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Cellular & Molecular Immunology 2010年第4期7卷 263-270页

作者： anna hing-yee law Davy Chun-Wai Lee Kwok-Yung Yuen Malik Peiris Allan Sik-Yin Lau Cytokine Biology Group Department of Paediatrics and Adolescent MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

Historically,influenza pandemics have arisen from avian influenza *** influenza viruses H5N1 and H9N2 are potential pandemic *** of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%,which has been attributed to dysregulation of the cytokine *** macrophages and epithelial cells infected with some genotypes of H5N1 and H9N2 viruses express markedly elevated cytokine and chemokine levels when compared with seasonal influenza A subtype H1N1 *** mechanisms underlying this cytokine and chemokine hyperinduction are not fully *** the present study,we demonstrate that autophagy,a tightly regulated homeostatic process for self-digestion of unwanted cellular subcomponents,plays a role in cytokine *** is induced to a greater extent by H9N2/G1,in association with cytokine hyperinduction,compared with H1N1 and the novel pandemic swine-origin influenza A/H1N1 *** 3-methyladenine to inhibit autophagy and small interfering RNA to silence the autophagy gene,Atg5,we further show that autophagic responses play a role in influenza virus-induced CXCL10 and interferon-a expression in primary human blood *** results provide new insights into the pathogenic mechanisms of avian influenza viruses.

关键词： autophagy CXCL10 influenza interferon

结构规整有序的寡聚噻吩修饰9,9′-螺二芴衍生物的光物理性质及其电化学聚合(英文)

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物理化学学报 2007年第4期23卷 459-465页

作者：金卫红倪菁 LAI yee-hing 裴坚浙江海洋学院海洋科学学院浙江舟山316004 新加坡材料研究与工程研究院新加坡国立大学化学系新加坡117602 北京大学化学与分子工程学院北京100871

研究了结构规整有序的寡聚噻吩修饰的9,9′-螺二芴衍生物在溶液中和在固体膜状态下的光物理性质,发现在四氢呋喃的稀溶液中,随着有效共轭长度的增加这些化合物的最大吸收峰和发射峰发生了明显的红移.实验结果表明,9,9′-螺二芴骨架中的... 详细信息

研究了结构规整有序的寡聚噻吩修饰的9,9′-螺二芴衍生物在溶液中和在固体膜状态下的光物理性质,发现在四氢呋喃的稀溶液中,随着有效共轭长度的增加这些化合物的最大吸收峰和发射峰发生了明显的红移.实验结果表明,9,9′-螺二芴骨架中的9位螺碳原子明显地阻断了二个共轭片段的共轭效应,使它们成为了二个独立的共轭链节.此外,还进一步研究了这些化合物的电化学聚合性质.

关键词：寡聚噻吩 9,9’-螺二芴光物理性质电化学聚合

Development of a Low-cost Polymerase Chain Reaction-based Method for Studying Differentially Expressed Genes in Developing Rice Leaves

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Journal of Integrative Plant Biology 2009年第6期51卷 614-621页

作者： Yin-Wan Wendy Fung Hoi yee Chow Tik Wan law Biao Dong Hoi Shan Kwan Faculty of Science The Chinese University of Hong Kong Shatin Hong Kong SAP China Department of Biology The Chinese University of Hong Kong Shatin Hong Kong SAR China

Gene expression studies are important for revealing gene functions putatively involved in biological processes. We were interested in identifying differentially expressed genes during leaf development in rice. We combined the RNA arbitrarily primed-polymerase chain reaction （***） and dot blot hybridization methods to screen a rice leaf primordium cDNA library. Three developmental stages during vegetative growth were examined. The cDNA clones showing different hybridization patterns were further analyzed and verified. Here we demonstrate that the combination of RAP-PCR and dot blot hybridization could provide an efficient and relatively low-cost cDNA library screening approach to discover genes not previously known to be associated with leaf development in rice, We believe that the findings described here will help to elucidate the molecular mechanism（s） underlying the developmental processes of rice leaf

关键词： cDNA clones development dot blot hybridization primordium RNA arbitrarily primed-polymerase chain reaction.

Contact Angle Hysteresis on Smooth/Flat and Rough ***,Mechanism,and Origin

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Accounts of Materials Research 2022年第1期3卷 1-7页

作者： Kock-yee law law−Research and Innovative Solutions PenfieldNew York 14526United States

*** Surface is a very important branch of science that touches all facets of our daily lives,such as washing,cleaning,writing,painting,*** understanding of liquid−solid interactions is crucial not only to the science itself but also to many seemingly unrelated industrial applications,ranging from self-cleaning and nonsticking surfaces to fluid transportation in oil pipeline and microfluidic devices to antifogging,anti-icing,and antifouling surfaces.

