无１例假阳性．２例假阴性病人有长期使用抗生素史．９９ｍＴｃ－ＨＭＰＡＯ－白细胞显像诊断感染的灵敏度为９０．５％，特异性为１００％，准确率为９２％，它为临床疑有骨关节感染病人的诊断提供了一种非创伤性的方法，并为临床治疗提供了依据．

关键词：关节感染放射性核素显像白细胞肟类诊断

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Pro-inflammatory cytokine;tumor-necrosis factor-alpha (TNF-α) inhibits astrocytic support of neuronal survival and neurites outgrowth

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Advances in Bioscience and Biotechnology 2013年第8期4卷 73-80页

作者： Ebtesam M. Abd-El-basse Department of Anatomy Faculty of Medicine Kuwait University Kuwait City Kuwait

Reactive astrogliosis has been implicated in the failure of axonal regeneration in adult mammalian Central Nervous System (CNS). It is our hypothesis that inflammatory cytokines act upon astrocytes to alter their biochemical and physical properties, which may in turn be responsible for the failure of neuronal regeneration. We have therefore examined the effect of tumor-necrosis factor-alpha (TNF-α) on the ability of astrocytes to support the survival of the cortical neurons and the growth of the neurites. Mouse astrocytes and cortical neuronal cultures were prepared. It was observed that when neurons were cultured in absence of astrocytes only a few of them grew and survived only for 5-6 days. These neurons had small cell bodies and few, short neurites. However, when the same numbers of neurons were cultured on the top of astrocytes, more neurons grew and survived up to 16-18 days. They had bigger cell bodies and many long branched neurites that formed anestamosing networks. The neurons then coalesced and the neurites formed thick bundles. When the same numbers of neurons were grown on the top of astrocytes pre-treated with TNF-α, few neurons survived up to 13 days. The neurites of the survived neurons were shorter than neurites of neurons grown on normal astrocytes and did not form bundles. In addition, TNF-α stimulated the expression of glial fibrillary acidic protein (GFAP) by astrocytes. These results support that the pro-inflammatory cytokine, TNF-α modulates the gliosis and that the astrocytic cell supports neuronal survival and neurite outgrowth.

关键词： Astrocytes Neurons Cytokines Tumor-Necrosis Factor-Alpha

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联合应用NK细胞及CTL对黑色素瘤B16细胞的影响

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重庆医学 2012年第9期41卷 878-880页

作者：余少鸿汤荣春 Per H basse 云南省昆明市第一人民医院普外科 650011 美国匹兹堡大学肿瘤中心宾夕法尼亚州匹兹堡152131863

目的探讨联合应用自然杀伤(NK)细胞及细胞毒T细胞(CTL)对黑色素瘤B16细胞的作用。方法提取NK细胞及CTL,分别用白细胞介素-2(IL-2)(6 000、600IU/L)及植物血凝素(8μg/mL)活化,流式细胞仪检测细胞表面受体,将NK细胞及CTL互为靶细胞及效... 详细信息

目的探讨联合应用自然杀伤(NK)细胞及细胞毒T细胞(CTL)对黑色素瘤B16细胞的作用。方法提取NK细胞及CTL,分别用白细胞介素-2(IL-2)(6 000、600IU/L)及植物血凝素(8μg/mL)活化,流式细胞仪检测细胞表面受体,将NK细胞及CTL互为靶细胞及效应细胞进行细胞毒性实验;以黑色素瘤B16细胞为靶细胞检测CTL的杀伤率。结果 NK细胞表面受体NK1.1+的百分比在87%以上,NKp46+在90%以上;CTL表面受体CD3+的百分比在99%以上,CD8+在98%以上。NK细胞与CTL相互无细胞毒性,联合应用NK细胞与CTL明显增加对黑色素瘤B16细胞的杀伤作用。结论联合应用NK细胞及CTL对黑色素瘤B16细胞有协同杀伤作用。

关键词：黑色素瘤,实验性 T淋巴细胞,细胞毒性自然杀伤细胞

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NK细胞上清液提高CTL细胞对肿瘤细胞杀伤力及机制的研究

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重庆医学 2012年第21期41卷 2136-2138页

作者：余少鸿汤荣春 Per H basse 云南省昆明市第一人民医院普外科 650011 美国匹兹堡大学肿瘤中心匹兹堡pa152131863

目的研究从白细胞介素2(IL-2)、IL-2+IL-12、IL-2+IL-18、IL-2+IL-12+IL-18活化的NK细胞提取的上清液是否能提高细胞毒性T细胞(CTL)对黑色素瘤细胞的杀伤率及其机制。方法提取NK细胞,IL-2 6 000IU/mL、IL-2 6 000IU/mL+IL-12 10ng/mL,IL-2 6 000IU/mL+IL-18 100ng/mL,IL-2 6 000IU/mL+IL-12 10ng/mL+IL-18 100ng/mL活化,3d后提取上清液,与M05细胞培养过夜,流式细胞仪检测肿瘤细胞表面Ⅰ类组织相容性抗原(MHCⅠ)表达,以其为靶细胞检测CTL细胞对M05细胞杀伤率。结果 NK细胞上清液提高M05细胞表面MHCⅠ分子表达及CTL细胞对M05细胞杀伤率。结论 NK细胞上清液能够增强CTL对肿瘤细胞的杀伤作用。

