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疟疾防治研究的回顾及今后工作要点

国际医学寄生虫病杂志 1988年第1期 1-5页

作者： John Maurice anna marina pearce 杨静妹

联合同开发计划署/世界银行╱世界卫生组织热带病研究培训特别规划局(TDR)对1976～1986年的工作作了总结,并且提出今后工作的要点。现将该总结中有关疟疾化疗、疟疾疫苗及丝虫病部分节译如下,供作参考。

关键词：疟原虫敏感性红外期药物敏感疟疾疫苗卤泛曲林

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丝虫病防治研究的回顾及今后工作要点

国际医学寄生虫病杂志 1988年第1期 9-13页

作者： John Maurice anna marina pearce 孙德建

概述在8种人体丝虫感染中,2种(或类)受到TDR的较大关注,即可引起象皮肿等严重临床表现的淋巴丝虫病和可引起河盲症的盘尾丝虫病。由不属于丝虫的麦地那龙线虫(几内亚虫)引起的麦地那龙线虫病也受TDR托管。淋巴丝虫病流行于有27亿人口(... 详细信息

概述在8种人体丝虫感染中,2种(或类)受到TDR的较大关注,即可引起象皮肿等严重临床表现的淋巴丝虫病和可引起河盲症的盘尾丝虫病。由不属于丝虫的麦地那龙线虫(几内亚虫)引起的麦地那龙线虫病也受TDR托管。淋巴丝虫病流行于有27亿人口(占世界总人口的56％)的许多热带和亚热带国家,受威胁的有9.05亿人,受感染的逾9000万人。盘尾丝虫病流行于有5.85亿人口的34个国家,受威胁的有8500万人,受感染的有

关键词：丝虫病临床试验免疫反应单克隆抗体 TDR 抗原蠕虫病伊维菌素抗丝虫药防治研究工作要点

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疟疾疫苗的发展

国际医学寄生虫病杂志 1988年第1期 5-9页

作者： John Maurice anna marina pearce 陆瑶

概述疫苗可为目前尚不完善的疟疾防治措施提供极有用的帮助,而制备疫苗则以几个前提为基础。例如,在一定情况下,可对实验动物和志愿者接种含各期原虫的疫苗从而对恶性疟原虫的攻击产生保护性;还有,许多生活

关键词：疟疾疫苗无性体疟原虫抗原恶性疟原虫原虫血症间日疟疟疾红内期猴疟原虫疫苗抗原

Rescue from complications after pancreaticoduodenectomies at a low-volume Caribbean center:Value of tailored peri-pancreatectomy protocols

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 681-688页

作者： Shamir O Cawich Elijah Dixon Parul J Shukla Shailesh V Shrikhande Rahul R Deshpande Fawwaz Mohammed Neil W pearce Wesley Francis Shaneeta Johnson Johann Bujhawan Department of Surgery University of the West IndiesSt Augustine 000000Trinidad and Tobago Department of Surgery Faculty of MedicineUniversity of CalgaryCalgaryAlberta T2N2T9Canada Department of Surgery Weill Cornell Medical CollegeNew YorkNY 10065United States Department of Surgical Oncology Tata Memorial CenterHomi Bhabha National UniversityMumbai 400012India Department of Surgery Manchester Royal InfirmaryManchester M139WLUnited Kingdom University Surgical Unit Southampton General HospitalSouthampton SO166YDUnited Kingdom Department of Surgery University of the West IndiesNassau N-1184Bahamas Department of Surgery Morehouse School of MedicineAtlantaGA 30310United States Department of Surgery General Hospital in Port of SpainPort of Spain 000000Trinidad and Tobago

BACKGROUND Pancreaticoduodenectomy(PD)is a technically complex operation,with a re-latively high risk for *** ability to rescue patients from post-PD complications is as a recognized quality *** protocols were instituted at our low volume facility in the year *** To document the rate of rescue from post-PD complications with tailored protocols in place as a measure of *** A retrospective audit was performed to collect data from patients who experienced major post-PD complications at a low volume pancreatic surgery unit in Trinidad and Tobago between January 1,2013 and June 30,***-dardized definitions from the International Study Group of Pancreatic Surgery were used to define post-PD complications,and the modified Clavien-Dindo classification was used to classify post-PD *** Over the study period,113 patients at a mean age of 57.5 years(standard deviation[SD]±9.23;range:30-90;median:56)underwent PDs at this *** complications were recorded in 33(29.2%)patients at a mean age of 53.8 years(SD:±7.9).Twenty-nine(87.9%)patients who experienced major morbidity were salvaged after aggre-ssive treatment of their ***(3.5%)died from bleeding pseudoaneurysm(1),septic shock secondary to a bile leak(1),anastomotic leak(1),and myocardial infarction(1).There was a significantly greater salvage rate in patients with American Society of Anesthesiologists scores≤2(93.3%vs 25%;P=0.0024).CONCLUSION This paper adds to the growing body of evidence that volume alone should not be used as a marker of quality for patients requiring *** low volumes at our facility,we demonstrated that 87.9%of patients were rescued from major *** attributed this to several factors including development of rescue protocols,the competence of the pancreatic surgery teams and continuous,and adaptive learning by the entire institution,cul-minating in the development of tailored peri-pancreatectomy protoc