关键词： branch Angle fouling

Rational design of platinum(Ⅱ)complexes with orthogonally oriented triazolyl ligand with emission enhancement characteristics for cancer chemotherapy in vivo

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Science China Chemistry 2023年第10期66卷 2878-2884页

作者： Yeye Ai Zherui Zhang Yuexuan Fei Ruirong Ye Angela Sin-yee law Zong-Wan Mao Junqiu Liu Yongguang Li Vivian Wing-Wah Yam Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China Institute of Molecular Functional Materials State Key Laboratory of Synthetic Chemistry and Department of ChemistryThe University of Hong KongHong KongChina School of Chemistry Sun Yat-Sen UniversityGuangzhou 510275China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012China

The mitochondria are essential for tumorigenesis and have been regarded as important targets in cancer ***,the mitochondria-targeted platinum(Ⅱ)complexes have been *** introduction of the triazole group with larger steric hindrance through post-click reaction converts the hybridization of carbon from sp to sp^(2),endowing the complexes with an orthogonally oriented ligand with restricted rotation and emission enhancement *** of the triazolyl ligand has led to platinum(Ⅱ)complexes that can efficiently enter cancer cells and selectively accumulate in mitochondria,leading to significant enhancement in *** vivo anti-cancer investigations have demonstrated their distinct antitumor efficacy in substantial inhibition of tumor growth in breast cancer mice through dissipation of mitochondrial membrane potential,inducing apoptosis of tumor cell with negligibly systemic cytotoxicity.

关键词： platinum(Ⅱ)complexes post-click reaction emission enhancement mitochondria-targeting antitumor

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真假针刺对原发性失眠症的作用比较研究

真假针刺对原发性失眠症的作用比较研究

作者： Jasmine yee hing Leung 广州中医药大学

学位级别：硕士

目的：本研究观察针刺在治疗原发性失眠中是否具有真正的临床效应或它只是安慰剂的另一种形式,做出单纯针刺和非穿透性的假针刺比较。通过观察患者治疗前后的症状评估是否得改善的情况下, 为针灸疗效提供进一步的证明和确认。方法：使... 详细信息

目的：本研究观察针刺在治疗原发性失眠中是否具有真正的临床效应或它只是安慰剂的另一种形式,做出单纯针刺和非穿透性的假针刺比较。通过观察患者治疗前后的症状评估是否得改善的情况下, 为针灸疗效提供进一步的证明和确认。方法：使用随机对照的实验方法, 将符合纳入表准的60例失眠患者按照1：1的比例随机分为常规体针针刺的治疗组与非穿刺假针刺的对照组。要求参与者在治疗的一个月前没有接受任何的针灸治疗, 选择的参与者都是进一年内很少接触或从未接受过针灸的参与者。两组失眠患者每周治疗的次数为2-3次, 每次间隔的时间为至少2天完成10次治疗为1个疗程。常规针刺治疗组主要选的穴位是内关、神门、百会、照海、申脉和三阴交;非穿刺假针刺对照组会在非经络穴位上进行运作。治疗结果是在治疗前后由匹兹堡睡眠质量评分量表衡量而做比较。结果：60位参与者当中,没有参与者脱落退出研究。共有60为患者完成治疗而被列入统计分析1.治疗前：有基线数据上两组间无统计学差异(P＞0.05),也在匹兹堡睡眠质量评分量表(PSQI)分数的差异,使得两组患者具有可比性。2.将常规针刺组和非穿刺假刺组治疗前后的匹兹堡睡眠质量评分量表的总分和其中的六项项目,睡眠时间、入睡时间、睡眠质量、睡眠效率、睡眠障碍、日常功能障碍积分进行组内比较, 经过t检验分析, P＜0.05, 差异有统计学意义。在治疗组的治疗前各成分和总分均比治疗后成分高, 研究显示常规针刺的治疗组对失眠在匹兹堡睡眠质量评分量表中的成分都有较好的改善作用。在对照组里,治疗前各成分,除了睡眠效率和睡眠障碍的部分,和总分均比治疗后成分高, 研究显示非穿刺假针的治疗组对失眠在匹兹堡睡眠质量评分量表中的成分也有部分的改善作用。对照组的匹兹堡睡眠质量评分量表治疗后的总分比对照组高, 而在各成分的积分经组间比较治疗组的疗效也优于对照组。3.观察的60例患者中,常规体刺针灸治疗组的临床总有效率为90%：9例治愈,13例显著改善,5例显效,和3例无效总30例患者;非穿刺假针灸的有效率为73.33%：6例治愈,7显著改善,9显效,和8例无效总30例患者.结论：在本临床研究结果发现, 常规针刺组和假针刺对照组对失眠的疗效都取得一定的效果, 都能一定的程度上改善失眠患者的匹兹堡睡眠质量评分量表的总分。治疗组在在治疗后的各成分积分上都比对照组优胜。虽然对照组大部分在治疗后的各成分评分都有好转, 却在睡眠效率和睡眠障碍上不没有改善。针灸是一个非药物治疗失眠的方法, 不但没有依赖性或耐药性的副作用, 也不会对人体造成严重的不良反应, 而且也是一个可以长期使用的一种治疗放法。