关键词：自然杀伤细胞白细胞介素12 白细胞介素18 组织相容性抗原Ⅰ类黑色素瘤细胞

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Creutzfeldt Jacob’s Disease: A Senegalese Observation

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Neuroscience & Medicine 2022年第1期13卷 43-48页

作者： Ahmadou Bamba Mbodji Alassane Mamadou Diop Momo Banda Ndiaye Serigne Saliou Mbacke Khalifa Ababacar Mbaye Rokhaya Diagne Ibrahima Niang Ndiaga Matar Gaye Maouly Fall Adjaratou Sow anna basse Lala Bouna Seck Moustapha Ndiaye Amadou Gallo Diop Department of Ibrahima Pierre Ndiaye Neuroscience Fann Hospital Dakar Sénégal Department of Neurology Pikine Hospital Dakar Sénégal Department of Radiology Fann Hospital Dakar Sénégal

Creuzfelt-Jakob Disease is a rare and progressive neurodegenerative disease that results in fatal, transmissible, subacute, spongiform encephalopathy characterized by rapidly progressive dementia and movement disorder. We present a 62-year-old male with no medical history who was admitted to our hospital because of gait and balance disturbance, language impairment and progressive motor deficit of the four limbs. A neurological examination found frontal lobe syndrome signs, myoclonic movements, pyramidal and extra-pyramidal signs. Brain Magnetic Resonance Imaging detected high intensity areas in the basal ganglia. EEG showed generalized triphasic sharp-wave complexes. A Cerebro Spinal Fluid examination found protein 14-3-3. Death occurred six months after onset. This is the first known case of Creuzfelt-Jakob Disease documented in Senegal.

关键词： Creutzfeldt-Jakob Disease Protein 14-3-3 Prion Disease Rapidly Progressive Dementia

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Management of Severe Acute Malnutrition in a Senegalese Paediatric Hospital

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Open Journal of Pediatrics 2021年第2期11卷 198-207页

作者： Ndiogou Seck Idrissa basse Djibril Boiro Younoussa Keïta Lamine Thiam Aliou Abdoulaye Ndongo Ndéye Rama Diagne-Gueye Service de péDiatrie Centre Hospitalier Régional de Saint-Louis Saint-Louis Sénégal Hô pital pour Enfants de Diamniadio Bargny Sénégal Service de péDiatrie Centre Hospitalier Abass Ndao Dakar Sénégal Service de péDiatrie Hô pital Aristide Ledantec Dakar Sénégal Service de PéDiatrie H&ocirc pital de la Paix Boucoutte Ziguinchor Sénégal

Malnutrition is a global health problem. It is very common in developing countries where it contributes to an increase in morbidity and mortality, especially among children under five years of age. The main objective of this study was to describe the management of severe acute malnutrition (SAM) in children six months to five years of age hospitalized at Diamniadio Children’s Hospital (DCH). This was an epidemiological, retrospective, descriptive and cross-sectional study of children aged six to 59 months hospitalized at DCH for SAM. The study took place over a 12-month period (from January 1, 2018 to December 31, 2018). During the study period, 67 children were admitted for SAM, representing a hospital prevalence of 8.4%. The majority (88%) children were less than 24 months old. Reasons for consultations were dominated by diarrhea (57.5%) vomiting (38.8%). Complications related to SAM were mainly: anaemia (74.6%), infections (85%) and severe acute dehydration (40.3%). Factors associated with SAM were young age (infants under 24 months of age), poverty, the first four children of a sibling, poor behaviour of food diversification. The average length of hospitalization was 12 days. The nutritional recovery rate was 73.1% and lethality was 3%. Conclusion: The prevention of malnutrition must involve the fight against poverty, an optimal and well-diversified diet, monitoring the nutritional status of children up to five years of age.

关键词： Severe Acute Malnutrition Children Complications Risk Factors Lethality

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某些铝合金在热带海面与深海海水中的腐蚀

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环境技术 1987年第5期 41-46页

作者： JornLarsen-basse,Sayed H.Zaidi,罗怀平美美

在模拟海洋热能转换(OTEC)热交换的条件下,以连续的实验研究来分析测定某些铝合金的腐蚀。包覆金属的和裸露的合金管(用7072金属包覆的合金3003和3004;不包覆金属的合金5052和3004)在流动的热带海面海水中和寒冷的深海海水中暴露试验两... 详细信息

在模拟海洋热能转换(OTEC)热交换的条件下,以连续的实验研究来分析测定某些铝合金的腐蚀。包覆金属的和裸露的合金管(用7072金属包覆的合金3003和3004;不包覆金属的合金5052和3004)在流动的热带海面海水中和寒冷的深海海水中暴露试验两年时间。结果在寒冷的海水中合金全部都形成点状腐蚀,而在温和的海水中的合金没有发现点状腐蚀。均匀腐蚀的速率很低,可能是由于早期形成连续的无机鳞状薄层的缘故。

关键词：点状腐蚀铝合金管海水海面深海

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