关键词： Pancreas Complication Rescue Failure Morbidity Mortality Pancreaticoduodenectomy

A King＇s Two Bodies： The Northern Wei Emperor Wencheng and Representations of the Power of His Monarchy

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Frontiers of History in China 2012年第1期7卷 90-105页

作者： Scott pearce Liberal Studies Department Western Washington University Bellingham WA 98225 USA

This article examines the various ways in which the Northern Wei emperor Wenchengdi （440465; r. 452-465） was portrayed to his subjects. As is the case with many monarchs in many countries, he played different parts before different groups. For his soldiers, he was represented as a great hunter and marksman; to farmers in the lowlands, as a caring protector and benefactor; to potentially rebellious groups on the periphery, as a strong and steady observer of their actions. At the same time, it was in his reign that the Northern Wei court began efforts to use Buddhism as an overarching way to justify rule to all within the realm, by initiating construction of the famous cave-temples at Yungang, where ＂Buddhas became emperors and emperors Buddhas.＂ The spectacles through which Wenchengdi was portrayed are contextualized by a parallel examination of the very difficult life of the person behind the pomp and circumstance.

关键词： Northern Wei Wenchengdi legitimation propaganda ErnstKantorowicz Buddhism military culture

Chronic disease in a digital health environment

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Family Medicine and Community Health 2018年第1期6卷 20-25页

作者： Christopher pearce Australasian College of Health Informatics Outcome Health Department of Health Informatics University of Melbourne Department of General Practice Monash University Digital Health Committee of the Australian College of Rural and Remote Medicine

Although we know that there are benefits to individual patients from electronic data,the next potential,and potentially the biggest,benefit will come from the technologies known as big data,machine learning,and artificial *** the potential of computers to sift through large amounts of data will result in the possibility of generating insights into individual patients,and into whole populations,predicting the risk of hospital admission for an individual,or track-ing influenza epidemics to prepare adequate *** the data are reliable,recorded in a computer-interpretable way,new horizons will open.

关键词： Ehealth digital health chronic disease patient centred medicine health systems

Cost-Effectiveness of Interventions for Alternate Food to Address Agricultural Catastrophes Globally

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International Journal of Disaster Risk Science 2016年第3期7卷 205-215页

作者： David C.Denkenberger Joshua M.pearce Global Catastrophic Risk Institute Department of Civil and Architectural Engineering Tennessee State University Department of Materials Science and Engineering Michigan Technological University Department of Electrical and Computer Engineering Michigan Technological University

The literature suggests there is about a 1 % risk per year of a 10 % global agricultural shortfall due to catastrophes such as a large volcanic eruption, a medium asteroid or comet impact, regional nuclear war, abrupt climate change, and extreme weather causing multiple breadbasket failures. This shortfall has an expected mortality of about 500 million people. To prevent such mass starvation, alternate foods can be deployed that utilize stored biomass. This study developed a model with literature values for variables and, where no values existed,used large error bounds to recognize uncertainty. Then Monte Carlo analysis was performed on three interventions: planning, research, and development. The results show that even the upper bound of USD 400 per life saved by these interventions is far lower than what is typically paid to save a life in a less-developed country. Furthermore, every day of delay on the implementation of these interventions costs 100–40,000 expected lives(number of lives saved multiplied by the probability that alternate foods would be required). These interventions plus training would save 1–300 million expected lives. In general, these solutions would reduce the possibility of civilization collapse, could assist in providing food outside of catastrophic situations, and would result in billions of dollars per year of return.

关键词： Agricultural catastrophe Alternate food Global catastrophic risk Intervention cost-effectiveness

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Simon pearce

Simon Pearce

eUREkA! T cells answer nature’s call

作者： Suokko Glenn. pearce Simon. Downes Margaret.

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Cellular & Molecular Immunology 2023年第7期20卷 692-693页

作者： Beth Kelly Erika L.pearce Bloomberg-Kimmel Institute of Immunotherapy Department of OncologyJohns Hopkins University School of MedicineBaltimoreMDUSA

Nitrogen is critical for cell growth, proliferation, and function. Amino acid (AA) catabolism is a major source of intracellular nitrogen for biosynthesis but also generates the nitrogen-containing molecule ammonia (NH3+), which can accumulate to toxic levels in a cell if not exported to the circulation and detoxified by the urea cycle in the liver. In a recent paper in Nature Immunology, Tang et al. [1] discovered a functional urea cycle in memory T cells, which metabolizes ammonia, prevents its toxic accumulation.

关键词： function. ammonia cycle