关键词：失眠针灸体针假针刺非穿刺匹兹堡睡眠质量评分

Comparison of implant related complications amongst patients with opioid use disorder and non-users following total knee arthroplasty

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World Journal of Orthopedics 2019年第3期10卷 137-144页

作者： Rushabh M Vakharia Karim G Sabeh Ajit M Vakharia Dhanur M Damodar Tsun yee law Martin W Roche Department of Orthopedic Surgery Holy Cross Orthopedic Institute Department of Orthopedic Surgery Massachusetts General Hospital Department of Medicine Morehouse School of Medicine Department of Orthopedic Surgery University of Miami Hospital

BACKGROUND The influence of opioid use disorder on implant related complications, infection and readmission rates, and total global episode-of-care costs following primary total knee arthroplasty(TKA) is *** To examine whether opioid abuse in patients undergoing primary *** A retrospective analysis of the Medicare dataset, using the PearlDiver database,from 2005-2014 comparing outcomes in patients with opioid abusers(OUD) to non-opioid abusers(NOU) undergoing primary TKA was performed. Patient outcomes were analyzed including implant complications, readmission rates, and day-of-surgery and 90-d cost. Statistical analysis was performed with R(University of Auckland, New Zealand) calculating odds-ratio(OR) along with their respective 95% confidence interval(95%CI) and *** The OUD group was at greater odds of having implant related complications overall(20.84% vs 11.25%; OR: 2.07; 95%CI: 1.93-2.23; P < 0.001). Revision(OR:2.07; 95%CI: 1.11-3.84; P < 0.001), infection(OR: 1.92; 95%CI: 1.72–2.18; P < 0.001),periprosthetic fractures(OR: 1.83; 95%CI: 1.16-4.79; P < 0.001), and 90-dreadmission rates(OR: 1.47, 95%CI: 1.35-1.61, P < 0.001) were also significantly increased. OUD patients also incurred in higher day-of-surgery and total global 90-d episode-of-care costs compared to *** Patients with OUD show an increased risk of complications compared to the nonopioid users group. Appropriate recognition, pre-surgical optimization, and patient education are essential to mitigate these complications and improve patient outcome.

关键词： Opioid use Total knee arthroplasty Medicare Database Cost Readmission rates

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一种抗污染攻击的传感器网络重编程方法

西北工业大学学报 2011年第3期29卷 443-448页

作者：张羽周兴社 yee Weilaw Marimuthu Palaniswami 西北工业大学计算机学院陕西西安710072 墨尔本大学电子工程系

现有安全重编程方案无法对基于网络编码技术的新一代重编程协议提供安全保护。文章针对上述缺陷,提出了一种抗污染攻击(pollution attacks)的安全重编程方法PRMR(Pollution-ResistantMethod for Reprogramm ing)。该方法利用组合技术实... 详细信息

现有安全重编程方案无法对基于网络编码技术的新一代重编程协议提供安全保护。文章针对上述缺陷,提出了一种抗污染攻击(pollution attacks)的安全重编程方法PRMR(Pollution-ResistantMethod for Reprogramm ing)。该方法利用组合技术实现污染攻击下的编码包正常译码;并通过邻居分类系统隔离污染者(polluters)。TOSSIM仿真实验表明在一个6度的无线传感器网络中,当20%的节点为污染者时,使用PRMR方法,重编程数据分发完成时间仅是无攻击情况下的2倍;每页也仅比无攻击情况下多执行70%的译码。

关键词：无线传感器网络重编程网络编码污染攻击组合技术邻居分类系统

新旧版马来西亚国小华文教材对比研究——以《一年级国小华文》和《一年级国小华语》为例

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新旧版马来西亚国小华文教材对比研究——以《一年级国小华文》和...

作者： law Puong yee（刘倗溢）华中师范大学

学位级别：硕士

在马来西亚这多种语言的环境下,非华裔的华语学习者学习华语并不容易。每一周学生学习华语的时间也受限制,这更增加了学校里华语教师在课堂上进行教学活动的难度。由此可见,一部好的华语教材对学生的学习、教师的授课扮演着重要的角色... 详细信息

在马来西亚这多种语言的环境下,非华裔的华语学习者学习华语并不容易。每一周学生学习华语的时间也受限制,这更增加了学校里华语教师在课堂上进行教学活动的难度。由此可见,一部好的华语教材对学生的学习、教师的授课扮演着重要的角色。马来西亚国民小学这近十五年期间的华语教材并不多,有《交际华语》、《国小华语》及《国小华文》。针对这些华语教材进行的研究可说是少之又少。因此,本文以马来西亚的两本国民小学汉语教材《一年级国小华文》和《一年级国小华语》为研究对象,对两本教材的基本信息、教材的编写体例以及教材语言知识的编排进行对比分析,指出两本教材的优缺点,并且提出改进的建议。本研究从五个角度展开,第一部分是本研究的绪论,介绍本研究的背景、研究现状、研究意义及研究方法;第二部分是对研究对象——新旧版马来西亚国民小学华语教材进行整体情况对比,从研究对象的书名、作者、编辑、出版社、印刷商、出版时间、适用对象、教材功能等角度展开;第三部分是对研究对象——新旧版马来西亚国民小学华语教材的编写体例进行对比分析,对教材的内容进行了探讨,分别从教材的单元导入、课文以及练习入手,具体分析两本教材在这些环节的呈现方式、编写所依据的原则及其编写的特点,同时也在对比分析后指出各环节所存在的问题,并给予相应的建议;第四部分是则对两本教材在语言知识编排上进行分析,主要从汉、词汇、语法和语音入手,对比分析两本教材在这些语言知识上具体选择的内容及在编写上的特色,同时也指出各部分在编写上存在的问题,提出一些针对性的建议;第五部分是本研究的结语,当中总结性地提出了马来西亚国民小学华语教材在编写上存在的问题及改进建议,也指出了本研究的不足之处及今后的研究计划。因编写理念与编写原则有别,两本教材的编写风格不同、各具特色。希望本研究能够为马来西亚汉语教材的编写提供一定的参考,同时也希望对今后马来西亚汉语教材的编写工作有所帮助。

关键词：马来西亚国民小学汉语教材一年级

Charge balance materials for homojunction and heterojunction OLED applications

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Frontiers of Optoelectronics 2009年第4期2卷 435-441页

作者： Louis M.LEUNG Yik-Chung law Michael Y.WONG Tik-Ho LEE Kin Ming LAI Lok-yee TANG Department of Chemistry and Centre for Advanced Luminescence Materials Hong Kong Baptist University

In a homojunction device, a single organic layer assumes the multiple roles of hole, electron transportation, and emitter. Its ease in processing is highly desirable from the manufacturing point of view. In this paper, we shall describe the synthesis of a range of bipolar small molecules and conductive vinyl polymers for application in homojunction and heterojunction organic light emitting diodes（OLEDs）. The bipolar materials, in general, consist of three basic building blocks: an arylamine, a 1,3,4-oxadiazole, and a polycyclic aromatic moiety. The achievement of charge balance can be validated either by direct measurement of electron/hole mobility or indirectly via optimization of device properties.A series of conductive vinyl copolymers containing hole transporting N-（4-methoxyphenyl）-N-（4-vinylphenyl）naphthalen-1-amine（4MeONPA） and electron transporting 2-phenyl-5-（4-vinylphenyl）-1,3,4-oxadiazole（OXA）at different compositions was applied for heterojunction and homojunction OLEDs. For heterojunction devices employed the copolymers as the hole transporting layer and Alq3as the electron transporting and emitting layer,a maximum luminance and current efficiency of over 23000 cd/m2and 4.2 cd/A（PL of Alq3）, respectively, were achieved at the charge balance composition. Homojunction devices for the copolymers were demonstrated by the addition of rubrene as a dopant. The single layer devices at the optimal copolymer composition has ca 1500 cd/m2and 0.74 cd/A.

关键词： homojunction devices charge balance bipolar small molecules conductive vinyl copolymers